She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    She was the real American heiress who lived long before Downton Abbey’s Lady Grantham arrived.Mme. Balsan is an unsnobbish and amused observer of the intricate hierarchy both upstairs and downstairs and a revealing witness to the glittering balls, huge weekend parties, and major state occasions she attended or hosted chronicling her encounters with every important figure of the day—from Queen Victoria, Edward VII and Queen Alexandra to Tsar Nicholas and the young Winston Churchill. This richly enjoyable memoir is a revealing portrait of a golden age now being celebrated every week behind the doors of Downton Abbey.

    and remarkable powers of concentration, Bobby memorized hundreds of chess books in several languages, and he was only 13 when he became the youngest chess master in U.S. history.   But his strange behavior started early.  In 1972, at the historic Cold War showdown in Reykjavik, Iceland, where he faced Soviet champion Boris Spassky, Fischer made headlines with hundreds of petty demands that nearly ended the competition.  It was merely a prelude to what was to come. Arriving back in the United States to a hero’s welcome, Bobby was mobbed wherever he went—a figure as exotic and improbable as any American pop culture had yet produced.  No player of a mere “board game” had ever ascended to such heights.  Commercial sponsorship offers poured in, ultimately topping $10 million—but Bobby demurred.  Instead, he began tithing his limited money to an apocalyptic religion and devouring anti-Semitic literature.   After years of poverty and a stint living on Los Angeles’ Skid Row, Bobby remerged in 1992 to play Spassky in a multi-million dollar rematch—but the experience only deepened a paranoia that had formed years earlier when he came to believe that the Soviets wanted him dead for taking away “their” title.  When the dust settled, Bobby was a wanted man—transformed into an international fugitive because of his decision to play in Montenegro despite U.S. sanctions.  Fearing for his life, traveling with bodyguards, and wearing a long leather coat to ward off knife attacks, Bobby lived the life of a celebrity fugitive – one drawn increasingly to the bizarre.  Mafiosi, Nazis, odd attempts to breed an heir who could perpetuate his chess-genius DNA—all are woven into his late-life tapestry.  And yet, as Brady shows, the most notable irony of Bobby Fischer’s strange descent – which had reached full plummet by 2005 when he turned down yet another multi-million dollar payday—is that despite his incomprehensible behavior, there were many who remained fiercely loyal to him.  Why that was so is at least partly the subject of this book—one that at last answers the question: “Who was Bobby Fischer?”

    The Muppets made Jim Henson a household name, but they were only part of his remarkable story.This extraordinary biography--written with the generous cooperation of the Henson family--covers the full arc of Henson's all-too-brief life: from his childhood in Leland, Mississippi, through the years of burgeoning fame in Washington D.C., New York, and London, to the decade of international celebrity that preceded his untimely death at age fifty-three. Drawing on hundreds of hours of new interviews with Jim Henson's family, friends, and closest collaborators, as well as unprecedented access to private family and company archives--including never-before-seen interviews, business documents, and Henson's private letters--Brian Jay Jones explores the creation of the Muppets, Henson's contributions to Sesame Street and Saturday Night Live, and his nearly ten year campaign to bring The Muppet Show to television. Jones provides the imaginative context for Henson's non-Muppet projects, including the richly imagined worlds of The Dark Crystal and Labyrinth-as well as fascinating misfires like Henson's dream of opening an inflatable psychedelic nightclub or of staging an elaborate, all-puppet Broadway show.An uncommonly intimate portrait, Jim Henson captures all the facets of this American original: the master craftsman who revolutionized the presentation of puppets on television, the savvy businessman whose deal making prowess won him a reputation as "the new Walt Disney," and the creative team leader whose collaborative ethos earned him the undying loyalty of everyone who worked for him. Here also is insight into Henson's intensely private personal life: his Christian Science upbringing; his love of fast cars, high-stakes gambling, and expensive art; and his weakness for women. Though an optimist by nature, Henson was haunted by the notion that he would not have time to do all the things he wanted to do in life-a fear that his heartbreaking final hours would prove all too well-founded.An up-close look at the charmed life of a legend, Jim Henson gives the full measure to a man whose joyful genius transcended age, language, geography, and culture-and continues to beguile audiences worldwide.

    Overnight, these women were transformed from military spouses into American royalty. They had tea with Jackie Kennedy, appeared on the cover of Life magazine, and quickly grew into fashion icons.Annie Glenn, with her picture-perfect marriage, was the envy of the other wives; JFK made it clear that platinum-blonde Rene Carpenter was his favorite; and licensed pilot Trudy Cooper arrived with a secret that needed to stay hidden from NASA. Together with the other wives they formed the Astronaut Wives Club, providing one another with support and friendship, coffee and cocktails.As their celebrity rose-and as divorce and tragedy began to touch their lives-the wives continued to rally together, forming bonds that would withstand the test of time, and they have stayed friends for over half a century. THE ASTRONAUT WIVES CLUB tells the story of the women who stood beside some of the biggest heroes in American history.

    By the age of twenty-three, he was on his first tour of America, facing an astonished audience in his tight silver hotpants, bare legs and a T-shirt with ROCK AND ROLL emblazoned across it in sequins. Elton John had arrived and the music world would never be the same again.His life has been full of drama, from the early rejection of his work with song-writing partner Bernie Taupin to spinning out of control as a chart-topping superstar; from half-heartedly trying to drown himself in his LA swimming pool to disco-dancing with the Queen; from friendships with John Lennon, Freddie Mercury and George Michael to setting up his AIDS Foundation. All the while, Elton was hiding a drug addiction that would grip him for over a decade.In Me Elton also writes about getting clean and changing his life, about finding love with David Furnish and becoming a father.

    But the true saga of her life has never been fully told. Now, drawing on unpublished manuscripts, letters, diaries, and land and financial records, Caroline Fraser—the editor of the Library of America edition of the Little House series—masterfully fills in the gaps in Wilder’s biography. Revealing the grown-up story behind the most influential childhood epic of pioneer life, she also chronicles Wilder's tumultuous relationship with her journalist daughter, Rose Wilder Lane, setting the record straight regarding charges of ghostwriting that have swirled around the books.The Little House books, for all the hardships they describe, are paeans to the pioneer spirit, portraying it as triumphant against all odds. But Wilder’s real life was harder and grittier than that, a story of relentless struggle, rootlessness, and poverty. It was only in her sixties, after losing nearly everything in the Great Depression, that she turned to children’s books, recasting her hardscrabble childhood as a celebratory vision of homesteading—and achieving fame and fortune in the process, in one of the most astonishing rags-to-riches episodes in American letters.Spanning nearly a century of epochal change, from the Indian Wars to the Dust Bowl, Wilder’s dramatic life provides a unique perspective on American history and our national mythology of self-reliance. With fresh insights and new discoveries, Prairie Fires reveals the complex woman whose classic stories grip us to this day.WINNER OF THE PULITZER PRIZEWINNER OF THE NATIONAL BOOK CRITICS CIRCLE AWARDWINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NON-FICTIONONE OF THE NEW YORK TIMES BOOK REVIEW'S 10 BEST BOOKS OF THE YEAROne of The New York Times Book Review's 10 Best Books of the YearThe first comprehensive historical biography of Laura Ingalls Wilder, the beloved author of the Little House on the Prairie books

    Over the course of two years, the impressionable teenager endured manipulation, psychological control, and physical abuse as the harsh realities and looming darkness of Charles Manson’s true nature revealed itself. From Spahn ranch and the group acid trips, to the Beatles’ White Album and Manson’s dangerous messiah-complex, Dianne tells the riveting story of the group’s descent into madness as she lived it.Though she never participated in any of the group’s gruesome crimes and was purposely insulated from them, Dianne was arrested with the rest of the Manson Family, and eventually learned enough to join the prosecution’s case against them. With the help of good Samaritans, including the cop who first arrested her and later adopted her, the courageous young woman eventually found redemption and grew up to lead an ordinary life.While much has been written about Charles Manson, this riveting account from an actual Family member is a chilling portrait that recreates in vivid detail one of the most horrifying and fascinating chapters in modern American history.Member of the Family includes 16 pages of photographs.

    Hotchner visited an old friend in the psychiatric ward of St. Mary's Hospital. It would be the last time they spoke: a few weeks later, Ernest Hemingway was released home, where he took his own life. Their final conversation was also the final installment in a story whose telling Hemingway had spread over nearly a decade.In characteristically pragmatic terms, Hemingway divulged to Hotchner the details of the affair that destroyed his first marriage: the truth of his romantic life in Paris and how he lost Hadley, the real part of each literary woman he'd later create and the great love he spent the rest of his life seeking. And he told of the mischief that made him a legend: of impotence cured in a house of God; of a plane crash in the African bush, from which he stumbled with a bunch of bananas and a bottle of gin in hand; of F. Scott Fitzgerald dispensing romantic advice; of midnight champagne with Josephine Baker; of adventure, human error, and life after lost love. This is Hemingway as few have known him: humble, thoughtful, and full of regret.To protect the feelings of Ernest's wife, Mary - also a close friend - Hotch kept the conversations to himself for decades. Now he tells the story as Hemingway told it to him. "Hemingway in Love "puts you in the room with the master as he remembers the definitive years that set the course for the rest of his life and dogged him until the end of his days.

    Selling the shoes from the trunk of his lime green Plymouth Valiant, Knight grossed $8,000 his first year. Today, Nike’s annual sales top $30 billion. In an age of startups, Nike is the ne plus ultra of all startups, and the swoosh has become a revolutionary, globe-spanning icon, one of the most ubiquitous and recognizable symbols in the world today.But Knight, the man behind the swoosh, has always remained a mystery. Now, for the first time, in a memoir that is candid, humble, gutsy, and wry, he tells his story, beginning with his crossroads moment. At 24, after backpacking around the world, he decided to take the unconventional path, to start his own business—a business that would be dynamic, different.Knight details the many risks and daunting setbacks that stood between him and his dream—along with his early triumphs. Above all, he recalls the formative relationships with his first partners and employees, a ragtag group of misfits and seekers who became a tight-knit band of brothers. Together, harnessing the transcendent power of a shared mission, and a deep belief in the spirit of sport, they built a brand that changed everything.

    Ted Williams was the best hitter in baseball history. This Red Sox legend's batting average of .406 in 1941 has not been topped since, and no player who has hit over 500 home runs has a higher career batting average. Those totals would have been even higher if Williams had not left baseball for nearly five years in the prime of his career to serve as a Marine pilot in World War II and Korea. He hit home runs as far as or farther than any player before him – and traveled a long way himself, as Ben Bradlee, Jr.'s, grand biography reveals. Born in 1918 in San Diego, Ted would spend most of his life disguising his Mexican heritage. During his 22 years with the Boston Red Sox, Williams electrified crowds across American–and shocked them, too: His notorious clashes with the press and fans threatened his reputation. Yet while he was a God in the batter's box, he was profoundly human once he stepped away from the plate. His ferocity came to define his troubled domestic life. While baseball might have been straightforward for Ted Williams, life was not. "The Kid" is biography of the highest literary order, a thrilling and honest account of a legend in all his glory and human complexity. In his final at-bat, Williams hit a home run. Bradlee's marvelous book clears the fences, too.

    Amaryllis Fox's memoir tells the story of her ten years in the most elite clandestine ops unit of the CIA, hunting the world's most dangerous terrorists in sixteen countries while marrying and giving birth to a daughter.

    The paint is the blood that splatters on the walls and floors. In the course of nearly five years of recorded interviews Frank Sheeran confessed to Charles Brandt that he handled more than twenty-five hits for the mob, and for his friend Hoffa. Sheeran learned to kill in the U.S. Army, where he saw an astonishing 411 days of active combat duty in Italy during World War II. After returning home he became a hustler and hit man, working for legendary crime boss Russell Bufalino. Eventually he would rise to a position of such prominence that in a RICO suit then-U.S. Attorney Rudy Giuliani would name him as one of only two non-Italians on a list of 26 top mob figures. When Bufalino ordered Sheeran to kill Hoffa, he did the deed, knowing that if he had refused he would have been killed himself. Sheeran's important and fascinating story includes new information on other famous murders, and provides rare insight to a chapter in American history. Charles Brandt has written a page-turner that is destined to become a true crime classic.

    What they don’t know is her trailblazing career was a happy accident. In this funny and intimate memoir, Penny takes us from the stage of The Jackie Gleason Show in 1955 to Hollywood’s star-studded sets, offering up some hilarious detours along the way.My Mother Was Nuts is an intimate backstage pass to Penny’s personal life, her breakout role on The Odd Couple, her exploits with Cindy Williams and John Belushi, and her travels across Europe with Art Garfunkel on the back of a motorcycle. We see Penny get married. And divorced. And married again (the second time to Rob Reiner). We meet a young Carrie Fisher, whose close friendship with Penny has spanned decades. And we see Penny at work with Tom Hanks, Mark Wahlberg, Whoopi Goldberg, Robert De Niro, and Whitney Houston.Throughout it all, from her childhood spent tap dancing in the Bronx, to her rise as the star of Laverne & Shirley, Penny lived by simple rules: “try hard, help your friends, don’t get too crazy, and have fun.” With humor and heart, My Mother Was Nuts reveals there’s no one else quite like Penny Marshall.