What happened, how it happened, and what it means to you today. A colorful cast of characters whose discoveries were often driven not only by personal tragedy, curiosity, and hard work, but petty bickering, dumb luck, and a healthy dose of humor. For anyone interested in science, medicine, and beyond... Why are you alive right now? Chances are, you owe your life to one of the remarkable medical discoveries in this book. Maybe it was vaccines. Or antibiotics. Or X-rays. Revolutionary medical breakthroughs like these haven’t just changed the way we treat disease, they’ve transformed how we understand ourselves and the world we live in. In Breakthrough!, Jon Queijo tells the hidden stories behind 10 of history’s most amazing medical discoveries. This isn’t dry history: These are life-and-death mysteries uncovered, tales of passionate, often-mocked individuals who stood their ground and were proven right. From germs to genetics, the ancient Hippocrates to the cutting edge, these are stories that have changed the world—and, quite likely, saved your life.

    But did you know your hair color may also affect how often you get sunburned? Or how often you need to take vitamin supplements?What's in Your Genes? goes beyond Gregor Mendel and dominant/recessive genes to show you all the ins and outs of what determines your DNA. Each entry provides you with a sneak peek into your DNA sequence and teaches you exactly how your body is able to create that wonderful you-ness that no one else has. From your tastebuds to your eye color to your obsession with clinical-strength deodorants, this book not only guides you through the history and study of genetics, but also shows you how those four little letters in your DNA make you who you are.Complete with imaginative illustrations, What's in Your Genes? reveals all there is to know about heredity--like the science behind vibrant red hair, perfect teeth, and your ability to see in color.

    In college, I ran against Kenyans, and wondered whether endurance genes might have traveled with them from East Africa. At the same time, I began to notice that a training group on my team could consist of five men who run next to one another, stride for stride, day after day, and nonetheless turn out five entirely different runners. How could this be?We all knew a star athlete in high school. The one who made it look so easy. He was the starting quarterback and shortstop; she was the all-state point guard and high-jumper. Naturals. Or were they?The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training?The truth is far messier than a simple dichotomy between nature and nurture. In the decade since the sequencing of the human genome, researchers have slowly begun to uncover how the relationship between biological endowments and a competitor’s training environment affects athleticism. Sports scientists have gradually entered the era of modern genetic research.In this controversial and engaging exploration of athletic success, Sports Illustrated senior writer David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving this great riddle. He investigates the so-called 10,000-hour rule to uncover whether rigorous and consistent practice from a young age is the only route to athletic excellence.Along the way, Epstein dispels many of our perceptions about why top athletes excel. He shows why some skills that we assume are innate, like the bullet-fast reactions of a baseball or cricket batter, are not, and why other characteristics that we assume are entirely voluntary, like an athlete’s will to train, might in fact have important genetic components.This subject necessarily involves digging deep into sensitive topics like race and gender. Epstein explores controversial questions such as:Are black athletes genetically predetermined to dominate both sprinting and distance running, and are their abilities influenced by Africa’s geography?Are there genetic reasons to separate male and female athletes in competition?Should we test the genes of young children to determine if they are destined for stardom?Can genetic testing determine who is at risk of injury, brain damage, or even death on the field?Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.

    By examining fossils and DNA, Shubin shows us that our hands actually resemble fish fins, our head is organized like that of a long-extinct jawless fish, and major parts of our genome look and function like those of worms and bacteria.Shubin makes us see ourselves and our world in a completely new light. Your Inner Fish is science writing at its finest-enlightening, accessible, and told with irresistible enthusiasm.

     NAMED ONE OF THE BEST BOOKS OF THE YEAR BY PUBLISHERS WEEKLYSet in an amoral future where genetically engineered monstrosities fight each other to the death in an Olympic event, The Games envisions a harrowing world that may arrive sooner than you think.   Silas Williams is the brilliant geneticist in charge of preparing the U.S. entry into the Olympic Gladiator competition, an internationally sanctioned bloodsport with only one rule: no human DNA is permitted in the design of the entrants. Silas lives and breathes genetics; his designs have led the United States to the gold in every previous event. But the other countries are catching up. Now, desperate for an edge in the upcoming Games, Silas’s boss engages an experimental supercomputer to design the genetic code for a gladiator that cannot be beaten.   The result is a highly specialized killing machine, its genome never before seen on earth. Not even Silas, with all his genius and experience, can understand the horror he had a hand in making. And no one, he fears, can anticipate the consequences of entrusting the act of creation to a computer’s cold logic.   Now Silas races to understand what the computer has wrought, aided by a beautiful xenobiologist, Vidonia João. Yet as the fast-growing gladiator demonstrates preternatural strength, speed, and—most disquietingly—intelligence, Silas and Vidonia find their scientific curiosity giving way to a most unexpected emotion: sheer terror.Praise for The Games   “Blends the best of Crichton and Koontz.”—Publishers Weekly (starred review)   “Outstanding . . . very like something Michael Crichton might have written . . . [a] bold mix of horror and SF . . . Expect big things from [Ted] Kosmatka.”—Booklist (starred review)   “Kosmatka successfully captures the thrill of groundbreaking technology. . . . The pleasure of his polished, action-packed storytelling is deepened by strong character development. This near-future SF thriller . . . seems destined for the big screen.”—Library Journal (starred review)

    Prepare. Trip. Transform!With so much misinformation surrounding magic mushrooms out there, it can be hard to separate fact from fiction. This is where Your Psilocybin Mushroom Companion comes in to help. In this book, you’ll find a comprehensive yet friendly guide to everything there is to know about magic mushrooms.Learn how to plan safe, effective trips with easy-to-follow step-by-step advice. Discover how to train a guide to take care of those on psychedelic voyages, as well as how to access the transformative nature of these experiences. Even learn how microdosing can improve your mood, cognitive functioning, creativity, physical stamina, and more.With the most up-to-date research, Your Psilocybin Mushroom Companion will put magic mushrooms into perspective, dispel myths and urban legends, and open your mind to the benefits of psychedelic tripping.

    The latest studies are revealing exciting new discoveries, such as how the DNA and related chemical compounds in our cells work together to direct the processes of life. Scientists are not only unraveling how life evolved in the ancient past, but are also finding the keys to creating a healthier future.  How does the minuscule chemical cluster in each of our 100 trillion cells accomplish the amazing feat of creating and maintaining our bodies? Frank Ryan, a physician and an evolutionary biologist, describes the complex ways in which the genome operates as a holistic system and not solely through genes coding for proteins—the building blocks of life. Also involved are elaborate switching mechanisms that regulate and control portions of our DNA, as well as the interplay of retroviruses and bacteria.This groundbreaking book explains that we are on the cusp of an amazing era of disease treatment and eradication.

    That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research—the Philadelphia chromosome. This book charts not only that landmark discovery, but also—for the first time, all in one place—the full sequence of scientific and medical discoveries that brought about the first-ever successful treatment of a lethal cancer at the genetic level.The significance of this mutant chromosome would take more than three decades to unravel; in 1990, it was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. This dramatic discovery launched a race involving doctors and researchers around the world, who recognized that in principle it might be possible to target CML at its genetic source.Science journalist Jessica Wapner brings extensive original reporting to this book, including interviews with more than thirty-five people with a direct role in this story. Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 70,000 people worldwide who are diagnosed with CML each year. Chief among them is researcher and oncologist Dr. Brian Druker, whose dedication to his patients fueled his quest to do everything within his power to save them.The Philadelphia Chromosome helps us to fully understand and appreciate just how pathbreaking, hard-won, and consequential are the achievements it recounts—and to understand the principles behind much of today’s most important cancer research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

    His journey into the past follows the clues left by Plato, and they take him far beyond Crete and the Mediterranean, where scholars in recent times have located Atlantis. So do mummies in Egypt, Roman wreckage in the West Atlantic, the African features of great stone heads in Mexico, and the explosion of a comet 10,500 years ago. For two millennia the fate of Atlantis has fascinated historians, philosophers, and explorers who have debated its reality and searched in vain for a kingdom shrouded in myth and legend. Collins's final destination will shock the experts and amaze all readers. "A bold and imaginative attempt to understand the destruction of the legendary city of Atlantis."—Kirkus Reviews "Probably the most substantial and well researched book on Atlantis since Ignatius Donnelly."—Colin Wilson, author of From Atlantis to the Sphinx

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.

    It draws on all the latest knowledge from anthropology and archaeology, via genetics and evolution, to psychology and medicine. It tackles issues such as hereditary genes in criminal behaviour and homosexuality.

    “Forget everything you think you know about genes, talent, and intelligence,” he writes. “In recent years, a mountain of scientific evidence has emerged suggesting a completely new paradigm: not talent scarcity, but latent talent abundance.” Integrating cutting-edge research from a wide swath of disciplines—cognitive science, genetics, biology, child development—Shenk offers a highly optimistic new view of human potential. The problem isn't our inadequate genetic assets, but our inability, so far, to tap into what we already have. IQ testing and widespread acceptance of “innate” abilities have created an unnecessarily pessimistic view of humanity—and fostered much misdirected public policy, especially in education. The truth is much more exciting. Genes are not a “blueprint” that bless some with greatness and doom most of us to mediocrity or worse. Rather our individual destinies are a product of the complex interplay between genes and outside stimuli-a dynamic that we, as people and as parents, can influence. This is a revolutionary and optimistic message. We are not prisoners of our DNA. We all have the potential for greatness.

    But she is a young woman on the brink of a whole new life when, in a moment of defiance, she forgets that warning and triggers a catastrophe that shatters all her hopes.Stricken with grief and seeking a way to correct her terrible mistake, Catrin risks everything on a dangerous bargain. Too late, she realizes just how much more she has to lose.With advice from a half-mad witch and help from companions she meets along the way, Catrin embarks on a desperate quest to defeat seven riddling Magpies--magical tricksters who can shapeshift into anything or anyone--and win back her book or face losing everything she holds dear.With each step the stakes get higher, and there are secrets she still doesn't suspect. How much is Catrin willing to sacrifice to finally unmask the Seventh Magpie?A dark fairy tale of loss and renewal.

    Darwin was only too aware of the storm his theory of evolution would provoke but he would surely have raised an incredulous eyebrow at the controversy still raging a century and a half later. Evolution is accepted as scientific fact by all reputable scientists and indeed theologians, yet millions of people continue to question its veracity.In The Greatest Show on Earth Richard Dawkins takes on creationists, including followers of ‘Intelligent Design’ and all those who question the fact of evolution through natural selection. Like a detective arriving on the scene of a crime, he sifts through fascinating layers of scientific facts and disciplines to build a cast-iron case: from the living examples of natural selection in birds and insects; the ‘time clocks’ of trees and radioactive dating that calibrate a timescale for evolution; the fossil record and the traces of our earliest ancestors; to confirmation from molecular biology and genetics. All of this, and much more, bears witness to the truth of evolution.The Greatest Show on Earth comes at a critical time: systematic opposition to the fact of evolution is now flourishing as never before, especially in America. In Britain and elsewhere in the world, teachers witness insidious attempts to undermine the status of science in their classrooms. Richard Dawkins provides unequivocal evidence that boldly and comprehensively rebuts such nonsense. At the same time he shares with us his palpable love of the natural world and the essential role that science plays in its interpretation. Written with elegance, wit and passion, it is hard-hitting, absorbing and totally convincing.

    John Sanford, a retired Cornell Professor, shows in "Genetic Entropy and the Mystery of the Genome" that the "Primary Axiom" is false. The Primary Axiom is the foundational evolutionary premise -- that life is merely the result of mutations and natural selection. In addition to showing compelling theoretical evidence that whole genomes must in fact degenerate over time, this book strongly refutes the Darwinian concept that man is just the result of a random and pointless natural process. This is an updated version of the October 2005 edition, which includes both a new appendix and glossary.