That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research—the Philadelphia chromosome. This book charts not only that landmark discovery, but also—for the first time, all in one place—the full sequence of scientific and medical discoveries that brought about the first-ever successful treatment of a lethal cancer at the genetic level.The significance of this mutant chromosome would take more than three decades to unravel; in 1990, it was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. This dramatic discovery launched a race involving doctors and researchers around the world, who recognized that in principle it might be possible to target CML at its genetic source.Science journalist Jessica Wapner brings extensive original reporting to this book, including interviews with more than thirty-five people with a direct role in this story. Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 70,000 people worldwide who are diagnosed with CML each year. Chief among them is researcher and oncologist Dr. Brian Druker, whose dedication to his patients fueled his quest to do everything within his power to save them.The Philadelphia Chromosome helps us to fully understand and appreciate just how pathbreaking, hard-won, and consequential are the achievements it recounts—and to understand the principles behind much of today’s most important cancer research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

    In The Compatibility Gene, one of our foremost immunologists tells the remarkable history of these genes' discovery and the unlocking of their secrets. Davis shows how the compatibility gene is radically transforming our knowledge of the way our bodies work - and is having profound consequences for medical research and ethics. Looking to the future, he considers the startling possibilities of what these wondrous discoveries might mean for you and me.

    Time-saving study tools help readers arrive at a complete understanding of human anatomy. KEY TOPICS: An Introduction to Anatomy, The Cell, Tissues and Early Embryology, The Integumentary System, The Skeletal System: Osseous Tissue and Skeletal Structure, The Skeletal System: Axial Division, The Skeletal System: Appendicular Division, The Skeletal System: Articulations, The Muscular System: Skeletal Muscle Tissue and Muscle Organization, The Muscular System: Axial Musculature, The Muscular System: Appendicular Musculature, Surface Anatomy and Cross-Sectional Anatomy, The Nervous System: Neural Tissue, The Nervous System: The Spinal Cord and Spinal Nerves, The Nervous System: The Brain and Cranial Nerves, The Nervous System: Pathways And Higher-Order Functions, The Nervous System:  Autonomic Division, The Nervous System: General and Special Senses, The Endocrine System, The Cardiovascular System: Blood, The Cardiovascular System: The Heart, The Cardiovascular System: Vessels and Circulation, The Lymphoid System, The Respiratory System, The Digestive System, The Urinary System, The Reproductive System, The Reproductive System: Embryology and HumanDevelopment. MARKET: For all readers interested in human anatomy.

    Roland grew up halfway to nowhere. His father is human and his mother is elf. Being Half-Elf would always bring difficulties and it also brought about innate magic. He heads off for adventure joining the Adventures Guild. The world is tough and Roland is an innocent. He discovers he is unique in more than one way. Danger is everywhere especially for those who adventure. He makes a decision that will affect him for the rest of his life. The he realizes he has made a rash decision. It might turn out good or it might turn out bad. He just doesn't know enough but he is committed. His unique gifts are needed and he heeds the call for help.

    This is not a book of swing techniques. There are plenty of other resources that teach you how to swing, chip and putt. What this book does provide is a true framework for breaking 80 based on sound principles that will work for any golfer of any level. Provided you faithfully follow and apply these principles, you will begin to improve surely and steadily, to the point where you will eventually gain the ability to break 80, not just as a one-time fluke, but over and over again as a reflection of your true new-found ability. Whether you're struggling to break 100, 90, 80 or even a complete beginner, the Little Book of Breaking 80 will help take your game to the next level!

    He was already a TV sensation as the benign extraterrestrial Mork from Ork on Mork & Mindy and had starred as a comic-strip sailor in Popeye. But that Tonight Show stint revealed the distilled form of Williams' unique genius in stand-up comedy and his visits with Carson, Dick Cavett, David Letterman, Jay Leno and the other late-night lions. This TIME Spotlight Story explores The Heart of Comedy, Mr, Robin Williams.

    From his perch as a staff writer at The New Yorker, Cuppy observed the world and found a great deal that annoyed him. This collection of essays on animals includes "Birds Who Can't Even Fly," "Optional Insects," "Octopuses and Those Things", and "How to Swat a Fly," which codifies the essentials in ten hilarious principles. And three essays on wombats. Perfect reading for the perplexed, befuddled, and perpetually irritated.

     A powerful true story revealing a remarkable relationship between a dying son - and a mother that refuses to let him go. At the age of 10, Deryn was diagnosed with Leukaemia. Then 18 months later he developed another rare form of cancer called Langerhan’s cell sarcoma. Only five other people in the world have it. He is the youngest of them all and the only person in the world known to be fighting it alongside another cancer, making him one in seven billion. Told there was no hope of survival, after four years of intensive treatment, exhausted by his fight and with just days left to live, Deryn planned his own funeral. But, Deryn’s desperate mother, Callie would not let him give in. Battling medical errors, impossible odds and years of hardship as the cancer consumed his body and their world, they looked for more answers. After making some startling discoveries and taking massive chances - something began to change… Would their lives as a family ever be the same again?

    But the theory of evolution did not spring full-blown from the head of Darwin. Since the dawn of humanity, priests, philosophers, and scientists have debated the origin and development of life on earth, and with modern science, that debate shifted into high gear.In this lively, deeply erudite work, Pulitzer Prize–winning science historian Edward J. Larson takes us on a guided tour of Darwin’s “dangerous idea,” from its theoretical antecedents in the early nineteenth century to the brilliant breakthroughs of Darwin and Wallace, to Watson and Crick’s stunning discovery of the DNA double helix, and to the triumphant neo-Darwinian synthesis and rising sociobiology today.Along the way, Larson expertly places the scientific upheaval of evolution in cultural perspective: the social and philosophical earthquake that was the French Revolution; the development, in England, of a laissez-faire capitalism in tune with a Darwinian ethos of “survival of the fittest”; the emergence of Social Darwinism and the dark science of eugenics against a backdrop of industrial revolution; the American Christian backlash against evolutionism that culminated in the famous Scopes trial; and on to today’s world, where religious fundamentalists litigate for the right to teach “creation science” alongside evolution in U.S. public schools, even as the theory itself continues to evolve in new and surprising directions.Throughout, Larson trains his spotlight on the lives and careers of the scientists, explorers, and eccentrics whose collaborations and competitions have driven the theory of evolution forward. Here are portraits of Cuvier, Lamarck, Darwin, Wallace, Haeckel, Galton, Huxley, Mendel, Morgan, Fisher, Dobzhansky, Watson and Crick, W. D. Hamilton, E. O. Wilson, and many others. Celebrated as one of mankind’s crowning scientific achievements and reviled as a threat to our deepest values, the theory of evolution has utterly transformed our view of life, religion, origins, and the theory itself, and remains controversial, especially in the United States (where 90% of adults do not subscribe to the full Darwinian vision). Replete with fresh material and new insights, Evolution will educate and inform while taking readers on a fascinating journey of discovery.From the Hardcover edition.

    This trial serves as the backdrop for Superbugs, and the results will impact nothing less than the future of humanity.Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more.

    Veil Kendry, an ex-CIA agent with a strange gift of vision, volunteers to undergo tests at the Institute for Human Studies, but unknown enemies seem determined to kill him and stop the tests

    To reach this unique audience, Whitlock and Schluter motivate learning with interesting biological and medical examples; they emphasize intuitive understanding; and they focus on real data. The book covers basic topics in introductory statistics, including graphs, confidence intervals, hypothesis testing, comparison of means, regression, and designing experiments. It also introduces the principles behind such modern topics as likelihood, linear models, meta-analysis and computer-intensive methods. Instructors and students consistently praise the book's clear and engaging writing, strong visualization techniques, and its variety of fascinating and relevant biological examples.

    He decried the internment of Japanese-Americans in World War Two, agitated against nuclear weapons, promoted vitamin C as a cure for the common cold and researched the idea of DNA.

    Fields Cookies... What backward messages on records are really trying to tell you... Frank Sinatra's real age... Why you can't counterfeit a lottery ticket... Barbra Streisand's blue movie... The other Boy Scout rituals... Ingmar Bergman's soap commercials... The formula for Play-Doh... and more.

    Despite advice from experts, governments and dieticians about the dangers of too much fat, sugar, protein and lack of exercise, our nutrition - and the global obesity crisis - is getting worse. Why can one person eat a certain meal and gain weight and another eat exactly the same food and lose pounds? Genes provide part of the answer, but we have been overlooking one vital aspect of diet that lies within us. Thanks to recent breakthroughs, scientists have begun to examine the permanent residents in our guts: the thousands of previously unknown but essential microbes whose job it is to digest our food and keep us alive. Drawing on the latest science and his own research team's pioneering work, Professor Tim Spector explores the hidden world of the microbiome and demystifies the common misconceptions about fat, calories, vitamins and nutrients. Only by understanding how our own microbes interact with our bodies can we overcome our confusion about modern diets and nutrition to regain the correct balance of our ancestors.Mixing cutting-edge discoveries, illuminating science and his own case studies, Spector shows why we should stop listening to the myths of diet fads and instead embrace diversity for a healthy gut and a healthy body.