Through horrible physical deformities which were almost impossible to describe, he spent much of his life exhibited as a fairground freak until even nineteenth-century sensibilities could take no more. Hounded, persecuted and starving, he ended up at London's Liverpool Street Station where he was rescued, housed and fed by the distinguished surgeon Frederick Treves. To Treves' surprise, he discovered during the course of their friendship that lurking beneath the mass of Merrick's corrupting flesh lived a spirit that was as courageous as it had been tortured, and a nature as gentle and dignified as it had been deprived and tormented. The subject of several books, a Broadway hit, and a film, Joseph Merrick has become part of popular mythology. Here, in this fully revised edition containing new details, are the true and unromantic facts of his life. This is an extraordinary and moving story, set among the brutal realities of the Victorian world, telling of a tragic individual and his survival against overwhelming odds."

    His staggering fortune was fought over by his heirs after his death in 1877, sowing familial discord that would never fully heal. Though his son Billy doubled the money left by “the Commodore,” subsequent generations competed to find new and ever more extraordinary ways of spending it. By 2018, when the last Vanderbilt was forced out of The Breakers—the seventy-room summer estate in Newport, Rhode Island, that Cornelius’s grandson and namesake had built—the family would have been unrecognizable to the tycoon who started it all.Now, the Commodore’s great-great-great-grandson Anderson Cooper, joins with historian Katherine Howe to explore the story of his legendary family and their outsized influence. Cooper and Howe breathe life into the ancestors who built the family’s empire, basked in the Commodore’s wealth, hosted lavish galas, and became synonymous with unfettered American capitalism and high society. Moving from the hardscrabble wharves of old Manhattan to the lavish drawing rooms of Gilded Age Fifth Avenue, from the ornate summer palaces of Newport to the courts of Europe, and all the way to modern-day New York, Cooper and Howe wryly recount the triumphs and tragedies of an American dynasty unlike any other.Written with a unique insider’s viewpoint, this is a rollicking, quintessentially American history as remarkable as the family it so vividly captures.

    In the same period it also produced treatments to control the progress of Parkinson's, rheumatoid arthritis, and schizophrenia. It made realities of open-heart surgery, organ transplants, test-tube babies. Unquestionably, the medical accomplishments of the postwar years stand at the forefront of human endeavor, yet progress in recent decades has slowed nearly to a halt. In this winner of the Los Angeles Times Book Prize, medical doctor and columnist James Le Fanu both surveys the glories of medicine in the postwar years and analyzes the factors that for the past twenty-five years have increasingly widened the gulf between achievement and advancement: the social theories of medicine, ethical issues, and political debates over health care that have hobbled the development of vaccines and discovery of new "miracle" cures. While fully demonstrating the extraordinary progress effected by medical research in the latter half of the twentieth century, Le Fanu also identifies the perils that confront medicine in the twenty-first. 16 pages of black-and-white photographs add to what the Los Angeles Times cited as "a sobering, contrarian challenge" to the "nostrum of medicine as a never-ending font of ‘miracle cures'." "[From] a respected science writer ... important information that ... has been overlooked or ignored by many physicians." —New Republic "Provocative and engrossing and informative." —Houston Chronicle "Marvelously written, meticulously researched ... one of the most thought-provoking and important works to appear in recent years." —Choice

    The doctor-patient relationship--the heart of medicine--is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard.Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, for all the humans involved.

    Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

    But doctors’ emotional responses to the life-and-death dramas of everyday practice have a profound impact on medical care. And while much has been written about the minds and methods of the medical professionals who save our lives, precious little has been said about their emotions. In What Doctors Feel, Dr. Danielle Ofri has taken on the task of dissecting the hidden emotional responses of doctors, and how these directly influence patients.How do the stresses of medical life—from paperwork to grueling hours to lawsuits to facing death—affect the medical care that doctors can offer their patients? Digging deep into the lives of doctors, Ofri examines the daunting range of emotions—shame, anger, empathy, frustration, hope, pride, occasionally despair, and sometimes even love—that permeate the contemporary doctor-patient connection. Drawing on scientific studies, including some surprising research, Dr. Danielle Ofri offers up an unflinching look at the impact of emotions on health care.With her renowned eye for dramatic detail, Dr. Ofri takes us into the swirling heart of patient care, telling stories of caregivers caught up and occasionally torn down by the whirlwind life of doctoring. She admits to the humiliation of an error that nearly killed one of her patients and her forever fear of making another. She mourns when a beloved patient is denied a heart transplant. She tells the riveting stories of an intern traumatized when she is forced to let a newborn die in her arms, and of a doctor whose daily glass of wine to handle the frustrations of the ER escalates into a destructive addiction. But doctors don’t only feel fear, grief, and frustration. Ofri also reveals that doctors tell bad jokes about “toxic sock syndrome,” cope through gallows humor, find hope in impossible situations, and surrender to ecstatic happiness when they triumph over illness.  The stories here reveal the undeniable truth that emotions have a distinct effect on how doctors care for their patients. For both clinicians and patients, understanding what doctors feel can make all the difference in giving and getting the best medical care.

    Turing’s openness about his homosexuality at a time when it was an imprisonable offense ultimately led to his untimely lo death at the age of only forty-one. In Alan Turing: Unlocking the Enigma, David Boyle reveals the mysteries behind the man and his remarkable career. Aged just 22, Turing was elected a fellow at King's College, Cambridge on the strength of a dissertation in which he proved the central limit theorem. By the age of 33, he had been awarded the OBE by King George VI for his wartime services: Turing was instrumental in cracking the Nazi Enigma machines at the top secret code breaking establishment at Bletchley Park during the Second World War.But his achievements were to be tragically overshadowed by the paranoia of the post-War years. Hounded for his supposedly subversive views and for his sexuality, Turing was prosecuted in 1952, and forced to accept the humiliation of hormone treatment to avoid a prison sentence. Just two years later, at the age of 41 he was dead. The verdict: cyanide poisoning.Was Turing’s death accidental as his mother always claimed? Or did persistent persecution drive him to take him own life?Alan Turing: Unlocking the Enigma seeks to find the man behind the science, illuminating the life of a person who is still a shadowy presence behind his brilliant achievements.

    Applying the same objective criteria to legal and illegal substances, an argument is made that legality is not a clear measure for harm. Tackling a variety of questions, such as Which is more harmful—Ecstasy or alcohol? Can addiction be cured? and Does the "War on Drugs" have serious unintended effects that can hurt children?, this analysis equips readers with the ability to make educated decisions regarding drugs both personally and in their communities. Broadening the scope of the discussion, a framework is explored for formulating national drug policies that will minimize a myriad of harms—social, medical, criminal, financial, and environmental.

    The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain.Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

    Bill Bass, one of the world's leading forensic anthropologists, gained international attention when he built a forensic lab like no other: The Body Farm. Now, this master scientist unlocks the gates of his lab to reveal his most intriguing cases-and to revisit the Lindbergh kidnapping and murder, fifty years after the fact.

    Alternating passages of extraordinarily lucid mathematical exposition with chapters of elegantly composed biography and history, Prime Obsession is a fascinating and fluent account of an epic mathematical mystery that continues to challenge and excite the world.

    Kathy Magliato is one of the few female heart surgeons practicing in the world today. She is also a member of an even more exclusive group—those surgeons specially trained to perform heart transplants. Heart Matters is the story of the making of a surgeon who is also a wife and mother. In this powerful and moving memoir, which inspired the NBC series Heart Beat, Dr. Magliato takes us into her highly demanding, physically intense, male-dominated world and shows us how she masterfully works to save patients' lives every day, while also maintaining balance at home. Heart Matters is also a wake-up call to all women about their number one killer - heart disease - and explains how to avoid becoming a victim. Magliato offers a vivid behind-the-scenes view of what really goes on in an operating room and the real-life drama that occurs there. She shows the passion and commitment between patient and doctor, revealing that, at the end of a long day, it's our hearts that matter most.

    and a PhD.  While he was a student, and later during his surgical internship at the Johns Hopkins Hospital, he began the series of animal experiments that led eventually to the world’s first transplantation of the human liver in 1963.Throughout his career, first at the University of Colorado and then at the University of Pittsburgh, he has aroused both worldwide admiration and controversy.  His technical innovations and medical genius have revolutionized the field, but Starzl has not hesitated to address the moral and ethical issues raised by transplantation.  In this book he clearly states his position on many hotly debated issues including brain death, randomized trials for experimental drugs, the costs of transplant operations, and the system for selecting organ recipients from among scores of desperately ill patients.There are many heroes in the story of transplantation, and many “puzzle people,” the patients who, as one journalist suggested, might one day be made entirely of various transplanted parts.  They are old and young, obscure and world famous.  Some have been taken into the hearts of America, like Stormie Jones, the brave and beautiful child from Texas.  Every patient who receives someone else’s organ - and Starzl remembers each one - is a puzzle.  “It was not just the acquisition of a new part,” he writes.  “The rest of the body had to change in many ways before the gift could be accepted.  It was necessary for the mind to see the world in a different way.”  The surgeons and physicians who pioneered transplantation were also changed: they too became puzzle people.  “Some were corroded or destroyed by the experience, some were sublimated, and none remained the same.”

    In Wicked Plants, Stewart takes on over two hundred of Mother Nature’s most appalling creations. It’s an A to Z of plants that kill, maim, intoxicate, and otherwise offend. You’ll learn which plants to avoid (like exploding shrubs), which plants make themselves exceedingly unwelcome (like the vine that ate the South), and which ones have been killing for centuries (like the weed that killed Abraham Lincoln's mother). Menacing botanical illustrations and splendidly ghastly drawings create a fascinating portrait of the evildoers that may be lurking in your own backyard. Drawing on history, medicine, science, and legend, this compendium of bloodcurdling botany will entertain, alarm, and enlighten even the most intrepid gardeners and nature lovers.

    A collection of letters written when Alcott was a Civil War army nurse, they garnered Alcott's first critical recognition for her observations and humour.