Robert Marion, whose bestselling book "The Intern Blues" is revered by doctors of all ages, offers a powerful and moving account of his experiences in modern genetics. His gripping stories illuminate a cutting-edge field of impossible moral complexities and incredible scientific breakthroughs that draw him deep into the lives of his patients and their families when they need him the most. Genetics is a specialty of secrets. After thirty years as a pediatric geneticist in New York City, Dr. Robert Marion knows things about his patients that their friends, their families, and even they themselves do not. Having access to this kind of inside information is at once a terrific honor and a terrible burden. It requires Dr. Marion to play detective, philosopher, physician, and friend, sometimes all over the course of a single visit.In "Genetic Rounds," he tells the surprising true stories of daily life as a clinical geneticist. From the girl whose bones break at the lightest touch to the boy who is unable to sweat, Dr. Marion imparts the life-long lessons he has learned from his most incredible cases. He walks us through perplexing medical puzzles that have sharpened his wit and transformed him into a Sherlock Holmes in his field. He shares ingenious practical insights that have changed his patients' lives. And he delves into the moral quandaries through which his patients in turn have changed his life: Should he wait until after Christmas to break bad news to a frightened family? Should he tell a close friend that his daughter may have a life-threatening, previously undiagnosed disease? And, most importantly, how can he persevere in a specialty that deals with so much heartbreak?The first book of its kind, "Genetic Rounds" is the story of a remarkable doctor in a field unlike any other. With unforgettable candor and compassion, Dr. Marion not only explores the human side of medicine: he shows what medicine can teach us about being human.""Genetic Rounds "is part medical detective story, part scientific tour de force, and part highly personal and emotional story of a doctor and the children and families who have shaped his career and his life in this fascinating field." --Perri Klass, MD, author of "Treatment Kind and Fair: Letters to a Young Doctor"From "Genetic Rounds""I've learned that in medicine, virtually anything is possible, that no matter how difficult or unlikely a situation might be, with hard work, perseverance, persistence, and the ability to work with people who are brilliant and creative, miracles can happen."Praise for "The Intern Blues""A candid . . . gripping account." --The New York Times Book Review"A thought-provoking study of real human beings." --Booklist"An important book for anyone contemplating the long, arduous task of becoming a doctor." --Library JournalPraise for "Learning to Play God""Clear, immediate and moving . . . provides as good a feel for the texture of medical training as any I've read." --The New York Times Book Review

    Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments — quite different from one patient to the next — of chronic multisystem inflammatory illnesses of unclear cause. Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease. The frequency and magnitude of the improvements Dr. Afrin has seen — even the relief that comes from finally having a unifying diagnosis other than "psychosomatism" — have spurred him to focus in this area, not only tending to the needs of his patients but also pursuing research to advance our understanding of the disease and helping to educate other professionals who in turn can help even more of the many people who have long been suffering not only the symptoms of the disease but also the natural concern of not understanding why one would be so "unlucky" to have acquired so many medical problems. As it turns out, such patients are not so unlucky and truly have just one root issue (and a very common one at that), which has the biological capability to develop, directly or indirectly, into most or all of their previously diagnosed problems. There is a great deal yet to learn about this, but even with just the present very limited understanding, the opportunity to diagnose and help patients with MCAS seems to be enormous and Dr. Afrin felt a description of the disease, written for the general public, might help lead some MCAS patients on a journey to diagnosis and improvement sooner rather than later. Dr. Afrin hopes this book will help people who might have, or do have, MCAS. A portion of the proceeds of purchases of this book will go to support research and education in this area.

    He, alone, masters in one mind the fields of aviation, health care safety, medical malpractice law, organizational sociology, media communication, and, as if that were not enough, the art of fine writing. Only he could have made sophisticated, scientifically disciplined instruction about the nature and roots of safety into a page-turner. Medical care has a ton yet to learn from the decades of progress that have brought aviation to unprecedented levels of safety, and, in instructing us all about those lessons, John Nance is not just a bridge-builder - he is the bridge. This book should be required reading for anyone willing to face the facts about what it will take for health care to be as safe as it truly can be." Donald M. Berwick, MD, MPP President and CEO Institute for Healthcare Improvement (IHI)

    But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still... until now. In this game-changing book, University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into the story of Western medicine, how we have got it wrong as well as right in the past, and how we could start getting to grips with depression and other mental disorders much more effectively in the future.

    And there is no more accomplished and accessible guide than renowned neuroscientist David Eagleman to help us understand the nature and changing texture of that fabric. With his hallmark clarity and enthusiasm he reveals the myriad ways that the brain absorbs experience: developing, redeploying, organizing, and arranging the data it receives from the body's own absorption of external stimuli, which enables us to gain the skills, the facilities, and the practices that make us who we are. Eagleman covers decades of the most important research into the functioning of the brain and presents new discoveries from his own research as well: about the nature of synesthesia, about dreaming, and about wearable devices that are revolutionizing how we think about the five human senses. Finally, Livewired is as deeply informative as it is accessible and brilliantly engaging.

    Useful for health workers, clinicians, and others involved in primary health care delivery and health promotion programs, with millions of copies in print in more than 75 languages, the manual provides practical, easily understood information on how to diagnose, treat, and prevent common diseases. Special attention is focused on mutrition, infection and disease prevention, and diagnostic techniques as primary ways to prevent and treat health problems. This 2010 reprint features updated medicines, plus information on tuberculosis and HIV, including guidelines for anti-retroviral therapy and preventing HIV in babies.

    Often they seem aloof, uncaring, and hurried. Of course, they’re not all like that, and most didn’t start out that way. Here are voices of third-year students just as they begin to take on clinical responsibilities. Their words focus on the odd transition students face when they must deal with real people in real time and in real crises and when they must learn to put aside their emotions to make quick, accurate, and sensitive decisions. Their decisions aren’t always right, and the consequences can be life-altering—for all involved. Moving, disturbing, and candid, their true stories show us a side of the profession that few ever see, or could even imagine. They show, often painfully, how medical students grow up, right at the bedside.

    The DSM is the bible of psychiatry; the go-to place to find out who is sick and who is not. Because it will radically stretch the boundaries of what is and what is not a psychiatric illness, DSM 5 will dramatically change how lives are lived. Under DSM 5's new definitions, millions of people now considered normal will be diagnosed as mentally ill, causing unnecessary, costly, and sometimes dangerous treatments for misidentified 'patients' who don't really need them.Will the DSM 5 destroy what is considered normal?Frances argues that DSM 5 offers a radical and reckless set of proposals that will overnight turn 'normal' people into 'mental patients'. Everyday aches, pains, disappointments, stresses, and existential sufferings are being reframed as mental illnesses with such exuberance that it is getting hard for anyone to get through life without a psychiatric diagnosis. Is grief a useful, inevitable and poignant sign of a broken heart or is it Major Depressive Disorder? Are temper tantrums a normal part of childhood or a sign of mental illness? Are you nervous about an upcoming presentation or job interview or do you have Mixed Anxiety Depression? If you don't remember a face or a fact once in a while, do you have Dementia?Frances maintains we all have psychiatric symptoms from time to time, but this doesn't mean we are all flirting with mental illness. Whenever we arbitrarily add a new 'disease', we subtract from what previously was 'normal' and lose something of ourselves in the process. Not all human suffering can or should be labeled and treated away. The grief and sorrows, the stresses, the disappointments, the aches and pains, the slings and arrows, the innate and acquired inequalities, the set-backs, the stumbles, the emotional gut-shots; this is part of life and of living in a complex and not always fair society- they should not all to be explained away as psychiatric disease.

    It provides information on how drugs enter the body, how they manipulate the brain, their short- & long-term effects, the high they produce & the circumstances in which they can be deadly. psychological & pharmacological research on drugs. Whether the reader is a student confronted by drugs for the first time, an accountant reaching for another cup of coffee, or a health educator, this book aims to provide a clear understanding of how drugs work & the consequences of their use.

    That means most people alive today will spend more years in elderhood than in childhood, and many will be elders for 40 years or more. Yet at the very moment that humans are living longer than ever before, we've made old age into a disease, a condition to be dreaded, denigrated, neglected, and denied. Reminiscent of Oliver Sacks, noted Harvard-trained geriatrician Louise Aronson uses stories from her quarter century of caring for patients, and draws from history, science, literature, popular culture, and her own life to weave a vision of old age that's neither nightmare nor utopian fantasy--a vision full of joy, wonder, frustration, outrage, and hope about aging, medicine, and humanity itself. Elderhood is for anyone who is, in the author's own words, "an aging, i.e., still-breathing human being."

    Yet when a friend or relative is under duress many of us feel uncertain about how to cope.Throughout her recent bout with breast cancer, Letty Cottin Pogrebin became fascinated by her friends’ and family’s diverse reactions to her and her illness: how awkwardly some of them behaved; how some misspoke or misinterpreted her needs; and how wonderful it was when people read her right. She began talking to her fellow patients and dozens of other veterans of serious illness, seeking to discover what sick people wished their friends knew about how best to comfort, help, and even simply talk to them.Now Pogrebin has distilled their collective stories and opinions into this wide-ranging compendium of pragmatic guidance and usable wisdom. Her advice is always infused with sensitivity, warmth, and humor. It is embedded in candid stories from her own and others’ journeys, and their sometimes imperfect interactions with well-meaning friends. How to Be a Friend to a Friend Who’s Sick is an invaluable guidebook for anyone hoping to rise to the challenges of this most important and demanding passage of friendship.

    Sarno saved me from a life of pain.” — Howard Stern  The New York Times bestseller that has helped thousands leverage the mind-body connection to heal lower back pain and live pain free—without drugs, surgery, or physical therapy.  Offering a surprising, noninvasive solution to an epidemic of pain, Dr. John E. Sarno’s research on TMS (Tension Myoneural Syndrome) reveals that stress, anxiety and other psychological factors, not structural abnormalities, are the root cause of chronic pain. TMS develops as a result of repressed emotions which trigger tension in the body and deprive muscles and nerves of oxygen. The solution? Recognize the emotional roots of your TMS and sever the connection between mental and physical pain. With Dr. Sarno’s expert guidance you will learn:How the mind-body connection can permanently heal shoulder, neck, and lower back painHow accepting negative emotions like anger, anxiety, fear, or grief can reverse physical symptomsHow we condition ourselves to think back pain is inevitableWhy you should resume physical activity as soon as possibleSharing case histories and the results of his extensive, groundbreaking research, Dr. Sarno’s life-changing insights show readers how to banish back pain and reclaim their lives for good.

    Understand how to use groundbreaking science to improve your health, mood, and more.In just the last few years, scientists have shown how the microscopic ecosystem within our bodies—particularly within our intestines—has an astonishing impact on our lives. Pioneering scientist Rob Knight and award-winning science journalist Brendan Buhler explain—with humor and witty metaphors—why these new findings matters to everyone.You are mostly not you. The human gut is host to trillions of microbes, and evidence shows that small changes in these microbes present (altered by antibiotics, diet, geographic region, and so on) may affect weight, likelihood of disease, and even psychological factors like risk-taking behavior. The evidence for their influence is astonishing. Rob Knight is one of the key figures driving forward this new science. His work demonstrates the startling connection between the presence of certain harmless bacteria and the health benefits we all seek for ourselves and our children.In Follow Your Gut, Knight pairs with Brendan Buhler, an award-winning science writer, to explore the previously unseen world inside our bodies. With a practical eye toward deeper knowledge and better decisions, they lead a detailed tour of our microbiome as well as an exploration of the known effects of antibiotics, probiotics, diet choices, birth method, and access to livestock on our children's lifelong health. Ultimately, this pioneering book explains how to learn about your own micro biome and take steps toward understanding and improving your health, using the latest research as a guide.

    And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization.From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again.Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

    But it was only when his own son-in the throes of a manic episode-broke into a neighbor's house that he learned what happens to mentally ill people who break a law. This is the Earley family's compelling story, a troubling look at bureaucratic apathy and the countless thousands who suffer confinement instead of care, brutal conditions instead of treatment, in the "revolving doors" between hospital and jail. With mass deinstitutionalization, large numbers of state mental patients are homeless or in jail-an experience little better than the horrors of a century ago. Earley takes us directly into that experience-and into that of a father and award-winning journalist trying to fight for a better way.