Drawing on newly available papers of Jonas Salk, Albert Sabin and other key players, Oshinsky paints a suspenseful portrait of the race for the cure, weaving a dramatic tale centered on the furious rivalry between Salk and Sabin. He also tells the story of Isabel Morgan, perhaps the most talented of all polio researchers, who might have beaten Salk to the prize if she had not retired to raise a family.Oshinsky offers an insightful look at the National Foundation for Infantile Paralysis, which was founded in the 1930s by FDR and Basil O'Connor, it revolutionized fundraising and the perception of disease in America. Oshinsky also shows how the polio experience revolutionized the way in which the government licensed and tested new drugs before allowing them on the market, and the way in which the legal system dealt with manufacturers' liability for unsafe products. Finally, and perhaps most tellingly, Oshinsky reveals that polio was never the raging epidemic portrayed by the media, but in truth a relatively uncommon disease. But in baby-booming America--increasingly suburban, family-oriented, and hygiene-obsessed--the specter of polio, like the specter of the atomic bomb, soon became a cloud of terror over daily life.Both a gripping scientific suspense story and a provocative social and cultural history, Polio opens a fresh window onto postwar America.

    In a flurry of shifting lights and serpentine spins, she inspired the earliest films of Georges Méliès and held Jean Cocteau spellbound. She even sought out the Curies for a radioactive showstopper. In this transportive and hypnotic historical narrative, the uninhibited Folies Bergère superstar la fée lumière is finally restored to her shimmering, glorious place in modern history.The Electricity Fairy is part of Inventions: Untold Stories of the Beautiful Era, a collection of incredible true stories from the belle epoque, an age of innovation, daring, bluster, and beauty when anything seemed possible. Each piece can be read, listened to, and marveled at in a single sitting.

    Harvey Washington Wiley, who fought for change.By the end of nineteenth century, food was dangerous. Lethal, even. "Milk" might contain formaldehyde, most often used to embalm corpses. Decaying meat was preserved with both salicylic acid, a pharmaceutical chemical, and borax, a compound first identified as a cleaning product. This was not by accident; food manufacturers had rushed to embrace the rise of industrial chemistry, and were knowingly selling harmful products. Unchecked by government regulation, basic safety, or even labelling requirements, they put profit before the health of their customers. By some estimates, in New York City alone, thousands of children were killed by "embalmed milk" every year. Citizens--activists, journalists, scientists, and women's groups--began agitating for change. But even as protective measures were enacted in Europe, American corporations blocked even modest regulations. Then, in 1883, Dr. Harvey Washington Wiley, a chemistry professor from Purdue University, was named chief chemist of the agriculture department, and the agency began methodically investigating food and drink fraud, even conducting shocking human tests on groups of young men who came to be known as, "The Poison Squad."Over the next thirty years, a titanic struggle took place, with the courageous and fascinating Dr. Wiley campaigning indefatigably for food safety and consumer protection. Together with a gallant cast, including the muckraking reporter Upton Sinclair, whose fiction revealed the horrific truth about the Chicago stockyards; Fannie Farmer, then the most famous cookbook author in the country; and Henry J. Heinz, one of the few food producers who actively advocated for pure food, Dr. Wiley changed history. When the landmark 1906 Food and Drug Act was finally passed, it was known across the land, as "Dr. Wiley's Law."Blum brings to life this timeless and hugely satisfying "David and Goliath" tale with righteous verve and style, driving home the moral imperative of confronting corporate greed and government corruption with a bracing clarity, which speaks resoundingly to the enormous social and political challenges we face today.

    Heroes are not only brave, but they’re also able to navigate the convoluted corridors of society, and to see through the respectable pretense of others to detect the evil that lies within. So, who better to take on the foggy, crime-ridden streets and strict social mores of Victorian London than the iconic literary detective Sherlock Holmes?In Sherlock Holmes: Beyond the Elementary, you’ll investigate the history behind Sir Arthur Conan Doyle’s whip-smart, charismatic detective. James Krasner, a scholar of British Victorian literature, will play the role of “Watson”, as he offers a clearer picture of the imaginative influence Sherlock Holmes has maintained over readers, from the 19th century through today. While you examine the secrets of novels like A Study in Scarlet and The Hound of the Baskervilles and stories like “A Scandal in Bohemia” and “The Final Problem”, you’ll deepen your appreciation of these enduring works. You’ll also gain insights into Holmes’ continued relevance to the social problems we face in our own world.What does the relationship between Holmes and Watson tell us about friendship? Is Sherlock Holmes just a “thinking machine”? How do these adventures lay bare gender dynamics in surprising ways? The answers are far from elementary.

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    Her father's hidden liquor bottles, the strange cancers in children in the neighborhood, the truth about what was made at Rocky Flats (cleaning supplies, her mother guessed)—best not to inquire too deeply into any of it.But as Iversen grew older, she began to ask questions. She learned about the infamous 1969 Mother's Day fire, in which a few scraps of plutonium spontaneously ignited and—despite the desperate efforts of firefighters—came perilously close to a "criticality," the deadly blue flash that signals a nuclear chain reaction. Intense heat and radiation almost melted the roof, which nearly resulted in an explosion that would have had devastating consequences for the entire Denver metro area. Yet the only mention of the fire was on page 28 of the Rocky Mountain News, underneath a photo of the Pet of the Week. In her early thirties, Iversen even worked at Rocky Flats for a time, typing up memos in which accidents were always called "incidents."And as this memoir unfolds, it reveals itself as a brilliant work of investigative journalism—a detailed and shocking account of the government's sustained attempt to conceal the effects of the toxic and radioactive waste released by Rocky Flats, and of local residents' vain attempts to seek justice in court. Here, too, are vivid portraits of former Rocky Flats workers—from the healthy, who regard their work at the plant with pride and patriotism, to the ill or dying, who battle for compensation for cancers they got on the job.Based on extensive interviews, FBI and EPA documents, and class-action testimony, this taut, beautifully written book promises to have a very long half-life.

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    The first small cities formed not only the cradle of civilization, but the spawning ground for the earliest viral epidemics, the first opportunity for viruses to find a home in the human herd. This is a story of fear and ignorance, as everything from demons and the wrath of the gods to minority groups have been blamed for epidemics from smallpox to yellow fever to AIDS. It is a story of grief and heartbreak, as hundreds of thousands, sometimes millions, are wiped out in a single year. And it is a story of great bravery and sacrifice, as doctors and nurses put themselves in harm's way to combat yellow fever in Memphis and Ebola in Zaire, and as researchers risk their own lives to test theories of vaccines and the transmission of disease. Now, in Viruses, Plagues, and History, Michael B. A. Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity.Oldstone focuses his tale on a few of the most famous viruses humanity has battled, beginning with some we have effectively defeated, such as smallpox, polio, and measles. Nearly 300 million people were killed by smallpox in this century alone -- more than were killed in all the wars of the twentieth century combined. The author presents a vivid account of the long campaign against the virus, the insightful work of Edward Jenner, who created the smallpox vaccine from cowpox virus in 1796, and the monumental efforts of D. A. Henderson and an army of W.H.O. health care workers to finally eradicate smallpox. The smallpox virus remains the only organism that we have deliberately pushed to complete extinction in the wild.Oldstone then describes the fascinating viruses that have captured headlines in more recent years: Ebola and other hemorrhagic fevers, which literally turn their victims' organs to a bloody pulp; the Hantavirus outbreaks in the southwestern United States and elsewhere; mad cow disease, a frightening illness made worse by government mishandling and secrecy; and, of course, AIDS, often called the plague of our time. And he tells us of the many scientists watching and waiting even now for the next great plague, monitoring influenza strains to see whether the deadly variant from 1918 -- a viral strain that killed over 20 million people in 1918-1919, more than twice the military and civilian casualties of the First World War -- will make a comeback.Viruses have enormous power. They have wiped out cities, brought down dynasties, and helped destroy civilizations. But, as Michael Oldstone reveals, scientific research has given us the power to tame many of these viruses as well. Viruses, Plagues, and History shows us the panorama of humanity's long-standing conflict with our unseen viral enemies, from our successes to our continuing struggles. Oldstone's book is a vivid history of a fascinating field, and a highly reliable dispatch from a worker on the frontiers of this ongoing campaign.

    In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future

    In Under the Knife, surgeon Arnold Van de Laar uses his own experience and expertise to tell the witty history of the past, present and future of surgery.From the story of the desperate man from seventeenth-century Amsterdam who grimly cut a stone out of his own bladder to Bob Marley's deadly toe, Under the Knife offers all kinds of fascinating and unforgettable insights into medicine and history via the operating theatre.What happens during an operation? How does the human body respond to being attacked by a knife, a bacterium, a cancer cell or a bullet? And, as medical advances continuously push the boundaries of what medicine can cure, what are the limits of surgery?From the dark centuries of bloodletting and of amputations without anaesthetic to today's sterile, high-tech operating theatres, Under the Knife is both a rich cultural history, and a modern anatomy class for us all.

    Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.

    And in doing so, you’ll get a fresher understanding of an era in history with which we’re still trying to come to terms.How the Crusades Changed History plunges you into the series of Crusades to the Holy Land (and elsewhere), from the calling of the First Crusade in November 1095 until the collapse of the last crusader state, the Kingdom of Jerusalem, in 1291. Delivered by master medieval historian and award-winning professor Philip Daileader of The College of William & Mary, these 24 lectures are more than just an enriching recount of captivating historical events. They’re an intellectually rewarding exploration of the ways in which the Crusades shaped the history of the medieval world—and laid the seeds for our own.Dispel Misconceptions about the CrusadesThe Crusades remain lively topics of debate among historians and scholars, and they’re rife with contradictions and misconceptions that require us to peel back layers of history and confront some startling truths that go against what we traditionally think about medieval crusading.Take, for example, these points:Most Christians weren’t motivated to join the Crusades out of economic considerations but in hopes of gaining indulgences from the Catholic Church to decrease or eliminate time in purgatory.Crusading campaigns reached far beyond Jerusalem and the surrounding Holy Land, extending all along the Mediterranean and throughout much of northern Europe.The Crusades were not universally supported; rather, the period saw critics who questioned particular campaigns—many of which were disastrous failures.As you’ll learn with this course, these and other truths about the Crusades demonstrate that, rather than being grand wars, many of these military campaigns were tangled misadventures. And yet you’ll see that, for all their messiness, the Crusades made an indelible impact on the identity of Western civilization.A Fascinating, In-Depth HistoryProfessor Daileader spends the first 17 lectures of the course delivering a riveting in-depth narrative history of the Crusades that takes you in and around the medieval world and sweeps you up in the crusading fervor that led to some of the era’s most intriguing—and disastrous—campaigns. You’ll immerse yourself in the causes, battles, and consequences of the period’s major crusades—as well as some campaigns often overlooked.The First Crusade: Rather than a single expedition, the First Crusade was a series of loosely coordinated waves that left Europe over the space of several years after Pope Urban II’s initial call in 1095. More than 90% of those who were part of the First Crusade were not professional knights; rather, they were the populous, peasants and craftsmen led by a smattering of minor nobles and a popular preacher named Peter the Hermit.The Northern Crusades: Crusading was not just relegated to the Holy Land. Crusading campaigns also took place in parts of Europe. The Northern Crusades facilitated German and Christian expansion into eastern Europe and opened up a theater of war that was easier for crusaders to access than Syria and Palestine, but they siphoned off crusaders who might otherwise have worked to reclaim Jerusalem from the Ottoman Turks.The Children’s Crusade: One of the period’s oddest crusades, the Children’s Crusade of 1212 consisted primarily of processions of French youths—many between the ages of 6 and 14—carrying religious symbols toward Jerusalem to reclaim it for Christendom. More peaceful than other crusades, the Children’s Crusade lacked the militaristic overtones of other campaigns; medieval chroniclers make no mention of its participants bearing arms.View the Era with a More Inquisitive EyeOnce you reach the end of the major crusading period in the late 13th century, you take a step back in a series of thematic lectures that treat a host of topics with an inquisitive eye. Professor Daileader’s goal with this section of the course: to clarify your picture of the Crusades and to provide you with a stronger grasp of their broader historical consequences.You’ll get a chance to probe issues and questions that have intrigued historians for centuries:What did contemporary religious thinkers and critics say about the Crusades? What effects did their views have?What was the experience like for individuals who took up the crusader’s call? Why did they go? What did they take with them? How did they live day to day?How did everyday life in western Europe compare with that in the vulnerable crusader states?How did medieval Islam respond to the Crusades?By taking this approach, you’ll come to see how this frenetic period of warfare paved the way for subsequent historical movements and moments, including the centuries-long dominance of the Ottoman Empire, the Protestant Reformation, the prevalence of missionary campaigns around the world, and more.Learn from One of America’s Best ProfessorsHow the Crusades Changed History places you in the hands of a historian and teacher named one of the best professors in the United States by The Princeton Review and a four-time winner of Harvard University’s Certificate of Distinction in Teaching.Just minutes into the first lecture of this engaging course, you’ll find out why Professor Daileader’s lecturing style—filled with eye-opening insights, clear-cut explanations, gripping stories, and touches of ironic humor—has been praised by so many of our customers around the world.“Whether the Crusades deserve admiration, opprobrium, or something else entirely is a matter for individuals to decide for themselves,” notes Professor Daileader at the start of his engrossing lecture series. “Our goals are to understand the Crusades and to assess their consequences.”And by doing so with this course, you’ll have the knowledge necessary to come to your own conclusions about just how important and consequential these centuries of warfare were to Western civilization.

    But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering.Gawande, a practicing surgeon, addresses his profession's ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person's last weeks or months may be rich and dignified.

    As recently as 1918, a pandemic of influenza claimed over 50 million lives worldwide. The advent of drugs and vaccines led to an era of hope when we thought our battles with infectious disease were won, but our optimism has been eroded by the recognition that many pathogens have the capacity to transform themselves and escape our efforts to eradicate them. Are we now facing an inevitable repeat of a calamity such as the 1918 influenza pandemic or the Black Death? Can we anticipate and thwart such an event, or are we wilfully creating the conditions that would promote the emergence of new and highly virulent human infectious disease?Sunetra Gupta is Professor of Theoretical Epidemiology at the University of Oxford specialising in infectious diseases. She holds a bachelor's degree from Princeton University and a Ph.D. from the University of London. She has been awarded the Scientific Medal by the Zoological Society of London and the Royal Society Rosalind Franklin Award for her scientific research. She is also a novelist whose books have been awarded the Sahitya Akademi Award, the Southern Arts Literature Prize, shortlisted for the Crossword Award, and longlisted for the DSC and Orange Prizes.

    In The Viral Storm, award-winning biologist Nathan Wolfe tells the story of how viruses and human beings have evolved side by side through history; how deadly viruses like HIV, swine flu, and bird flu almost wiped us out in the past; and why modern life has made our species vulnerable to the threat of a global pandemic.Wolfe's research missions to the jungles of Africa and the rain forests of Borneo have earned him the nickname "the Indiana Jones of virus hunters," and here Wolfe takes readers along on his groundbreaking and often dangerous research trips—to reveal the surprising origins of the most deadly diseases and to explain the role that viruses have played in human evolution.In a world where each new outbreak seems worse than the one before, Wolfe points the way forward, as new technologies are brought to bear in the most remote areas of the world to neutralize these viruses and even harness their power for the good of humanity. His provocative vision of the future will change the way we think about viruses, and perhaps remove a potential threat to humanity's survival.