But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    His destination was the uncharted end of the earth: the icy continent of Antarctica. But the commandant's plans for a three-year expedition to reach the magnetic South Pole would be thwarted at each turn. Before the ship cleared South America, it had already broken down, run aground, and lost several key crew members, leaving behind a group with dubious experience for such an ambitious voyage.As the ship progressed into the freezing waters, the captain had to make a choice: turn back and spare his men the potentially devastating consequences of getting stuck, or recklessly sail deeper into the ice pack to chase glory and fame. He sailed on, and the Belgica soon found itself stuck fast in the icy hold of the Antarctic continent. The ship would winter on the ice. Plagued by a mysterious, debilitating illness and besieged by the monotony of their days, the crew deteriorated as their confinement in suffocating close quarters wore on and their hope of escape dwindled daily. As winter approached the days grew shorter, until the sun set on the magnificent polar landscape one last time, condemning the ship's occupants to months of quarantine in an endless night.Forged in fire and carved by ice, Antarctica proved a formidable opponent for the motley crew. Among them was Frederick Cook, an American doctor--part scientist, part adventurer, part P.T. Barnum--whose unorthodox methods delivered many of the crew from the gruesome symptoms of scurvy and whose relentless optimism buoyed their spirits through the long, dark polar night. Then there was Roald Amundsen, a young Norwegian who went on to become a storied polar explorer in his own right, exceeding de Gerlache's wildest dreams by leading the first expeditions to traverse the Northwest Passage and reach the South Pole.Drawing on firsthand accounts of the Belgica's voyage and exclusive access to the ship's logbook, Sancton tells the tale of its long, isolated imprisonment on the ice--a story that NASA studies today in its research on isolation for missions to Mars. In vivid, hair-raising prose, Sancton recounts the myriad forces that drove these men right up to and over the brink of madness.

    He dropped out of school and joined a group of Dené, Secwépemc, Gitxsan, Dakelh, Apache, Tohono O’odham, Seri, Purépecha, and Maya runners, all fleeing difficult beginnings. Telling their stories alongside his own, Álvarez writes about a four-month-long journey from Canada to Guatemala that pushed him to his limits. He writes not only of overcoming hunger, thirst, and fear―dangers included stone-throwing motorists and a mountain lion―but also of asserting Indigenous and working-class humanity in a capitalist society where oil extraction, deforestation, and substance abuse wreck communities.Running through mountains, deserts, and cities, and through the Mexican territory his parents left behind, Álvarez forges a new relationship with the land, and with the act of running, carrying with him the knowledge of his parents’ migration, and―against all odds in a society that exploits his body and rejects his spirit―the dream of a liberated future.

    But while laid up after surgery, she read an article about the staggering amount of plastic polluting the oceans and decided then and there to kick her plastic habit. Now she wants to teach you how you can too. In her quirky and humorous style well known to the readers of her popular blog, My Plastic-Free Life, Terry provides personal anecdotes, stats about the environmental and health problems related to plastic, and personal solutions and tips on how to limit your plastic footprint. Terry includes handy lists and charts for easy reference, ways to get involved in larger community actions, and profiles of individuals--Plastic-Free Heroes who have gone beyond personal solutions to create a change on a larger scale. Plastic-Free also includes chapters on letting go of eco-guilt, strategies for coping with overwhelming problems, and ways to relate to other people who aren't as far along on the plastic-free path. Both a practical guide and the story of a personal journey from helplessness to empowerment, Plastic-Free is a must-read for anyone concerned about the ongoing health and happiness of themselves, their children, and the planet.

    Few people, however, know that research into tree rings has also made amazing contributions to our understanding of Earth's climate history and its influences on human civilization over the past 2,000 years. In her captivating new book, Tree Story, Valerie Trouet reveals how the seemingly simple and relatively familiar concept of counting tree rings has inspired far-reaching scientific breakthroughs that illuminate the complex interactions between nature and people.Trouet, a leading tree-ring scientist, takes us out into the field, from remote African villages to radioactive Russian forests, offering readers an insider's look at tree-ring research, a discipline formally known as dendrochronology. Tracing her own professional journey while exploring dendrochronology's history and applications, Trouet describes the basics of how tell-tale tree cores are collected and dated with ring-by-ring precision, explaining the unexpected and momentous insights we've gained from the resulting samples.Blending popular science, travelogue, and cultural history, Tree Story highlights exciting findings of tree-ring research, including the fate of lost pirate treasure, successful strategies for surviving California wildfire, the secret to Genghis Khan's victories, the connection between Egyptian pharaohs and volcanoes, and even the role of olives in the fall of Rome. These fascinating tales are deftly woven together to show us how dendrochronology sheds light on global climate dynamics and uncovers the clear links between humans and our leafy neighbors. Trouet delights us with her dedication to the tangible appeal of studying trees, a discipline that has taken her to austere and beautiful landscapes around the globe and has enabled scientists to solve long-pondered mysteries of Earth and its human inhabitants.

    And yet she is often confounded by the cases she describes in her column: unexpected collections of symptoms that she and other physicians struggle to diagnose.A twenty-eight-year-old man, vacationing in the Bahamas for his birthday, tries some barracuda for dinner. Hours later, he collapses on the dance floor with crippling stomach pains. A middle-aged woman returns to her doctor, after visiting two days earlier with a mild rash on the back of her hands. Now the rash has turned purple and has spread across her entire body in whiplike streaks. A young elephant trainer in a traveling circus, once head-butted by a rogue zebra, is suddenly beset with splitting headaches, as if someone were "slamming a door inside his head."In each of these cases, the path to diagnosis--and treatment--is winding, sometimes frustratingly unclear. Dr. Sanders shows how making the right diagnosis requires expertise, painstaking procedure, and sometimes a little luck. Intricate, gripping, and full of twists and turns, Diagnosis puts readers in the doctor's place. It lets them see what doctors see, feel the uncertainty they feel--and experience the thrill when the puzzle is finally solved.

    . .Their bestselling memoir, Come Back, moved and inspired readers with the story of Mia Fontaine's harrowing drug addiction and her mother, Claire's, desperate and ultimately successful attempts to save her. Now it's a decade later and Claire and Mia each face a defining moment in her life, and a mother-daughter relationship that has frayed around the edges. At fifty-one, Claire's shed her identity as Mia's savior but realizes that, oops, she forgot to plan for life after motherhood; Mia, twenty-five and eager to step outside her role as recovery's poster child, finds adult life isn't all it's cracked up to be. Determined to transform themselves and their relationship once again, the pair sets off on a five-month around-the-world adventure.What awaits them is an extraordinary, often hilarious journey through twenty cities and twelve countries—one that includes mishaps, mayhem, and unexpected joys, from a passport-eating elephant to a calamitous camel ride around the Pyramids—and finally making peace with their tumultuous past in the lavender fields of France, where they live for the last four months of the trip. Seeing how self-possessed and community-minded twentysomethings are in other countries broadens Mia's perspective, helping her grow, and grow up. Claire uses the trip to examine her broken relationship with her own mother, a Holocaust survivor, and to create a vision for her second act. Watching her mom assess half a century of life, Mia comes to know her as Claire has always known Mia—as all mothers know their daughters—better than anyone else, and often better than themselves.Wiser for what they've learned from women in other cultures, and from each other, they return with a deepened sense of who they are and where they want to go—and with each embracing the mature friendship they've discovered and the profound love they share.Alternating between Claire and Mia's compelling and distinct voices, Have Mother, Will Travel is a testament to the power and beauty of the mother-daughter relationship, one that illuminates possibilities for our own lives.

    Before Ofir arrived in Cameroon, no one had ever even tried.The Last Great Ape follows a young Ofir on fantastical adventures as he crosses remote African lands by camel, on a horse, and in dug-out canoes, while living with exotic tribes and struggling against nature at its rawest: charging elephants and hyenas, flash floods, and the need to eat river algae and snails to stay alive.  The story moves from places of extreme beauty to those of the darkest horror: the war zones of Sierra Leone and Liberia. Ofir begins to work as a photojournalist in order to expose his shocking encounter with war victims and child soldiers. His experiences forge in him a resolution to become an activist and to fight for justice.The search for a cause eventually leads him to Cameroon. When Ofir discovers that no one is fighting to disprove Jane Goodall's dark prophesy that apes in the wild will be extinct in twenty years, he decides that he is the man to step in; because he knows he can make a difference, he sees it as his responsibility. And LAGA is born.The Last Great Ape is a story of the fight against extinction and the tragedy of endangered worlds, not just of animals but of people struggling to hold onto their culture. This book reveals the intense beauty and strife that exist side by side in Africa, and Ofir makes the case that activism and dedication to a cause are still relevant in a cynical modern world. This dangerous and dramatic story is one of courage and hope and, most importantly, a search for meaning.

    It’s a staple of small talk, the app on our smartphones, and often the first thing we check each morning. Yet behind these quotidian interactions is one of the most expansive machines human beings have ever constructed—a triumph of science, technology and global cooperation. But what is this ‘weather machine’ and who created it? In The Weather Machine, Andrew Blum takes readers on a fascinating journey through an everyday miracle. In a quest to understand how the forecast works, he visits old weather stations and watches new satellites blast off. He follows the dogged efforts of scientists to create a supercomputer model of the atmosphere and traces the surprising history of the algorithms that power their work. He discovers that we have quietly entered a golden age of meteorology—our tools allow us to predict weather more accurately than ever, and yet we haven’t learned to trust them, nor can we guarantee the fragile international alliances that allow our modern weather machine to exist.Written with the sharp wit and infectious curiosity Andrew Blum is known for, The Weather Machine pulls back the curtain on a universal part of our everyday lives, illuminating our relationships with technology, the planet, and the global community.

    On March 27, 1964, at 5:36 p.m., the biggest earthquake ever recorded in North America—and the second biggest ever in the world, measuring 9.2 on the Richter scale—struck Alaska, devastating coastal towns and villages and killing more than 130 people in what was then a relatively sparsely populated region. In a riveting tale about the almost unimaginable brute force of nature, New York Times science journalist Henry Fountain, in his first trade book, re-creates the lives of the villagers and townspeople living in Chenega, Anchorage, and Valdez; describes the sheer beauty of the geology of the region, with its towering peaks and 20-mile-long glaciers; and reveals the impact of the quake on the towns, the buildings, and the lives of the inhabitants. George Plafker, a geologist for the U.S. Geological Survey with years of experience scouring the Alaskan wilderness, is asked to investigate the Prince William Sound region in the aftermath of the quake, to better understand its origins. His work confirmed the then controversial theory of plate tectonics that explained how and why such deadly quakes occur, and how we can plan for the next one.

    The answers are best found not in jurisprudence but in science: the curious science of human-wildlife conflict, a discipline at the crossroads of human behavior and wildlife biology.Roach tags along with animal-attack forensics investigators, human-elephant conflict specialists, bear managers, and "danger tree" faller blasters. Intrepid as ever, she travels from leopard-terrorized hamlets in the Indian Himalaya to St. Peter’s Square in the early hours before the pope arrives for Easter Mass, when vandal gulls swoop in to destroy the elaborate floral display. She taste-tests rat bait, learns how to install a vulture effigy, and gets mugged by a macaque.Combining little-known forensic science and conservation genetics with a motley cast of laser scarecrows, langur impersonators, and trespassing squirrels, Roach reveals as much about humanity as about nature’s lawbreakers. When it comes to "problem" wildlife, she finds, humans are more often the problem—and the solution. Fascinating, witty, and humane, Fuzz offers hope for compassionate coexistence in our ever-expanding human habitat.

    In this riveting examination of one of the last wild places on earth, Adam Weymouth canoes along the river's length, from Canada's Yukon Territory, through Alaska, to the Bering Sea. The result is a book that shows how even the most remote wilderness is affected by the same forces reshaping the rest of the planet.Every summer, hundreds of thousands of king salmon migrate the distance of the Yukon to their spawning grounds, where they breed and die, in what is the longest salmon run in the world. For the communities that live along the river, salmon was once the lifeblood of the economy and local culture. But climate change and a globalized economy have fundamentally altered the balance between man and nature; the health and numbers of king salmon are in question, as is the fate of the communities that depend on them.Traveling along the Yukon as the salmon migrate, a four-month journey through untrammeled landscape, Adam Weymouth traces the fundamental interconnectedness of people and fish through searing and unforgettable portraits of the individuals he encounters. He offers a powerful, nuanced glimpse into indigenous cultures, and into our ever-complicated relationship with the natural world. Weaving in the rich history of salmon across time as well as the science behind their mysterious life cycle, Kings of the Yukon is extraordinary adventure and nature writing at its most urgent and poetic.