If America could send a man to the moon, shouldn’t the best surgeons in the world be able to build an artificial heart? In Ticker, Texas Monthly executive editor and two time National Magazine Award winner Mimi Swartz shows just how complex and difficult it can be to replicate one of nature’s greatest creations. Part investigative journalism, part medical mystery, Ticker is a dazzling story of modern innovation, recounting fifty years of false starts, abysmal failures and miraculous triumphs, as experienced by one the world’s foremost heart surgeons, O.H. “Bud” Frazier, who has given his life to saving the un-savable. His journey takes him from a small town in west Texas to one of the country’s most prestigious medical institutions, The Texas Heart Institute, from the halls of Congress to the animal laboratories where calves are fitted with new heart designs. The roadblocks to success —medical setbacks, technological shortcomings, government regulations – are immense. Still, Bud and his associates persist, finding inspiration in the unlikeliest of places. A field beside the Nile irrigated by an Archimedes screw. A hardware store in Brisbane, Australia. A seedy bar on the wrong side of Houston. Until post WWII, heart surgery did not exist. Ticker provides a riveting history of the pioneers who gave their all to the courageous process of cutting into the only organ humans cannot live without. Heart surgeons Michael DeBakey and Denton Cooley, whose feud dominated the dramatic beginnings of heart surgery. Christian Barnaard, who changed the world overnight by performing the first heart transplant. Inventor Robert Jarvik, whose artificial heart made patient Barney Clark a worldwide symbol of both the brilliant promise of technology and the devastating evils of experimentation run amuck. Rich in supporting players, Ticker introduces us to Bud’s brilliant colleagues in his quixotic quest to develop an artificial heart: Billy Cohn, the heart surgeon and inventor who devotes his spare time to the pursuit of magic and music; Daniel Timms, the Brisbane biomedical engineer whose design of a lightweight, pulseless heart with but a single moving part offers a new way forward. And, as government money dries up, the unlikeliest of backers, Houston’s furniture king, Mattress Mack. In a sweeping narrative of one man’s obsession, Swartz raises some of the hardest questions of the human condition. What are the tradeoffs of medical progress? What is the cost, in suffering and resources, of offering patients a few more months, or years of life? Must science do harm to do good? Ticker takes us on an unforgettable journey into the power and mystery of the human heart.

    One of the world's leading astronomers, Robert Kirshner, takes readers inside a lively research team on the quest that led them to an extraordinary cosmological discovery: the expansion of the universe is accelerating under the influence of a dark energy that makes space itself expand. In addition to sharing the story of this exciting discovery, Kirshner also brings the science up-to-date in a new epilogue. He explains how the idea of an accelerating universe--once a daring interpretation of sketchy data--is now the standard assumption in cosmology today.This measurement of dark energy--a quality of space itself that causes cosmic acceleration--points to a gaping hole in our understanding of fundamental physics. In 1917, Einstein proposed the cosmological constant to explain a static universe. When observations proved that the universe was expanding, he cast this early form of dark energy aside. But recent observations described first-hand in this book show that the cosmological constant--or something just like it--dominates the universe's mass and energy budget and determines its fate and shape.Warned by Einstein's blunder, and contradicted by the initial results of a competing research team, Kirshner and his colleagues were reluctant to accept their own result. But, convinced by evidence built on their hard-earned understanding of exploding stars, they announced their conclusion that the universe is accelerating in February 1998. Other lines of inquiry and parallel supernova research now support a new synthesis of a cosmos dominated by dark energy but also containing several forms of dark matter. We live in an extravagant universe with a surprising number of essential ingredients: the real universe we measure is not the simplest one we could imagine.

    Scientists such as Richard Dawkins, Lawrence Krauss, and Sam Harris tell us that our most intimate actions, thoughts, and values are mere byproducts of thousands of generations of mindless adaptation. We are just one species among multitudes, and therefore no more significant than any other living creature. Now comes Brown University biologist Kenneth R. Miller to make the case that this view betrays a gross misunderstanding of evolution. Natural selection surely explains how our bodies and brains were shaped, but Miller argues that it’s not a social or cultural theory of everything. In The Human Instinct, he rejects the idea that our biological heritage means that human thought, action, and imagination are pre-determined, describing instead the trajectory that ultimately gave us reason, consciousness and free will. A proper understanding of evolution, he says, reveals humankind in its glorious uniqueness—one foot planted firmly among all of the creatures we’ve evolved alongside, and the other in the special place of self-awareness and understanding that we alone occupy in the universe. Equal parts natural science and philosophy, The Human Instinct is a moving and powerful celebration of what it means to be human.

    On that day, astronomer Arthur Eddington and his team observed a solar eclipse and found something extraordinary: gravity bends light, just as Einstein predicted. The finding confirmed the theory of general relativity, fundamentally changing our understanding of space and time.A century later, another group of astronomers is performing a similar experiment on a much larger scale. The Event Horizon Telescope, a globe-spanning array of radio dishes, is examining space surrounding Sagittarius A*, the supermassive black hole at the center of the Milky Way. As Ron Cowen recounts, the foremost goal of the experiment is to determine whether Einstein was right on the details. Gravity lies at the heart of what we don't know about quantum mechanics, but tantalizing possibilities for deeper insight are offered by black holes. By observing starlight wrapping around Sagittarius A*, the telescope will not only provide the first direct view of an event horizon--a black hole's point of no return--but will also enable scientists to test Einstein's theory under the most extreme conditions.Gravity's Century shows how we got from the pivotal observations of the 1919 eclipse to the Event Horizon Telescope, and what is at stake today. Breaking down the physics in clear and approachable language, Cowen makes vivid how the quest to understand gravity is really the quest to comprehend the universe.

    We’ll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.

    health care system is in a state of disrepair, but the rabbit hole goes deeper than even the staunchest critics may realize. In Primal Prescription, authors Doug McGuff and Robert Murphy combine their expertise in economics and medicine to offer a shocking, disturbing, and ultimately enlightening view into America’s health care system. You’ll discover the real history of what went wrong with U.S. health care and insurance, and why current efforts to clean up the mess are only making things worse.But far from leaving you feeling helpless at the dismal—and sometimes deadly—state of affairs, Primal Prescription equips you with both the knowledge to understand the health care conundrum and the tools for navigating your way out of it. McGuff and Murphy offer an evidence-based “game plan” for taking control of your own medical care, protecting yourself and your loved ones regardless of what the future holds for the rest of the nation.Whether you’re currently tangled in America’s broken health care system or simply trying to avoid its clutches, Primal Prescription is a must-have resource for taking your health into your own hands.

    Lewis Dartnell considers some of the fascinating questions facing researchers today. Could life exist anywhere else in the universe? What might aliens really look like? Dartnell explains why Earth is uniquely suited for life and reveals our profound connection to the cosmos.

    Bejan explores controversial and relevant issues such as sustainability, water and food supply, fuel, and economy, to critique the state in which the world understands positions of power and freedom. Breaking down concepts such as desire and power, sports health and culture, the state of economy, water and energy, politics and distribution, Bejan uses the language of physics to explain how each system works in order to clarify the meaning of evolution in its broadest scientific sense, moving the reader towards a better understand of the world's systems and the natural evolution of cultural and political development. What Life Is argues that the evolution phenomenon is much broader and older than the evolutionary designs that constitute the biosphere, empowering readers with a new view of the globe, revealing that the urge to have better ideas has the same physical effect as the urge to have better laws and better government. This is evolution explained loudly but also elegantly, forging a path that flows sustainability.

    For this understandable reason, the idea has been banished from polite academic conversation. Arguing that race is more than just a social construct can get a scholar run out of town, or at least off campus, on a rail. Human evolution, the consensus view insists, ended in prehistory. Inconveniently, as Nicholas Wade argues in A Troublesome Inheritance, the consensus view cannot be right. And in fact, we know that populations have changed in the past few thousand years—to be lactose tolerant, for example, and to survive at high altitudes. Race is not a bright-line distinction; by definition it means that the more human populations are kept apart, the more they evolve their own distinct traits under the selective pressure known as Darwinian evolution. For many thousands of years, most human populations stayed where they were and grew distinct, not just in outward appearance but in deeper senses as well. Wade, the longtime journalist covering genetic advances for The New York Times, draws widely on the work of scientists who have made crucial breakthroughs in establishing the reality of recent human evolution. The most provocative claims in this book involve the genetic basis of human social habits. What we might call middle-class social traits—thrift, docility, nonviolence—have been slowly but surely inculcated genetically within agrarian societies, Wade argues. These “values” obviously had a strong cultural component, but Wade points to evidence that agrarian societies evolved away from hunter-gatherer societies in some crucial respects. Also controversial are his findings regarding the genetic basis of traits we associate with intelligence, such as literacy and numeracy, in certain ethnic populations, including the Chinese and Ashkenazi Jews. Wade believes deeply in the fundamental equality of all human peoples. He also believes that science is best served by pursuing the truth without fear, and if his mission to arrive at a coherent summa of what the new genetic science does and does not tell us about race and human history leads straight into a minefield, then so be it. This will not be the last word on the subject, but it will begin a powerful and overdue conversation.

    James Cleaves II seek to answer the most crucial question in science: How did life begin? They trace the trials and triumphs of the iconoclastic scientists who have sought to solve the mystery, from Darwin’s theory of evolution to Crick and Watson’s unveiling of DNA. This fascinating exploration not only examines the origin-of-life question, but also interrogates the very nature of scientific discovery and objectivity.

    The first person to live to 150 years has probably already been born. What will your life look like when you live to be over 100? Will you be healthy? Will your marriage need a sunset clause? How long will you have to work? Will you finish one career at sixty-five only to go back to school to learn a new one? And then, will you be happily working for another sixty years? Maybe you’ll be a parent to a newborn and a grandparent at the same time. Will the world become overpopulated? And how will living longer affect your finances, your family life, and your views on religion and the afterlife? In 100 Plus, futurist Sonia Arrison takes us on an eye-opening journey to the future at our doorsteps, where science and technology are beginning to radically change life as we know it. She introduces us to the people transforming our lives: the brilliant scientists and genius inventors and the billionaires who fund their work. The astonishing advances to extend our lives—and good health—are almost here. In the very near future fresh organs for transplants will be grown in laboratories, cloned stem cells will bring previously unstoppable diseases to their knees, and living past 100 will be the rule, not the exception. Sonia Arrison brings over a decade of experience researching and writing about cutting-edge advances in science and technology to 100 Plus, painting a vivid picture of a future that only recently seemed like science fiction, but now is very real. 100 Plus is the first book to give readers a comprehensive understanding of how life-extending discoveries will change our social and economic worlds. This illuminating and indispensable text will help us navigate the thrilling journey of life beyond 100 years.

    It will make you angry. It will amaze you with the courage of some of the people described in the book...The Autoimmune Epidemic is every bit as compelling as Upton Sinclair's The Jungle...It is also every bit as necessary as An Inconvenient Truth.... You will leave this book with no reservations about the veracity of the conclusions: put simply, there is no doubt that autoimmune diseases are on the rise and increasing environmental exposures of toxins and chemicals is fueling this rise. The research is sound. The conclusions unassailable.... Reading The Autoimmune Epidemic is a necessary first step. Reading The Autoimmune Epidemic is a life-altering event. It needs to be."

    Some are bright and famous, some shine so feebly you need a huge telescope. There are big stars, small stars, nearby stars and faraway stars. Some died a while ago, others have not even yet come into being. Collectively they tell the story of the whole world, according to Freistetter. There is Algol, for example, the Demon Star, whose strange behaviour has long caused people sleepless nights. And Gamma Draconis, from which we know that the earth rotates around its own axis. There is also the star sequence 61 Cygni, which revealed the size of the cosmos to us.Then there are certain stars used by astronomers to search for extra-terrestrial life, to explore interstellar space travel, or to explain why the dinosaurs became extinct.In 100 short, fascinating and entertaining chapters, Freistetter not only reveals the past and future of the cosmos, but also the story of the people who have tried to understand the world in which we live.

    David Peat explains the development and meaning of this Superstring Theory in a thoroughly readable, dramatic manner accessible to lay readers with no knowledge of mathematics. The consequences of the Superstring Theory are nothing less than astonishing.

    The more we discover, the more puzzling the universe appears to be. How and why are the laws of nature what they are? A philosopher and a physicist, world-renowned for their radical ideas in their fields, argue for a revolution. To keep cosmology scientific, we must replace the old view in which the universe is governed by immutable laws by a new one in which laws evolve. Then we can hope to explain them. The revolution that Roberto Mangabeira Unger and Lee Smolin propose relies on three central ideas. There is only one universe at a time. Time is real: everything in the structure and regularities of nature changes sooner or later. Mathematics, which has trouble with time, is not the oracle of nature and the prophet of science; it is simply a tool with great power and immense limitations. The argument is readily accessible to non-scientists as well as to the physicists and cosmologists whom it challenges.