But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    Almost a decade earlier, Dr. Sacks had published his masterpiece Awakenings but the book had hardly been an immediate success, and the rumpled clinician was still largely unknown. Over the ensuing four years, the two men worked closely together until Sacks asked Weschler to abandon the profile, a request to which Weschler acceded. The two remained close friends, however, across the next thirty years and then, just as Sacks was dying, he urged Weschler to take up the project once again. This book is the result of that entreaty.Weschler sets Sacks's brilliant table talk and extravagant personality in vivid relief. We see Sacks rowing and ranting and caring deeply; composing the essays that would form The Man Who Mistook His Wife for a Hat ; recalling his turbulent drug-fueled younger days; helping his patients and exhausting his friends; and waging intellectual war against a medical and scientific establishment that failed to address his greatest concern: the spontaneous specificity of the individual human soul. And all the while he is pouring out a stream of glorious, ribald, hilarious, and often profound conversation that establishes him as one of the great talkers of the age.

    Tedford have spent the past 20 years studying the evolutionary history of the family Canidae. Both are well known for having established the modern framework for the evolutionary relationship of canids. Combining their research with Mauricio Ant�n's impeccable reconstructions of both extinct and extant species, Wang and Tedford present a remarkably detailed and nuanced portrait of the origin and evolution of canids over the past 40 million years.The authors cull their history from the most recent scientific research conducted on the vast collections of the American Museum of Natural History and other leading institutions. The fossil record of the Canidae, particularly those from their birth place in North America, are the strongest of their kind among known groups of carnivorans. Such a wonderfully detailed evolutionary history provides access to a natural history that is not possible with many other groups of carnivorans.With their rich fossil record, diverse adaptations to various environments, and different predatory specializations, canids are an ideal model organism for the mapping of predator behavior and morphological specializations. They also offer an excellent contrast to felids, which remain entrenched in extreme predatory specializations. The innovative illustrated approach in this book is the perfect accompaniment to an extremely important branch of animal and fossil study. It transforms the science of paleontology into a thrilling visual experience and provides an unprecedented reference for anyone fascinated by dogs.

    Indeed, many view religion in general, and Christianity in particular, as unfounded and unreasonable.Norman Geisler and Frank Turek argue, however, that Christianity is not only more reasonable than all other belief systems, but is indeed more rational than unbelief itself. With conviction and clear thinking, Geisler and Turek guide readers through some of the traditional, tested arguments for the existence of a creator God. They move into an examination of the source of morality and the reliability of the New Testament accounts concerning Jesus. The final section of the book deals with a detailed investigation of the claims of Christ. This volume will be an interesting read for those skeptical about Christianity, as well as a helpful resource for Christians seeking to articulate a more sophisticated defense of their faith.

    Drawing partly on his own career—from young scientist in awe of his elders to crotchety elder statesman—Tattersall offers an idiosyncratic look at the competitive world of paleoanthropology, beginning with Charles Darwin 150 years ago, and continuing through the Leakey dynasty in Africa, and concluding with the latest astonishing findings in the Caucasus.The book's title refers to the 1856 discovery of a clearly very old skull cap in Germany's Neander Valley. The possessor had a brain as large as a modern human, but a heavy low braincase with a prominent brow ridge. Scientists tried hard to explain away the inconvenient possibility that this was not actually our direct relative. One extreme interpretation suggested that the preserved leg bones were curved by both rickets, and by a life on horseback. The pain of the unfortunate individual's affliction had caused him to chronically furrow his brow in agony, leading to the excessive development of bone above the eye sockets.The subsequent history of human evolutionary studies is full of similarly fanciful interpretations. With tact and humor, Tattersall concludes that we are not the perfected products of natural processes, but instead the result of substantial doses of random happenstance.

    Grab your copy of Secret Hollywood and start gossiping!

    The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.In Pandemics: What Everyone Needs to Know�, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know� series.What Everyone Needs to Know� is a registered trademark of Oxford University Press.

    

    Its full-colour illustration program includes many novel, visually effective features to help students learn.

    Richard Dawkins, for example, jolted us into realizing that we are just survival mechanisms for our own genes, sophisticated robots in service of huge colonies of replicators to whom concepts of rationality, intelligence, agency, and even the human soul are irrelevant.Accepting and now forcefully responding to this decentering and disturbing idea, Keith Stanovich here provides the tools for the "robot's rebellion," a program of cognitive reform necessary to advance human interests over the limited interest of the replicators and define our own autonomous goals as individual human beings. He shows how concepts of rational thinking from cognitive science interact with the logic of evolution to create opportunities for humans to structure their behavior to serve their own ends. These evaluative activities of the brain, he argues, fulfill the need that we have to ascribe significance to human life. We may well be robots, but we are the only robots who have discovered that fact. Only by recognizing ourselves as such, argues Stanovich, can we begin to construct a concept of self based on what is truly singular about humans: that they gain control of their lives in a way unique among life forms on Earth—through rational self-determination.

    The prolonged encounter between the Cro-Magnons and the archaic Neanderthals and between 45,000 and 30,000 years ago was one of the defining moments of history. The Neanderthals survived for some 15,000 years in the face of the newcomers, but were finally pushed aside by the Cro-Magnons' vastly superior intellectual abilities and cutting-edge technologies, which allowed them to thrive in the intensely challenging climate of the Ice Age.What do we know about this remarkable takeover? Who were the first modern Europeans and what were they like? How did they manage to thrive in such an extreme environment? And what legacy did they leave behind them after the cold millennia? The age of the Cro-Magnons lasted some 30,000 years?longer than all of recorded history. Cro-Magnon is the story of a little known, yet seminal, chapter of human experience.

    Under the spell of its low heat, lean meats, whole grains, legumes, vegetables, and fruits transform into succulent meals. From appetizers to desserts and everything in between, the 200 recipes in American Heart Association Healthy Slow Cooker Cookbook will surprise you with their variety and depth of flavor. Braised Curry-Rubbed Chicken slow cooks among Middle Eastern spices, including ginger, cumin, cinnamon, and curry, in a pool of citrus juice and honey. Cioppino with White Wine features a saucy tomato base that simmers until scallops, mussels, and bite-size pieces of mild fish are added to finish this hearty fish stew. Vegetables, beans, and beef stew together to make for a mouthwatering rustic Country Cassoulet, and chopped zucchini, tomato, and basil along with bulgur and provolone cheese are packed into Italian Artichoke-Stuffed Bell Peppers that cook until tender. With some easy planning before or after the slow cooking, such as browning meats or boiling water for pasta, you’ll have tasty meals chock full of good nutrition on your kitchen table night after night.This cookbook also includes nineteen full-color photographs as well as information on the benefits of slow cooking and how a slow cooker can help you eat well. The best way to ensure good food comes out of your cooker is to put only good-for-you ingredients into it, and with American Heart Association Healthy Slow Cooker Cookbook, you’ll learn how much your slow cooker can do for you while you’re enjoying a healthy lifestyle.

    They develop an interpretation of quantum mechanics which gives a clear, intuitive understanding of its meaning and in which there is a coherent notion of the reality of the universe without assuming a fundamental role for the human observer. With the aid of new concepts such as active information together with non-locality, they provide a comprehensive account of all the basic features of quantum mechanics, including the relativistic domain and quantum field theory. It is shown that, with the new approach, paradoxical or unsatisfactory features associated with the standard approaches, such as the wave-particle duality and the collapse of the wave function, do not arise. Finally, the authors make new suggestions and indicate some areas in which one may expect quantum theory to break down in a way that will allow for a test. The Undivided Universe is an important book especially because it provides a different overall world view which is neither mechanistic nor reductionist. This view will ultimately have radical implications not only in physics but also in our general approach to all areas of life.

    On the cusp of decoding brain signals that govern motor skills, they are developing miraculous technologies to enable paraplegics and wounded soldiers to move prosthetic limbs, and the rest of us to manipulate computers and other objects through thought alone. These fiercely competitive scientists are vying for Defense Department and venture capital funding, prestige, and great wealth. Part life-altering cure, part science fiction, part military dream, these cutting-edge brain-computer interfaces promise to improve lives—but also hold the potential to augment soldiers' combat capabilities. In The Brain Electric, Malcolm Gay follows the dramatic emergence of these technologies, taking us behind the scenes into the operating rooms, start-ups, and research labs where the future is unfolding. With access to many of the field's top scientists, Gay illuminates this extraordinary race—where science, medicine, profit, and war converge—for the first time. But this isn't just a story about technology. At the heart of this research is a group of brave, vulnerable patient-volunteers whose lives are given new meaning through participating in these experiments. The Brain Electric asks us to rethink our relationship to technology, our bodies, even consciousness itself—challenging our assumptions about what it means to be human.

    But what sort of person was the young Albert Einstein, before he became universally acclaimed as the archetypal genius? And how did his genius unfold? In this brilliant new Kindle Single, scientist Robyn Arianrhod blends biography with popular science to tell the story of how young Albert developed a theory that – unknown to him at first – contained the seeds of his extraordinary equation E = mc2. Arianrhod, who wrote her PhD on Einstein’s general theory of relativity, makes the ideas behind the equation accessible to the lay reader, and sets young Einstein’s exploration of these ideas against the backdrop of his first loves, his family and marriage, and, above all, his childlike wonder at the nature of the universe. She introduces his heroes and scientific inspirations, and the friends who believed in him when no one else did. In personalising Einstein, she brings to life both the man and his science, in a short, easy-to-read narrative. In showing how he discovered his famous equation, and what it means, she draws a compelling portrait of this prodigious intellect whose unfathomable grasp of the building blocks of physics would change our world forever. About the Author: Dr Robyn Arianrhod is the author of two critically acclaimed works of popular science and scientific history: Einstein’s Heroes: Imagining the World Through the Language of Mathematics, and Seduced by Logic: Émilie du Châtelet, Mary Somerville and the Newtonian Revolution. Both were shortlisted for major book awards and are published in the USA. Einstein’s Heroes was translated into several languages. Robyn was awarded her PhD for research on Einstein’s general theory of relativity and has lectured in applied mathematics (including special relativity) for many years. She is currently an Adjunct Research Fellow in the School of Mathematical Sciences at Monash University in Melbourne, where she is undertaking research on the structure of relativistic space-times. She is also a technical reviewer for the American Mathematical Society. Praise for Robyn Arianrhod's books: Einstein’s Heroes ‘Arianrhod’s achievement is to so masterfully combine history, biography, and mathematics as to absorb and enlighten even the mathematically maladroit’ – Booklist ‘An intriguing blend of science, history, and biography . . . Arianrhod’s well-written, fascinating discussion of intertwined topics is highly recommended’ – Library Journal (starred review) ‘A thrilling story . . . Arianrhod brings out the human side of the scientists’ – Bloombergnews ‘Offers readers an engaging intellectual exercise combining physics, language, mathematics, and biography’ – Science News Seduced by Logic ‘Seduced by Logic offers the lay reader an easy and agreeable introduction to the evolution of some crucial scientific debates . . . One cannot help be captivated by her intellectual honesty and enthusiasm’ – Times Higher Education ‘An elegant and inspiring history of how scientific revolutions make their way’ – Edward Dolnick, The Clockwork Universe ‘Here is a skillfully written tapestry of the science, history and portrayal of two of the most charismatic women of mathematical science. Robyn Arianrhod has produced a captivating masterpiece’ – Joseph Mazur, author of Euclid in the Rainforest and What’s Luck Got to Do with It?