The germ revolution came after two decades of scientific virtuosity, outstanding feats of intellectual courage and bitter personal rivalries, doctors at last recognised that infectious diseases are caused by mircoscopic organisms.

    A bold foray into the heart of the American West’s final frontier, the expedition was achieved without benefit of modern river-running equipment, supplies, or a firm sense of the region’s perilous topography and the attitudes of the native inhabitants towards whites.For more than seventy years, Penguin has been the leading publisher of classic literature in the English-speaking world. With more than 1,700 titles, Penguin Classics represents a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.

    But AIDS is just one of the many emerging viruses for which we have, as yet, no cure. Even the old plagues – TB, cholera, bubonic plague – are making a comeback, resistant now to our drugs.Frank Ryan, a leading authority on disease, describes the groundbreaking research of the world’s leading experts in the field to show both where these viruses come from and why they prove to be so lethal, and advances a radical new biological theory for the origins and behaviour of plague viruses. Full of vivid despatches from the front line of research and medicine, 'Virus X' is terrifying and essential reading for anyone interested in the effects of plague viruses on human evolution.“Extremely well written…Frank Ryan has the page-turning and spine-chilling ability of a good novelist”MATT RIDLEY, 'Sunday Telegraph'“Compelling and frightening…the plot could not be bettered”MICHAEL SMITH, 'Scotsman'“Ryan is very good at making technical matters comprehensible to the lay reader but more impressive still is the way he conveys the intellectual excitement and elation of scientific discovery”ANTHONY DANIELS, 'Literary Review'“Ryan takes us through the drama of discovery and challenges the notion that certain questions are too appalling to contemplate”DAVID BRADLEY, 'New Scientist'“Dr Ryan writes well in a difficult technical field, weaving the technicalities of scientific history, medicine, molecular biology and evolution into the human narratives…very readable and disturbing”JOHN R.G. TURNER, 'New York Times'

    In this groundbreaking analysis, over thirty of the most popular treatments—acupuncture, homeopathy, aromatherapy, reflexology, chiropractic, and herbal medicines—are examined for their benefits and potential dangers. Questions answered include: What works and what doesn't? What are the secrets, and what are the lies? Who can you trust, and who is ripping you off? Can science decide what is best, or do the old wives' tales really tap into ancient, superior wisdom?In their scrutiny of alternative and complementary cures, authors Simon Singh and Edzard Ernst also strive to reassert the primacy of the scientific method as a means for determining public health practice and policy.

    But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them.   A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

    Researchers are delving into the mysteries of stem cells and the human genome, discovering what it means to grow old and how to keep those processes from happening. This isn't science fiction; it's real, it's serious, and it's on track to revolutionize our definitions of life and mortality.In Immortality, Inc., veteran science journalist Chip Walter gains exclusive access to the champions of this radical cause, delivering a book that brings together for the first time the visions of molecular biologist and Apple chairman Arthur Levinson, genomics entrepreneur Craig Venter, futurist Ray Kurzweil, rejuvenation trailblazer Aubrey de Grey, and stem cell expert Robert Hariri. Along the way, Walter weaves in fascinating conversations about life, death, aging, and the future of the human race.

    Garfield was one of the most extraordinary men ever elected president. Born into abject poverty, he rose to become a wunderkind scholar, a Civil War hero, and a renowned and admired reformist congressman. Nominated for president against his will, he engaged in a fierce battle with the corrupt political establishment. But four months after his inauguration, a deranged office seeker tracked Garfield down and shot him in the back. But the shot didn’t kill Garfield. The drama of what hap­pened subsequently is a powerful story of a nation in tur­moil. The unhinged assassin’s half-delivered strike shattered the fragile national mood of a country so recently fractured by civil war, and left the wounded president as the object of a bitter behind-the-scenes struggle for power—over his administration, over the nation’s future, and, hauntingly, over his medical care. A team of physicians administered shockingly archaic treatments, to disastrous effect. As his con­dition worsened, Garfield received help: Alexander Graham Bell, the inventor of the telephone, worked around the clock to invent a new device capable of finding the bullet. Meticulously researched, epic in scope, and pulsating with an intimate human focus and high-velocity narrative drive, The Destiny of the Republic will stand alongside The Devil in the White City and The Professor and the Madman as a classic of narrative history.

    . . refuge and home to poets and gangsters, tycoons and politicians, preachers and outlaws, musicians and spiritualists, outcasts and rebels . . . Stephen Silverman and Raphael Silver tell of the turning points that made the Catskills so vital to the development of America: Henry Hudson’s first spotting the distant blue mountains in 1609; the New York State constitutional convention, resulting in New York’s own Declaration of Independence from Great Britain and its own constitution, causing the ire of the invading British army . . . the Catskills as a popular attraction in the 1800s, with the construction of the Catskill Mountain House and its rugged imitators that offered WASP guests “one-hundred percent restricted” accommodations (“Hebrews will knock vainly for admission”), a policy that remained until the Catskills became the curative for tubercular patients, sending real-estate prices plummeting and the WASP enclave on to richer pastures . . . Here are the gangsters (Jack “Legs” Diamond and Dutch Schultz, among them) who sought refuge in the Catskill Mountains, and the resorts that after World War II catered to upwardly mobile Jewish families, giving rise to hundreds of hotels inspired by Grossinger’s, the original “Disneyland with knishes”—the Concord, Brown’s Hotel, Kutsher’s Hotel, and others—in what became known as the Borscht Belt and Sour Cream Alps, with their headliners from movies and radio (Phil Silvers, Eddie Cantor, Milton Berle, et al.), and others who learned their trade there, among them Moss Hart (who got his start organizing summer theatricals), Sid Caesar, Lenny Bruce, Mel Brooks, Woody Allen, and Joan Rivers. Here is a nineteenth-century America turning away from England for its literary and artistic inspiration, finding it instead in Washington Irving’s “Rip Van Winkle” and his childhood recollections (set in the Catskills) . . . in James Fenimore Cooper’s adventure-romances, which provided a pastoral history, describing the shift from a colonial to a nationalist mentality . . . and in the canvases of Thomas Cole, Asher B. Durand, Frederick Church, and others that caught the grandeur of the wilderness and that gave texture, color, and form to Irving’s and Cooper’s imaginings. Here are the entrepreneurs and financiers who saw the Catskills as a way to strike it rich, plundering the resources that had been likened to “creation,” the Catskills’ tanneries that supplied the boots and saddles for Union troops in the Civil War . . . and the bluestone quarries whose excavated rock became the curbs and streets of the fast-growing Eastern Seaboard.  Here are the Catskills brought fully to life in all of their intensity, beauty, vastness, and lunacy.

    But James Oakes’s brilliant history of Lincoln’s antislavery strategies reveals a striking consistency and commitment extending over many years. The linchpin of antislavery for Lincoln was the Constitution of the United States.Lincoln adopted the antislavery view that the Constitution made freedom the rule in the United States, slavery the exception. Where federal power prevailed, so did freedom. Where state power prevailed, that state determined the status of slavery, and the federal government could not interfere. It would take state action to achieve the final abolition of American slavery. With this understanding, Lincoln and his antislavery allies used every tool available to undermine the institution. Wherever the Constitution empowered direct federal action—in the western territories, in the District of Columbia, over the slave trade—they intervened. As a congressman in 1849 Lincoln sponsored a bill to abolish slavery in Washington, DC. He reentered politics in 1854 to oppose what he considered the unconstitutional opening of the territories to slavery by the Kansas–Nebraska Act. He attempted to persuade states to abolish slavery by supporting gradual abolition with compensation for slaveholders and the colonization of free Blacks abroad.President Lincoln took full advantage of the antislavery options opened by the Civil War. Enslaved people who escaped to Union lines were declared free. The Emancipation Proclamation, a military order of the president, undermined slavery across the South. It led to abolition by six slave states, which then joined the coalition to affect what Lincoln called the "King’s cure": state ratification of the constitutional amendment that in 1865 finally abolished slavery.

    Drawing partly on his own career—from young scientist in awe of his elders to crotchety elder statesman—Tattersall offers an idiosyncratic look at the competitive world of paleoanthropology, beginning with Charles Darwin 150 years ago, and continuing through the Leakey dynasty in Africa, and concluding with the latest astonishing findings in the Caucasus.The book's title refers to the 1856 discovery of a clearly very old skull cap in Germany's Neander Valley. The possessor had a brain as large as a modern human, but a heavy low braincase with a prominent brow ridge. Scientists tried hard to explain away the inconvenient possibility that this was not actually our direct relative. One extreme interpretation suggested that the preserved leg bones were curved by both rickets, and by a life on horseback. The pain of the unfortunate individual's affliction had caused him to chronically furrow his brow in agony, leading to the excessive development of bone above the eye sockets.The subsequent history of human evolutionary studies is full of similarly fanciful interpretations. With tact and humor, Tattersall concludes that we are not the perfected products of natural processes, but instead the result of substantial doses of random happenstance.

     The Viking Age! A brief footprint in the course of history that impacted generations hundreds of years into the future. You will dive into the depths of Scandinavia to find out what made the Vikings the most feared group of people in the European Middle Ages. Experts at warfare and navigating the high seas, the Vikings were on a mission and would not let anyone stand in their way! Brutal conquerors they were, but the Vikings were no mere savages. The Vikings had a unique culture and society that spread much influence through transcontinental trade and exploration into unknown worlds. Navigate the Vikings' journey from their first encounters with the inhabitants of the British Isles to their discoveries of Greenland and North America. Along the way, meet some of the most famous Vikings to ever walk the face of the Earth. You will meet the infamous legend Ragnar Lothbrok whose very existence is shrouded in mystery. Step into the shoes of the first European explorer to step foot onto the lands of North America, Leif Erikson. Countless other warriors, kings, and explorers left their mark that paved the path the world has taken to this very day. Get your copy now! Relive their journeys through the eyes of a Viking and discover the makings of this fascinating civilization!

    Written in a concise, bulleted outline format, this well-illustrated text offers 500 USMLE-style review questions, answers, and explanations and features comprehensive content and upgraded USMLE Step 1 information.

     Three and a half billion years ago, Mars resembled earth. It was warm and wet and could have supported primitive organisms. If life once existed on Mars, might it have originated there and traveled to earth inside meteorites blasted into space by cosmic impacts? Davies builds on recent scientific discoveries and theories to address larger questions of existence: What, exactly, is life? Is it the inevitable by-product of physical laws, as many scientists maintain, or an almost miraculous accident? Are we alone in the universe, or will life emerge on all earthlike planets? And if there is life elsewhere in the universe, is it preordained to evolve toward greater complexity and intelligence? Through his search for answers to these questions, Davies explores the ultimate mystery of mankind's existence -- who we are and what our place might be in the unfolding drama of the cosmos.

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

    It housed America's most impoverished immigrants-the Irish, Jews, Germans, Italians, and African-Americans. Located in today's Chinatown and Little Italy, Five Points played host to more riots, scams, prostitution, and drunkenness than any other neighborhood in America. But it was also crammed full of cheap theaters, dance halls, prizefighting venues, and political arenas that would one day dominate the national scene. From Jacob Riis to Abraham Lincoln, Davy Crockett to Charles Dickens, Five Points horrified and enthralled everyone who saw it. Drawing from letters, diaries, newspapers, bank records, police reports, and archeological digs, award-winning historian Tyler Anbinder has written the first history of this remarkable neighborhood. Beginning with the Irish potato famine influx in 1840 and ending with the rise of Chinatown in the early 20th century, the story of Five Points serves as a microcosm of the American immigrant experience.