Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the desert island book of all medical pharmacology - if you can own just one pharmacology book, this is it.

    Darwin was only too aware of the storm his theory of evolution would provoke but he would surely have raised an incredulous eyebrow at the controversy still raging a century and a half later. Evolution is accepted as scientific fact by all reputable scientists and indeed theologians, yet millions of people continue to question its veracity.In The Greatest Show on Earth Richard Dawkins takes on creationists, including followers of ‘Intelligent Design’ and all those who question the fact of evolution through natural selection. Like a detective arriving on the scene of a crime, he sifts through fascinating layers of scientific facts and disciplines to build a cast-iron case: from the living examples of natural selection in birds and insects; the ‘time clocks’ of trees and radioactive dating that calibrate a timescale for evolution; the fossil record and the traces of our earliest ancestors; to confirmation from molecular biology and genetics. All of this, and much more, bears witness to the truth of evolution.The Greatest Show on Earth comes at a critical time: systematic opposition to the fact of evolution is now flourishing as never before, especially in America. In Britain and elsewhere in the world, teachers witness insidious attempts to undermine the status of science in their classrooms. Richard Dawkins provides unequivocal evidence that boldly and comprehensively rebuts such nonsense. At the same time he shares with us his palpable love of the natural world and the essential role that science plays in its interpretation. Written with elegance, wit and passion, it is hard-hitting, absorbing and totally convincing.

    One of the most important achievements of the past millennium, it did for biology what Galileo did for astronomy: made it into a single science rather than a collection of unrelated facts. Important though Origin remains, its examples and intricate Victorian prose are now a century and a half old. They are ripe for renewal and reaffirmation. Writing as "Darwin's ghost," eminent geneticist Steve Jones updates this seminal work—and restates evolution's case for the 21st century.Jones is a writer of engaging wit and dazzling erudition and has been called "the British Carl Sagan." Using modern examples—the AIDS virus, the puzzles of sexual selection, the physiology and psychology of pets, and the unparalleled genetic success of our own species—he shows the power and immediacy of Darwin's great argument and makes us appreciate how it makes life make sense. Eye-opening and entertaining, filled with astonishing facts, amusing anecdotes, and the very latest research, Darwin's Ghost is contemporary science writing at its very best.

    Part One presents the general principles of pathophysiology and discusses the influence of the environment and the role of genetics in the development of disease. Part Two, organized by body system, examines normal anatomy and physiology, alterations of function in adults, and alterations of function in children.

    Conventional wisdom may be wrong. In this controversial book, the eminent biologist Paul W. Ewald offers some startling arguments:-Germs appear to be at the root of heart disease, Alzheimer’s, schizophrenia, many forms of cancer, and other chronic diseases.-The greatest threats to our health come not from sensational killers such as Ebola, West Nile virus, and super-virulent strains of influenza, but from agents that are already here causing long-term infections, which eventually lead to debilitation and death. -The medical establishment has largely ignored the evidence that implicates these germs, to the detriment of our public health.-New evolutionary theories are available, which explain how germs function and offer opportunities for controlling these modern plagues — if we are willing to listen to them.Plague Time is an eye-opening exploration of the revolutionary new understanding of disease that may set the course of medical research for the twenty-first century.

    Goljan, MD, makes it easy for you to master all of the pathology material covered on the USMLE™ Step 1 Exam. It combines an outline-format review of key concepts with over 400 hundred USMLE-style practice questions - online - that give you all the practice you need to succeed! Book • Outline format: Concise, high-yield subject matter is presented in a study-friendly format.• High-yield margin notes: Key content that is most likely to appear on the exam is reinforced in the margin notes.• Visual elements: Full-color photographs are utilized to enhance your study and recognition of key pathology images. Abundant two-color schematics and summary tables enhance your study experience.• Two-color design: Colored text and headings make studying more efficient and pleasing.New! Online Study and Testing Tool• A minimum of 350 USMLE Step 1–type MCQs: Clinically oriented, multiple-choice questions that mimic the current USMLE format, including high-yield images and complete rationales for all answer options. • Online benefits: New review and testing tool delivered via the USMLE Consult platform, the most realistic USMLE review product on the market. Online feedback includes results analyzed to the subtopic level (discipline and organ system). • Test mode: Create a test from a random mix of questions or by subject or keyword using the timed test mode. USMLE Consult simulates the actual test-taking experience using NBME’s FRED interface, including style and level of difficulty of the questions and timing information. Detailed feedback and analysis shows your strengths and weaknesses and allows for more focused study. • Practice mode: Create a test from randomized question sets or by subject or keyword for a dynamic study session. The practice mode features unlimited attempts at each question, instant feedback, complete rationales for all answer options, and a detailed progress report. • Online access: Online access allows you to study from an internet-enabled computer wherever and whenever it is convenient. This access is activated through registration on www.studentconsult.com with the pin code printed inside the front cover.Student Consult• Full online access: You can access the complete text and illustrations of this book on www.studentconsult.com. • Save content to your PDA: Through our unique Pocket Consult platform, you can clip selected text and illustrations and save them to your PDA for study on the fly! • Free content: An interactive community center with a wealth of additional valuable resources is available.

    Now with a built-in Resource Manual and Study Guide, Language, Culture, and Society is the teaching text for the linguistic anthropology course.

    Finally, this book does it for the Seneca. It is enthralling history, told in a knowledgeable, highly readable way."-- Alvin M. Joseph, Jr., author of The Indian Heritage of America"This book is at once troubling and richly textured; for it draws skillfully and impartially on the resources of history, ethnology and psychology to chronicle the agony and decline of one of the proudest of American Indian peoples."-- Morris Opler Book World"Here is a carefully crafted masterpiece of anthropological and historical investigation. It is about both the specific renaissance of the Seneca and the possible renaissance of any people. On its specific subject matter, it will probably remain the definitive study for a long time."-- Christian Science Monitor"

    Its presence in nature was dismissed as a desperate response to starvation or other life-threatening circumstances, and few spent time studying it. A taboo subject in our culture, the behavior was portrayed mostly through horror movies or tabloids sensationalizing the crimes of real-life flesh-eaters. But the true nature of cannibalism--the role it plays in evolution as well as human history--is even more intriguing (and more normal) than the misconceptions we've come to accept as fact. In Cannibalism: A Perfectly Natural History, zoologist Bill Schutt sets the record straight, debunking common myths and investigating our new understanding of cannibalism's role in biology, anthropology, and history in the most fascinating account yet written on this complex topic. Schutt takes readers from Arizona's Chiricahua Mountains, where he wades through ponds full of tadpoles devouring their siblings, to the Sierra Nevadas, where he joins researchers who are shedding new light on what happened to the Donner Party--the most infamous episode of cannibalism in American history. He even meets with an expert on the preparation and consumption of human placenta (and, yes, it goes well with Chianti). Bringing together the latest cutting-edge science, Schutt answers questions such as why some amphibians consume their mother's skin; why certain insects bite the heads off their partners after sex; why, up until the end of the twentieth century, Europeans regularly ate human body parts as medical curatives; and how cannibalism might be linked to the extinction of the Neanderthals. He takes us into the future as well, investigating whether, as climate change causes famine, disease, and overcrowding, we may see more outbreaks of cannibalism in many more species--including our own.Cannibalism places a perfectly natural occurrence into a vital new context and invites us to explore why it both enthralls and repels us.

    This class-tested and successful textbook synthesizes the established facts of immunology into a comprehensible, coherent, and up-to-date account of how the immune system works, rather than presenting immunology as a chronology of experiments and discoveries. Emphasizing the human immune system the text has been designed to break down the barriers which often divide basic and clinical immunology. The reader-friendly text, section and chapter summaries, and full-color illustrations make the book accessible and easily understandable to students. The Immune System is adapted from Immunobiology by Janeway, Travers & Walport.

    Using his own research and experiences throughout the world, Lieberman recounts without jargon how and why humans evolved to walk, run, dig, and do other necessary and rewarding physical activities while avoiding needless exertion.Exercised is entertaining and enlightening but also constructive. As our increasingly sedentary lifestyles have contributed to skyrocketing rates of obesity and diseases such as diabetes, Lieberman audaciously argues that to become more active we need to do more than medicalize and commodify exercise.Drawing on insights from evolutionary biology and anthropology, Lieberman suggests how we can make exercise more enjoyable, rather than shaming and blaming people for avoiding it. He also tackles the question of whether you can exercise too much, even as he explains why exercise can reduce our vulnerability to the diseases mostly likely to make us sick and kill us.

    An evolutionary perspective forms the foundation of the entire discussion. The book begins with the natural history of the planet, considers portions of the whole in the middle chapters, and ends with another perspective of the entire planet in the concluding chapter. Its unique organization of focusing only on several key concepts in each chapter sets it apart from the competition. .

    No one can stop him--but he walks away. A miracle? No...dysentery. Microbes saved the Roman Empire. Nearly a millennium later, the microbes of the Black Death ended the Middle Ages, making possible the Renaissance, western democracy, and the scientific revolution. Soon after, microbes ravaged the Americas, paving the way for their European conquest. Again and again, microbes have shaped our health, our genetics, our history, our culture, our politics, even our religion and ethics. This book reveals much that scientists and cultural historians have learned about the pervasive interconnections between infectious microbes and humans. It also considers what our ongoing fundamental relationship with infectious microbes might mean for the future of the human species. The "good side" of history's worst epidemics The surprising debt we owe to killer diseases Where diseases came from... ...and where they may be going Children of pestilence: disease and civilization From Egypt to Mexico, the Romans to Attila the Hun STDs, sexual behavior, and culture How microbes may shape cultural cycles of puritanism and promiscuity

    Encompassing recent advances in molecular pharmacology and brain imaging, Drugs, The Brain and Behavior offers a unique breadth of coverage from historical accounts of drug use, through clinical and preclinical behavioural studies, to the latest research on drug effects in transgenic mouse models.

    Yet The Origin of Species (1859) is also a humane and inspirational vision of ecological interrelatedness, revealing the complex mutual interdependencies between animal and plant life, climate and physical environment, and—by implication—within the human world. Written for the general reader, in a style which combines the rigour of science with the subtlety of literature, The Origin of Species remains one of the founding documents of the modern age.