Told here for the first time, the dramatic tale of how the secrets of the brain were discovered in seventeenth-century England unfolds against a turbulent backdrop of civil war, the Great Fire of London, and plague. At the beginning of that chaotic century, no one knew how the brain worked or even what it looked like intact. But by the century's close, even the most common conceptions and dominant philosophies had been completely overturned, supplanted by a radical new vision of man, God, and the universe. Presiding over the rise of this new scientific paradigm was the founder of modern neurology, Thomas Willis, a fascinating, sympathetic, even heroic figure at the center of an extraordinary group of scientists and philosophers known as the Oxford circle. Chronicled here in vivid detail are their groundbreaking revelations and the often gory experiments that first enshrined the brain as the physical seat of intelligence -- and the seat of the human soul. Soul Made Flesh conveys a contagious appreciation for the brain, its structure, and its many marvelous functions, and the implications for human identity, mind, and morality.

    The Other Brain is the story of glia, which make up approximately 85 percent of the cells in the brain. Long neglected as little more than cerebral packing material ("glia" means glue), glia are sparking a revolution in brain science.Glia are completely different from neurons, the brain cells that we are familiar with. Scientists are discovering that glia have their own communication network, which operates in parallel to the more familiar communication among neurons. Glia provide the insulation for the neurons, and glia even regulate the flow of information between neurons.But it is the potential breakthroughs for medical science that are the most exciting frontier in glia research today. Diseases such as brain cancer and multiple sclerosis are caused by diseased glia. Glia are now believed to play an important role in such psychiatric illnesses as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson's and Alzheimer's. They are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. Scientists have discovered that glia repair the brain and spinal cord after injury and stroke. The more we learn about these cells that make up the "other" brain, the more important they seem to be.Written by a neuroscientist who is a leader in the research to reveal the secrets of these brain cells, The Other Brain offers a firsthand account of science in action. It takes us into the laboratories where important discoveries are being made, and it explains how scientists are learning that glial cells come in different types, with different capabilities. It tells the story of glia research from its origins to the most recent discoveries and gives readers a much more complete understanding of how the brain works and where the next breakthroughs in brain science and medicine are likely to come.

    Now he stands ready to revolutionize both neuroscience and computing in one stroke, with a new understanding of intelligence itself.Hawkins develops a powerful theory of how the human brain works, explaining why computers are not intelligent and how, based on this new theory, we can finally build intelligent machines.The brain is not a computer, but a memory system that stores experiences in a way that reflects the true structure of the world, remembering sequences of events and their nested relationships and making predictions based on those memories. It is this memory-prediction system that forms the basis of intelligence, perception, creativity, and even consciousness.In an engaging style that will captivate audiences from the merely curious to the professional scientist, Hawkins shows how a clear understanding of how the brain works will make it possible for us to build intelligent machines, in silicon, that will exceed our human ability in surprising ways.Written with acclaimed science writer Sandra Blakeslee, On Intelligence promises to completely transfigure the possibilities of the technology age. It is a landmark book in its scope and clarity.

    Indeed, the brain's power is being confirmed every day in new studies and research. But there is a brain we don't generally hear about, a brain we might not want to hear about…the "prima donna within."Exposing the mind's deceptions and exploring how the mind defends and glorifies the ego, Dr. Cordelia Fine illustrates the brain's tendency to self-delusion. Whether it be hindsight bias, wishful thinking, unrealistic optimism, or moral excuse-making, each of us has a slew of inborn mind-bugs and ordinary prejudices that prevent us from seeing the truth about the world and ourselves. With fascinating studies to support her arguments, Dr. Fine takes us on an insightful, rip-roaringly funny tour through the brain you never knew you had.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Its greatest detriment to the world has been its unfettered desire to play with and alter them: science for science's sake, as if it offered the only path to knowledge.According to Lehrer, when it comes to the human brain, the world of art unraveled such mysteries long before the neuroscientists: "This book is about artists who anticipated the discoveries of science who discovered truths about the human mind that science is only now discovering." 'Proust Was a Neuroscientist' is a dazzling inquiry into the nature of the mind and of the truths harvested by its first explorers: artists like Walt Whitman, George Eliot, Auguste Escoffier, Marcel Proust, Paul Cozanne, Igor Stravinsky, Gertrude Stein, and Virginia Woolf. What they understood intuitively and expressed through their respective art forms -- the fallibility of memory, the malleability of the brain, the subtleties of vision, and the deep structure of language -- science has only now begun to measure and confirm. Blending biography, criticism, and science writing, Lehrer offers a lucid examination of eight artistic thinkers who lit the path toward a greater understanding of the human mind and a deeper appreciation of the ineffable mystery of life.

    Updated to reflect the latest research in the field, and enhanced with more than 1,000 illustrations, most in full-color, the 12th Edition is the most comprehensive and modern approach to understanding medical histology available anywhere.Features: NEW full-color micrographs that comprise a complete atlas of tissue sections highlight the important features of every tissue and organ in the human body. New full-color, easy-to-understand drawings provide just the right level of detail necessary to clarify the text and make learning easier A valuable introductory chapter on laboratory methods used for the study of tissues, including the most important types of microscopy A logical organization that features chapters focusing on the cytoplasmic and nuclear compartment of the cell, the four basic tissues that form the organs, and each organ system Expanded legends that accompany each figure emphasize important points and eliminate the need to jump from image to text Medical applications explain the clinical relevance of each topic Complete coverage of every tissue of the body CD-ROM with all the images from the textVisit www.LangeTextbooks.com to access valuable resources and study aids

    Murray's best-selling book "the most colorful and fun text to read in medical microbiology." Now it's back in an updated New Edition-and it's as succinct, user-friendly, and authoritative as ever. Readers will continue to enjoy its lucid discussions of how microbes cause disease in humans. Expert coverage of basic principles, the immune response, laboratory diagnosis, bacteriology, virology, mycology, and parasitology ensures they understand all the facts vital to the practice of medicine today. More than 550 brilliant full-color images make complex information easy to understand and illustrate the appearance of disease.The smart way to study!Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.

    Dennett's exposition is nothing short of brilliant." --George Johnson, New York Times Book ReviewConsciousness Explained is a a full-scale exploration of human consciousness. In this landmark book, Daniel Dennett refutes the traditional, commonsense theory of consciousness and presents a new model, based on a wealth of information from the fields of neuroscience, psychology, and artificial intelligence. Our current theories about conscious life-of people, animal, even robots--are transformed by the new perspectives found in this book.

    But it’s also messy, fallible, and about 50,000 years out of date. We cling to superstitions, remember faces but not names, miss things sitting right in front of us, and lie awake at night while our brains endlessly replay our greatest fears. Idiot Brain is for anyone who has ever wondered why their brain appears to be sabotaging their life—and what on earth it is really up to.A Library Journal Science Bestseller and a Finalist for the Goodreads Choice Award in Science Technology.

    Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

    For the first time in history, the secrets of the living brain are being revealed by a battery of high tech brain scans devised by physicists. Now what was once solely the province of science fiction has become a startling reality. Recording memories, telepathy, videotaping our dreams, mind control, avatars, and telekinesis are not only possible; they already exist. The Future of the Mind gives us an authoritative and compelling look at the astonishing research being done in top laboratories around the world—all based on the latest advancements in neuroscience and physics. One day we might have a "smart pill" that can enhance our cognition; be able to upload our brain to a computer, neuron for neuron; send thoughts and emotions around the world on a "brain-net"; control computers and robots with our mind; push the very limits of immortality; and perhaps even send our consciousness across the universe. Dr. Kaku takes us on a grand tour of what the future might hold, giving us not only a solid sense of how the brain functions but also how these technologies will change our daily lives. He even presents a radically new way to think about "consciousness" and applies it to provide fresh insight into mental illness, artificial intelligence and alien consciousness. With Dr. Kaku's deep understanding of modern science and keen eye for future developments, The Future of the Mind is a scientific tour de force--an extraordinary, mind-boggling exploration of the frontiers of neuroscience.

    In over 540 beautifully colored and easily understood illustrations, it teaches the complete human body with unsurpassed clarity and accuracy. This new edition features 45 revised, 290 relabeled and 17 wholly new plates, drawn fully in the tradition of Frank Netter, and includes more imaging and clinical images than ever before. Six Consulting Editors have worked together to ensure the new edition's accuracy and usefulness in the lecture theatre, classroom and dissection lab. Ninety plates from the book as well as a powerful and varied bank of ancillary material, unique to this atlas, are available online through www.netteranatomy.com.Includes uniquely informative drawings that allow you - and have allowed generations of students - to learn structures with confidence. Associates normal anatomy with an application of that knowledge in a clinical setting. Offers a strong selection of imaging to show you what is happening three dimensionally in the human body, the way you see it in practice.Provides clinically applicable information right from the start, to mirror the way that most anatomy courses are now taught.At www.netteranatomy.com, you'll access...- Over 90 of the most important anatomy illustrations from the book.- Interactive Anatomy Dissection Modules.- Radiographs, CT scans, MRIs, and angiograms, with labels on/off buttons for self testing.- QuickTime movies of stacked, transverse, and sectional images from the Visible Human Project (VHP).- Review Center with Identification Spot Tests and USMLE-style multiple-choice questions.- Integration links to other STUDENT CONSULT titles.- and more!

    Their dedication and hard work have yielded an authoritative volume that defines and classifies mental disorders in order to improve diagnoses, treatment, and research.The criteria are concise and explicit, intended to facilitate an objective assessment of symptom presentations in a variety of clinical settings -- inpatient, outpatient, partial hospital, consultation-liaison, clinical, private practice, and primary care. New features and enhancements make DSM-5 easier to use across all settings:- The chapter organization reflects a lifespan approach, with disorders typically diagnosed in childhood (such as neurodevelopmental disorders) at the beginning of the manual, and those more typical of older adults (such as neurocognitive disorders) placed at the end. Also included are age-related factors specific to diagnosis. - The latest findings in neuroimaging and genetics have been integrated into each disorder along with gender and cultural considerations.- The revised organizational structure recognizes symptoms that span multiple diagnostic categories, providing new clinical insight in diagnosis. - Specific criteria have been streamlined, consolidated, or clarified to be consistent with clinical practice (including the consolidation of autism disorder, Asperger's syndrome, and pervasive developmental disorder into autism spectrum disorder; the streamlined classification of bipolar and depressive disorders; the restructuring of substance use disorders for consistency and clarity; and the enhanced specificity for major and mild neurocognitive disorders).- Dimensional assessments for research and validation of clinical results have been provided.- Both ICD-9-CM and ICD-10-CM codes are included for each disorder, and the organizational structure is consistent with the new ICD-11 in development.The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, is the most comprehensive, current, and critical resource for clinical practice available to today's mental health clinicians and researchers of all orientations. The information contained in the manual is also valuable to other physicians and health professionals, including psychologists, counselors, nurses, and occupational and rehabilitation therapists, as well as social workers and forensic and legal specialists.

    But new research from neuroscientists and psychologists suggests that, in fact, the brain reorganizes, improves in important functions, and even helps us adopt a more optimistic outlook in middle age. Growth of white matter and brain connectors allow us to recognize patterns faster, make better judgments, and find unique solutions to problems. Scientists call these traits cognitive expertise and they reach their highest levels in middle age. In her impeccably researched book, science writer Barbara Strauch explores the latest findings that demonstrate, through the use of technology such as brain scans, that the middle-aged brain is more flexible and more capable than previously thought. For the first time, long-term studies show that our view of middle age has been misleading and incomplete. By detailing exactly the normal, healthy brain functions over time, Strauch also explains how its optimal processes can be maintained. Part scientific survey, part how-to guide, "The Secret Life of the Grown-Up Brain" is a fascinating glimpse at our surprisingly talented middle-aged minds."