Indeed, these tiny structures inside our cells are important beyond imagining. Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures.

    Readers will find excerpts from bestsellers such as Douglas R. Hofstadter's Gödel, Escher, Bach, Francis Crick's Life Itself, Loren Eiseley's The Immense Journey, Daniel Dennett's Darwin's Dangerous Idea, and Rachel Carson's The Sea Around Us. There are classic essays ranging from J.B.S. Haldane's "On Being the Right Size" and Garrett Hardin's "The Tragedy of the Commons" to Alan Turing's "Computing Machinery and Intelligence" and Albert Einstein's famed New York Times article on "Relativity." And readers will also discover lesser-known but engaging pieces such as Lewis Thomas's "Seven Wonders of Science," J. Robert Oppenheimer on "War and Physicists," and Freeman Dyson's memoir of studying under Hans Bethe.A must-read volume for all science buffs, The Oxford Book of Modern Science Writing is a rich and vibrant anthology that captures the poetry and excitement of scientific thought and discovery.One of New Scientist's Editor's Picks for 2008.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    This Harriman House edition includes Charles Mackay's account of the three infamous financial manias - John Law's Mississipi Scheme, the South Sea Bubble, and Tulipomania.Between the three of them, these historic episodes confirm that greed and fear have always been the driving forces of financial markets, and, furthermore, that being sensible and clever is no defence against the mesmeric allure of a popular craze with the wind behind it.In writing the history of the great financial manias, Charles Mackay proved himself a master chronicler of social as well as financial history. Blessed with a cast of characters that covered all the vices, gifted a passage of events which was inevitably heading for disaster, and with the benefit of hindsight, he produced a record that is at once a riveting thriller and absorbing historical document. A century and a half later, it is as vibrant and lurid as the day it was written.For modern-day investors, still reeling from the dotcom crash, the moral of the popular manias scarcely needs spelling out. When the next stock market bubble comes along, as it surely will, you are advised to recall the plight of some of the unfortunates on these pages, and avoid getting dragged under the wheels of the careering bandwagon yourself.

    Literate and authoritative--.Marvelously exciting." --The New York Times Book ReviewJonathan Weiner, winner of the Pulitzer Prize for The Beak of the Finch, brings his brilliant reporting skills to the story of Seymour Benzer, the Brooklyn-born maverick scientist whose study of genetics and experiments with fruit fly genes has helped revolutionize or knowledge of the connections between DNA and behavior both animal and human.How much of our fate is decided before we are born?  Which of our characteristics is inscribed in our DNA? Weiner brings us into Benzer's Fly Rooms at the California Institute of Technology, where Benzer, and his asssociates are in the process of finding answers, often astonishing ones, to these questions. Part biography, part thrilling scientific detective story, Time, Love, Memory forcefully demonstrates how Benzer's studies are changing our world view--and even our lives.

    The author, a clinical psychologist, examines religious scriptures, rituals, and canon law, highlighting the many ways in which our evolutionary legacy has shaped the development of religion and continues to profoundly influence its expression. The book focuses on the image of God as the dominant male in Judaism, Christianity, and Islam. This traditional God concept is seen as a reflection of the “dominant ape” paradigm so evident in the hierarchical social structures of primates, with whom we have a strong genetic connection.The author describes the main features of male-dominated primate social hierarchies— specifically, the role of the alpha male as the protector of the group; his sexual dominance and use of violence and oppression to attain food, females, and territory; in-group altruism vs. out-group hostility (us vs. them); and displays of dominance and submission to establish roles within the social hierarchy. The parallels between these features of primate society and human religious rituals and concepts make it clear that religion, especially its oppressive and violent tendencies, is rooted in the deep evolutionary past.This incisive analysis goes a long way toward explaining the historic and ongoing violence committed in the name of religion.

    Sexy and shrewd, she quickly went from streetwalker to madam and by 1920 had opened what became a legendary house of prostitution. There she entertained a steady stream of governors, gangsters, and movie stars until she was arrested at last in 1962. Shortly before she died in 1974, she tape—recorded her memories-the scandalous stories of a powerful woman who had the city's politicians in her pocket and whose lovers included the twenty-five-year-old boy next door, whom she married when she was sixty-four. Combining those tapes with original research, Christine Wiltz chronicles not just Norma's rise and fall but also the social history of New Orleans, thick with the vice and corruption that flourished there—and, like Midnight in the Garden of Good and Evil and Philistines at the Hedgerow, resurrects a vanished secret world.

    . . when it comes to the legacy of this country's war on drugs, we should all share his outrage." --The New York Times Book Review From one of the world's foremost experts on the subject, a powerful argument that the greatest damage from drugs flows from their being illegal, and a hopeful reckoning with the possibility of their use as part of a responsible and happy lifeDr. Carl L. Hart, Ziff Professor at Columbia University and former chair of the Department of Psychology, is one of the world's preeminent experts on the effects of so-called recreational drugs on the human mind and body. Dr. Hart is open about the fact that he uses drugs himself, in a happy balance with the rest of his full and productive life as a colleague, husband, father, and friend. In Drug Use for Grown-Ups, he draws on decades of research and his own personal experience to argue definitively that the criminalization and demonization of drug use--not drugs themselves--have been a tremendous scourge on America, not least in reinforcing this country's enduring structural racism.Dr. Hart did not always have this view. He came of age in one of Miami's most troubled neighborhoods at a time when many ills were being laid at the door of crack cocaine. His initial work as a researcher was aimed at proving that drug use caused bad outcomes. But one problem kept cropping up: the evidence from his research did not support his hypothesis. From inside the massively well-funded research arm of the American war on drugs, he saw how the facts did not support the ideology. The truth was dismissed and distorted in order to keep fear and outrage stoked, the funds rolling in, and Black and brown bodies behind bars.Drug Use for Grown-Ups will be controversial, to be sure: the propaganda war, Dr. Hart argues, has been tremendously effective. Imagine if the only subject of any discussion about driving automobiles was fatal car crashes. Drug Use for Grown-Ups offers a radically different vision: when used responsibly, drugs can enrich and enhance our lives. We have a long way to go, but the vital conversation this book will generate is an extraordinarily important step.

    It explains all this and much more. It discloses the best time to have a sex change, how to have a virgin birth, when to seduce your sisters or eat your lover. Quirky and brilliant, it takes as its starting point all creatures great and small worried about their bizarre sex lives, and the letters they write to the wise Dr Tatiana, the only agony aunt in all creation with a prodigious knowledge of both natural history and evolutionary biology.

    With blazing originality, The Fourth Turning illuminates the past, explains the present, and reimagines the future. Most remarkably, it offers an utterly persuasive prophecy about how America's past will predict its future.Strauss and Howe base this vision on a provocative theory of American history. The authors look back five hundred years and uncover a distinct pattern: Modern history moves in cycles, each one lasting about the length of a long human life, each composed of four eras--or turnings--that last about twenty years and that always arrive in the same order. In The Fourth Turning, the authors illustrate these cycles using a brilliant analysis of the post-World War II period.First comes a High, a period of confident expansion as a new order takes root after the old has been swept away. Next comes an Awakening, a time of spiritual exploration and rebellion against the now-established order. Then comes an Unraveling, an increasingly troubled era in which individualism triumphs over crumbling institutions. Last comes a Crisis--the Fourth Turning--when society passes through a great and perilous gate in history. Together, the four turnings comprise history's seasonal rhythm of growth, maturation, entropy, and rebirth.The Fourth Turning offers bold predictions about how all of us can prepare, individually and collectively, for America's next rendezvous with destiny.

    Beginning with the above questions, she began informally researching every affliction that she encountered in humans to learn whether it happened with animals, too. And usually, it did: dinosaurs suffered from brain cancer, koalas can catch chlamydia, reindeer seek narcotic escape in hallucinogenic mushrooms, stallions self-mutilate, and gorillas experience clinical depression. Natterson-Horowitz and science writer Kathryn Bowers have dubbed this pan-species approach to medicine zoobiquity. Here, they present a revelatory understanding of what animals can teach us about the human body and mind, exploring how animal and human commonality can be used to diagnose, treat, and heal patients of all species.

    It is a scientific look at how ancient humans made sense of the world and the phenomena they encountered around them.In the past, arguments against the existence of gods have mainly come in the form of scientific inquiries that attempt to show there is no evidence for their existence. The Invention of Religion, however, investigates the psychological mechanisms that cause religions to originate and it sets out to prove that when humans have neither science nor religion, these mechanisms cause them to invent new religions. It also investigates how the differences (like monotheism vs. pantheism) between religions arise and how probable these differences are.

    While we are similar to other mammals in many ways, our behavior sets us apart. Our unparalleled ability to adapt has allowed us to occupy virtually every habitat on earth using an incredible variety of tools and subsistence techniques. Our societies are larger, more complex, and more cooperative than any other mammal's. In this stunning exploration of human adaptation, Peter J. Richerson and Robert Boyd argue that only a Darwinian theory of cultural evolution can explain these unique characteristics.Not by Genes Alone offers a radical interpretation of human evolution, arguing that our ecological dominance and our singular social systems stem from a psychology uniquely adapted to create complex culture. Richerson and Boyd illustrate here that culture is neither superorganic nor the handmaiden of the genes. Rather, it is essential to human adaptation, as much a part of human biology as bipedal locomotion. Drawing on work in the fields of anthropology, political science, sociology, and economics—and building their case with such fascinating examples as kayaks, corporations, clever knots, and yams that require twelve men to carry them—Richerson and Boyd convincingly demonstrate that culture and biology are inextricably linked, and they show us how to think about their interaction in a way that yields a richer understanding of human nature.In abandoning the nature-versus-nurture debate as fundamentally misconceived, Not by Genes Alone is a truly original and groundbreaking theory of the role of culture in evolution and a book to be reckoned with for generations to come. “I continue to be surprised by the number of educated people (many of them biologists) who think that offering explanations for human behavior in terms of culture somehow disproves the suggestion that human behavior can be explained in Darwinian evolutionary terms. Fortunately, we now have a book to which they may be directed for enlightenment . . . . It is a book full of good sense and the kinds of intellectual rigor and clarity of writing that we have come to expect from the Boyd/Richerson stable.”—Robin Dunbar, Nature “Not by Genes Alone is a valuable and very readable synthesis of a still embryonic but very important subject straddling the sciences and humanities.”—E. O. Wilson, Harvard University

    We see it everywhere - from Pearl Harbour to 9/11, from the assassination of Kennedy to the death of Diana. Bookshop shelves threaten to collapse under the weight of texts devoted to proving myriad conspiracy theories true, while even quality newspapers and serious TV channels are prepared to give them credence.For David Aaronovitch, there came a time when he started to see a pattern. These theories used similar dodgy methods with which to insinuate their claims: they linked themselves to the supposed conspiracies of the past (it happened then so it can happen now); they carefully manipulated their evidence to hide its holes; they relied on the authority of dubious academic sources. Most importantly, they elevated their believers to membership of an elite - a group of people able to see beyond lies to a higher reality. But why believe something that entails stretching the bounds of probability so far? Surely it is more likely that men did actually land on the moon in 1969 than that thousands of people were enlisted to fabricate a deception that they did.In this entertaining and enlightening book - aimed to provide ammunition for those who have found themselves at the wrong end of a conversation about moon landings or twin towers - Aaronovitch carefully probes and explodes a dozen of the major conspiracy theories. In doing so, he looks at why people believe them, and makes an argument for a true scepticism: one based on a thorough knowledge of history and a strong dose of common sense.