This cycle is at the root of all addictions, addictions to drugs, sex, love, cigarettes, soap operas, wealth, and wisdom itself. But why should this be so? Why are we desperate for what we don't have, or can't have, often at great cost to what we do have, thereby risking our peace and contentment, our safety, and even our lives?"The answer, says Dr. Marc Lewis, lies in the structure and function of the human brain. Marc Lewis is a distinguished neuroscientist. And, for many years, he was a drug addict himself, dependent on a series of dangerous substances, from LSD to heroin. His narrative moves back and forth between the often dark, compellingly recounted story of his relationship with drugs and a revelatory analysis of what was going on in his brain. He shows how drugs speak to the brain - which is designed to seek rewards and soothe pain - in its own language. He shows in detail the neural mechanics of a variety of powerful drugs and of the onset of addiction, itself a distortion of normal perception.Dr. Lewis freed himself from addiction and ended up studying it. At the age of 30 he traded in his pharmaceutical supplies for the life of a graduate student, eventually becoming a professor of developmental psychology, and then of neuroscience - his field for the last 12 years. This is the story of his journey, seen from the inside out.

    Can a person think herself to orgasm? Why doesn't Viagra help women-or, for that matter, pandas? Can a dead man get an erection? Is vaginal orgasm a myth? Mary Roach shows us how and why sexual arousal and orgasm-two of the most complex, delightful, and amazing scientific phenomena on earth-can be so hard to achieve and what science is doing to make the bedroom a more satisfying place.

    As the creator and star of Mister Rogers’ Neighborhood, he was a champion of compassion, equality, and kindness. Rogers was fiercely devoted to children and to taking their fears, concerns, and questions about the world seriously.The Good Neighbor, the first full-length biography of Fred Rogers, tells the story of this utterly unique and enduring American icon. Drawing on original interviews, oral histories, and archival documents, Maxwell King traces Rogers’s personal, professional, and artistic life through decades of work, including a surprising decision to walk away from the show to make television for adults, only to return to the neighborhood with increasingly sophisticated episodes, written in collaboration with experts on childhood development. An engaging story, rich in detail, The Good Neighbor is the definitive portrait of a beloved figure, cherished by multiple generations.

    By investing some of the lesser-known corners of psychology, neuroscience, physics, history, and even crime, all through the lens of trickery and illusion, Fooling Houdini arrives at a host of startling revelations about how the mind works--and why, sometimes, it doesn’t.

    This is a heartbreakingly honest yet hopeful memoir reminiscent of Manic, Electroboy, and An Unquiet Mind.During the 1990s, three-time Olympian Suzy Favor Hamilton was the darling of American track and field. An outstanding runner, a major sports apparel spokesperson, and a happily married wife, she was the model for an active, healthy, and wholesome life. But her perfect facade masked a dark truth: manic depression and bipolar disorder that drove her obsession to perform and win. For years after leaving the track, Suzy wrestled with her condition, as well as the loss of a close friend, conflicted feelings about motherhood and her marriage, and lingering shame about her athletic career. After a misdiagnosis and a recommendation for medication that only exacerbated her mania and made her hypersexual, Suzy embarked on a new path, and assumed a new identity. Fueled by a newfound confidence, a feeling of strength and independence and a desire she couldn’t tamp down, she became a high-priced escort in Las Vegas, working as “Kelly.”But Suzy could not keep her double life a secret forever. When it was eventually exposed, it sent her into a reckless suicidal period where the only option seemed out. Finally, with the help of her devoted husband, Suzy finally got the proper medical help she needed. In this startling frank memoir, she recounts the journey to outrun her demons, revealing how a woman used to physically controlling her body learned to come to terms with her unstable mind. It is the story of a how a supreme competitor scored her most important victory of all—reclaiming her life from the ravages of an untreated mental illness. Today, thanks to diagnosis, therapy, Kelly has stepped into the shadows, but Suzy is building a better life, one day at a time. Sharing her story, Suzy is determined to raise awareness, provide understanding, and offer inspiration to others coping with their own challenges.

    A self-assured adman and former all-American lacrosse player (now part-time coach), he shines brightly, and his daughter appears content to live in his reflected glory.Kelly considers herself lucky for this great touchstone in her life, and her dad's can-do spirit becomes her greatest asset when she's diagnosed with breast cancer as a young mother. It is her dad's pluck and resolve that will see her through the oncoming battles -- including the realization that her "cure" will mean the end of her ability to bear children and her dream of having a large family of her own.Though Kelly writes of her husband and daughters, her mother and her brothers, it is her father's love that sustains her. And so, readers fear for her when she reveals that George has been diagnosed with cancer, too. It is at this nadir, facing not only her own mortality but her father's as well, that Kelly finally begins to emerge as a survivor -- a wife, a mother, and more herself. Yet, she will always be her father's daughter.(Spring 2008 Selection)

    Having covered the war in Iraq and moved to Mexico City with two babies in nappies, he and his wife Diana thought they understood something about the subject.But when they arrived in Sydney so that Cave could establish The New York Times's Australia Bureau, life near the ocean confronted them with new ideas and questions, at odds with their American mindset that risk was a matter of individual choices. Surf-lifesaving and Nippers showed that perhaps it could be managed together, by communities. And instead of being either eliminated or romanticised, it might instead be respected and even embraced.And so Cave set out to understand how our current attitude to risk developed - and why it's not necessarily good for us.Into the Rip is partly the story of this New York family learning to live better by living with the sea and it is partly the story of how humans manage the idea of risk. Interviewing experts and everyday heroes, Cave asks critical questions like: Is safety overrated? Why do we miscalculate risk so often and how can we improve? Is it selfish to take risks or can more exposure make for stronger families, citizens and nations? And how do we factor in legitimate fears and major disasters like Cave has covered in his time here: the Black Summer fires; the Christchurch massacre; and, of course, Covid?The result is Grit meets Phosphorescence and Any Ordinary Day - a book that will change the way you and your family think about facing the world's hazards.

      In this transporting book, David Oliver Relin shines a light on the work of Geoffrey Tabin and Sanduk Ruit, gifted ophthalmologists who have dedicated their lives to restoring sight to some of the world’s most isolated, impoverished people through the Himalayan Cataract Project, an organization they founded in 1995. Tabin was the high-achieving bad boy of Harvard Medical School, an accomplished mountain climber and adrenaline junkie as brilliant as he was unconventional. Ruit grew up in a remote Nepalese village, where he became intimately acquainted with the human costs of inadequate access to health care. Together they found their life’s calling: tending to the afflicted people of the Himalayas, a vast mountainous region with an alarmingly high incidence of cataract blindness.  Second Suns takes us from improvised plywood operating tables in villages without electricity or plumbing to state-of-the-art surgical centers at major American universities where these two driven men are restoring sight—and hope—to patients from around the world. With their revolutionary, inexpensive style of surgery, Tabin and Ruit have been able to cure tens of thousands—all for about twenty dollars per operation. David Oliver Relin brings the doctors’ work to vivid life through poignant portraits of patients helped by the surgery, from old men who cannot walk treacherous mountain trails unaided to cataract-stricken children who have not seen their mothers’ faces for years. With the dexterity of a master storyteller, Relin shows the profound emotional and practical impact that these operations have had on patients’ lives.  Second Suns is the moving, unforgettable story of how two men with a shared dream are changing the world, one pair of eyes at a time.Praise for Second Suns   “As miracles go, it’s hard to beat making the blind see. Yet that’s exactly what the eye surgeon Dr. Geoffrey Tabin can do. He services poor people in the developing world who have developed cataracts—a clouding of the lens of the eye that is the world’s leading cause of blindness. . . . Second Suns is a hopeful work, a profile of two doctors who have dedicated their lives to bringing light to those in darkness.”—Time   “A compelling and inspiring book . . . Second Suns portrays heroic health care delivered under harrowing conditions: Ruit and his teams carry their equipment on multi-day treks up steep mountain trails, sometimes hiking at night with flashlights or head lamps, to reach settlements where they typically spend several days operating on hundreds of villagers in makeshift surgical theaters.”—The Washington Post   “Second Suns should be required reading for anybody with an interest in humanitarian philanthropy—or, for that matter, a desire to feel a little better about the world.”—Outside   “A detailed, heartfelt account of the work of [two] dedicated pioneers.”—Kirkus Reviews

    In this compelling memoir, his first wife, Jane Hawking, relates the inside story of their extraordinary marriage. As Stephen's academic renown soared, his body was collapsing under the assaults of a motor neuron disease. Jane's candid account of trying to balance his 24-hour care with the needs of their growing family reveals the inner strength of the author, while the self-evident character and achievements of her husband make for an incredible tale presented with unflinching honesty. Jane's candor is no less apparent when the marriage finally ends in a high-profile meltdown, with Stephen leaving Jane for one of his nurses and Jane marrying an old family friend. In this exceptionally open, moving, and often funny memoir, Jane Hawking confronts not only the acutely complicated and painful dilemmas of her first marriage, but also the relationship's fault lines exposed by the pervasive effects of fame and wealth. The result is a book about optimism, love, and change that will resonate with readers everywhere.

    EMERGENCY 24/7: Nurses of the Emergency Room, portrays thirty-one nurses, each with a distinctive voice and unique view of what really goes on behind the closed doors of the secret and chaotic world of the emergency room. Also included are the moment-by-moment chronicles of eleven nurses who worked in New York City and Washington, D.C., on September 11, 2001. These compelling accounts give new perspectives on the horrors and heroics of that tragic day. Ranging from inspiring to heart-rending to outrageously funny, these gripping narratives make EMERGENCY 24/7 a fascinating and provocative book—a fitting tribute to the frontline nurses.

    Vincent DiMaio and veteran crime writer Ron Franscell guide us behind the morgue doors to tell a fascinating life story through the cases that have made Di Maio famous-from the exhumation of assassin Lee Harvey Oswald to the complex issues in the shooting of Florida teenager Trayvon Martin.Beginning with his street-smart Italian origins in Brooklyn, the book spans 40 years of work and more than 9,000 autopsies, and Di Maio's eventual rise into the pantheon of forensic scientists. One of the country's most methodical and intuitive criminal pathologists will dissect himself, maintaining a nearly continuous flow of suspenseful stories, revealing anecdotes, and enough macabre insider details to rivet the most fervent crime fans.

    Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system.In Pain in America is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.

    history. The Tennessee town of Oak Ridge was created from scratch in 1942. One of the Manhattan Project’s secret cities, it didn’t appear on any maps until 1949, and yet at the height of World War II it was using more electricity than New York City and was home to more than 75,000 people, many of them young women recruited from small towns across the South. Their jobs were shrouded in mystery, but they were buoyed by a sense of shared purpose, close friendships—and a surplus of handsome scientists and Army men!But against this vibrant wartime backdrop, a darker story was unfolding. The penalty for talking about their work—even the most innocuous details—was job loss and eviction. One woman was recruited to spy on her coworkers. They all knew something big was happening at Oak Ridge, but few could piece together the true nature of their work until the bomb "Little Boy" was dropped over Hiroshima, Japan, and the secret was out. The shocking revelation: the residents of Oak Ridge were enriching uranium for the atomic bomb.Though the young women originally believed they would leave Oak Ridge after the war, many met husbands there, made lifelong friends, and still call the seventy-year-old town home. The reverberations from their work there—work they didn’t fully understand at the time—are still being felt today. In The Girls of Atomic City, Denise Kiernan traces the astonishing story of these unsung WWII workers through interviews with dozens of surviving women and other Oak Ridge residents. Like The Immortal Life of Henrietta Lacks, this is history and science made fresh and vibrant—a beautifully told, deeply researched story that unfolds in a suspenseful and exciting way.

    He was given four years to live. In 2010, in a state of lung-function collapse, Simon knew with crystal clarity that now was not his time to die. Against all prevailing medical opinion, he chose to ventilate in order to stay alive.Here, the young filmmaker, a husband and father of five small children draws us deeply into his inner world. Told in simply expressed and beautifully stark prose - in the vein of such memoirs as Jean-Dominique Bauby's The Diving Bell and the Butterfly - the result is an astonishing journey into a life which, though brutally compromised, is lived more fully and in the moment than most, revealing at its core the power of love its most potent.Written using an eye-gaze computer, It's Not Yet Dark is an unforgettable book about relationships and family, about what connects and separates us as people and, ultimately, about what it means to be alive.

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.