This class-tested and successful textbook synthesizes the established facts of immunology into a comprehensible, coherent, and up-to-date account of how the immune system works, rather than presenting immunology as a chronology of experiments and discoveries. Emphasizing the human immune system the text has been designed to break down the barriers which often divide basic and clinical immunology. The reader-friendly text, section and chapter summaries, and full-color illustrations make the book accessible and easily understandable to students. The Immune System is adapted from Immunobiology by Janeway, Travers & Walport.

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    Part One presents the general principles of pathophysiology and discusses the influence of the environment and the role of genetics in the development of disease. Part Two, organized by body system, examines normal anatomy and physiology, alterations of function in adults, and alterations of function in children.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Never shy about offering his opinion or afraid to step in and separate an on-ice fight, Fraser is arguably the most respected referee in the history of the game. Over the course of the 2,165 NHL contests he oversaw, Fraser has shown himself to be an unbiased, courageous, and sometimes controversial judge.In The Final Call, Fraser provides a highly entertaining, honest, and sometimes hard-hitting look at the game and its many faces and changes over his record-breaking career. Go to ice level and experience first-hand the interactions of your favourite players and coaches from the man you love to hate!

    There's a whole new chapter devoted to fashion describing what it's like for Mary-Kate and Ashley to design and own their own fashion line. They have also added insights on being executive producers and what it's like to have fashion dolls made in their image, as well as personal information about what kind of clothes they like to wear, what kind of guys they like, where they'd like to go to college, and what their plans are after college.

    Interspersed with these stories from Jennifer's post-midwife career are the histories of her patients, from the family divided by a decision nobody could bear to make, to the mother who comes to her son's adopted country and joins his family without being able to speak a word of English.

    But if he must die, I want it to be for something big. I want someone’s life to be changed forever.”This is what Laura Sobiech prayed when she found out her seventeen-year-old son had only one year to live. With this desperate prayer, she released her son to God’s will.At that point, Zach Sobiech was just another teenager battling cancer. When his mother told him to think about writing good-bye letters to family and friends, he decided instead to write songs. One of them, “Clouds,” captured hearts and changed not one life but millions, making him an international sensation.But Zach’s story is not just about music. It’s a testament to what can happen when you live as if each day might be your last. It’s a story about the human spirit. It’s about how God used a dying boy from a small town in Minnesota to touch the hearts of millions—including top executives in the music industry, major music artists, news anchors, talk show hosts, actors, priests and pastors, and school children across the globe.Zach once said, “I want to be known as the kid who went down fighting, and didn’t really lose.” Fly a Little Higher is about how God used Zach to do something big.

    Against all odds, Northup eventually manages to get word to his family – and the ensuing rescue from the drunken and sadistic Mr Epps and subsequent legal cases are no less shocking than the rest of the tale.Northup’s meticulous first-hand recordings of slave life, written in conjunction with a white lawyer called David Wilson, provide a true-life testament to tremendous courage and resolve in the face of unspeakable injustice.Now a major Hollywood film, nominated for Best Picture at the 2014 Academy Awards, and directed by Steve McQueen – starring Chiwetel Ejiofor, Brad Pitt, Michael Fassbender and Benedict Cumberbatch.

    Chris Jericho has known what he wanted out of life since he was a teenager: to be a pro wrestler and to be in a rock 'n' roll band. Most of his high school friends felt that he lacked the tools necessary to get into either, but Chris believed in himself. With the wise words of Master Yoda echoing through his head ("Do or do not. There is no try."), he made it happen. As a result, Chris has spent a lifetime doing instead of merely trying, managing to achieve his dreams while learning dozens of invaluable lessons along the way.No Is a Four-Letter Word distills more than two decades of showbiz wisdom and advice into twenty easy-to-carry chapters, including:Developing a strong work ethic thanks to WWE chairman Vince McMahon,Remembering to always look like a star from Gene Simmons of KISS,Learning to let it go when the America's Funniest Home Videos hosting gig goes to his rival,Adopting a sense of perpetual reinvention from the late David Bowie,Making sure to sell himself like his NHL-legend father Ted Irvine taught him, andGoing the extra mile to meet Keith Richards (with an assist from Jimmy Fallon). Now, in the hopes that those same principles might help and inspire his legions of fans, Chris has decided to share them while recounting the fantastic and hilarious stories that led to the birth of these rules. The result is a fun, entertaining, practical, and inspiring book from the man with many scarves but only one drive: to be the best. After reading No Is a Four-Letter Word, you'll discover that you might have what it takes to succeed as well...you just need to get out there and do it. That's what Jericho would do.

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Fox: Actor. Husband. Father. Activist. But readers of Always Looking Up will soon add another to the list: Optimist. Michael writes about the hard-won perspective that helped him see challenges as opportunities. Instead of building walls around himself, he developed a personal policy of engagement and discovery: an emotional, psychological, intellectual, and spiritual outlook that has served him throughout his struggle with Parkinson's disease. Michael's exit from a very demanding, very public arena offered him the time-and the inspiration-to open up new doors leading to unexpected places. One door even led him to the center of his own family, the greatest destination of all. The last ten years, which is really the stuff of this book, began with such a loss: my retirement from Spin City. I found myself struggling with a strange new dynamic: the shifting of public and private personas. I had been Mike the actor, then Mike the actor with PD. Now was I just Mike with PD Parkinson's had consumed my career and, in a sense, had become my career. But where did all of this leave Me? I had to build a new life when I was already pretty happy with the old one. .Always Looking Up is a memoir of this last decade, told through the critical themes of Michael's life: work, politics, faith, and family. The book is a journey of self-discovery and reinvention, and a testament to the consolations that protect him from the ravages of Parkinson's.With the humor and wit that captivated fans of his first book, Lucky Man, Michael describes how he became a happier, more satisfied person by recognizing the gifts of everyday life.

    The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Learn What You Should Really Be Thankful For! **** Read On Your PC, Mac, Smartphone, Tablet Or Kindle! **** FREE For Kindle Prime Or Kindle Unlimited Members About The Book Griffy is known as the luckiest puppy in the world! But why do people think he is lucky? What does it really mean to be lucky? This book discovers what is really important and what your kids should really be thankful for! Griffy is the luckiest puppy in the world because he has good friends, a good family, and a good spirit! Grab Your Copy Now! ------ Tags: Kids Books, Children's Books, Bedtime Stories For Kids, Bedtime Storybook Collection, Bedtime Storybook, Kids Stories, Bedtime Stories For Children, Bedtime Reading, Free Childrens Books