As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    You discover that she has the same birthday, the same allergies, the same tics, and the same way of laughing. Looking at this person, you are able to gaze into your own eyes and see yourself from the outside. This identical individual has the exact same DNA as you and is essentially your clone.We don’t have to imagine.Elyse Schein had always known she was adopted, but it wasn’t until her mid-thirties while living in Paris that she searched for her biological mother. When Elyse contacted her adoption agency, she was not prepared for the shocking, life-changing news she received: She had an identical twin sister. Elyse was then hit with another bombshell: she and her sister had been separated as infants, and for a time, had been part of a secret study on separated twins.Paula Bernstein, a married writer and mother living in New York, also knew she was adopted, but had no inclination to find her birth mother. When she answered a call from the adoption agency one spring afternoon, Paula’s life suddenly divided into two starkly different periods: the time before and the time after she learned the truth. As they reunite and take their tentative first steps from strangers to sisters, Paula and Elyse are also left with haunting questions surrounding their origins and their separation. They learn that the study was conducted by a pair of influential psychiatrists associated with a prestigious adoption agency. As they investigate their birth mother’s past, Paula and Elyse move closer toward solving the puzzle of their lives.In alternating voices, Paula and Elyse write with emotional honesty about the immediate intimacy they share as twins and the wide chasm that divides them as two complete strangers. Interweaving eye-opening studies and statistics on twin science into their narrative, they offer an intelligent and heartfelt glimpse into human nature. Identical Strangers is the amazing story of two women coming to terms with the strange and unbelievable hand fate has dealt them, an account that broadens the definition of family and provides insight into our own DNA and the singularly exceptional imprint it leaves on our lives.

    Brought up in Washington, DC, in an abusive family, she went to Harvard, where she met her husband. They stayed together through medical school until two months before she was scheduled to join the staff of a hospital in central Philadelphia, when he told her he couldn't move with her. Her marriage at an end, Harper began her new life in a new city, in a new job, as a newly single woman.In the ensuing years, as Harper learned to become an effective ER physician, bringing insight and empathy to every patient encounter, she came to understand that each of us is broken—physically, emotionally, psychically. How we recognize those breaks, how we try to mend them, and where we go from there are all crucial parts of the healing process.The Beauty in Breaking is the poignant true story of Harper's journey toward self-healing. Each of the patients Harper writes about taught her something important about recuperation and recovery. How to let go of fear even when the future is murky. How to tell the truth when it's simpler to overlook it. How to understand that compassion isn't the same as justice. As she shines a light on the systemic disenfranchisement of the patients she treats as they struggle to maintain their health and dignity, Harper comes to understand the importance of allowing ourselves to make peace with the past as we draw support from the present. In this hopeful, moving, and beautiful book, she passes along the precious, necessary lessons that she has learned as a daughter, a woman, and a physician.

    . . or it might have been last night, when you watched three episodes in a row. But either way, fifteen years after the show first aired, it's more popular than ever, and fans have only one problem--what to watch, or read, next.Fortunately, Rolling Stone writer Andy Greene has that answer. In his brand-new oral history, The Office: The Untold Story of the Greatest Sitcom of the 2000s, Greene will take readers behind the scenes of their favorite moments and characters. Greene gives us the true inside story behind the entire show, from its origins on the BBC through its impressive nine-season run in America, with in-depth research and exclusive interviews. Fans will get the inside scoop on key episodes from "The Dundies" to "Threat Level Midnight" and "Goodbye, Michael," including behind-the-scenes details like the battle to keep it on the air when NBC wanted to pull the plug after just six episodes and the failed attempt to bring in James Gandolfini as the new boss after Steve Carell left, spotlighting the incredible, genre-redefining show created by the family-like team, who together took a quirky British import with dicey prospects and turned it into a primetime giant with true historical and cultural significance.Hilarious, heartwarming, and revelatory, The Office gives fans and pop culture buffs a front-row seat to the phenomenal sequence of events that launched The Office into wild popularity, changing the face of television and how we all see our office lives for decades to come.

    Though he grew up in a large Irish-Catholic family, Jim was satisfied with the nomadic, nocturnal life of a standup comedian, and was content to be "that weird uncle who lives in an apartment by himself in New York that everyone in the family speculates about." But all that changed when he married and found out his wife, Jeannie "is someone who gets pregnant looking at babies."Five kids later, the comedian whose riffs on everything from Hot Pockets to Jesus have scored millions of hits on YouTube, started to tweet about the mistakes and victories of his life as a dad. Those tweets struck such a chord that he soon passed the million followers mark. But it turns out 140 characters are not enough to express all the joys and horrors of life with five kids, so hes' now sharing it all in Dad Is Fat.From new parents to empty nesters to Jim's twenty-something fans, everyone will recognize their own families in these hilarious takes on everything from cousins ("celebrities for little kids") to growing up in a big family ("I always assumed my father had six children so he could have a sufficient lawn crew") to changing diapers in the middle of the night ("like The Hurt Locker but much more dangerous") to bedtime (aka "Negotiating with Terrorists").Dad is Fat is sharply observed, explosively funny, and a cry for help from a man who has realized he and his wife are outnumbered in their own home.

    Every passerby was an actor; every car would magically stop for him; everything he saw was a cue from "The Producer" to help inspire the performance of a lifetime. After a manic spree around Manhattan, Zack, who is bipolar, was arrested on a subway platform and admitted to Bellevue Hospital. So begins the story of Zack's freefall into psychosis and his desperate, poignant, often darkly funny struggle to claw his way back to sanity. It's a journey that will take him from New York City back to his Kansas roots and to the one person who might be able to save him, his tough, big-hearted Midwestern mother, nicknamed the Bird, whose fierce and steadfast love is the light in Zack's dark world. Before his odyssey is over, Zack will be tackled by guards in mental wards, run naked through cornfields, receive secret messages from the TV, befriend a former Navy Seal and his talking stuffed monkey, and see the Virgin Mary in the whorls of his own back hair. But with the Bird's help, he just might have a shot at pulling through, starting over, and maybe even meeting a woman who can love him back, bipolar and all. Written with raw emotional power, humor, and tenderness, GORILLA AND THE BIRD is a bravely honest account of a young man's unraveling and the relationship that saves him.

    A failed salesman turned local reporter, he wanted to test himself, see how he might respond to pressure and danger. He signed up for emergency medical training and became, at age twenty-six, a newly minted EMT running calls in the worst sections of Atlanta. His life entered a different realm—one of blood, violence, and amazing grace.Thoroughly intimidated at first and frequently terrified, he experienced on a nightly basis the adrenaline rush of walking into chaos. But in his downtime, Kevin reflected on how people’s facades drop away when catastrophe strikes. As his hours on the job piled up, he realized he was beginning to see into the truth of things. There is no pretense five beats into a chest compression, or in an alley next to a crack den, or on a dimly lit highway where cars have collided. Eventually, what had at first seemed impossible happened: Kevin acquired mastery. And in the process he was able to discern the professional differences between his freewheeling peers, what marked each—as he termed them—as “a tourist,” “true believer,” or “killer.”Combining indelible scenes that remind us of life’s fragile beauty with laugh-out-loud moments that keep us smiling through the worst, A Thousand Naked Strangers is an absorbing read about one man’s journey of self-discovery—a trip that also teaches us about ourselves.

    She takes us by her side down hospital corridors to visit the wards and meet her unforgettable patients.In the neonatal unit, premature babies fight for their lives, hovering at the very edge of survival, like tiny Emmanuel, wrapped up in a sandwich bag. On the cancer wards, the nurses administer chemotherapy and, long after the medicine stops working, something more important--which Watson learns to recognize when her own father is dying of cancer. In the pediatric intensive care unit, the nurses wash the hair of a little girl to remove the smell of smoke from the house fire. The emergency room is overcrowded as ever, with waves of alcohol and drug addicted patients as well as patients like Betty, a widow suffering chest pain, frail and alone. And the stories of the geriatric ward--Gladys and older patients like her--show the plight of the most vulnerable members of our society.

    As Farrow drew closer to the truth, shadowy operatives, from high-priced lawyers to elite war-hardened spies, mounted a secret campaign of intimidation, threatening his career, following his every move and weaponizing an account of abuse in his own family.All the while, Farrow and his producer faced a degree of resistance that could not be explained - until now. And a trail of clues revealed corruption and cover-ups from Hollywood, to Washington, and beyond.This is the untold story of the exotic tactics of surveillance and intimidation deployed by wealthy and connected men to threaten journalists, evade accountability and silence victims of abuse - and it's the story of the women who risked everything to expose the truth and spark a global movement.Both a spy thriller and a meticulous work of investigative journalism, Catch and Kill breaks devastating new stories about the rampant abuse of power - and sheds far-reaching light on investigations that shook the culture.In a dramatic account of violence and espionage, Pulitzer Prize-winning investigative reporter Ronan Farrow exposes serial abusers and a cabal of powerful interests hell-bent on covering up the truth, at any cost.

    airspace on September 11, the population of this small town on Newfoundland Island swelled from 10,300 to nearly 17,000. The citizens of Gander met the stranded passengers with an overwhelming display of friendship and goodwill. As the passengers stepped from the airplanes, exhausted, hungry and distraught after being held on board for nearly 24 hours while security checked all of the baggage, they were greeted with a feast prepared by the townspeople. Local bus drivers who had been on strike came off the picket lines to transport the passengers to the various shelters set up in local schools and churches. Linens and toiletries were bought and donated. A middle school provided showers, as well as access to computers, email, and televisions, allowing the passengers to stay in touch with family and follow the news.Over the course of those four days, many of the passengers developed friendships with Gander residents that they expect to last a lifetime. As a show of thanks, scholarship funds for the children of Gander have been formed and donations have been made to provide new computers for the schools. This book recounts the inspiring story of the residents of Gander, Canada, whose acts of kindness have touched the lives of thousands of people and been an example of humanity and goodwill.

    She is immediately rushed to the hospital. Once More We Saw Stars begins with this event, leading the reader into the unimaginable.But although it begins with the anguish Jayson and his wife Stacy confront in the wake of their daughter’s trauma and the hours leading up to her death, it quickly becomes a narrative that is as much about hope and healing as it is about grief and loss. Jayson recognizes, even in the very midst of his ordeal, that there will be a life for him beyond it—that if only he can continue moving forward, from one moment to the next, he will survive what seems un-survivable.With raw honesty, deep emotion, and exquisite tenderness, he captures both the fragility of life and absoluteness of death, and most important of all, the unconquerable power of love. This is an unforgettable memoir of courage and transformation—and a book that will change the way you look at the world.

    On a hot July night on Cape Cod when Adrienne was fourteen, her mother, Malabar, woke her at midnight with five simple words that would set the course of both of their lives for years to come: Ben Souther just kissed me.    Adrienne instantly became her mother’s confidante and helpmate, blossoming in the sudden light of her attention, and from then on, Malabar came to rely on her daughter to help orchestrate what would become an epic affair with her husband’s closest friend. The affair would have calamitous consequences for everyone involved, impacting Adrienne’s life in profound ways, driving her into a precarious marriage of her own, and then into a deep depression. Only years later will she find the strength to embrace her life—and her mother—on her own terms.  Wild Game is a brilliant, timeless memoir about how the people close to us can break our hearts simply because they have access to them, and the lies we tell in order to justify the choices we make. It’s a remarkable story of resilience, a reminder that we need not be the parents our parents were to us.

    Recounts stories from her vast case files that are alternately terrifying, tragically comic, and profoundly moving, all while she deals with her best friend and fellow doctor's fight with cancer.

    But when she least expects it, her reckless past catches up with her; convicted and sentenced to fifteen months at an infamous women's prison in Connecticut, Piper becomes inmate #11187-424. From her first strip search to her final release, she learns to navigate this strange world with its arbitrary rules and codes, its unpredictable, even dangerous relationships. She meets women from all walks of life, who surprise her with tokens of generosity, hard truths and simple acts of acceptance.

    Schizophrenia is not a single unifying diagnosis, and Esme Weijun Wang writes not just to her fellow members of the "collected schizophrenias" but to those who wish to understand it as well. Opening with the journey toward her diagnosis of schizoaffective disorder, Wang discusses the medical community's own disagreement about labels and procedures for diagnosing those with mental illness, and then follows an arc that examines the manifestations of schizophrenia in her life. In essays that range from using fashion to present as high-functioning to the depths of a rare form of psychosis, and from the failures of the higher education system and the dangers of institutionalisation to the complexity of compounding factors such as PTSD and Lyme disease, Wang's analytical eye, honed as a former lab researcher at Stanford, allows her to balance research with personal narrative. An essay collection of undeniable power, The Collected Schizophrenias dispels misconceptions and provides insight into a condition long misunderstood.