These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Muir went from impassioned author to leading activist. He would popularize glaciers unlike anybody else, and be to glaciers what Jacques Cousteau would be to the oceans and Carl Sagan to the starsThe book also offers an environmental caveat on global climate change and the glaciers' retreat alongside a beacon of hope: Muir shows us how one person changed America, helped it embrace its wilderness, and in turn, gave us a better world.In 2005, Californians had to choose a design for its commemorative quarter. Hundreds of submissions – the iconic Hollywood sign above Hollywood Hills, the 1849 Gold Rush, the Golden Gate Bridge, etc. – fell away until one remained: an image of John Muir.  2014 will mark the 100th anniversary of Muir’s death. Muir’s legacy is that he reordered our priorities and contributed to a new scientific revolution that was picked up a generation later by Aldo Leopold and Rachel Carson, and is championed today by influential writers like E.O. Wilson and Jared Diamond.Heacox takes us into how Muir changed our world, advanced the science of glaciology and popularized geology. How he got people out there. How he gave America a new vision of Alaska, and of itself.

    Peter Stark offers a harrowing saga in which a band of explorers battled nature, starvation, and madness to establish the first American settlement in the Pacific Northwest and opened up what would become the Oregon trail, permanently altering the nation's landscape and its global standing.Six years after Lewis and Clark began their journey to the Pacific Northwest, two of the Eastern establishment's leading figures, John Jacob Astor and Thomas Jefferson, turned their sights to founding a colony akin to Jamestown on the West Coast and transforming the nation into a Pacific trading power. Author and correspondent for Outside magazine Peter Stark recreates this pivotal moment in American history for the first time for modern readers, drawing on original source material to tell the amazing true story of the Astor Expedition.Unfolding over the course of three years, from 1810 to 1813, Astoria is a tale of high adventure and incredible hardship in the wilderness and at sea. Of the more than one hundred-forty members of the two advance parties that reached the West Coast—one crossing the Rockies, the other rounding Cape Horn—nearly half perished by violence. Others went mad. Within one year, the expedition successfully established Fort Astoria, a trading post on the Columbia River. Though the colony would be short-lived, it opened provincial American eyes to the potential of the Western coast and its founders helped blaze the Oregon Trail.

    The effects of homeopathy don’t go away under rigorous scientific conditions. The laws of nature aren’t what they used to be. Thirty years on, no one has an explanation for a seemingly intelligent signal received from outer space. The US Department of Energy is re-examining cold fusion because the experimental evidence seems too solid to ignore. The placebo effect is put to work in medicine while doctors can’t agree whether it even exists.In an age when science is supposed to be king, scientists are beset by experimental results they simply can’t explain. But, if the past is anything to go by, these anomalies contain the seeds of future revolutions. While taking readers on an entertaining tour d’horizon of the strangest of scientific findings – involving everything from our lack of free will to Martian methane that offers new evidence of life on the planet – Michael Brooks argues that the things we don’t understand are the key to what we are about to discover.This mind-boggling but entirely accessible survey of the outer limits of human knowledge is based on a short article by Michael Brooks for New Scientist magazine. It became the sixth most circulated story on the internet in 2005, and provoked widespread comment and compliments (Google “13 things that do not make sense” to see).Michael Brooks has now dug deeply into those mysteries, with extraordinary results.

    News of both the Ice Man's discovery and his age, which was put at over five thousand years, fascinated scientists and newspapers throughout the world. But what made Sykes's story particularly revelatory was his successful identification of a genetic descendant of the Ice Man, a woman living in Great Britain today. How was Sykes able to locate a living relative of a man who died thousands of years ago?In The Seven Daughters of Eve, he gives us a firsthand account of his research into a remarkable gene, which passes undiluted from generation to generation through the maternal line. After plotting thousands of DNA sequences from all over the world, Sykes found that they clustered around a handful of distinct groups. Among Europeans and North American Caucasians, there are, in fact, only seven. This conclusion was staggering: almost everyone of native European descent, wherever they may live throughout the world, can trace their ancestry back to one of seven women, the Seven Daughters of Eve.Naming them Ursula, Xenia, Helena, Velda, Tara, Katrine, and Jasmine, Sykes has created portraits of their disparate worlds by mapping the migratory patterns followed by millions of their ancestors. In reading the stories of these seven women, we learn exactly how our origins can be traced, how and where our ancient genetic ancestors lived, and how we are each living proof of the almost indestructible strands of DNA, which have survived over so many thousands of years. Indeed, The Seven Daughters of Eve is filled with dramatic stories: from Sykes's identification, using DNA samples from two living relatives, of the remains of Tsar Nicholas and Tsaress Alexandra, to the Caribbean woman whose family had been sold into slavery centuries before and whose ancestry Sykes was able to trace back to the Eastern coast of central Africa. Ultimately, Sykes's investigation reveals that, as a race, what humans have in common is more deeply embedded than what separates us.

    In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation. Among the questions the obituary—and consequent outcry—prompted were, Who are the role models for today’s female scientists, and where can we find the stories that cast them in their true light?      Headstrong delivers a powerful, global, and engaging response. Covering Nobel Prize winners and major innovators, as well as lesser-known but hugely significant scientists who influence our every day, Rachel Swaby’s vibrant profiles span centuries of courageous thinkers and illustrate how each one’s ideas developed, from their first moment of scientific engagement through the research and discovery for which they’re best known. This fascinating tour reveals these 52 women at their best—while encouraging and inspiring a new generation of girls to put on their lab coats.

    But the president insisted there was nothing to worry about.Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios. Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19.The characters you will meet in these pages are as fascinating as they are unexpected. A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

    Vowell tackles subjects such as identity, politics, religion, art, and history with a biting humor. She searches the streets of Hoboken for traces of the town's favorite son, Frank Sinatra. She goes under cover of heavy makeup in an investigation of goth culture, blasts cannonballs into a hillside on a father-daughter outing, and maps her family's haunted history on a road trip down the Trail of Tears. Vowell has an irresistible voice—caustic and sympathetic, insightful and double-edged—that has attracted a loyal following for her magazine writing and radio monologues on This American Life.

    Alexander von Humboldt (1769 – 1859) was an intrepid explorer and the most famous scientist of his age. In North America, his name still graces four counties, thirteen towns, a river, parks, bays, lakes, and mountains. His restless life was packed with adventure and discovery, whether he was climbing the highest volcanoes in the world or racing through anthrax-infected Siberia or translating his research into bestselling publications that changed science and thinking. Among Humboldt's most revolutionary ideas was a radical vision of nature, that it is a complex and interconnected global force that does not exist for the use of humankind alone. Now Andrea Wulf brings the man and his achievements back into focus: his daring expeditions and investigation of wild environments around the world and his discoveries of similarities between climate and vegetation zones on different continents. She also discusses his prediction of human-induced climate change, his remarkable ability to fashion poetic narrative out of scientific observation, and his relationships with iconic figures such as Simón Bolívar and Thomas Jefferson. Wulf examines how Humboldt's writings inspired other naturalists and poets such as Darwin, Wordsworth, and Goethe, and she makes the compelling case that it was Humboldt's influence that led John Muir to his ideas of natural preservation and that shaped Thoreau's Walden.With this brilliantly researched and compellingly written book, Andrea Wulf shows the myriad fundamental ways in which Humboldt created our understanding of the natural world, and she champions a renewed interest in this vital and lost player in environmental history and science.

    A story of defiance and determination by a controversial scientist, this is Lee Berger's own take on finding Homo naledi, an all-new species on the human family tree and one of the greatest discoveries of the 21st century.In 2013, Berger, a National Geographic Explorer-in-Residence, caught wind of a cache of bones in a hard-to-reach underground cave in South Africa. He put out a call around the world for petite collaborators--men and women small and adventurous enough to be able to squeeze through 8-inch tunnels to reach a sunless cave 40 feet underground. With this team of "underground astronauts," Berger made the discovery of a lifetime: hundreds of prehistoric bones, including entire skeletons of at least 15 individuals, all perhaps two million years old. Their features combined those of known prehominids like Lucy, the famous Australopithecus, with those more human than anything ever before seen in prehistoric remains. Berger's team had discovered an all new species, and they called it Homo naledi.The cave quickly proved to be the richest primitive hominid site ever discovered, full of implications that shake the very foundation of how we define what makes us human. Did this species come before, during, or after the emergence of Homo sapiens on our evolutionary tree? How did the cave come to contain nothing but the remains of these individuals? Did they bury their dead? If so, they must have had a level of self-knowledge, including an awareness of death. And yet those are the very characteristics used to define what makes us human. Did an equally advanced species inhabit Earth with us, or before us? Berger does not hesitate to address all these questions.Berger is a charming and controversial figure, and some colleagues question his interpretation of this and other finds. But in these pages, this charismatic and visionary paleontologist counters their arguments and tells his personal story: a rich and readable narrative about science, exploration, and what it means to be human.

    Nature enthusiasts and fans of fine literature alike will find Beautiful Swimmers a timeless and enchanting study in the tradition of Rachel Carson and Annie Dillard. In these pages, we are immersed not only in the world of the Chesapeake's most intriguing crustaceans, but in the winds and tides of the Bay itself and the struggles of the watermen who make their living in pursuit of the succulent, pugnacious blue crab. "This is a book of rare grace and meditation, one that ranges from adventure to zoology, with no small measure of mystery and history." --Miami Herald "Beautiful Swimmers is wonderful to read and a distinguished addition to our literature." --Larry McMurtry

    With two whip-like tentacles, eight arms studded with toothed suckers, and two lidless eyes the size of dinner plates, Architeurthis has inspired myths and movies, nightmares and religious conversions. Yet it has never been studied while alive.Marin biologist, explorer, and artist Richard Ellis delves into myth, literature, and science to bring readers face-to-face with this remarkable creature as it terrifies sailors ad fishermen throughout history and battles for its life against the great sperm whale. Ellis continues his exploration into the modern era, when scientists rush to study a rare carcass, and the giant squid is a staple on the big screen.Interweaving his narrative with a wralth of illustrations and photographs, Ellis gives us the first scientific and cultural history of the only living creature that can still truly be called a sea monster.

    It explains all this and much more. It discloses the best time to have a sex change, how to have a virgin birth, when to seduce your sisters or eat your lover. Quirky and brilliant, it takes as its starting point all creatures great and small worried about their bizarre sex lives, and the letters they write to the wise Dr Tatiana, the only agony aunt in all creation with a prodigious knowledge of both natural history and evolutionary biology.

     Celebrated writer and contrarian Bill James has voraciously read true crime throughout his life and has been interested in writing a book on the topic for decades. Now, with Popular Crime, James takes readers on an epic journey from Lizzie Borden to the Lindbergh baby, from the Black Dahlia to O. J. Simpson, explaining how crimes have been committed, investigated, prosecuted and written about, and how that has profoundly influenced our culture over the last few centuries— even if we haven’t always taken notice. Exploring such phenomena as serial murder, the fluctuation of crime rates, the value of evidence, radicalism and crime, prison reform and the hidden ways in which crimes have shaped, or reflected, our society, James chronicles murder and misdeeds from the 1600s to the present day. James pays particular attention to crimes that were sensations during their time but have faded into obscurity, as well as still-famous cases, some that have never been solved, including the Lindbergh kidnapping, the Boston Strangler and JonBenet Ramsey. Satisfyingly sprawling and tremendously entertaining, Popular Crime is a professed amateur’s powerful examination of the incredible impact crime stories have on our society, culture and history.

    A stunning collection of personal observations that uses images of the American West to probe larger concerns in lyrical, evocative prose that is a true celebration of the region.