This cycle is at the root of all addictions, addictions to drugs, sex, love, cigarettes, soap operas, wealth, and wisdom itself. But why should this be so? Why are we desperate for what we don't have, or can't have, often at great cost to what we do have, thereby risking our peace and contentment, our safety, and even our lives?"The answer, says Dr. Marc Lewis, lies in the structure and function of the human brain. Marc Lewis is a distinguished neuroscientist. And, for many years, he was a drug addict himself, dependent on a series of dangerous substances, from LSD to heroin. His narrative moves back and forth between the often dark, compellingly recounted story of his relationship with drugs and a revelatory analysis of what was going on in his brain. He shows how drugs speak to the brain - which is designed to seek rewards and soothe pain - in its own language. He shows in detail the neural mechanics of a variety of powerful drugs and of the onset of addiction, itself a distortion of normal perception.Dr. Lewis freed himself from addiction and ended up studying it. At the age of 30 he traded in his pharmaceutical supplies for the life of a graduate student, eventually becoming a professor of developmental psychology, and then of neuroscience - his field for the last 12 years. This is the story of his journey, seen from the inside out.

    The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain.Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

    A new mother is admitted with incessant visions of harming her child. A recent graduate, dressed in a tunic and declaring that love emanates from everything around him, is brought to A&E by his alarmed girlfriend. These are among the patients new physician Christine Montross meets during rounds at her hospital’s locked inpatient ward – and who we meet as she struggles to understand the mysteries of the mind, most especially when the tools of modern medicine are failing us. Beautifully written and deeply felt, Falling into the Fire is an intimate portrait of psychiatry and a moving reminder, in the words of the New York Times, of 'our fragile, shared humanity'

    Recounts stories from her vast case files that are alternately terrifying, tragically comic, and profoundly moving, all while she deals with her best friend and fellow doctor's fight with cancer.

    But Folds will be the first to tell you he's an unconventional icon, more normcore than hardcore. Now, in his first book, Folds looks back at his life so far in a charming and wise chronicle of his artistic coming of age, infused with the wry observations of a natural storyteller.In the title chapter, "A Dream About Lightning Bugs," Folds recalls his earliest childhood dream--and realizes how much it influenced his understanding of what it means to be an artist. In "Measure Twice, Cut Once" he learns to resist the urge to skip steps during the creative process. In "Hall Pass" he recounts his 1970s North Carolina working-class childhood, and in "Cheap Lessons" he returns to the painful life lessons he learned the hard way--but that luckily didn't kill him.In his inimitable voice, both relatable and thought-provoking, Folds digs deep into the life experiences that shaped him, imparting hard-earned wisdom about both art and life. Collectively, these stories embody the message Folds has been singing about for years: Smile like you've got nothing to prove, because it hurts to grow up, and life flies by in seconds.

    It's about a bus trip really, because it's my view from the Number 12 bus (mostly top deck, the seat at the front on the right), a double-decker that plies its way from Dulwich, in South East London, where I was living, to where I sometimes work - at the BBC, in the heart of the capital. It's not a sensible way to write a memoir at all, probably, but it's the way things pop into your head as you travel, so it's my way'.From London facts including where to find the blue plaque for Una Marson, 'The first black woman programme maker at the BBC', to discovering the best Spanish coffee under Southwark's railway arches; from a brief history of lady gangsters at Elephant and Castle to memories of climbing Mount Sinai and, at the request of a fellow traveller, reading aloud the Ten Commandments; from the story behind Pissarro's painting of Dulwich Station to performing in Footlights with Emma Thompson; from painful memoires of being sent to Coventry while at a British boarding school to thinking about how Wombells Travelling Circus of 1864 haunts Peckham Rye;from anecdotes about meeting Prince Charles, Monica Lewinsky and Grayson Perry to Bake-Off antics; from stories of a real and lasting friendship with John McCarthy to the importance of family and the daunting navigation of the Zambezi River in her father's canoe, this Sandi Toksvig-style memoir is, as one would expect and hope, packed full of surprises. A funny and moving trip through memories, musings and the many delights on the Number 12 route, Between the Stops is also an inspiration to us all to get off our phones, look up and to talk to each other because as Sandi says: 'some of the greatest trips lie on our own doorstep'.

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    So at the age of twelve, Burroughs found himself amidst Victorian squalor living with the doctor’s bizarre family, and befriending a pedophile who resided in the backyard shed. The story of an outlaw childhood where rules were unheard of, and the Christmas tree stayed up all year round, where Valium was consumed like candy, and if things got dull an electroshock- therapy machine could provide entertainment. The funny, harrowing and bestselling account of an ordinary boy’s survival under the most extraordinary circumstances.

    In a raw, first-person account, Waite recounts each heartbreaking discovery, every life-destroying lie, and reveals what happens once the dust finally settles on her demolished marriage.After a disturbing email sparks Waite's suspicion that her husband is having an affair, she tries to uncover the truth and rebuild trust in her marriage. Instead, she finds more lies, infidelity, and betrayal than she could have imagined. Waite obsessively analyzes her relationship, trying to find a single moment from the last five years that isn't part of the long-con of lies and manipulation. With a dual-timeline narrative structure, we see Waite's romance bud, bloom, and wither simultaneously, making the heartbreak and disbelief even more affecting.

    I was mentally and physically broken. So fractured, I hadn't eaten properly or slept well, or even changed my expression for months. I sat in a cubicle, behind paper-thin curtains, listening to the rest of the hospital happen around me, and I shook with the effort of not crying. I was an inch away from defeat, from the acceptance of a failure I assumed would be inevitable, but I knew I had to carry on. I had to somehow walk through it.Because I wasn't the patient. I was the doctor."A frank account of mental health from both sides of the doctor-patient divide, from the bestselling author of The Trouble with Goats and Sheep and Three Things About Elsie, based on her own experience as a doctor working on a psychiatric ward.

    Water pours from the faucet in crystalline patterns, numbers call to mind distinct geometric shapes, and intricate fractal patterns emerge from the movement of tree branches, revealing the intrinsic mathematical designs hidden in the objects around us.Yet Padgett wasn’t born this way. Twelve years ago, he had never made it past pre-algebra. But a violent mugging forever altered the way his brain works, giving him unique gifts. His ability to understand math and physics skyrocketed, and he developed the astonishing ability to draw the complex geometric shapes he saw everywhere. His stunning, mathematically precise artwork illustrates his intuitive understanding of complex mathematics.The first documented case of acquired savant syndrome with mathematical synesthesia, Padgett is a medical marvel. Struck by Genius recounts how he overcame huge setbacks and embraced his new mind. Along the way he fell in love, found joy in numbers, and spent plenty of time having his head examined. Like Born on a Blue Day and My Stroke of Insight, his singular story reveals the wondrous potential of the human brain.www.struckbygenius.com

    Odder still, she reveals that she’s suffering from a persistent memory problem. Routinely, she “loses” parts of her day, finding herself in places she doesn’t remember going to or being told about conversations she doesn’t remember having. Her problems are so pervasive that she often feels like an impersonator in her own life; she doesn’t recognize the people who call themselves her friends, and she can’t even remember being intimate with her own husband. Baer recognizes that Karen is on the verge of suicide and, while trying various medications to keep her alive, attempts to discover the root cause of her strange complaints. It’s the work of months, and then years, to gain Karen’s trust and learn the true extent of the trauma buried in her past. What she eventually reveals is nearly beyond belief, a narrative of a childhood spent grappling with unimaginable horror. How has Karen survived with even a tenuous grasp on sanity?Then Baer receives an envelope in the mail. It’s marked with Karen’s return address but contains a letter from a little girl who writes that she’s seven years old and lives inside of Karen. Soon Baer receives letters from others claiming to be parts of Karen. Under hypnosis, these alternate Karen personalities reveal themselves in shocking variety and with undeniable traits—both physical and psychological. One “alter” is a young boy filled with frightening aggression; another an adult male who considers himself Karen’s protector; and a third a sassy flirt who seeks dominance over the others. It’s only by compartmentalizing her pain, guilt, and fear in this fashion—by “switching time” with alternate selves as the situation warrants—that Karen has been able to function since childhood.Realizing that his patient represents an extreme case of multiple personality disorder, Baer faces the daunting task of creating a therapy that will make Karen whole again. Somehow, in fact, he must gain the trust of each of Karen’s seventeen “alters” and convince them of the necessity of their own annihilation.As powerful as Sybil or The Three Faces of Eve, Switching Time is the first complete account of such therapy to be told from the perspective of the treating physician, a stunningly devoted healer who worked selflessly for decades so that Karen could one day live as a single human being.From the Hardcover edition.

    In this riveting work of true crime, he spotlights four of the most diabolical criminals he’s confronted, interviewed and learned from. Going deep into each man’s life and crimes, he outlines the factors that led them to murder and how he used his interrogation skills to expose their means, motives, and true evil. Like the hit Netflix show, The Killer Across the Table is centered around Douglas’ unique interrogation and profiling process. With his longtime collaborator Mark Olshaker, Douglas recounts the chilling encounters with these four killers as he experienced them—revealing for the first time his profile methods in detail. Going step by step through his interviews, Douglas explains how he connects each killer’s crimes to the specific conversation, and contrasts these encounters with those of other deadly criminals to show what he learns from each one. In the process, he returns to other famous cases, killers and interviews that have shaped his career, describing how the knowledge he gained from those exchanges helped prepare him for these.A glimpse into the mind of a man who has pierced the heart of human darkness, The Killer Across the Table unlocks the ultimate mystery of depravity and the techniques and approaches that have countered evil in the name of justice.

    The enemy sits across the table and sleeps in the next room. Her husband of twenty-one years is plotting against her because he feels increasingly threatened - by Elizabeth's intellect, independence, and unwillingness to stifle her own thoughts. So Theophilus makes a plan to put his wife back in her place. One summer morning, he has her committed to an insane asylum.The horrific conditions inside the Illinois State Hospital in Jacksonville, Illinois, are overseen by Dr. Andrew McFarland, a man who will prove to be even more dangerous to Elizabeth than her traitorous husband. But most disturbing is that Elizabeth is not the only sane woman confined to the institution. There are many rational women on her ward who tell the same story: they've been committed not because they need medical treatment, but to keep them in line - conveniently labeled "crazy" so their voices are ignored.No one is willing to fight for their freedom and, disenfranchised both by gender and the stigma of their supposed madness, they cannot possibly fight for themselves. But Elizabeth is about to discover that the merit of losing everything is that you then have nothing to lose...

    She was ambitious and worked hard; she had just bought an apartment; she was falling in love. But then she started to develop worrying symptoms: her face felt like it was burning whenever she was in front of the computer. Soon this progressed to an intolerance of fluorescent light, then of sunlight itself. The reaction soon spread to her entire body. Now, when her symptoms are at their worst, she must spend months on end in a blacked-out room, losing herself in audio books and elaborate word games in an attempt to ward off despair. It was during this period she began to write this book.