A killer with little respect for class or wealth, cholera ravaged the squalid streets of Soho and rocked the great centers of Victorian power. In this gripping book, Sandra Hempel tells the story of John Snow, a reclusive doctor without money or social position, who—alone and unrecognized—had the genius to look beyond the conventional wisdom of his day and uncover the truth behind the pandemic. She describes how Snow discovered that cholera was spread through drinking water and how this subsequently laid the foundations for the modern, scientific investigation of today's fatal plagues. A dramatic account with a colorful cast of characters, The Strange Case of the Broad Street Pump features diversions into fascinating facets of medical and social history, such as Snow's tending of Queen Victoria in childbirth, Dutch microbiologist Leeuwenhoek's deliberate breeding of lice in his socks, Dickensian children's farms, and riotous nineteenth-century anesthesia parties. An afterword discusses the new threat of infectious diseases—including malaria, yellow fever, and cholera—with today's global warming. Copub: Granta

    Simon Winchester has also fashioned an enthralling and informative informative look at the tumultuous subterranean world that produces earthquakes, the planet's most sudden and destructive force.In the early morning hours of April 18, 1906, San Francisco and a string of towns to its north-northwest and the south-southeast were overcome by an enormous shaking that was compounded by the violent shocks of an earthquake, registering 8.25 on the Richter scale. The quake resulted from a rupture in a part of the San Andreas fault, which lies underneath the earth's surface along the northern coast of California. Lasting little more than a minute, the earthquake wrecked 490 blocks, toppled a total of 25,000 buildings, broke open gas mains, cut off electric power lines throughout the Bay area, and effectively destroyed the gold rush capital that had stood there for a half century.Perhaps more significant than the tremors and rumbling, which affected a swatch of California more than 200 miles long, were the fires that took over the city for three days, leaving chaos and horror in its wake. The human tragedy included the deaths of upwards of 700 people, with more than 250,000 left homeless. It was perhaps the worst natural disaster in the history of the United States.Simon Winchester brings his inimitable storytelling abilities -- as well as his unique understanding of geology -- to this extraordinary event, exploring not only what happened in northern California in 1906 but what we have learned since about the geological underpinnings that caused the earthquake in the first place. But his achievement is even greater: he positions the quake's significance along the earth's geological timeline and shows the effect it had on the rest of twentieth-century California and American history.A Crack in the Edge of the World is the definitive account of the San Francisco earthquake. It is also a fascinating exploration of a legendary event that changed the way we look at the planet on which we live.

    By the summer of 1918, the second wave struck as a highly contagious and lethal epidemic and within weeks exploded into a pandemic, an illness that travels rapidly from one continent to another. It would impact the course of the war, and kill many millions more soldiers than warfare itself.Of all diseases, the 1918 flu was by far the worst that has ever afflicted humankind; not even the Black Death of the Middle Ages comes close in terms of the number of lives it took. No war, no natural disaster, no famine has claimed so many. In the space of eighteen months in 1918-1919, about 500 million people--one-third of the global population at the time--came down with influenza. The exact total of lives lost will never be known, but the best estimate is between 50 and 100 million. In this powerful book, filled with black and white photographs, nonfiction master Albert Marrin examines the history, science, and impact of this great scourge--and the possibility for another worldwide pandemic today.

    Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic; the visionary scientist Gregory Pincus, who was dismissed by Harvard in the 1930s as a result of his experimentation with in vitro fertilization but who, after he was approached by Sanger and McCormick, grew obsessed with the idea of inventing a drug that could stop ovulation; and the telegenic John Rock, a Catholic doctor from Boston who battled his own church to become an enormously effective advocate in the effort to win public approval for the drug that would be marketed by Searle as Enovid.Spanning the years from Sanger’s heady Greenwich Village days in the early twentieth century to trial tests in Puerto Rico in the 1950s to the cusp of the sexual revolution in the 1960s, this is a grand story of radical feminist politics, scientific ingenuity, establishment opposition, and, ultimately, a sea change in social attitudes. Brilliantly researched and briskly written, The Birth of the Pill is gripping social, cultural, and scientific history.

     Early studies of the functions of the human brain used a simple method: wait for misfortune to strike-strokes, seizures, infectious diseases, lobotomies, horrendous accidents-and see how the victim coped. In many cases survival was miraculous, and observers could only marvel at the transformations that took place afterward, altering victims' personalities. An injury to one section can leave a person unable to recognize loved ones; some brain trauma can even make you a pathological gambler, pedophile, or liar. But a few scientists realized that these injuries were an opportunity for studying brain function at its extremes. With lucid explanations and incisive wit, Sam Kean explains the brain's secret passageways while recounting forgotten stories of common people whose struggles, resiliency, and deep humanity made modern neuroscience possible.

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

    In the mountains above Johnstown, an old earth dam had been hastily rebuilt to create a lake for an exclusive summer resort patronized by the tycoons of that same industrial prosperity, among them Andrew Carnegie, Henry Clay Frick, and Andrew Mellon. Despite repeated warnings of possible danger, nothing was done about the dam. Then came May 31, 1889, when the dam burst, sending a wall of water thundering down the mountain, smashing through Johnstown, and killing more than 2,000 people. It was a tragedy that became a national scandal. Graced by David McCullough's remarkable gift for writing richly textured, sympathetic social history, The Johnstown Flood is an absorbing, classic portrait of life in nineteenth-century America, of overweening confidence, of energy, and of tragedy. It also offers a powerful historical lesson for our century and all times: the danger of assuming that because people are in positions of responsibility they are necessarily behaving responsibly.

    It was like roaring surf, one of them said later. Like a runaway two-horse team smashing through a fence, said another. A third firefighter jumped up from his chair to look out a window-"Oh my God!" he shouted to the other men, "Run!"A 50-foot-tall steel tank filled with 2.3 million gallons of molasses had just collapsed on Boston's waterfront, disgorging its contents as a 15-foot-high wave of molasses that at its outset traveled at 35 miles an hour. It demolished wooden homes, even the brick fire station. The number of dead wasn't known for days. It would be years before a landmark court battle determined who was responsible for the disaster.

    The American experiment rests on three ideas—“these truths,” Jefferson called them—political equality, natural rights, and the sovereignty of the people. But has the nation, and democracy itself, delivered on that promise?These Truths tells this uniquely American story, beginning in 1492, asking whether the course of events over more than five centuries has proven the nation’s truths, or belied them. To answer that question, Lepore wrestles with the state of American politics, the legacy of slavery, the persistence of inequality, and the nature of technological change. “A nation born in contradiction… will fight, forever, over the meaning of its history,” Lepore writes, but engaging in that struggle by studying the past is part of the work of citizenship. With These Truths, Lepore has produced a book that will shape our view of American history for decades to come.

    Starting with the earliest encounters between black Americans and Western medical researchers and the racist pseudoscience that resulted, it details the ways both slaves and freedmen were used in hospitals for experiments conducted without their knowledge—a tradition that continues today within some black populations. It reveals how blacks have historically been prey to grave-robbing as well as unauthorized autopsies and dissections. Moving into the twentieth century, it shows how the pseudoscience of eugenics and social Darwinism was used to justify experimental exploitation and shoddy medical treatment of blacks, and the view that they were biologically inferior, oversexed, and unfit for adult responsibilities. Shocking new details about the government’s notorious Tuskegee experiment are revealed, as are similar, less-well-known medical atrocities conducted by the government, the armed forces, prisons, and private institutions.The product of years of prodigious research into medical journals and experimental reports long undisturbed, Medical Apartheid reveals the hidden underbelly of scientific research and makes possible, for the first time, an understanding of the roots of the African American health deficit. At last, it provides the fullest possible context for comprehending the behavioral fallout that has caused black Americans to view researchers—and indeed the whole medical establishment—with such deep distrust. No one concerned with issues of public health and racial justice can afford not to read Medical Apartheid, a masterful book that will stir up both controversy and long-needed debate.

    Early in that fateful year, a second American revolution unfolded, inspiring a new generation to reject their parents’ faith in compromise and appeasement, to do the unthinkable in the name of an ideal. It set Abraham Lincoln on the path to greatness and millions of slaves on the road to freedom.The book introduces us to a heretofore little-known cast of Civil War heroes—among them an acrobatic militia colonel, an explorer’s wife, an idealistic band of German immigrants, a regiment of New York City firemen, a community of Virginia slaves, and a young college professor who would one day become president. Adam Goodheart takes us from the corridors of the White House to the slums of Manhattan, from the mouth of the Chesapeake to the deserts of Nevada, from Boston Common to Alcatraz Island, vividly evoking the Union at this moment of ultimate crisis and decision.

    In this sensational and macabre story, we meet the surgeon who counted not only luminaries Benjamin Franklin, Lord Byron, Adam Smith, and Thomas Gainsborough among his patients but also “resurrection men” among his close acquaintances. A captivating portrait of his ruthless devotion to uncovering the secrets of the human body, and the extraordinary lengths to which he went to do so—including body snatching, performing pioneering medical experiments, and infecting himself with venereal disease—this rich historical narrative at last acknowledges this fascinating man and the debt we owe him today.

    Beginning with a dramatic account of the SARS pandemic at the start of the 21st century, Dorothy Crawford takes us back in time to follow the interlinked history of microbes and humanity, offering an up-to-date look at ancient plagues and epidemics, and identifying key changes in the way humans have lived--such as our move from hunter-gatherer to farmer to city-dweller--which made us ever more vulnerable to microbe attack. Showing that how we live our lives today--with increased crowding and air travel--puts us once again at risk, Crawford asks whether we might ever conquer microbes completely. Among the possible answers, one thing becomes clear: that for generations to come, our deadly companions will continue to influence our lives. New in Paperback

    Modernizers had an audacious, expensive plan to turn the city from a brawling, unglamorous place into "the Metropolis of the World." But just as the dream seemed within reach, pandemonium broke loose and the city's highest ambitions were suddenly under attack by the same unbridled energies that had given birth to them in the first place.It began on a balmy Monday afternoon when a blimp in flames crashed through the roof of a busy downtown bank, incinerating those inside. Within days, a racial incident at a hot, crowded South Side beach spiraled into one of the worst urban riots in American history, followed by a transit strike that paralyzed the city. Then, when it seemed as if things could get no worse, police searching for a six-year-old girl discovered her body in a dark North Side basement.Meticulously researched and expertly paced, City of Scoundrels captures the tumultuous birth of the modern American city, with all of its light and dark aspects in vivid relief.

      We think of the FBI as America’s police force. But secret intelligence is the Bureau’s first and foremost mission. Enemies is the story of how presidents have used the FBI as the most formidable intelligence force in American history.   Here is the hidden history of America’s hundred-year war on terror. The FBI has fought against terrorists, spies, anyone it deemed subversive—and sometimes American presidents. The FBI’s secret intelligence and surveillance techniques have created a tug-of-war between protecting national security and infringing upon civil liberties. It is a tension that strains the very fabric of a free republic.