Then, slowly, a mist settled deep inside the mind she once knew so well, blurring the world around her. She didn't know it then, but dementia was starting to take hold. In 2014, at age fifty-eight, she was diagnosed with young-onset Alzheimer's.Mitchell shares the heartrending story of her cognitive decline and how she has fought to stave it off. What lay ahead of her after the diagnosis was scary and unknowable, but Mitchell was determined and resourceful, and she vowed to outwit the disease for as long as she could.As Mitchell learned to embrace her new life, she began to see her condition as a gift, a chance to experience the world with fresh eyes and to find her own way to make a difference. Even now, her sunny outlook persists: She devotes her time to educating doctors, caregivers, and other people living with dementia, helping to reduce the stigma surrounding this insidious disease.Still living independently, Mitchell now uses Post-it notes and technology to remind her of her routines and has created a "memory room" where she displays photos--with labels--of her daughters, friends, and special places. It is a room where she feels calm and happy, especially on days when the mist descends.

    But with the unexpected death of her husband, her life became an empty, lightless space. Suddenly she was the single mother of two young boys, a widow at forty, clinging to three crumpled pages of instructions her husband had written for things like grocery shopping--things he had done while she did pioneering work as a planetary scientist at MIT. She became painfully conscious of her Asperger's, which before losing her husband had felt more like background noise. She felt, for the first time, alone in the universe.In this probing, invigoratingly honest memoir, Seager tells the story of how, as she stumblingly navigated the world of grief, she also kept looking for other worlds. She continues to develop groundbreaking projects, such as the Starshade, a sunflower-shaped instrument that, when launched into space, unfurls itself so as to block planet-obscuring starlight, and she takes solace in the alien beauty of exoplanets. At the same time, she discovers what feels every bit as wondrous: other people, reaching out across the space of her grief. Among them are the Widows of Concord, a group of women offering consolation and advice; and her beloved sons, Max and Alex. Most unexpected of all, there is another kind of one-in-a-billion match with an amateur astronomer.Equally attuned to the wonders of deep space and human connection, The Smallest Lights in the Universe is its own light in the dark.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    But I was getting there. I wanted the world to know that all of this pain I had been feeling…that it was related to my vagina. Thus, Vagina Problems was born. It was a cutesy name. It was my way of taking this pain and saying, “Whatever. I’m here. I have it. It sucks. Let’s talk about it.”In April 2014, Deputy Editorial Director at BuzzFeed Lara Parker opened up to the world in an article on the website: she suffers from endometriosis. And beyond that? She let the whole world know that she wasn’t having any sex, as sex was excruciatingly painful. Less than a year before, she received not only the diagnosis of endometriosis, but also a diagnosis of pelvic floor dysfunction, vulvodynia, vaginismus, and vulvar vestibulitis. Combined, these debilitating conditions have wreaked havoc on her life, causing excruciating pain throughout her body since she was fourteen years old. These are her Vagina Problems. It was five years before Lara learned what was happening to her body. Five years of doctors insisting she just had “bad period cramps,” or implying her pain was psychological. Shamed and stigmatized, Lara fought back against a medical community biased against women and discovered that the ignorance of many doctors about women’s anatomy was damaging more than just her own life. One in ten women have endometriosis and it takes an average of seven years before they receive an accurate diagnosis—or any relief from this incurable illness’ chronic pain. With candid revelations about her vaginal physical therapy, dating as a straight woman without penetrative sex, coping with painful seizures while at the office, diet and wardrobe malfunctions when your vagina hurts all the time, and the depression and anxiety of feeling unloved, Lara tackles it all in Vagina Problems: Endometriosis, Painful Sex, and Other Taboo Topics with courage, wit, love, and a determination to live her best life."

    For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    Self-taught, introspective, and from a stiflingly boring farm town, he couldn’t relate to his neighbors. While other boys played outside, he stayed indoors reading Greek mythology. And being gay and overweight, he got used to diminishing himself. But little by little, he started learning from all the sad, strange, lonely outcasts in history who had come before him, and he started to feel hope. In this collection of personal essays, Guy talks about finding a sense of belonging at Berkeley—and stirring up controversy in a newspaper column that led to a run‑in with the Secret Service. He recounts the pitfalls of being typecast as the “Sassy Gay Friend,” and how, after taking a wrong turn in life (i.e. law school), he found stand‑up comedy and artistic freedom. He analyzes society’s calculated deprivation of personhood from fat people, and how, though it’s taken him a while to accept who he is, he has learned that with a little patience and a lot of humor, self-acceptance is possible. Written with Guy’s characteristic blend of wit, guile, and rumination, My Life as a Goddess is an unforgettable and deeply moving book by one of today’s most endearing and galvanizing voices in comedy.

    "Here’s a partial list of things I don’t believe in: God. The Devil. Heaven. Hell. Bigfoot. Ancient Aliens. Past lives. Life after death. Vampires. Zombies. Reiki. Homeopathy. Rolfing. Reflexology. Note that 'witches' and 'witchcraft' are absent from this list. The thing is, I wouldn’t believe in them, and I would privately ridicule any idiot who did, except for one thing: I am a witch."For as long as Augusten Burroughs could remember, he knew things he shouldn't have known. He manifested things that shouldn't have come to pass. And he told exactly no one about this, save one person: his mother. His mother reassured him that it was all perfectly normal, that he was descended from a long line of witches, going back to the days of the early American colonies. And that this family tree was filled with witches. It was a bond that he and his mother shared--until the day she left him in the care of her psychiatrist to be raised in his family (but that's a whole other story). After that, Augusten was on his own. On his own to navigate the world of this tricky power; on his own to either use or misuse this gift.From the hilarious to the terrifying, Toil & Trouble is a chronicle of one man's journey to understand himself, to reconcile the powers he can wield with things with which he is helpless. There are very few things that are coincidences, as you will learn in Toil & Trouble. Ghosts are real, trees can want to kill you, beavers are the spawn of Satan, houses are alive, and in the end, love is the most powerful magic of all.

      We swim in freezing Arctic waters and piranha-infested rivers to test our limits. We swim for pleasure, for exercise, for healing. But humans, unlike other animals that are drawn to water, are not natural-born swimmers. We must be taught. Our evolutionary ancestors learned for survival; now, in the twenty-first century, swimming is one of the most popular activities in the world.Why We Swim is propelled by stories of Olympic champions, a Baghdad swim club that meets in Saddam Hussein’s palace pool, modern-day Japanese samurai swimmers, and even an Icelandic fisherman who improbably survives a wintry six-hour swim after a shipwreck. New York Times contributor Bonnie Tsui, a swimmer herself, dives into the deep, from the San Francisco Bay to the South China Sea, investigating what about water—despite its dangers—seduces us and why we come back to it again and again.

    A loving home, shared with squabbling siblings, overseen by devoted parents. Yet in other ways it was the precise opposite: a revolving door of TV camera crews and documentary makers, a world of extreme discipline, of siblings vanishing in the night.Megan Phelps-Roper was raised in the Westboro Baptist Church - the fire-and-brimstone religious sect at once aggressively homophobic and anti-Semitic, rejoiceful for AIDS and natural disasters, and notorious for its picketing the funerals of American soldiers. From her first public protest, aged five, to her instrumental role in spreading the church's invective via social media, her formative years brought their difficulties. But being reviled was not one of them. She was preaching God's truth. She was, in her words, 'all in'.In November 2012, at the age of twenty-six, she left the church, her family, and her life behind. Unfollow is a story about the rarest thing of all: a person changing their mind. It is a fascinating insight into a closed world of extreme belief, a biography of a complex family, and a hope-inspiring memoir of a young woman finding the courage to find compassion for others, as well as herself.

    When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    In riveting first-person prose, Dr. Brendan Reilly takes us to the front lines of medicine today. Whipsawed by daily crises and frustrations, Reilly must deal with several daunting challenges simultaneously: the extraordinary patients under his care on the teeming wards of a renowned teaching hospital; the life-threatening illnesses of both of his ninety-year-old parents; and the tragic memory of a cold case from long ago that haunts him still. As Reilly’s patients and their families survive close calls, struggle with heartrending decisions, and confront the limits of medicine’s power to cure, One Doctor lays bare a fragmented, depersonalized, business-driven health-care system where real caring is hard to find. Every day, Reilly sees patients who fall through the cracks and suffer harm because they lack one doctor who knows them well and relentlessly advocates for their best interests.Filled with fascinating characters in New York City and rural New England — people with dark secrets, mysterious illnesses, impossible dreams, and many kinds of courage — One Doctor tells their stories with sensitivity and empathy, reminding us of professional values once held dear by all physicians. But medicine has changed enormously during Reilly’s career, for both better and worse, and One Doctor is a cautionary tale about those changes. It is also a hopeful, inspiring account of medicine’s potential to improve people’s lives, Reilly’s quest to understand the "truth" about doctoring, and a moving testament to the difference one doctor can make.

    Gifted Hands will transplace you into the operating room to witness surgeries that made headlines around the world, and into the private mind of a compassionate, God-fearing physician who lives to help others. In 1987, Dr. Carson gained worldwide recognition for his part in the first successful separation of Siamese twins joined at the back of the head -- an extremely complex and delicate operation that was five months of planning and twenty-two hours of actual surgery, involving a surgical plan that Carson helped initiate. Gifted Hands reveals a man with humility, decency, compassion, courage, and sensitivity who serves as a role model for young people (and everyone else) in need of encouragement to attempt the seemingly impossible and to excel in whatever they attempt. Dr. Carson also describes the key role that his highly intelligent though relatively uneducated mother played in his metamorphosis from an unmotivated ghetto youngster into one of the most respected neurosurgeons in the world.

    A month later, none of that was true. Levy picks you up and hurls you through the story of how she built an unconventional life and then watched it fall apart with astonishing speed. Like much of her generation, she was raised to resist traditional rules—about work, about love, and about womanhood. “I wanted what we all want: everything. We want a mate who feels like family and a lover who is exotic, surprising. We want to be youthful adventurers and middle-aged mothers. We want intimacy and autonomy, safety and stimulation, reassurance and novelty, coziness and thrills. But we can’t have it all.” In this profound and beautiful memoir, Levy chronicles the adventure and heartbreak of being “a woman who is free to do whatever she chooses.” Her own story of resilience becomes an unforgettable portrait of the shifting forces in our culture, of what has changed—and of what is eternal.

    She had fallen in love and moved to Paris to pursue her dream of becoming a war correspondent. The real world she found, however, would take her into a very different kind of conflict zone.It started with an itch—first on her feet, then up her legs, like a thousand invisible mosquito bites. Next came the exhaustion, and the six-hour naps that only deepened her fatigue. Then a trip to the doctor and, a few weeks shy of her twenty-third birthday, a diagnosis: leukemia, with a 35 percent chance of survival. Just like that, the life she had imagined for herself had gone up in flames. By the time Jaouad flew home to New York, she had lost her job, her apartment, and her independence. She would spend much of the next four years in a hospital bed, fighting for her life and chronicling the saga in a column for The New York Times.When Jaouad finally walked out of the cancer ward—after three and a half years of chemo, a clinical trial, and a bone marrow transplant—she was, according to the doctors, cured. But as she would soon learn, a cure is not where the work of healing ends; it’s where it begins. She had spent the past 1,500 days in desperate pursuit of one goal—to survive. And now that she’d done so, she realized that she had no idea how to live.How would she reenter the world and live again? How could she reclaim what had been lost? Jaouad embarked—with her new best friend, Oscar, a scruffy terrier mutt—on a 100-day, 15,000-mile road trip across the country. She set out to meet some of the strangers who had written to her during her years in the hospital: a teenage girl in Florida also recovering from cancer; a teacher in California grieving the death of her son; a death-row inmate in Texas who’d spent his own years confined to a room. What she learned on this trip is that the divide between sick and well is porous, that the vast majority of us will travel back and forth between these realms throughout our lives. Between Two Kingdoms is a profound chronicle of survivorship and a fierce, tender, and inspiring exploration of what it means to begin again.

    Her pixyish appearance and ferocious competitive drive quickly earned her the status of media darling. But behind the fame, the flawless floor routines, and the million-dollar smile, her life was a series of challenges and hardships.Off Balance vividly delineates each of the dominating characters who contributed to Moceanu's rise to the top, from her stubborn father and long-suffering mother to her mercurial coach, Bela Karolyi. Here, Moceanu finally shares the haunting stories of competition, her years of hiding injuries and pain out of fear of retribution from her coaches, and how she hit rock bottom after a public battle with her parents.But medals, murder plots, drugs, and daring escapes aside (all of which figure into Moceanu's incredible journey), the most unique aspect of her life is the family secret that Moceanu discovers, opening a new and unexpected chapter in her adult life. A mysterious letter from a stranger reveals that she has a second sister--born with a physical disability and given away at birth--who has nonetheless followed in Moceanu's footsteps in an astonishing way.A multilayered memoir that transcends the world of sports, Off Balance will touch anyone who has ever dared to dream of a better life.