Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    Memetics is the science of memes, the invisible but very real DNA of human society.

    An exhilarating account of Sapolsky’s twenty-one-year study of a troop of rambunctious baboons in Kenya, A Primate’s Memoir interweaves serious scientific observations with wry commentary about the challenges and pleasures of living in the wilds of the Serengeti — for man and beast alike. Over two decades, Sapolsky survives culinary atrocities, gunpoint encounters, and a surreal kidnapping, while witnessing the encroachment of the tourist mentality on the farthest vestiges of unspoiled Africa. As he conducts unprecedented physiological research on wild primates, he becomes evermore enamored of his subjects — unique and compelling characters in their own right — and he returns to them summer after summer, until tragedy finally prevents him.By turns hilarious and poignant, A Primate’s Memoir is a magnum opus from one of our foremost science writers.

    Far less well-known is a much greater catastrophe that took place at the end of the Permian period 251 million years ago: 90 percent of life was destroyed, including saber-toothed reptiles and their rhinoceros-sized prey on land, as well as vast numbers of fish and other species in the sea.This book documents not only what happened during this gigantic mass extinction but also the recent rekindling of the idea of catastrophism. Was the end-Permian event caused by the impact of a huge meteorite or comet, or by prolonged volcanic eruption in Siberia? The evidence has been accumulating through the 1990s and into the new millennium, and Michael Benton gives his verdict at the very end. From field camps in Greenland and Russia to the laboratory bench, When Life Nearly Died involves geologists, paleontologists, environmental modelers, geochemists, astronomers, and experts on biodiversity and conservation. Their working methods are vividly described and explained, and the current disputes are revealed. The implications of our understanding of crises in the past for the current biodiversity crisis are also presented in detail. 46 b/w illustrations.

    The authors argue that only by having a sense of common ground between mind in Science and mind in experience can our understanding of cognition be more complete. Toward that end, they develop a dialogue between cognitive science and Buddhist meditative psychology and situate it in relation to other traditions such as phenomenology and psychoanalysis.

    It is one of many awe-inspiring, magical processes that have evolved among the fungi, yet this group remains the least studied and most poorly understood kingdom of organisms. In Mushroom, NicholasMoney offers a vibrant introduction to the world of mushrooms, investigating the science behind these organisms as well as their enduring cultural and imaginative appeal. Beginning with the basics of mushroom biology, Money leads us through a history of mushroom research, painting portraits of thecolorful characters involved in their study--among them, Beatrix Potter, the celebrated author and creator of Peter Rabbit, and Captain Charles McIlvaine, a Civil War veteran who engaged in a dangerous quest to determine the edibility of every mushroom in North America. Money also discusses the usesof mushrooms today, exploring their importance as food and medicine, their use as recreational drugs, and as the cause of horrific poisonings. A cultural, natural, and scientific history in one, Mushroom is a must-read for mycophiles, mushroom gatherers, and nature lovers alike.

    The authors capture students' interest with up-to-date coverage of cutting edge topics and research. This text will help students connect the science of genetics to the issues of today through interesting and thought-provoking applications. The sixth edition boasts the next generation of media integration including Gen CD-X (student CD-ROM and Companion Website).

    To find a meal, the female bolas spider releases pheromones that mimic a female moth, luring male moths into her sticky lasso web. The Glyptapanteles wasp injects a caterpillar with her young, which feed on the victim, erupt out of it, then mind-control the poor (and somehow still living) schmuck into protecting them from predators.These are among the curious critters of The Wasp That Brainwashed the Caterpillar, a jaunt through evolution’s most unbelievable, most ingenious solutions to the problems of everyday life, from trying to get laid to finding food. Join Wired science writer Matt Simon as he introduces you to the creatures that have it figured out, the ones that joust with their mustaches or choke sharks to death with snot, all in a wild struggle to survive and, of course, find true love.

    Tameness is the key trait in the domestication of cats, dogs, horses, cows, and other mammals, from rats to reindeer. Surprisingly, with selection for tameness comes a suite of seemingly unrelated alterations, including floppy ears, skeletal and coloration changes, and sex differences. It’s a package deal known as the domestication syndrome, elements of which are also found in humans. Our highly social nature—one of the keys to our evolutionary success—is due to our own tameness. In Domesticated, Richard C. Francis weaves history and anthropology with cutting-edge ideas in genomics and evo devo to tell the story of how we domesticated the world, and ourselves in the process.

    Here he tackles all the "big questions," including the biggest of them all: Why does the universe seem so well adapted for life? In his characteristically clear and elegant style, Davies shows how recent scientific discoveries point to a perplexing fact: many different aspects of the cosmos, from the properties of the humble carbon atom to the speed of light, seem tailor-made to produce life. A radical new theory says it's because our universe is just one of an infinite number of universes, each one slightly different. Our universe is bio-friendly by accident -- we just happened to win the cosmic jackpot. While this "multiverse" theory is compelling, it has bizarre implications, such as the existence of infinite copies of each of us and Matrix-like simulated universes. And it still leaves a lot unexplained. Davies believes there's a more satisfying solution to the problem of existence: the observations we make today could help shape the nature of reality in the remote past. If this is true, then life -- and, ultimately, consciousness -- aren't just incidental byproducts of nature, but central players in the evolution of the universe. Whether he's elucidating dark matter or dark energy, M-theory or the multiverse, Davies brings the leading edge of science into sharp focus, provoking us to think about the cosmos and our place within it in new and thrilling ways.

    Their struggle to survive on the open grasslands required a shift from individualism to a new form of collectivism, which forever altered the way our mind works. It changed the way we fight and our proclivity to make peace, it changed the way we lead and the way we follow, it made us innovative but not inventive, it created a new kind of social intelligence, and it led to new sources of life satisfaction.In The Social Leap, William von Hippel lays out this revolutionary hypothesis, tracing human development through three critical evolutionary inflection points to explain how events in our distant past shape our lives today. From the mundane, such as why we exaggerate, to the surprising, such as why we believe our own lies and why fame and fortune are as likely to bring misery as happiness, the implications are far reaching and extraordinary.Blending anthropology, biology, history, and psychology with evolutionary science, The Social Leap is a fresh and provocative look at our species that provides new clues about who we are, what makes us happy, and how to use this knowledge to improve our lives.

    Hazen writes of how the co-evolution of the geosphere and biosphere—of rocks and living matter—has shaped our planet into the only one of its kind in the Solar System, if not the entire cosmos.With an astrobiologist’s imagination, a historian’s perspective, and a naturalist’s passion for the ground beneath our feet, Hazen explains how changes on an atomic level translate into dramatic shifts in Earth’s makeup over its 4.567 billion year existence. He calls upon a flurry of recent discoveries to portray our planet’s many iterations in vivid detail. Through his theory of “co-evolution,” we learn how reactions between organic molecules and rock crystals may have generated Earth’s first organisms, which in turn are responsible for more than two-thirds of the mineral varieties on the planet.The Story of Earth is also the story of the pioneering men and women behind the sciences. Readers will meet black-market meteorite hawkers of the Sahara Desert, the gun-toting Feds who guarded the Apollo missions’ lunar dust, and the World War II Navy officer whose super-pressurized “bomb”—recycled from military hardware—first simulated the molten rock of Earth’s mantle. As a mentor to a new generation of scientists, Hazen introduces the intrepid young explorers whose dispatches from Earth’s harshest landscapes will revolutionize geology.

    But what would it look like to study the whole of history, from the big bang through the present day -- and even into the remote future? How would looking at the full span of time change the way we perceive the universe, the earth, and our very existence?These were the questions David Christian set out to answer when he created the field of "Big History," the most exciting new approach to understanding where we have been, where we are, and where we are going. In Origin Story, Christian takes readers on a wild ride through the entire 13.8 billion years we've come to know as "history." By focusing on defining events (thresholds), major trends, and profound questions about our origins, Christian exposes the hidden threads that tie everything together -- from the creation of the planet to the advent of agriculture, nuclear war, and beyond.With stunning insights into the origin of the universe, the beginning of life, the emergence of humans, and what the future might bring, Origin Story boldly reframes our place in the cosmos.

    Our brains, therefore, are designed not just to hunt and gather, but also to help us get ahead socially, often via deception and self-deception. But while we may be self-interested schemers, we benefit by pretending otherwise. The less we know about our own ugly motives, the better - and thus we don't like to talk or even think about the extent of our selfishness. This is "the elephant in the brain." Such an introspective taboo makes it hard for us to think clearly about our nature and the explanations for our behavior. The aim of this book, then, is to confront our hidden motives directly - to track down the darker, unexamined corners of our psyches and blast them with floodlights. Then, once everything is clearly visible, we can work to better understand ourselves: Why do we laugh? Why are artists sexy? Why do we brag about travel? Why do we prefer to speak rather than listen?Our unconscious motives drive more than just our private behavior; they also infect our venerated social institutions such as Art, School, Charity, Medicine, Politics, and Religion. In fact, these institutions are in many ways designed to accommodate our hidden motives, to serve covert agendas alongside their "official" ones. The existence of big hidden motives can upend the usual political debates, leading one to question the legitimacy of these social institutions, and of standard policies designed to favor or discourage them. You won't see yourself - or the world - the same after confronting the elephant in the brain.

    Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: The Man Who Mistook His Wife for a Hat, An Anthropologist on Mars, Musicophilia: Tales of Music and the Brain, Seeing Voices, Migraine, Uncle Tungsten: Memories of a Chemical Boyhood, Awakenings, The Island of the Colorblind, . Source: Wikipedia. Free updates online. Not illustrated. Excerpt: The Man Who Mistook His Wife for a Hat and Other Clinical Tales is a 1985 book by neurologist Oliver Sacks describing the case histories of some of his patients. The title of the book comes from the case study of a man with visual agnosia. The Man Who Mistook His Wife for a Hat became the basis of an opera of the same name by Michael Nyman, which premiered in 1986. The book comprises 24 essays split into 4 sections which each deal with a particular aspect of brain function such as deficits and excesses in the first two sections (with particular emphasis on the right hemisphere of the brain) while the third and fourth describe phenomenological manifestations with reference to spontaneous reminiscences, altered perceptions, and extraordinary qualities of mind found in "retardates." The individual essays in this book include, but are not limited to: Christopher Rawlence wrote the libretto for a chamber opera, directed by Michael Morris with music by Michael Nyman, based on the title story. "The Man Who Mistook His Wife for a Hat" was first produced by the Institute of Contemporary Arts in London in 1986. A television version of the opera was subsequently broadcast in the UK. Peter Brook adapted Sacks's book into an acclaimed theatrical production, "L'Homme Qui...," which premiered at the Theatre des Bouffes du Nord, Paris, in 1993. An Indian theatre company, performed a play The Blue Mug, based on the book, starring Rajat Kapoor, Konkona Sen Sharma, Ranvir Shorey a...More: http: //booksllc.net/?id=3371