In riveting first-person prose, Dr. Brendan Reilly takes us to the front lines of medicine today. Whipsawed by daily crises and frustrations, Reilly must deal with several daunting challenges simultaneously: the extraordinary patients under his care on the teeming wards of a renowned teaching hospital; the life-threatening illnesses of both of his ninety-year-old parents; and the tragic memory of a cold case from long ago that haunts him still. As Reilly’s patients and their families survive close calls, struggle with heartrending decisions, and confront the limits of medicine’s power to cure, One Doctor lays bare a fragmented, depersonalized, business-driven health-care system where real caring is hard to find. Every day, Reilly sees patients who fall through the cracks and suffer harm because they lack one doctor who knows them well and relentlessly advocates for their best interests.Filled with fascinating characters in New York City and rural New England — people with dark secrets, mysterious illnesses, impossible dreams, and many kinds of courage — One Doctor tells their stories with sensitivity and empathy, reminding us of professional values once held dear by all physicians. But medicine has changed enormously during Reilly’s career, for both better and worse, and One Doctor is a cautionary tale about those changes. It is also a hopeful, inspiring account of medicine’s potential to improve people’s lives, Reilly’s quest to understand the "truth" about doctoring, and a moving testament to the difference one doctor can make.

    The latest edition offers greatly expanded coverage of directed mutagenesis and protein engineering, therapeutic agents, and genetic engineering of plants. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. Over 480 figures, including 200 that are new in this edition, illustrate all key concepts. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. As in previous editions, the authors clearly explain all concepts and techniques to provide maximum understanding of the subject, avoiding confusing scientific jargon and excessive detail wherever possible. Each chapter concludes with a summary, references, and review questions. Ideally suited as a text for third- and fourth-year undergraduates as well as graduate students, this book is also an excellent reference for health professionals, scientists, engineers, or attorneys interested in biotechnology.

    Packed with more than 400 photographs arranged in chronological order, this book covers everything from arson to connibalism, con men, mass murderers, sabotage, victims and vital clues.

    Jones was employed, confident, talented, smart, assertive and involved in many community activities in Indianapolis, Indiana. In contrast, when he was last seen, Brandon Sims, an only child, was a serious, quiet, thin boy who rarely maintained eye contact with his mother. After that night, he was never seen again. His body has never been found. For years Jones lied to her friends about Brandon, telling some that he was living with his father and others that he was staying with his grandmother in another state. When Brandon's father, who had been in jail, came looking for Brandon, Michelle's shocked friends confronted her. She confessed that Brandon was dead. She repeated her story of how Brandon died to a detective, after she admitted herself to the local psych unit. Days later she checked out of the unit and refused to reveal where he had hidden Brandon's body. She was sure she had gotten away with murder. And she would have except the detective didn't believe her story. He enlisted the help of a novice prosecutor because no experienced prosecutor would take the case. In Indiana, no one had ever been convicted of murder without a body. That prosecutor has written a book that reads like a mystery novel instead of the real murder prosecution. Truth is stranger than fiction where Santeria curses, the law and politics are only a few of obstacles to justice.

     In the vein of In Cold Blood, Closing Time is the stunning story of good and evil colliding in the most tragic of ways, both for the victims and their loved ones left behind to re-live their horror. Kenneth Staton was the well-respected owner of a jewelry store in Van Buren, Arkansas. Although crippled with rheumatoid arthritis and unable to walk without crutches, he had built his business through excellent watch repair work, fine quality jewelry sold at fair prices, and a dedication to his customers that surpassed all other merchants. He was the quintessential gentleman in all aspects of his life, and a beloved father. Unknown to him, two men—a seasoned criminal with a propensity for violence and a younger man, handsome, but broke and with an obsessive thirst for alcohol—plotted to rob the jewelry store at closing time on September 10, 1980. The thugs had only met each other days before, and it was the younger one's first venture into armed robbery. When Staton and his daughter Suzanne didn't show up for supper, his other two daughters became alarmed and went to the store. There they found the bodies of their father and youngest sister lying in pools of blood, gagged, hogtied, and shot twice in the head. Close to $100,000 dollars in diamonds and other jewelry had been stolen. This senseless, bloody crime rocked the town of Van Buren and set its lawmen, sworn to find the killers, on a fiercely determined hunt that led from Rogers, Arkansas to Jacksonville, Florida, and all the way to Vancouver, Canada. Seventeen years later, was justice served? Praise for Closing Time “Anita Paddock is the newest and strongest voice in true crime writing. Closing Time makes you feel as if you are there, seeing what happened, and feeling the terror and sorrow of those felled by these brutal crimes.” – Marla Cantrell, Editor of Do South Magazine and an Arkansas Art Council Fellow “Anita Paddock delivers again. Closing Time reveals an unvarnished truth that will, at times, leave her readers breathless. Those familiar with her work will quickly conclude that Closing Time is a worthy successor to her previous best seller, Blind Rage. Get ready for some late nights because you won’t be able to put this one down.” – Greg Shepard, author of Earthstains, the story of Matt and George Kimes who came of age in the Roaring Twenties with a string of sensational bank robberies.

    As gripping as CSI and as eye-opening as Mary Roach’s Stiff, Carney’s The Red Market sheds a blazing new light on the disturbing, billion-dollar business of trading in human body parts, bodies, and child trafficking, raising issues and exposing corruptions almost too bizarre and shocking to imagine.

    December 4, 1978.In an appalling demonstration of the way in which a charismatic leader can bend the minds of his followers with a devilish blend of professed altruism and psychological tyranny, some 900 members of the California-based Peoples Temple died in a self-imposed ritual of mass suicide and murder.The followers of the Rev. Jim Jones, 47, a once respected Indianaborn humanitarian who degenerated into egomania and paranoia, had first ambushed a party of visiting Americans, killing California Congressman Leo Ryan, 53, three newsmen and one defector from their heavily guarded colony at Jones-town. Then, exhorted by their leader, intimidated by armed guards and lulled with sedatives and painkillers, parents and nurses used syringes to squirt a concoction of potassium cyanide and potassium chloride onto the tongues of babies. The adults and older children picked up paper cups and sipped the same deadly poison sweetened by purple Kool-Aid.This story is part of the TIME Classic Coverage Collection from Time Inc. This is a reproduction of a story that appeared in the December 4, 1978 issue of TIME magazine. Time Inc. is one of the world’s most influential media companies – home to 90 iconic brands like People, Sports Illustrated, Time, InStyle, Real Simple, Food & Wine, and Fortune. The Spotlight Stories in this collection aim to provide you with a quick read on a single subject, highlighting our readers’ most popular stories and featuring great reporting from our Time Inc. journalists.

    John Snow. It's the summer of 1854, and London is just emerging as one of the first modern cities in the world. But lacking the infrastructure—garbage removal, clean water, sewers—necessary to support its rapidly expanding population, the city has become the perfect breeding ground for a terrifying disease no one knows how to cure. As the cholera outbreak takes hold, a physician and a local curate are spurred to action—and ultimately solve the most pressing medical riddle of their time. In a triumph of multidisciplinary thinking, Johnson illuminates the intertwined histories and inter-connectedness of the spread of disease, contagion theory, the rise of cities, and the nature of scientific inquiry, offering both a riveting history and a powerful explanation of how it has shaped the world we live in.

    Mumia Abu-Jamal was unanimously convicted of the crime by a racially mixed jury based on: the testimony of several eyewitnesses, his ownership of the murder weapon, matching ballistics, and Abu-Jamal’s own confession.After his conviction, however, a national anti-death penalty movement was started to “Free Mumia;” Mike Farrell, Ed Asner, Whoopi Goldberg, and Jesse Jackson rallied on his behalf, and led the charge.  For his part, while on death row, Abu-Jamal published several books, delivered radio commentaries, was a college commencement speaker, found himself named an Honorary Citizen of France, and had his defense coffers enhanced by ticket sales from a sold out (16,000-person) concert featuring Rage Against the Machine.Here, from Maureen Faulkner and acclaimed talk show host / journalist Michael Smerconish, is the first book to carefully and definitively lay out the case against Abu-Jamal, and those who’ve elevated him to the status of political prisoner. Smerconish, a lawyer, has provided pro bono legal counsel to Faulkner for over a decade and knows both the legal intricacies and personal subtleties of the case like no other person.  He’s personally acquainted himself with the more than five thousand pages of trial transcript.  “My reading starkly revealed that Abu-Jamal murdered Danny Faulkner in cold blood and that the case tried in Philadelphia in 1982 bore no resemblance to the one being home-cooked by the Abu-Jamal defense team.”As Abu-Jamal’s lawyers contemplate their final appeal, Faulkner and Smerconish weave a compelling, never-before-told account of one fateful night and the 25-year-long rewriting of history.

    An unpopular war. A military and diplomatic team in disarray. Those are the challenges President Obama has faced as he attempts to make a success of U.S involvement in Afghanistan. They are also the challenges President Truman surmounted in the winter of 1950 as he began managing a war in Korea that risked becoming bigger and more costly. It was the first significant armed conflict of the Cold War: United States troops under the command of General Douglas MacArthur came to the aid of the South Koreans after North Korea invaded. When Communist China entered the conflict on the side of the North Koreans, the crisis seemed on the verge of flaring into a world war. Truman was determined not to let that happen. MacArthur kept urging a widening of the war into China itself and ignoring his Commander in Chief. On April 11, 1951, after MacArthur had “shot his mouth off,” as one diplomat put it, one too many times, Truman fired him. The story of their showdown—one of the most dramatic in U.S. history between a Commander in Chief and his top soldier in the field—is captured in all its detail by David McCullough in his biography Truman, and presented here in a e-book called Truman Fires MacArthur (an excerpt of Truman, McCullough’s Pulitzer Prize-winning biography), which was the headline carried in many newspapers around the country the next day. Truman Fires MacArthur will continue to ride the headlines. It will go on sale as an ebook just as the Rolling Stone profile that exposed General Stanley McChrystal’s insurrection and forced his resignation hits newsstands, and media coverage of the showdown continues to draw historical analogies between Truman and Obama.

    In 1789 Ben Franklin wrote, "In this world nothing is certain but death and taxes." Death remains a certainty. But how do we die? It's the enormous variety of how that enlivens final exits.According to death certificates, in 1700 there were less than 100 causes of death. Today there are 3,000. With each advance of technology, people find new ways to become deceased, often causing trends that peak in the first year. People are now killed by everything, from cell phones, washing machines, lawn mowers and toothpicks, to the boundless catalog of man—made medicines. In Final Exits the causes of death—bizarre or common—are alphabetically arranged and include actual accounts of people, both famous and ordinary, who unfortunately died that way. (Ants, bad words, Bingo, bean bag chairs, flying cows, frozen toilets, hiccups, lipstick, moray eels, road kill, starfish, and toupees are only some of the more unusual causes.)

    This latest book gives you a precise regimen for self-treatment along with extensive information on other resources now available to you.

    Your brain can't function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together.Sekeres, who writes regularly for the Well section of the New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family's wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimacy of the conversations Sekeres has with his patients, and watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it--describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia.The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

    The Crime of the Decade in Wisconsin. WITH PHOTOS Teri Jendusa never dreamed she would marry a violent, malignant narcissist like David Larsen. But she did. Why? Simple. Larsen cleverly concealed his true nature until the marriage vows were final. David, an eventual church council president and model citizen, rapidly began to morph into a monster and sociopath, telling Teri on their wedding day, “Now, I own you.” Beaten and Left For Dead is a book about extreme marital violence, dominant control and psychological torment through the mind of the out-of-control David Larsen. It's also about survival, faith and a mother’s will to live for her children’s sake...as she faces death, face to face. This is an ideal book for women’s studies and book clubs as it looks inside a large women’s shelter, giving the reader a glimpse of a support network. The author also interviews a counselor who works with violent men with surprising results. Teri Jendusa-Nicolai continues to crusade for women’s issues to this day and currently works with a Wisconsin commission on domestic violence. EDITORIAL PRAISE "Teri Jendusa-Nicolai's story is a powerful example of the horrific lengths of barbarism a man can go to when he considers a woman his personal property. And it is, equally, an inspiring, riveting story of a woman's courage and clear thinking under the absolute worst of conditions, and of her tenacious hold to life...I am so grateful to Teri Jendusa-Nicolai and to Dave Alfvin for getting this story out to us. Don't miss it." --Lundy Bancroft, best-selling author on domestic violence, trainer, and activist on male violence against women "This book is important because it gets our message out as to what we do to help abusers change their value systems." --Maureen Manning-Rosenfeld, Clinical Professional Counselor

    In this groundbreaking analysis, over thirty of the most popular treatments—acupuncture, homeopathy, aromatherapy, reflexology, chiropractic, and herbal medicines—are examined for their benefits and potential dangers. Questions answered include: What works and what doesn't? What are the secrets, and what are the lies? Who can you trust, and who is ripping you off? Can science decide what is best, or do the old wives' tales really tap into ancient, superior wisdom?In their scrutiny of alternative and complementary cures, authors Simon Singh and Edzard Ernst also strive to reassert the primacy of the scientific method as a means for determining public health practice and policy.