As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    She conjures up early operating theaters--no place for the squeamish--and surgeons, working before anesthesia, who were lauded for their speed and brute strength. These medical pioneers knew that the aftermath of surgery was often more dangerous than their patients' afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn't have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the deadly riddle and change the course of history.Fitzharris dramatically recounts Lister's discoveries in gripping detail, culminating in his audacious claim that germs were the source of all infection--and could be countered by antiseptics. Focusing on the tumultuous period from 1850 to 1875, she introduces us to Lister and his contemporaries--some of them brilliant, some outright criminal--and takes us through the grimy medical schools and dreary hospitals where they learned their art, the deadhouses where they studied anatomy, and the graveyards they occasionally ransacked for cadavers.Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.

    But long before the world took notice, Chip was a serial entrepreneur who was always ready for the next challenge, even if it didn’t quite work out as planned. Whether it was buying a neighborhood laundromat or talking a bank into a loan for some equipment to start a lawn-mowing service, Chip always knew that the most important thing was to take that first step.In Capital Gaines, we walk alongside him as he relives some of his craziest antics and the lessons learned along the way. His mentors taught him to never give up and his family showed him what it meant to always have a positive attitude despite your circumstances. Throw in a natural daredevil personality and a willingness to do (or eat!) just about anything, and you have the life and daily activity of Chip Gaines.Capital Gaines is the perfect book for anyone looking to succeed not only in business but more importantly in life.

    This early-20th-century battle centers on one man: Tom Anderson, the undisputed czar of the city's Storyville vice district, who fights desperately to keep his empire intact as it faces onslaughts from all sides. Surrounding him are the stories of flamboyant prostitutes, crusading moral reformers, dissolute jazzmen, ruthless Mafiosi, venal politicians, and one extremely violent serial killer, all battling for primacy in a wild and wicked city unlike any other in the world.

    As the storytellers in this book start careers, build homes, and raise families, we witness the life-affirming joy of partnership, the comfort of shared sorrows, and profound gratitude in the face of loss.These stories are also testament to the heart’s remarkable endurance. In ALL THERE IS we encounter love that survives discrimination, illness, poverty, distance—even death. In the courage of people’s passion we are reminded of the strength and resilience of the human spirit. This powerful collection bares witness to real love, in its many varied forms, enriching our understanding of that most magical feeling.

    But street addresses were not invented to help you find your way; they were created to find you. In many parts of the world, your address can reveal your race and class.In this wide-ranging and remarkable book, Deirdre Mask looks at the fate of streets named after Martin Luther King Jr., the wayfinding means of ancient Romans, and how Nazis haunt the streets of modern Germany. The flipside of having an address is not having one, and we also see what that means for millions of people today, including those who live in the slums of Kolkata and on the streets of London. Filled with fascinating people and histories, The Address Book illuminates the complex and sometimes hidden stories behind street names and their power to name, to hide, to decide who counts, who doesn’t―and why.

    A dynamic YouTube star and Animal Planet personality with a fresh approach, Zak helps you tailor training to your dog’s unique traits and energy level—leading to quicker results and a much happier pet. For the first time, Zak has distilled the information from his hundreds of videos and experience with thousands of dogs into this comprehensive guide that includes·      Choosing the right pup for you ·      Housetraining and basic training ·      Handling biting, leash pulling, jumping up, barking, aggression, chewing, and other behavioral issues ·      Health care essentials like finding a vet and selecting the right food ·      Cool tricks, traveling tips, and activities to enjoy with your dog ·      Topics with corresponding videos on Zak’s YouTube channel so you can see his advice in action  Packed with everything you need to know to raise and care for your dog, this book will help you communicate and bond with one another in a way that makes training easier, more rewarding, and—most of all—fun!From the Trade Paperback edition.

    (Why? Shush, dear. A lady doesn't question.) UNMENTIONABLE is your hilarious, illustrated, scandalously honest (yet never crass) guide to the secrets of Victorian womanhood, giving you detailed advice on: ~ What to wear ~ Where to relieve yourself ~ How to conceal your loathsome addiction to menstruating ~ What to expect on your wedding night ~ How to be the perfect Victorian wife ~ Why masturbating will kill you ~ And moreIrresistibly charming, laugh-out-loud funny, and featuring nearly 200 images from Victorian publications, UNMENTIONABLE will inspire a whole new level of respect for Elizabeth Bennett, Scarlet O'Hara, Jane Eyre, and all of our great, great grandmothers. (And it just might leave you feeling ecstatically grateful to live in an age of pants, super absorbency tampons, epidurals, anti-depressants, and not-dying-of-the-syphilis-your-husband-brought-home.)

    While paintings of Picasso and Jackson Pollock sell for a hundred million dollars or more, and lines from T. S. Eliot are quoted on the yearbook pages of alienated teenagers across the land, twentieth-century classical music still sends ripples of unease through audiences. At the same time, its influence can be felt everywhere. Atonal chords crop up in jazz. Avant-garde sounds populate the soundtracks of Hollywood thrillers. Minimalism has had a huge effect on rock, pop, and dance music from the Velvet Underground onward.The Rest Is Noise shows why twentieth-century composers felt compelled to create a famously bewildering variety of sounds, from the purest beauty to the purest noise. It tells of a remarkable array of maverick personalities who resisted the cult of the classical past, struggled against the indifference of a wide public, and defied the will of dictators. Whether they have charmed audiences with sweet sounds or battered them with dissonance, composers have always been exuberantly of the present, defying the stereotype of classical music as a dying art. The narrative goes from Vienna before the First World War to Paris in the twenties, from Hitler's Germany and Stalin's Russia to downtown New York in the sixties and seventies. We follow the rise of mass culture and mass politics, of dramatic new technologies, of hot and cold wars, of experiments, revolutions, riots, and friendships forged and broken. The end result is not so much a history of twentieth-century music as a history of the twentieth century through its music.

    Handsome and charismatic, he was known to frequent the dive bars and gin joints of the Five Points, the most dangerous neighborhood in maritime Manhattan. For years, he operated out of the public eye, rambling from crime to crime, working on the water, in ships, sleeping in the nickel-a-night flops, drinking in barrooms where rat-baiting and bear-baiting were great entertainments.Hicks's criminal career reached its peak in 1860, when he was hired, under an alias, as an extra hand on an oyster sloop. His plan was to rob the ship, make his getaway, and disappear in the teeming streets of lower Manhattan, as he'd done numerous times before. But the plan went awry, and the voyage turned into a massacre. In the straits of Coney Island, on a foggy night, the ghost sloop, adrift and unmanned, was rammed by another vessel. When police boarded the ship to investigate, they found blood and gore everywhere, no bodies, only the grisly signs of struggle. A manhunt was launched for the mysterious merchant seaman on the manifest.Long fascinated by gangster legends, Rich Cohen tells the story of this notorious underworld figure for the first time, from his humble origins to his incarnation as a demon who terrorized the Five Points and became the gangster most feared by other gangsters, at a time when pirates anchored off of 14th street.

    Do cats do things they don’t want to do? Definitely not. Do cats rush around at all hours of the day when they’d rather be licking their paws and looking out a window? Please. Calm, free, charismatic, wise, elegant, self-assured—our beloved feline pets strut those traits that we humans spend a lifetime aspiring to. No wonder everybody wants to be more like a cat.After observing his own cat, Ziggy, for years, bestselling French author Stéphane Garnier decided that he would be much happier if he could just live more like Ziggy. Closer study only confirmed his suspicion that cats have that je ne sais quoi, and he set out to share Ziggy’s innate wisdom with the world.Whether at work, at home, or in your social life, your cat can teach you how to manage stress, cultivate independence, and live life on your terms. Peppered with humorous yet inspiring tips for living a day in the life of a cat, cat secrets from Ziggy, and a quiz to assess your “cat quotient,” How to Think Like a Cat is an inspiring, humorous, and remarkably insightful guide to the subtle art of living like a feline.

    Reporters flocked to the scene. Well-known columnists took up conspicuous seats in the courtroom. The defendant was relentlessly scrutinized for signs of guilt or innocence. Everyone—rich and poor, suffragists and social conservatives, legal scholars and laypeople—had an opinion about Lizzie Borden’s guilt or innocence.The popular fascination with the Borden murders and its central, enigmatic character has endured for more than a hundred years, but the legend often outstrips the story. Based on transcripts of the Borden legal proceedings, contemporary newspaper articles, previously withheld lawyer's journals, unpublished local reports, and recently unearthed letters from Lizzie herself, The Trial of Lizzie Borden is a definitive account of the Borden murder case and offers a window into America in the Gilded Age, showcasing its most deeply held convictions and its most troubling social anxieties.

    But as Ocean Guardian founder William McKeever reveals, sharks are evolutionary marvels essential to maintaining a balanced ecosystem. We can learn much from sharks, he argues, and our knowledge about them continues to grow. The first book to reveal in full the hidden lives of sharks, Emperors of the Deep examines four species—Mako, Tiger, Hammerhead, and Great White—as never before, and includes fascinating details such as:Sharks are 50-million years older than trees;Sharks have survived five extinction level events, including the one that killed off the dinosaurs;Sharks have electroreception, a sixth-sense that lets them pick up on electric fields generated by living things;Sharks can dive 4,000 feet below the surface;Sharks account for only 6 human fatalities per year, while humans kill 100 million sharks per year.McKeever goes back through time to probe the shark’s pre-historic secrets and how it has become the world’s most feared and most misunderstood predator, and takes us on a pulse-pounding tour around the world and deep under the water’s surface, from the frigid waters of the Arctic Circle to the coral reefs of the tropical Central Pacific, to see sharks up close in their natural habitat. He also interviews ecologists, conservationists, and world-renowned shark experts, including the founders of Greenpeace’s Rainbow Warrior, the head of the Massachusetts Shark Research Program, and the self-professed “last great shark hunter.”At once a deep-dive into the misunderstood world of sharks and an urgent call to protect them, Emperors of the Deep celebrates this wild species that hold the key to unlocking the mysteries of the ocean—if we can prevent their extinction from climate change and human hunters.

    In Broken, Jenny brings readers along on her mental and physical health journey, offering heartbreaking and hilarious anecdotes along the way.With people experiencing anxiety and depression now more than ever, Jenny humanizes what we all face in an all-too-real way, reassuring us that we’re not alone and making us laugh while doing it. From the business ideas that she wants to pitch to Shark Tank to the reason why Jenny can never go back to the post office, Broken leaves nothing to the imagination in the most satisfying way. And of course, Jenny’s long-suffering husband Victor―the Ricky to Jenny’s Lucille Ball―is present throughout.A treat for Jenny Lawson’s already existing fans, and destined to convert new ones, Broken is a beacon of hope and a wellspring of laughter when we all need it most.

    Soon the Camp Fire was upon them, gobbling an acre a second. Less than two hours after it ignited, residents were trapped in flames, cremated in their homes and cars. By the next morning, eighty-five people were dead.San Francisco Chronicle reporter Lizzie Johnson was there as the town of Paradise burned. She saw the smoldering rubble of a historic covered bridge and the beloved Black Bear Diner, and she stayed long afterward, visiting shelters, hotels, and makeshift camps. Drawing on years of on-the-ground reporting and reams of public records, including 911 calls and testimony from a grand jury investigation, Johnson provides a minute-by-minute account of the Camp Fire, following residents and first responders as they fight to save themselves and their town. We see a young mother fleeing with her newborn; a school bus full of children in search of an escape route; and a group of paramedics, patients, and nurses trapped in a cul-de-sac, fending off the fire with rakes and hoses.Johnson documents the unfolding tragedy with empathy and nuance. But she also investigates the root causes, from runaway climate change to a deeply flawed alert system to Pacific Gas and Electric's decades-long neglect of critical infrastructure. A cautionary tale for a new era of megafires, Paradise is the gripping story of a town wiped off the map and the determination of its people to rise again.