But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

    No academic analysis or bystander’s account can capture it. Now Doug Edwards, Employee Number 59, offers the first inside view of Google, giving readers a chance to fully experience the bizarre mix of camaraderie and competition at this phenomenal company. Edwards, Google’s first director of marketing and brand management, describes it as it happened. We see the first, pioneering steps of Larry Page and Sergey Brin, the company’s young, idiosyncratic partners; the evolution of the company’s famously nonhierarchical structure (where every employee finds a problem to tackle or a feature to create and works independently); the development of brand identity; the races to develop and implement each new feature; and the many ideas that never came to pass. Above all, Edwards—a former journalist who knows how to write—captures the “Google Experience,” the rollercoaster ride of being part of a company creating itself in a whole new universe. I’m Feeling Lucky captures for the first time the unique, self-invented, yet profoundly important culture of the world’s most transformative corporation.

    As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"-- an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes--which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones--each custom-designed for maximum health benefits.

    The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published.This commemorative edition, honoring the memory of the author who died in 2011, contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin. It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA.

    They distill more than 20 years of research and first-hand accounts from the most biodiverse ecosystems on Earth into straightforward principles and guidance for confronting our culture of hyper-novelty.For evolutionary biologists Heather Heying and Bret Weinstein, the cause of our woes is clear: the modern world is out of sync with our ancient brains and bodies. We evolved to live in clans, but today most people don't even know their neighbors' names. Differences between the sexes once served a necessary evolutionary purpose, but today many dismiss the concept of biological sex as offensive. The cognitive dissonance spawned by trying to live in a society we're not built for is killing us.

    A defiant atheist, Chapman is confronted not only by the fundamentalist beliefs that continue to banish the theory of evolution but by his own spiritual malaise as the outward journey becomes an inward quest, a tragicomic "accidental memoir"."First there was Charles Darwin, two yards long and nobody's fool. Then there was his son, my great-grandfather, Sir Francis Darwin, an eminent botanist. Then came my grandmother Frances, a modest poet who spent a considerable amount of time in rest-homes for depression From her issued my beloved mother, Clare, who was extremely short, failed to complete medical school, and eventually became an alcoholic. Then we get down to me. I'm in the movie business."Trials of the Monkey combines travel writing and reportage, as Chapman records his encounters in the South, with history and the accidental memoir of a man full of mid-life doubts in a genre-breaking first book that is darkly funny, provocative and poignant.

    In its sweeping survey of the history of Internet search technologies, its gossip about and analysis of Google, and its speculation on the larger cultural implications of a Web-connected world, it will likely receive attention from a variety of businesspeople, technology futurists, journalists, and interested observers of mid-2000s zeitgeist. This ambitious book comes with a strong pedigree. Author John Battelle was a founder of The Industry Standard and then one of the original editors of Wired, two magazines which helped shape our early perceptions of the wild world of the Internet. Battelle clearly drew from his experience and contacts in writing The Search. In addition to the sure-handed historical perspective and easy familiarity with such dot-com stalwarts as AltaVista, Lycos, and Excite, he speckles his narrative with conversational asides from a cast of fascinating characters, such Google's founders, Larry Page and Sergey Brin; Yahoo's, Jerry Yang and David Filo; key executives at Microsoft and different VC firms on the famed Sandhill road; and numerous other insiders, particularly at the company which currently sits atop the search world, Google. The Search is not exactly the corporate history of Google. At the book's outset, Battelle specifically indicates his desire to understand what he calls the cultural anthropology of search, and to analyze search engines' current role as the "database of our intentions"--the repository of humanity's curiosity, exploration, and expressed desires. Interesting though that beginning is, though, Battelle's story really picks up speed when he starts dishing inside scoop on the darling business story of the decade, Google. To Battelle's credit, though, he doesn't stop just with historical retrospective: the final part of his book focuses on the potential future directions of Google and its products' development. In what Battelle himself acknowledges might just be a "digital fantasy train", he describes the possibility that Google will become the centralizing platform for our entire lives and quotes one early employee on the weightiness of Google's potential impact: "Sometimes I feel like I am on a bridge, twenty thousand feet up in the air. If I look down I'm afraid I'll fall. I don't feel like I can think about all the implications." Some will shrug at such words; after all, similar hype has accompanied other technologies and other companies before. Many others, though, will search Battelle's story for meaning--and fast. --Peter Han

    Nature’s many innovations—some uncannily perfect—call for natural principles that accelerate life’s ability to innovate.”Darwin’s theory of natural selection explains how useful adaptations are preserved over time. But the biggest mystery about evolution eluded him. As genetics pioneer Hugo de Vries put it, “natural selection may explain the survival of the fittest, but it cannot explain the arrival of the fittest.”Can random mutations over a mere 3.8 billion years really be responsible for wings, eyeballs, knees, camouflage, lactose digestion, photosynthesis, and the rest of nature’s creative marvels? And if the answer is no, what is the mechanism that explains evolution’s speed and efficiency?In Arrival of the Fittest, renowned evolutionary biologist Andreas Wagner draws on over fifteen years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take.Consider the Arctic cod, a fish that lives and thrives within six degrees of the North Pole, in waters that regularly fall below 0 degrees. At that temperature, the internal fluids of most organisms turn into ice crystals. And yet, the arctic cod survives by producing proteins that lower the freezing temperature of its body fluids, much like antifreeze does for a car’s engine coolant. The invention of those proteins is an archetypal example of nature’s enormous powers of creativity. Meticulously researched, carefully argued, evocatively written, and full of fascinating examples from the animal kingdom, Arrival of the Fittest offers up the final puzzle piece in the mystery of life’s rich diversity.

    The Structure of Scientific Revolutions is that kind of book. When it was first published in 1962, it was a landmark event in the history and philosophy of science. Fifty years later, it still has many lessons to teach. With The Structure of Scientific Revolutions, Kuhn challenged long-standing linear notions of scientific progress, arguing that transformative ideas don’t arise from the day-to-day, gradual process of experimentation and data accumulation but that the revolutions in science, those breakthrough moments that disrupt accepted thinking and offer unanticipated ideas, occur outside of “normal science,” as he called it. Though Kuhn was writing when physics ruled the sciences, his ideas on how scientific revolutions bring order to the anomalies that amass over time in research experiments are still instructive in our biotech age. This new edition of Kuhn’s essential work in the history of science includes an insightful introduction by Ian Hacking, which clarifies terms popularized by Kuhn, including paradigm and incommensurability, and applies Kuhn’s ideas to the science of today. Usefully keyed to the separate sections of the book, Hacking’s introduction provides important background information as well as a contemporary context.  Newly designed, with an expanded index, this edition will be eagerly welcomed by the next generation of readers seeking to understand the history of our perspectives on science.

    Literate and authoritative--.Marvelously exciting." --The New York Times Book ReviewJonathan Weiner, winner of the Pulitzer Prize for The Beak of the Finch, brings his brilliant reporting skills to the story of Seymour Benzer, the Brooklyn-born maverick scientist whose study of genetics and experiments with fruit fly genes has helped revolutionize or knowledge of the connections between DNA and behavior both animal and human.How much of our fate is decided before we are born?  Which of our characteristics is inscribed in our DNA? Weiner brings us into Benzer's Fly Rooms at the California Institute of Technology, where Benzer, and his asssociates are in the process of finding answers, often astonishing ones, to these questions. Part biography, part thrilling scientific detective story, Time, Love, Memory forcefully demonstrates how Benzer's studies are changing our world view--and even our lives.

    The earthworm may be small, spineless, and blind, but its impact on the ecosystem is profound. It ploughs the soil, fights plant diseases, cleans up pollution, and turns ordinary dirt into fertile land. Who knew? In her witty, offbeat style, Stewart shows that much depends on the actions of the lowly worm. Charles Darwin devoted his last years to the meticulous study of these creatures, praising their remarkable abilities. With the august scientist as her inspiration, Stewart investigates the worm's subterranean realm, talks to oligochaetologists—the unsung heroes of earthworm science—who have devoted their lives to unearthing the complex life beneath our feet, and observes the thousands of worms in her own garden. From the legendary giant Australian worm that stretches to ten feet in length to the modest nightcrawler that wormed its way into the heart of Darwin's last book to the energetic red wigglers in Stewart's compost bin, The Earth Moved gives worms their due and exposes their hidden and extraordinary universe. This book is for all of us who appreciate Mother Nature's creatures, no matter how humble.

    government for trying to steal trade secrets, by a finalist for the Pulitzer Prize in nonfiction.In September 2011, sheriff's deputies in Iowa encountered three ethnic Chinese men near a field where a farmer was growing corn seed under contract with Monsanto. What began as a simple trespassing inquiry mushroomed into a two-year FBI operation in which investigators bugged the men's rental cars, used a warrant intended for foreign terrorists and spies, and flew surveillance planes over corn country--all in the name of protecting trade secrets of corporate giants Monsanto and DuPont Pioneer. In The Scientist and the Spy, Hvistendahl gives a gripping account of this unusually far-reaching investigation, which pitted a veteran FBI special agent against Florida resident Robert Mo, who after his academic career foundered took a questionable job with the Chinese agricultural company DBN--and became a pawn in a global rivalry.Industrial espionage by Chinese companies lies beneath the United States' recent trade war with China, and it is one of the top counterintelligence targets of the FBI. But a decade of efforts to stem the problem have been largely ineffective. Through previously unreleased FBI files and her reporting from across the United States and China, Hvistendahl describes a long history of shoddy counterintelligence on China, much of it tinged with racism, and questions the role that corporate influence plays in trade secrets theft cases brought by the U.S. government. The Scientist and the Spy is both an important exploration of the issues at stake and a compelling, involving read.

    Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of one hundred letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto. His succinct, opinionated, passionate, and often funny responses reflect his popularity and standing as a leading educator.Tyson’s 2017 bestseller Astrophysics for People in a Hurry offered more than one million readers an insightful and accessible understanding of the universe. Now, revealing Tyson’s most candid and heartfelt writing yet, Letters from an Astrophysicist introduces us to a newly personal dimension of Tyson’s quest to understand our place in the cosmos.

    He had eighty seconds to exceed the speed of sound and begin the climb to a target no civilian pilot had ever reached. There was a chance he would not come back alive. If he did, he would make history as the world’s first commercial astronaut. The spectacle defied reason, the result of an improbable contest dreamed up by entrepreneur Peter Diamandis, whose vision for a new race to space – requiring small teams to do what only the world’s largest governments had done before – had been dismissed as fantastical. The tale begins in Mount Vernon, N.Y. Diamandis was the son of hard working Greek immigrants who wanted their science prodigy to do the family proud and become a doctor. Peter was a dutiful son, but from the time he was eight years old, staying up late to watch Apollo 11 land on the moon, he had one goal: getting to space. He started a national student space club while at MIT. He launched a rocket company in Houston while getting a medical degree from Harvard - a degree he pursued to improve his chances of becoming an astronaut. But when he realized NASA was winding down manned space flight, Diamandis set out on one of the great entrepreneurial adventure stories of our time. If the government wouldn’t send him to space, he would create a private spaceflight industry and get there himself.In the 1990s, the idea of private space flight was the stuff of science fiction. The undaunted Diamandis found inspiration in an unlikely place: the first golden age of aviation. Reading Charles Lindbergh’s The Spirit of St. Louis, Diamandis was stunned that the aviator had attempted the first transatlantic flight from New York to Paris to win a $25,000 prize. The historic flight galvanized the commercial airline industry. Why, Diamandis thought, couldn’t a similar contest be held for space flight? In 1996, standing under the arch of St. Louis – the city where Lindbergh found his backers - Diamandis announced the $10 million Xprize. To win, a privately funded team would have to build and fly a manned rocket into space twice – in two weeks. The deadline: December 31, 2004.   On a brilliant morning in the Mojave Desert, with little time to spare, a bullet-shaped rocket called SpaceShipOne was launched. The story of SS1, and other scrappy teams in the hunt – all spurred by Diamandis as he struggled to keep the prize afloat – became a testament to the American spirit of ingenuity and oversized dreams. The winning of the Xprize marked the end of the government’s monopoly over space.   Julian Guthrie, author of The Billionaire and The Mechanic, an acclaimed bestselling account of Oracle CEO Larry Ellison’s pursuit of the America’s Cup, thought she knew about obsessive pursuits, but the XPrize race spurred another level of drama, sacrifice, and technical wizardry. With Diamandis’ cooperation, Guthrie had access to all of the players – from Richard Branson and John Carmack to Burt Rutan – and has melded their stories into a spellbinding narrative, a combination of Rocket Boys and The New New Thing. In the end, as Diamandis dreamed, the result wasn’t just a victory for one team; it was the foundation for a new industry, including SpaceX, Virgin Galactic, Blue Origin and others. Today, SpaceShipOne hangs in the Smithsonian’s Air and Space Museum, above the Apollo 11 capsule and next to Lindbergh’s Spirit of St. Louis plane.

    From Sarajevo under siege in 1993 to clandestine hospitals in rebel-held eastern Aleppo, he has carried out lifesaving operations in the most challenging conditions, and with none of the resources of a major metropolitan hospital. He is now widely acknowledged as the most experienced trauma surgeon in the world.War Doctor is his extraordinary story, encompassing his surgeries in nearly every major conflict zone since the end of the Cold War, as well as his struggles to return to a “normal” life and routine after each trip. Culminating in his recent trips to war-torn Syria—and the untold story of his efforts to help secure a humanitarian corridor out of besieged Aleppo to evacuate some 50,000 people—War Doctor is a blend of medical memoir, personal journey, and nonfiction thriller that provides unforgettable, at times raw, insight into the human toll of war.