The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    The sun is rising behind Downton Abbey, a great and splendid house in a great and splendid park. So secure does it appear that it seems as if the way it represents will last for another thousand years. It won't.   Millions of American viewers were enthralled by the world of Downton Abbey, the mesmerizing TV drama of the aristocratic Crawley family--and their servants--on the verge of dramatic change. On the eve of Season 2 of the TV presentation, this gorgeous book--illustrated with sketches and research from the production team, as well as on-set photographs from both seasons--takes us even deeper into that world, with fresh insights into the story and characters as well as the social history.

    Beyond the political sphere his intellectual pursuits ranged from the scientific to the occult. His mathematics anticipated Isaac Newton by nearly a century, while his mapmaking and navigation were critical to exploration. He was also obsessed with alchemy, astrology, and mysticism. His library was one of the finest in Europe, a vast compendium of thousands of volumes. Yet, despite his powerful position and prodigious intellect, Dee died in poverty and obscurity, reviled and pitied as a madman. Benjamin Woolley tells the engrossing story of the rise and fall of this remarkable man, who wielded great influence during the pivotal era when the age of superstition collided with the new world of science and reason. Written with flair and vigor, based on numerous surviving diaries of the period, The Queen's Conjurer is a highly readable account of an extraordinary life.

    January 12, 1888, began as an unseasonably warm morning across Nebraska, the Dakotas, and Minnesota, the weather so mild that children walked to school without coats and gloves. But that afternoon, without warning, the atmosphere suddenly, violently changed. One moment the air was calm; the next the sky exploded in a raging chaos of horizontal snow and hurricane-force winds. Temperatures plunged as an unprecedented cold front ripped through the center of the continent. By Friday morning, January 13, some five hundred people lay dead on the drifted prairie, many of them children who had perished on their way home from country schools. In a few terrifying hours, the hopes of the pioneers had been blasted by the bitter realities of their harsh environment. Recent immigrants from Germany, Norway, Denmark, and the Ukraine learned that their free homestead was not a paradise but a hard, unforgiving place governed by natural forces they neither understood nor controlled. With the storm as its dramatic, heartbreaking focal point, The Children's Blizzard captures this pivotal moment in American history by tracing the stories of five families who were forever changed that day. Drawing on family interviews and memoirs, as well as hundreds of contemporary accounts, David Laskin creates an intimate picture of the men, women, and children who made choices they would regret as long as they lived. Here too is a meticulous account of the evolution of the storm and the vain struggle of government forecasters to track its progress. The blizzard of January 12, 1888, is still remembered on the prairie. Children fled that day while their teachers screamed into the relentless roar. Husbands staggered into the blinding wind in search of wives. Fathers collapsed while trying to drag their children to safety. In telling the story of this meteorological catastrophe, the deadliest blizzard ever to hit the prairie states, David Laskin has produced a masterful portrait of a tragic crucible in the settlement of the American heartland.

    This country house was home to Britain's most brilliant mathematical brains, like Alan Turing, and the scene of immense advances in technology—indeed, the birth of modern computing. The military codes deciphered there were instrumental in turning both the Battle of the Atlantic and the war in North Africa. But, though plenty has been written about the scientists and the codebreaking, fictional and non-fiction—from Robert Harris and Ian McEwan to Andrew Hodges' biography of Turing—what of the thousands of men and women who lived and worked there during the war? The first history for the general reader of life at Bletchley Park, this is also an amazing compendium of memories from people now in their eighties of skating on the frozen lake in the grounds (a depressed Angus Wilson, the novelist, once threw himself in), of a youthful Roy Jenkins—useless at codebreaking, of the high jinks at nearby accommodation hostels, and of the implacable secrecy that meant girlfriend and boyfriend working in adjacent huts knew nothing about each other's work.

    It can also mean the humbler tools of everyday cooking and eating: a wooden spoon and a skillet, chopsticks and forks.Since prehistory, humans have braved sharp knives, fire, and grindstones to transform raw ingredients into something delicious - or at least edible. Tools shape what we eat, but they have also transformed how we consume, and how we think about, our food. Technology in the kitchen does not just mean the Pacojets and sous-vide of the modernist kitchen. It can also mean the humbler tools of everyday cooking and eating: a wooden spoon and a skillet, chopsticks and forks. In Consider the Fork, award-winning food writer Bee Wilson provides a wonderful and witty tour of the evolution of cooking around the world, revealing the hidden history of everyday objects we often take for granted. Knives - perhaps our most important gastronomic tool - predate the discovery of fire, whereas the fork endured centuries of ridicule before gaining widespread acceptance; pots and pans have been around for millennia, while plates are a relatively recent invention. Many once-new technologies have become essential elements of any well-stocked kitchen - mortars and pestles, serrated knives, stainless steel pots, refrigerators. Others have proved only passing fancies, or were supplanted by better technologies; one would be hard pressed now to find a water-powered egg whisk, a magnet-operated spit roaster, a cider owl, or a turnspit dog. Although many tools have disappeared from the modern kitchen, they have left us with traditions, tastes, and even physical characteristics that we would never have possessed otherwise. Blending history, science, and anthropology, Wilson reveals how our culinary tools and tricks came to be, and how their influence has shaped modern food culture. The story of how we have tamed fire and ice and wielded whisks, spoons, and graters, all for the sake of putting food in our mouths, Consider the Fork is truly a book to savor.

    These are today's sins of science—as deplorable as mistaken past ideas about advocating racial purity or using lobotomies as a cure for mental illness. These unwitting errors add up to seven lessons both cautionary and profound, narrated by renowned author and speaker Paul A. Offit. Offit uses these lessons to investigate how we can separate good science from bad, using some of today's most controversial creations—e-cigarettes, GMOs, drug treatments for ADHD—as case studies. For every "Aha!" moment that should have been an "Oh no," this book is an engrossing account of how science has been misused disastrously—and how we can learn to use its power for good.

    This took but little time. Two members of my family elected to go with me. Also a carbuncle. The dictionary says a carbuncle is a kind of jewel. Humor is out of place in a dictionary." — Following the EquatorSo begins this classic piece of travel writing, brimming with Twain's celebrated brand of ironic, tongue-in-cheek humor. Written just before the turn of the century, the book recounts a lecture tour in which he circumnavigated the globe via steamship, including stops at the Hawaiian Islands, Australia, Fiji Islands, New Zealand, India, South Africa and elsewhere.View the world through the eyes of the celebrated author as he describes a rich range of experiences — visiting a leper colony in Hawaii, shark fishing in Australia, tiger hunting, diamond mining in South Africa, and riding the rails in India, an activity Twain enjoyed immensely as suggested by this description of a steep descent in a hand-car:"The road fell sharply down in front of us and went corkscrewing in and out around the crags and precipices, down, down, forever down, suggesting nothing so exactly or so uncomfortably as a crooked toboggan slide with no end to it. . . . I had previously had but one sensation like the shock of that departure, and that was the gaspy shock that took my breath away the first time that I was discharged from the summit of a toboggan slide. But in both instances the sensation was pleasurable — intensely so; it was a sudden and immense exaltation, a mixed ecstasy of deadly fright and unimaginable joy. I believe that this combination makes the perfection of human delight."A wealth of similarly revealing observations enhances this account, along with perceptive descriptions and discussions of people, climate, flora and fauna, indigenous cultures, religion, customs, politics, food, and many other topics. Despite its jocular tone, this book has a serious thread running through it, recording Twain's observations of the mistreatments and miseries of mankind. Enhanced by over 190 illustrations, including 173 photographs, this paperback edition — the only one avai1able — will be welcomed by all admirers of Mark Twain or classic travel books.

    Hemmed in by overwhelming Nazi strength, the 338,000 men gathered on the beach were all that stood between Hitler and Western Europe. Crush them, and the path to Paris and London was clear.Unable to retreat any farther, the Allied soldiers set up defense positions and prayed for deliverance. Prime Minister Winston Churchill ordered an evacuation on May 26, expecting to save no more than a handful of his men. But Britain would not let its soldiers down. Hundreds of fishing boats, pleasure yachts, and commercial vessels streamed into the Channel to back up the Royal Navy, and in a week nearly the entire army was ferried safely back to England.Based on interviews with hundreds of survivors and told by “a master narrator,” The Miracle of Dunkirk is a striking history of a week when the outcome of World War II hung in the balance (Arthur Schlesinger Jr.).

    Some sacrificed everything for love, while others met a cruel fate at the edge of an axman's blade. From the truth behind the supposed madness of King George to Queen Victoria's surprisingly daring taste in sculpture, Behind the Palace Doors ventures beyond the rumors to tell the unvarnished history of Britain's monarchs, highlighting the unique mix of tragedy, comedy, romance, heroism, and incompetence that has made the British throne a seat of such unparalleled fascination.Featuring: - stories covering every monarch, from randy Henry VIII to reserved Elizabeth II - historical myths debunked and surprising "Did you know . . . ?" anecdotes - four family trees spanning every royal house, from the Tudors to the Windsors

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    Eventually the group came to include among its members Edmund Burke, Adam Smith, Edward Gibbon, and James Boswell. It was known simply as “the Club.”     In this captivating book, Leo Damrosch brings alive a brilliant, competitive, and eccentric cast of characters. With the friendship of the “odd couple” Samuel Johnson and James Boswell at the heart of his narrative, Damrosch conjures up the precarious, exciting, and often brutal world of late eighteenth‑century Britain. This is the story of an extraordinary group of people whose ideas helped to shape their age, and our own.

    She’s since returned to the United States, but this distillation of incisive—and irreverent—insights, now updated with a new preface, is just as illuminating today. And perhaps even more so, in the wake of Brexit and the attendant national identity crisis.While there may be no easy answer to the question of how, exactly, to understand the English, The Anglo Files—part anthropological field study, part memoir—helps point the way.

    In Wicked Plants, Stewart takes on over two hundred of Mother Nature’s most appalling creations. It’s an A to Z of plants that kill, maim, intoxicate, and otherwise offend. You’ll learn which plants to avoid (like exploding shrubs), which plants make themselves exceedingly unwelcome (like the vine that ate the South), and which ones have been killing for centuries (like the weed that killed Abraham Lincoln's mother). Menacing botanical illustrations and splendidly ghastly drawings create a fascinating portrait of the evildoers that may be lurking in your own backyard. Drawing on history, medicine, science, and legend, this compendium of bloodcurdling botany will entertain, alarm, and enlighten even the most intrepid gardeners and nature lovers.

    One was a Prince, one was a Count, and the third was a commoner with an Italian name, who four years earlier had been the subject of one of John Singer Sargent’s greatest portraits. The commoner was Samuel Pozzi, society doctor, pioneer gynaecologist and free-thinker – a rational and scientific man with a famously complicated private life.Pozzi's life played out against the backdrop of the Parisian Belle Epoque. The beautiful age of glamour and pleasure more often showed its ugly side: hysterical, narcissistic, decadent and violent, a time of rampant prejudice and blood-and-soil nativism, with more parallels to our own age than we might imagine.The Man in the Red Coat is at once a fresh and original portrait of the Belle Epoque – its heroes and villains, its writers, artists and thinkers – and a life of a man ahead of his time. Witty, surprising and deeply researched, the new book from Julian Barnes illuminates the fruitful and longstanding exchange of ideas between Britain and France, and makes a compelling case for keeping that exchange alive.