Jerry Avorn has some sobering news. Drawing on more than twenty-five years of patient care, teaching, and research at Harvard Medical School, he shares his firsthand experience of the wide gap in our knowledge of the effectiveness of one medication as compared to another. In Powerful Medicines, he reminds us that every pill we take represents a delicate compromise between the promise of healing, the risk of side effects, and an increasingly daunting price. The stakes on each front grow higher every year as new drugs with impressive power, worrisome side effects, and troubling costs are introduced.This is a comprehensive behind-the-scenes look at issues that affect everyone: our shortage of data comparing the worth of similar drugs for the same condition; alarming lapses in the detection of lethal side effects; the underuse of life-saving medications; lavish marketing campaigns that influence what doctors prescribe; and the resulting upward spiral of costs that places vital drugs beyond the reach of many Americans.In this engagingly written book, Dr. Avorn asks questions that will interest every consumer: How can a product judged safe by the Food and Drug Administration turn out to have unexpectedly lethal side effects? Why has the nation’s drug bill been growing at nearly 20 percent per year? How can physicians and patients pick the best medication in its class? How do doctors actually make their prescribing decisions, and why do those decisions sometimes go wrong? Why do so many Americans suffer preventable illnesses and deaths that proper drug use could have averted? How can the nation gain control over its escalating drug budget without resorting to rationing or draconian governmental controls?Using clinical case histories taken from his own work as a practitioner, researcher, and advocate, Dr. Avorn demonstrates the impressive power of the well-conceived prescription as well as the debacles that can result when medications are misused. He describes an innovative program that employs the pharmaceutical industry’s own marketing techniques to reduce use of some of the most overprescribed and overpriced products. Powerful Medicines offers timely and practical advice on how the nation can improve its drug-approval process, and how patients can work with doctors to make sure their prescriptions are safe, effective, and as affordable as possible. This is a passionate and provocative call for action as well as a compelling work of clear-headed science.From the Hardcover edition.

    But after a devastatingly difficult winter, with sky high bills, she didn't know if she could afford to carry on - or if she had the physical strength to keep going. Then, in the first week of January, the phone rang. A donkey had been abandoned 130 miles away. Rushing to his rescue Tracy found Alan - forlorn, balding and shivering - tethered up tightly in a supermarket car park. Barely able to walk on his painfully overgrown hooves, he had been left to die. Tracy ran her hands gently over Alan's protruding ribs, and whispered in his ear: 'Don't worry boy, I won't give up on you.' Over the next twelve months, as Tracy grappled with attacks from vandals and perilous flash floods and desperately tried to raise money, Alan gradually recovered - turning into a loveable rogue. As Christmas rolled around, Tracy was too worried about the future to enjoy the festive season. She had no idea that the shy skinny animal she'd rescued was going to give her the greatest gift of all . . . For animal lovers everywhere, Alan The Christmas Donkey is a funny, warm and inspiring read.

    But what if books like that seem a little too “out there” for you? Enter Deanna Davis, whose down-to-earth approach stems from her own change of heart (it happened at the Olive Garden). In this fun, quirky, and decidedly straightforward guide, Deanna shares the science, strategy, and stories of how to create your ideal life using a universal key to success called the Law of Attraction, whether you seek health, wealth, happiness, success, or anything else, large or small. The book blends cutting-edge research, practical techniques, and a conversational, light, funny tone to make the information both meaningful and memorable. Like a talk by your favorite college professor, it provides brilliant concepts in a downto- earth manner—an uncommon blend of wisdom, creativity, inspiration, and practical strategies that work.

    Curious about what had prompted a young urban artist to suddenly embrace nature she decided to follow him for a year to find out.Observing two artists through seasonal shifts and migrations, Birds Art Life celebrates the particular madness of chasing after birds in a big city, and explores what happens when the principles of birdwatching are applied to other aspects of art and life. It looks at the ecology of urban spaces and the creative and liberating effects of keeping your eyes and ears wide open. Far from seeking the exotic, Kyo discovers joy in the birds she spots in city parks and harbours, along eaves and on wires. In a world that values big and fast, Kyo begins to look to the small, steady, slow accumulations of knowledge, and the lulls that give way to contemplation.Moving between the granular and the grand, peering into the inner landscape as much as the outer one, Birds Art Life asks how we are shaped and nurtured by our passions, and how we might come to love and protect not only the world’s natural places but also the challenging urban spaces where so many of us live.

    From the minutiae of Future World to the farthest reaches of World Showcase this guide covers it all in intimate detail. No stone is left unturned, and no legacy tile left unmocked. With a little bit of wit and a whole lot of heart you'll be led through the splendorific sprawl of the most endearing monument to humanity that has ever been created. Highlights include: A history of each pavilion and the forces that shaped its existence - or the end thereof. Insight into the inner-workings of the park. What makes it tick and why things happen the way they do. A scene-by-scene analysis of Horizons, quite possibly the most beloved attraction in the company's history and all of the World Disney World resort.

    Full of the personality that David brings to every wedding he plans and every TV show or magazine article he appears in, Big White Book of Weddings is the book every bride needs to make her wedding unforgettable for all the right reasons!Includes sections such as:- Create engaging menus and creative cocktails in "Eat, Drink and Be Married!"- Be Perfectly Polished with "Etiquette for the Elegant"- Make your entertainment a hit without needing a rock-star budget in "Strike up the Band"- Go from "Ordinary to Extraordinary" with decor and floral tips from the pro