How many of us understand the way seizures affect the brain, how the heart is connected to wellbeing, or the why the foot carries the key to our humanity? In Adventures in Human Being, award-winning author Gavin Francis leads readers on a journey into the hidden pathways of the human body, offering a guide to its inner workings and a celebration of its marvels.Drawing on his experiences as a surgeon, ER specialist, and family physician, Francis blends stories from the clinic with episodes from medical history, philosophy, and literature to describe the body in sickness and in health, in living and in dying. At its heart, Adventures in Human Being is a meditation on what it means to be human. Poetic, eloquent, and profoundly perceptive, this book will transform the way you view your body.

    Whether it's something as minor as a brush with the common cold or as serious as Ebola, we all have grappled with infections and will continue to encounter them as we age.On a worldwide scale, infectious diseases account for 26 percent of all deaths, second only to cardiovascular diseases. And unlike chronic diseases, infectious diseases are unique in their potential for explosive global impacts.Now, in the 24 engaging lectures of Introduction to Infectious Diseases, you can get a comprehensive overview of diseases from the mundane to the fatal from renowned physician and award-winning professor Dr. Barry Fox.Begin with an overview of the microscopic particles responsible for disease: bacteria, fungi, hybrid germs, and viruses. You will see how they invade the body; look through the microscope at pathogens to identify their inner components; follow germs through to different body systems and see what effects they have; and learn why we may be losing the battle against some germs.

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.

    Our language even has a word—Machiavellian—that encapsulates the images those responses conjure up: An indistinct figure quietly making his way through the darkest corridors of power, hatching plots to play one rival against another A cold-blooded political liar, ready to justify any duplicity undertaken in the name of a noble end that will ultimately justify the most malignant means A coolly practical leader—amoral at best—willing to do whatever is necessary in a world governed not by ideas of right or wrong, but by solutions dictated by realpolitik.But does the Machiavelli most of us think we know bear any resemblance to the Machiavelli who lived, pondered, and wrote?According to Professor William R. Cook, a reading of Machiavelli that considers only those qualities that we today call "Machiavellian" is incomplete, and Machiavelli himself "certainly would not recognize" such sinister interpretations or caricatures of his writings and beliefs. Indeed, The Prince—on the pages of which so much of this image was built—was not even published in his lifetime.In the 24 lectures that make up Machiavelli in Context, Professor Cook offers the opportunity to meet an extraordinarily thoughtful and sincere student of history and its lessons, and to learn that there is far more to him than can be gleaned from any reading of The Prince, no matter how thorough.Although The Prince is the work by which most of us think we know Machiavelli, and although some have indeed called it the first and most important book of political science ever written, it was not, according to Professor Cook, either Machiavelli's most important work or the one most representative of his beliefs. Those distinctions belong, instead, to his Discourses on the First Ten Books of Livy, a longer work started at about the same time and which would, like The Prince, not be published until well after his death."Everyone who has seriously studied the works of Machiavelli agrees that he ... believed in the superiority of a republican form of government, defined as a mixed constitution with elements of monarchy, aristocracy, and democracy."Once we recover the context of the writing of The Prince, and analyze it along with the Discourses on the First Ten Books of Livy, it will be clear how The Prince can be read as a book designed to guide leaders in the creation—for Machiavelli, restoration—of republican government in Italy."Ultimately, Machiavelli's goal wasn't much different from ours. It was to live in a free and equal participatory society, because he believed that was the greatest way in which human beings could live and flourish."In fact, says Professor Cook, "Machiavelli's republican thought influenced the development of institutions and values both in Europe and in America."To present a complete and well-rounded picture of Machiavelli's ideas on how human societies should be organized and governed, Professor Cook sets aside much of Machiavelli's written output—which included the political work The Art of War, a biography, many letters, and even some plays—to focus on The Prince, the Discourses, and, more briefly, his Florentine Histories.In doing so, Professor Cook draws on the same qualities so evident in his previous courses for The Teaching Company: Tocqueville and the American Experience, Dante's Divine Comedy, Francis of Assisi, and St. Augustine's Confessions.Teaching in the relaxed and informal style of those courses, Professor Cook moves easily among the different disciplines so pertinent to an understanding of Machiavelli's ideas, including history, philosophy, government, and the elements of leadership. He is unfailingly clear, always provides any definitions needed to understand the material at hand, and is always ready with a touch of wit whenever that is appropriate.Because so much of our contemporary misunderstanding of Machiavelli's ideas comes from a lack of context, Professor Cook carefully sets the stage for a complete perspective of Machiavelli's world.Long before he turns to the works themselves, you'll have learned about Florence and its political history, both before and during Machiavelli's lifetime; the developing Renaissance culture of Machiavelli's time, especially as it bears on the use of ancient political thought by writers and political leaders; and Machiavelli's own life story, including his education, service to the Florentine Republic, years spent in exile south of Florence, and the ways each period of his life affected his writings.The result is a thorough grounding in the information one needs to understand and appreciate this stunningly original thinker.You'll learn, for example, what Machiavelli means when he discusses the important ideas of virtù and Fortuna.Though these are today invariably translated as virtue and fortune, Machiavelli's meanings can involve much more. Though he sometimes uses virtù in the sense we would understand today, he often uses the word—which comes from the classical Latin word for Man—as a means of describing the way one practices successful statecraft: aggressively, with no reluctance to use lies, deceit, and cruelty that may be required to maintain power, and hence the stability the people deserve.In a similar way Machiavelli uses Fortuna in a different sense than might have been used by, say, Dante when he describes the vagaries of fate over which we have no control.Instead, Machiavelli uses the adage, "Fortune is like a river." Though we cannot control fortune, which may well choose to make the river flood, a good ruler, practicing virtù, can indeed prepare for it, and thus modify its effects.You'll see how Machiavelli first became exposed to history and one of its earliest great practitioners—the Roman historian, Livy—through his own experience of Fortuna.Though printed books such as Livy's Early History of Rome were too expensive for a family like the young Machiavelli's in the 15th century, his father did own a copy. He had written the index, and a copy of the book had been part of his payment. Thus Machiavelli grew up with the volumes about which he would one day write his own most important work, Discourses on the First Ten Books of Livy.You'll be introduced to Cesare Borgia, the son of Pope Alexander VI and the man regarded as Machiavelli's model for The Prince, especially in the way his actions embodied the virtù so important to Machiavelli.Professor Cook brings this out in a shocking story of Borgia's use of a tough and merciless Spaniard—Ramiro d'Orco—to impose order and stability on the area of north central Italy known as the Romagna that had come under Borgia's rule and was beset by crime and violence.D'Orco's brutal methods had the desired effect. And when the job was completed, the local people emerged from their homes one morning to find the two halves of Ramiro d'Orco's body on opposite sides of the town square of Cesana, because d'Orco had been too tough, and Cesare Borgia needed a way to advertise further his concern for the people whose loyalty he wanted.The story also embodies, for Machiavelli, the idea that cruelty can be "well-used," just as being merciful—withholding such cruelty when a leader deems it needed—may be less than merciful in its long-term impact.Finally, you will get to see, throughout these lectures, the development of Machiavelli's reliance on history for its lessons, his role as a Renaissance Humanist thinker, and the emergence of his republican views, which still have tremendous influence today as we ask how republics start, grow, succeed, or fail.As Professor Cook notes, we are not going to agree with all of Machiavelli's answers. But his commitment to asking the right questions—to thinking, reflecting, and learning everything history has to teach us about the best ways to govern and safeguard the future—was total.

    We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    By the summer of 1918, the second wave struck as a highly contagious and lethal epidemic and within weeks exploded into a pandemic, an illness that travels rapidly from one continent to another. It would impact the course of the war, and kill many millions more soldiers than warfare itself.Of all diseases, the 1918 flu was by far the worst that has ever afflicted humankind; not even the Black Death of the Middle Ages comes close in terms of the number of lives it took. No war, no natural disaster, no famine has claimed so many. In the space of eighteen months in 1918-1919, about 500 million people--one-third of the global population at the time--came down with influenza. The exact total of lives lost will never be known, but the best estimate is between 50 and 100 million. In this powerful book, filled with black and white photographs, nonfiction master Albert Marrin examines the history, science, and impact of this great scourge--and the possibility for another worldwide pandemic today.

    In Counting Backwards, pediatric anesthesiologist Dr. Henry Jay Przybylo delivers an unforgettable account of the procedure’s daily dramas and fundamental mysteries. Przybylo has administered anesthesia more than 30,000 times over his thirty-year career: on newborn babies, screaming toddlers, sullen teenagers, even a gorilla. Filled with intense moments of near-disaster, life-saving successes, and simple grace, Counting Backwards is for anyone curious about what happens after we lose consciousness.

    It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    These are today's sins of science—as deplorable as mistaken past ideas about advocating racial purity or using lobotomies as a cure for mental illness. These unwitting errors add up to seven lessons both cautionary and profound, narrated by renowned author and speaker Paul A. Offit. Offit uses these lessons to investigate how we can separate good science from bad, using some of today's most controversial creations—e-cigarettes, GMOs, drug treatments for ADHD—as case studies. For every "Aha!" moment that should have been an "Oh no," this book is an engrossing account of how science has been misused disastrously—and how we can learn to use its power for good.

    Judy Melinek began her training as a New York City forensic pathologist. With her husband T.J. and their toddler Daniel holding down the home front, Judy threw herself into the fascinating world of death investigation, performing autopsies, investigating death scenes, counseling grieving relatives. Working Stiff chronicles Judy's two years of training, taking readers behind the police tape of some of the most harrowing deaths in the Big Apple, including a firsthand account of the events of September 11, the subsequent anthrax bio-terrorism attack, and the disastrous crash of American Airlines flight 587.Lively, action-packed, and loaded with mordant wit, Working Stiff offers a firsthand account of daily life in one of America's most arduous professions, and the unexpected challenges of shuttling between the domains of the living and the dead. The body never lies, and through the murders, accidents, and suicides that land on her table, Dr. Melinek lays bare the truth behind the glamorized depictions of autopsy work on shows like CSI and Law and Order to reveal the secret story of the real morgue.

    When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    In a lab filled with curiosities--beakers, microscopes, Bunsen burners, and hundreds upon hundreds of books--sat an investigator who would go on to crack at least two thousand cases in his forty-year career. Known as the "American Sherlock Holmes," Edward Oscar Heinrich was one of America's greatest--and first--forensic scientists, with an uncanny knack for finding clues, establishing evidence, and deducing answers with a skill that seemed almost supernatural.Heinrich was one of the nation's first expert witnesses, working in a time when the turmoil of Prohibition led to sensationalized crime reporting and only a small, systematic study of evidence. However with his brilliance, and commanding presence in both the courtroom and at crime scenes, Heinrich spearheaded the invention of a myriad of new forensic tools that police still use today, including blood spatter analysis, ballistics, lie-detector tests, and the use of fingerprints as courtroom evidence. His work, though not without its serious--some would say fatal--flaws, changed the course of American criminal investigation.Based on years of research and thousands of never-before-published primary source materials, American Sherlock captures the life of the man who pioneered the science our legal system now relies upon--as well as the limits of those techniques and the very human experts who wield them.

    With a slow chill that intensifies with each heart-pounding page, Rule describes her dawning awareness that Ted Bundy, her sensitive coworker on a crisis hotline, was one of the most prolific serial killers in America. He would confess to killing at least thirty-six young women from coast to coast, and was eventually executed for three of those cases. Drawing from their correspondence that endured until shortly before Bundy's death, and striking a seamless balance between her deeply personal perspective and her role as a crime reporter on the hunt for a savage serial killer -- the brilliant and charismatic Bundy, the man she thought she knew -- Rule changed the course of true-crime literature with this unforgettable chronicle.

    In 24 enthralling lectures, Professor Miller guides you through a core selection of the major books of the Old Testament, inviting you to probe their meaning and relevance in incisive and thought-provoking commentary. Among the books of the Old Testament, you’ll explore:• Genesis: Uncover fascinating features of the Old Testament’s opening, such as how the events of the first week of creation form an elaborate pattern, expressing the complex order of the universe; and how the text does not lay primary blame for “the fall” on the woman, Eve;• Deuteronomistic History: Study the epic history of the people of Israel in the Promised Land; follow the story of the Israelites’ disobedience to God, and its tragic consequences; • The Prophets: Through the dramatic stories of the prophets, take account of the challenges faced by those who sought to actualize God’s plan for humanity; • The Books of Ruth and Esther: Among notable women in the Old Testament, explore two stories of women who are doubly at risk, and who prevail through loyalty, resourcefulness, and integrity; and• Daniel and the Apocalyptic: In the Book of Daniel, encounter the genre of apocalyptic literature - revelation initiated by God - and contemplate the figure of “the Son of Man,” a promised redeemer.Throughout the lectures, Professor Miller offers a wealth of perspectives on how to approach the texts. You’ll assess the role of translation in the understanding of the texts, studying the meanings of key Hebrew words; you’ll also look in depth at the history, dating, and writing of the texts, and you’ll study their literary and linguistic features, noting how they achieve their impact on the reader.In Understanding the Old Testament, you’ll take a revelatory look at this epically impactful document, finding its deeper historical and religious meanings, as well as its sublime literary treasures.

    In Wicked Plants, Stewart takes on over two hundred of Mother Nature’s most appalling creations. It’s an A to Z of plants that kill, maim, intoxicate, and otherwise offend. You’ll learn which plants to avoid (like exploding shrubs), which plants make themselves exceedingly unwelcome (like the vine that ate the South), and which ones have been killing for centuries (like the weed that killed Abraham Lincoln's mother). Menacing botanical illustrations and splendidly ghastly drawings create a fascinating portrait of the evildoers that may be lurking in your own backyard. Drawing on history, medicine, science, and legend, this compendium of bloodcurdling botany will entertain, alarm, and enlighten even the most intrepid gardeners and nature lovers.