In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection—a type of HGT.David Quammen chronicles these discoveries through the lives of the researchers who made them—such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health.

    Ernst Stromer led an expedition to Egypt’s Bahariya Oasis in the Sahara and discovered four new species of dinosaurs, including the Tyrannosaurus rex–size predator Spinosaurus. But tragically, all his work was incinerated in 1944 during the Allied bombing of Munich.In 1999, Josh Smith, then a graduate student at the University of Pennsylvania, took his brilliant, precocious team to Egypt under the direction of world-renowned paleontologist Dr. Peter Dodson and blundered onto an archaeological site that yielded awe-inspiring results: all of Dr. Stromer’s early findings, and also an entirely new genus of dinosaur, Paralititan stromeri, one of the largest creatures ever to inhabit the planet.

    That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research—the Philadelphia chromosome. This book charts not only that landmark discovery, but also—for the first time, all in one place—the full sequence of scientific and medical discoveries that brought about the first-ever successful treatment of a lethal cancer at the genetic level.The significance of this mutant chromosome would take more than three decades to unravel; in 1990, it was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. This dramatic discovery launched a race involving doctors and researchers around the world, who recognized that in principle it might be possible to target CML at its genetic source.Science journalist Jessica Wapner brings extensive original reporting to this book, including interviews with more than thirty-five people with a direct role in this story. Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 70,000 people worldwide who are diagnosed with CML each year. Chief among them is researcher and oncologist Dr. Brian Druker, whose dedication to his patients fueled his quest to do everything within his power to save them.The Philadelphia Chromosome helps us to fully understand and appreciate just how pathbreaking, hard-won, and consequential are the achievements it recounts—and to understand the principles behind much of today’s most important cancer research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

    But while this medieval medicine now seems archaic, it also made a critical contribution to modern science.Medieval Bodies guides us on a head-to-heel journey through this era’s revolutionary advancements and disturbing convictions. We learn about the surgeons who dissected a living man’s stomach, then sewed him up again; about the geographers who delineated racial groups by skin color; and about the practice of fasting to gain spiritual renown. Encompassing medicine and mysticism, politics and art—and complete with vivid, full-color illustrations—Medieval Bodies shows us how it felt to live and die a thousand years ago.

    If we started off with rudimentary utterances on the level of "man throw spear," how did we end up with sophisticated grammars, enormous vocabularies, and intricately nuanced degrees of meaning?Drawing on recent groundbreaking discoveries in modern linguistics, Deutscher exposes the elusive forces of creation at work in human communication, giving us fresh insight into how language emerges, evolves, and decays. He traces the evolution of linguistic complexity from an early "Me Tarzan" stage to such elaborate single-word constructions as the Turkish sehirlilestiremediklerimizdensiniz ("you are one of those whom we couldn't turn into a town dweller"). Arguing that destruction and creation in language are intimately entwined, Deutscher shows how these processes are continuously in operation, generating new words, new structures, and new meanings.

    Ronald L. Numbers chronicles the astonishing resurgence of this belief since the 1960s, as well as the creationist movement's tangled religious roots in the theologies of late-nineteenth - and early twentieth century Baptists, Presbyterians, Lutherans, Adventists, and other religious groups. Even more remarkable than Numbers's story of today's widespread rejection of the theory of evolution is the dramatic shift from acceptance of the earth's antiquity (even for William Jennings Bryan the biblical "days" of Genesis represented long geological ages) to the insistence of present-day scientific creationists that most fossils date back to Noah's flood and its aftermath, and that the earth itself is no more than ten thousand years old. The author focuses especially on the rise of this "flood geology, " popularized in 1961 by John Whitcomb and Henry Morris's book, The Genesis Flood, which defended the theory that creation took place in six literal days, and updated the old arguments purporting to prove that a geologically significant worldwide flood actually took place. Numbers gives particular attention to the development of creation research institutes and societies, and to those creationists - including the half of the founders of the Creation Research Society with doctorates in biology - who possessed, or claimed to possess, scientific credentials. On the basis of dozens of interviews and scores of little-known manuscript collections, Numbers delineates the competing scientific and biblicalinterpretations, and reports on the debates between creationists and evolutionists - in courthouses, legislative halls, and on school boards - over the boundaries between science and religion. He traces the evolution of scientific creationism up to our own time and shows how the creationist

    When he emerged three years later, the summation of his efforts only hinted at what he'd experienced in one of the most dangerous regions on earth. Armed with an astonishing collection of zoological specimens, Du Chaillu leapt from the physical challenges of the jungle straight into the center of the biggest issues of the time--the evolution debate, racial discourse, the growth of Christian fundamentalism--and helped push each to unprecedented intensities. He experienced instant celebrity, but with that fame came whispers--about his past, his credibility, and his very identity--which would haunt the young man. Grand in scope, immediate in detail, and propulsively readable, Between Man and Beast brilliantly combines Du Chaillu's personal journey with the epic tale of a world hovering on the sharp edge of transformation.

    Some are so rare, they were once more valuable than gold. Some found in ancient mythology hold magical abilities, including the power to turn a person to stone. Others have been used by assassins to kill kings, and sorcerers to revive the dead. Here, too, is vegetation with astonishing properties to cure and heal, many of which have long since been lost with the advent of modern medicine.Organized alphabetically, The Big, Bad Book of Botany combines the latest in biological information with bizarre facts about the plant kingdom's oddest members, including a species that is more poisonous than a cobra and a prehistoric plant that actually "walked." Largo takes you through the history of vegetables and fruits and their astonishing agricultural evolution. Throughout, he reveals astonishing facts, from where the world's first tree grew to whether plants are telepathic.Featuring more than 150 photographs and illustrations, The Big, Bad Book of Botany is a fascinating, fun A-to-Z encyclopedia for all ages that will transform the way we look at the natural world.

    Around 95% of all living species died out--a global catastrophe far greater than the dinosaurs' demise 65 million years ago. How this happened remains a mystery. But there are many competing theories. Some blame huge volcanic eruptions that covered an area as large as the continental United States; others argue for sudden changes in ocean levels and chemistry, including burps of methane gas; and still others cite the impact of an extraterrestrial object, similar to what caused the dinosaurs' extinction. Extinction is a paleontological mystery story. Here, the world's foremost authority on the subject provides a fascinating overview of the evidence for and against a whole host of hypotheses concerning this cataclysmic event that unfolded at the end of the Permian.After setting the scene, Erwin introduces the suite of possible perpetrators and the types of evidence paleontologists seek. He then unveils the actual evidence--moving from China, where much of the best evidence is found; to a look at extinction in the oceans; to the extraordinary fossil animals of the Karoo Desert of South Africa. Erwin reviews the evidence for each of the hypotheses before presenting his own view of what happened.Although full recovery took tens of millions of years, this most massive of mass extinctions was a powerful creative force, setting the stage for the development of the world as we know it today.

    In this book, he expands the points he has made, and claims that this debate is not so much about religion versus science, as about the nature of science itself. With infectious enthusiasm, he reveals the mechanics of evolutionary theory, explains how it is rooted in the testable and verifiable scientific method, and why it is therefore a sound explanation of our beginning. He argues passionately that to continue to assert otherwise, to continue to insist that creationism has a place in the science classroom is harmful not only to our children, but to the future of the greater world as well.

    A distinguished businesswoman and writer, she examines the phenomenon and traces its imprint in our private and working lives, and within governments and organizations, and asks: What makes us prefer ignorance? What are we so afraid of? Why do some people see more than others? And how can we change?We turn a blind eye in order to feel safe, to avoid conflict, to reduce anxiety, and to protect prestige. Greater understanding leads to solutions, and Heffernan shows how--by challenging our biases, encouraging debate, discouraging conformity, and not backing away from difficult or complicated problems--we can be more mindful of what's going on around us and be proactive instead of reactive.Covering everything from our choice of mates to the SEC, Bernard Madoff's investors, the embers of BP's refinery, the military in Afghanistan, and the dog-eat-dog world of subprime mortgage lenders, this provocative book demonstrates how failing to see--or admit to ourselves or our colleagues--the issues and problems in plain sight can ruin private lives and bring down corporations. Heffernan explains how willful blindness develops before exploring ways that institutions and individuals can combat it. In the tradition of Malcolm Gladwell and Nassim Nicholas Taleb, Margaret Heffernan's Willful Blindness, is a tour de force on human behavior that will open your eyes.

    Ranging from the depths of the ocean to the most arid corners of the land, Caspar Henderson captures the beauty and bizzareness of the many living forms we thought we knew and some we could never have contemplated, inviting us to better imagine the precarious world we inhabit.A witty, vivid blend of cutting edge natural history and meditative reflections, The Book of Barely Imagined Beings is infectious and celebratory about the sheer ingenuity and variety of life.

    Isolated and desolate, they were largely overlooked by early explorers until Charles Darwin arrived there in the 1830s. It was Darwin who recognized that Galapagos' isolation and desolation were advantages: the paucity of species and lack of outside influences made the workings of natural selection crystal clear. Since then, every important advance and controversy in evolutionary thinking has had its reflection on the Galapagos. In every sense-intellectually, institutionally, and culturally-the history of science on these islands is a history of the way evolutionary science was done for the past 150 years. Evolution's Workshop tells the story of Darwin's explorations there; the fabulous Gilded Age expeditions, run from rich men's gigantic yachts, that featured rough-and-ready science during the day and black-tie dinners every night; the struggle for control of research on the Galapagos; the current efforts by "creation scientists" to use the Galapagos to undercut evolutionary teaching; and many other compelling stories.

    But what were and are the true potentates of our planet? Insects, says Scott Richard Shaw—millions and millions of insect species. Starting in the shallow oceans of ancient Earth and ending in the far reaches of outer space—where, Shaw proposes, insect-like aliens may have achieved similar preeminence—Planet of the Bugs spins a sweeping account of insects’ evolution from humble arthropod ancestors into the bugs we know and love (or fear and hate) today. Leaving no stone unturned, Shaw explores how evolutionary innovations such as small body size, wings, metamorphosis, and parasitic behavior have enabled insects to disperse widely, occupy increasingly narrow niches, and survive global catastrophes in their rise to dominance. Through buggy tales by turns bizarre and comical—from caddisflies that construct portable houses or weave silken aquatic nets to trap floating debris, to parasitic wasp larvae that develop in the blood of host insects and, by storing waste products in their rear ends, are able to postpone defecation until after they emerge—he not only unearths how changes in our planet’s geology, flora, and fauna contributed to insects’ success, but also how, in return, insects came to shape terrestrial ecosystems and amplify biodiversity. Indeed, in his visits to hyperdiverse rain forests to highlight the current insect extinction crisis, Shaw reaffirms just how crucial these tiny beings are to planetary health and human survival. In this age of honeybee die-offs and bedbugs hitching rides in the spines of library books, Planet of the Bugs charms with humor, affection, and insight into the world’s six-legged creatures, revealing an essential importance that resonates across time and space.

    Building on twenty-three years' experience at the helm of the world's preeminent science magazine, Nature, Maddox identifies new areas of discovery in physics, biology, health, intelligence, and global catastrophe. As Maddox shows, the rate of scientific discovery will continue to accelerate, hurtling us toward ever more exciting discoveries in the next century.