Cross-country truckers and suburban mothers. Trailer parks, gay sex clubs, college campuses, and military battlefields. In this fascinating book, Frank Owen traces the spread of methamphetamine—meth—from its origins as a cold and asthma remedy to the stimulant wiring every corner of American culture.            Meth is the latest “epidemic” to attract the attention of law enforcement and the media, but like cocaine and heroin its roots are medicinal. It was first synthesized in the late nineteenth century and applied in treatment of a wide range of ailments; by the 1940s meth had become a wonder drug, used to treat depression, hyperactivity, obesity, epilepsy, and addictions to other drugs and alcohol. Allied, Nazi, and Japanese soldiers used it throughout World War II, and the returning waves of veterans drove demand for meth into the burgeoning postwar suburbs, where it became the “mother’s helper” for a bored and lonely generation.            But meth truly exploded in the 1960s and ’70s, when biker gang cooks using burners, beakers, and plastic tubes brought their expertise from California to the Ozarks, the Southwest, and other remote rural areas where the drug could be manufactured in kitchen labs. Since then, meth has been the target of billions of dollars in federal, state, and local anti-drug wars. Murders, violent assaults, thefts, fires, premature births, and AIDS—rises in all of these have been blamed on the drug that crosses classes and subcultures like no other.            Acclaimed journalist Frank Owen follows the users, cooks, dealers, and law enforcers to uncover a dramatic story being played out in cities, small towns, and farm communities across America. No Speed Limit is a panoramic, high-octane investigation by a journalist who knows firsthand the powerful highs and frightening lows of meth.

    is an American Board of Emergency Medicine certified ED doctor. His journey began in the mid-1970s, when he chose to pursue a career in medicine. In his youthful perspective, he came to regard doctors as the good guys, the ones who healed people and saved lives. He knew he’d be one of those good guys one day. Now, with a career spanning more than thirty years, he works as an emergency-room physician in North Carolina. In A License to Heal: Random Memories of an ER Doctor, Bentley describes the real world of emergency medicine from the viewpoint of a practicing physician. This memoir is filled with real-life stories of the ER, including life and death, triumph and tragedy. Meet a man named Solomon Darby, who spoke to long-dead relatives during his own near-death experience. Bentley also recalls the heartbreaking story of a young widow who desperately needed to understand and cope with the death of her husband. Amid the grief, there are also episodes of great humor and human comedy. In the dynamic world of emergency medicine, there is a great deal of pain, blood, and tragedy, but there is also hope, compassion, and excitement—for both the patients and the staff."

    Includes tables to compare different agents within a given class of drugs. For use as a review for Boards, self-testing, or reference. Previous edition: c1997.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    

    "Chillingly entertaining and thought-provoking".--Associated Press.

    Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in 100 percent of cases, and has a 50 percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. Their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this incredible narrative redefines courage in the face of one of the most pervasive and mysterious pandemics of our time.

    Extraordinary.” — Elizabeth Cohen, MPH, CNN Senior Medical CorrespondentCritical Care is the powerful and absorbing memoir of Theresa Brown—a regular contributor to the New York Times blog “Well”—about her experiences during the first year on the job as an oncology nurse; in the process, Brown sheds brilliant light on issues of mortality and meaning in our lives.

    What she did not count on was how much death would be a part of her work. Almost immediately, Chen found herself wrestling with medicine’s most profound paradox, that a profession premised on caring for the ill also systematically depersonalizes dying. Final Exam follows Chen over the course of her education, training, and practice as she grapples at strikingly close range with the problem of mortality, and struggles to reconcile the lessons of her training with her innate knowledge of shared humanity, and to separate her ideas about healing from her fierce desire to cure.From her first dissection of a cadaver in gross anatomy to the moment she first puts a scalpel to a living person; from the first time she witnesses someone flatlining in the emergency room to the first time she pronounces a patient dead, Chen is struck by her own mortal fears: there was a dying friend she could not call; a young patient’s tortured death she could not forget; even the sense of shared kinship with a corpse she could not cast aside when asked to saw its pelvis in two. Gradually, as she confronts the ways in which her fears have incapacitated her, she begins to reject what she has been taught about suppressing her feelings for her patients, and she begins to carve out a new role for herself as a physician and as human being. Chen’s transfixing and beautiful rumination on how doctors negotiate the ineluctable fact of death becomes, in the end, a brilliant questioning of how we should live.Moving and provocative, motored equally by clinical expertise and extraordinary personal grace, this is a piercing and compassionate journey into the heart of a world that is hidden and yet touches all of our lives. A superb addition to the best medical literature of our time.

    Your brain can't function. You are asked to make decisions about treatment almost immediately, when you are not in your right mind. And yet you pull yourself together and start asking questions. Beside you is your doctor, whose job it is to solve the awful puzzle of bone marrow gone wrong. The two of you are in it together. In When Blood Breaks Down, Mikkael Sekeres, a leading cancer specialist, takes readers on the journey that patient and doctor travel together.Sekeres, who writes regularly for the Well section of the New York Times, tells the compelling stories of three people who receive diagnoses of adult leukemia within hours of each other: Joan, a 48-year-old surgical nurse, a caregiver who becomes a patient; David, a 68-year-old former factory worker who bows to his family's wishes and pursues the most aggressive treatment; and Sarah, a 36-year-old pregnant woman who must decide whether to undergo chemotherapy and put her fetus at risk. We join the intimacy of the conversations Sekeres has with his patients, and watch as he teaches trainees. Along the way, Sekeres also explores leukemia in its different forms and the development of drugs to treat it--describing, among many other fascinating details, the invention of the bone marrow transplant (first performed experimentally on beagles) and a treatment that targets the genetics of leukemia.The lessons to be learned from leukemia, Sekeres shows, are not merely medical; they teach us about courage and grace and defying the odds.

    We know her today primarily as a saintly character, perhaps as a heroic reformer of Britain’s health-care system. The reality is more involved and far more fascinating. In an utterly beguiling narrative that reads like the best Victorian fiction, acclaimed author Gillian Gill tells the story of this richly complex woman and her extraordinary family.Born to an adoring wealthy, cultivated father and a mother whose conventional facade concealed a surprisingly unfettered intelligence, Florence was connected by kinship or friendship to the cream of Victorian England’s intellectual aristocracy. Though moving in a world of ease and privilege, the Nightingales came from solidly middle-class stock with deep traditions of hard work, natural curiosity, and moral clarity. So it should have come as no surprise to William Edward and Fanny Nightingale when their younger daughter, Florence, showed an early passion for helping others combined with a precocious bent for power. Far more problematic was Florence’s inexplicable refusal to marry the well-connected Richard Monckton Milnes. As Gill so brilliantly shows, this matrimonial refusal was at once an act of religious dedication and a cry for her freedom–as a woman and as a leader. Florence’s later insistence on traveling to the Crimea at the height of war to tend to wounded soldiers was all but incendiary–especially for her older sister, Parthenope, whose frustration at being in the shade of her more charismatic sibling often led to illness. Florence succeeded beyond her wildest dreams. But at the height of her celebrity, at the age of thirty-seven, she retired to her bedroom and remained there for most of the rest of her life, allowing visitors only by appointment.Combining biography, politics, social history, and consummate storytelling, Nightingales is a dazzling portrait of an amazing woman, her difficult but loving family, and the high Victorian era they so perfectly epitomized. Beautifully written, witty, and irresistible, Nightingales is truly a tour de force.From the Hardcover edition.

    Christine Gleason, one of today's most prominent pediatricians, is also a born storyteller who takes readers into life and death situations encountered in the neonatal intensive care unit.

    Explaining the truth behind the screening statistics and investigating the evidence behind the hype, Margaret McCartney, an award-winning writer and doctor, argues that this patient paradox - too much testing of well people and not enough care for the sick - worsens health inequalities and drains professionalism.

    You'll make an appointment months in advance. You'll probably wait for several hours until you hear "the doctor will see you now"—but only for fifteen minutes! Then you'll wait even longer for lab tests, the results of which you'll likely never see, unless they indicate further (and more invasive) tests, most of which will probably prove unnecessary (much like physicals themselves). And your bill will be astronomical.In The Patient Will See You Now, Eric Topol, one of the nation’s top physicians, shows why medicine does not have to be that way. Instead, you could use your smartphone to get rapid test results from one drop of blood, monitor your vital signs both day and night, and use an artificially intelligent algorithm to receive a diagnosis without having to see a doctor, all at a small fraction of the cost imposed by our modern healthcare system.The change is powered by what Topol calls medicine's "Gutenberg moment." Much as the printing press took learning out of the hands of a priestly class, the mobile internet is doing the same for medicine, giving us unprecedented control over our healthcare. With smartphones in hand, we are no longer beholden to an impersonal and paternalistic system in which "doctor knows best." Medicine has been digitized, Topol argues; now it will be democratized. Computers will replace physicians for many diagnostic tasks, citizen science will give rise to citizen medicine, and enormous data sets will give us new means to attack conditions that have long been incurable. Massive, open, online medicine, where diagnostics are done by Facebook-like comparisons of medical profiles, will enable real-time, real-world research on massive populations. There's no doubt the path forward will be complicated: the medical establishment will resist these changes, and digitized medicine inevitably raises serious issues surrounding privacy. Nevertheless, the result—better, cheaper, and more human health care—will be worth it.Provocative and engrossing, The Patient Will See You Now is essential reading for anyone who thinks they deserve better health care. That is, for all of us.