Leeuwenhoek proceeded to examine the microscopic activity of his spittle, teeth plaque, and feces, and as the result of his findings the field of bacteriology was born. Some two hundred years later, Wilhelm Conrad Roentgen, a professor of theoretical physics at the University of Wurzburg, invited his wife to his laboratory, asked her to place her hand on an unexposed photographic plate, turned on an electric current, and showed this terrified woman a picture of the bones of her hand. And so came the discovery of the X-ray.This absorbing book is the first to describe these and eight other monumental medical discoveries throughout history, bringing to life the scientific pioneers responsible for them and the excitement, frustrations, and jealousies that surrounded the final achievements. Two distinguished physicians, Meyer Friedman and Gerald W. Friedland, have drawn on their many years of experience as well as on that of world-renowned antiquarian book dealers, physician collectors of old and new medical publications, and medical school professors to single out these medical breakthroughs from thousands of candidates, and, in several cases, to provide information never before available. Their engrossing stories of the ten most significant discoveries will be read with enjoyment by anyone fascinated by the mysteries of medicine.

    Born to survivalists in the mountains of Idaho, she prepared for the end of the world by stockpiling home-canned peaches and sleeping with her "head-for-the-hills bag". In the summer she stewed herbs for her mother, a midwife and healer, and in the winter she salvaged in her father's junkyard.Her father forbade hospitals, so Tara never saw a doctor or nurse. Gashes and concussions, even burns from explosions, were all treated at home with herbalism. The family was so isolated from mainstream society that there was no one to ensure the children received an education and no one to intervene when one of Tara's older brothers became violent.Then, lacking any formal education, Tara began to educate herself. She taught herself enough mathematics and grammar to be admitted to Brigham Young University, where she studied history, learning for the first time about important world events like the Holocaust and the civil rights movement. Her quest for knowledge transformed her, taking her over oceans and across continents, to Harvard and to Cambridge. Only then would she wonder if she'd traveled too far, if there was still a way home.Educated is an account of the struggle for self-invention. It is a tale of fierce family loyalty and of the grief that comes with severing the closest of ties. With the acute insight that distinguishes all great writers, Westover has crafted a universal coming-of-age story that gets to the heart of what an education is and what it offers: the perspective to see one's life through new eyes and the will to change it.

    When she was 11 years old, her parents both had their identities stolen. Their credit ratings were ruined, and they were constantly fighting over money. This was before the age of the Internet, when identity theft became more commonplace, so authorities and banks were clueless and reluctant to help Axton's parents.Axton's family changed all of their personal information and moved to different addresses, but the identity thief followed them wherever they went. Convinced that the thief had to be someone they knew, Axton and her parents completely cut off the outside world, isolating themselves from friends and family. Axton learned not to let anyone into the house without explicit permission, and once went as far as chasing a plumber off their property with a knife.As a result, Axton spent her formative years crippled by anxiety, quarantined behind the closed curtains in her childhood home. She began starving herself at a young age in an effort to blend in--her appearance could be nothing short of perfect or she would be scolded by her mother, who had become paranoid and consumed by how others perceived the family.Years later, her parents' marriage still shaken from the theft, Axton discovered that she, too, had fallen prey to the identity thief, but by the time she realized, she was already thousands of dollars in debt and her credit was ruined.

    Failing to gain recognition for his music in his native United States, he achieved celebrity in South America in the early 1960s and then, unbelievably, became the biggest rock star in the Soviet Union, where he was awarded the Lenin Prize and his icons were sold alongside those of Josef Stalin. His albums went gold from Bulgaria to Berlin. He made highly successful movies and, naively earnest, was an unwitting acolyte for socialism; everywhere he went, he was mobbed by his fans. And then, in 1986, at the height of his fame, right after 60 Minutes had devoted a segment to him, finally giving him the recognition he had never attained at home, he drowned in mysterious circumstances in East Berlin.Drawn magnetically to his story, Reggie Nadelson pursued the mystery of Dean Reed's life and death across America and Eastern Europe, her own journey mirroring his. As she traveled, the Berlin Wall came down, the Soviet Union crumbled, and Reed became an increasingly alluring figure, his life an unrepeatable tale of the Cold War world. Encountering the characters— musicians and DJs, politicians and public figures, lovers and wives—who peopled Reed's life, Nadelson was drawn further and further into a seedy, often hilarious subculture of sex, politics, and rock 'n' roll. Part biography, part memoir and personal journey, Comrade Rockstar is an unforgettable chronicle of an utterly improbable life

    His more famous stage name, Flea, and his wild ride as the renowned bass player for the Red Hot Chili Peppers was in a far and distant future. Little Michael from Oz moved with his very conservative, very normal family to Westchester, New York, where life as he knew it was soon turned upside down. His parents split up and he and his sister moved into the home of his mother's free-wheeling, jazz musician boyfriend, Walt--trading in rules, stability, and barbecues for bohemian values, wildness, and Sunday afternoon jazz parties where booze, weed, and music flowed in equal measure. Michael was frightened by the lack of order in his new reality and his volatile new stepfather, but found his salvation in the world of passionate musicians the Walt exposed him to. There began his life-long journey to channel all the frustration, loneliness, love, and joy he felt into incredible rhythm.When Michael's family moved to Los Angeles in 1972, his home situation was rockier than ever. He sought out a sense of belonging elsewhere, spending most of his days partying, playing basketball, and committing petty crimes. At Fairfax High School, he met another social outcast, Anthony Kiedis, who quickly became his soul brother, the yin to his yang, his partner in mischief. Michael joined some bands, fell in love with performing, and honed his skills. But it wasn't until the night when Anthony, excited after catching a Grandmaster Flash concert, suggested they start their own band that he is handed the magic key to the cosmic kingdom.Acid for the Children is as raw, entertaining and wildly unpredictable as its author. It's both a tenderly evocative coming of age story and a raucous love letter to the power of music and creativity.

    Misty and her sister were kept as slaves on a mountain ranch and subjected to almost complete isolation, sexual abuse, and extreme physical violence. Their step-father kept a loaded rifle by the door to make sure the young girls were too terrified to try to escape. No rescue would ever come since the few people who knew they existed did not care.When Misty reached her teens, her parents feared she and her sister would escape and took them to an Amish community. Devastated to again find herself in a world of fear, cruelty, and abuse, Misty was sexually assaulted by the bishop. As Misty recalls, "Amish sexual abusers are only shunned by the church for six weeks, a punishment that never seems to work... I knew I had to get help, and one freezing morning in early March, I made a dash for a tiny police station in rural Minnesota. After reporting the bishop, I left the Amish and found myself plummeted into a strange modern world with only a second-grade education and no ID or social security card."

    William Wright’s best-selling, award-winning books in a single volume! Maximum Insecurity chronicles Wright’s true-life metamorphosis from suburban ear surgeon to life as the sole physician at Colorado’s maximum-security prison. Jailhouse Doc follows Wright’s transition from prison medicine to running the clinic at the county jail. Should be easy right? Not on your life. Told with a humor and biting wit, both books reveal the real inside operation of correctional facilities.

    In the stirring, highly anticipated first volume of his presidential memoirs, Barack Obama tells the story of his improbable odyssey from young man searching for his identity to leader of the free world, describing in strikingly personal detail both his political education and the landmark moments of the first term of his historic presidency—a time of dramatic transformation and turmoil.Obama takes readers on a compelling journey from his earliest political aspirations to the pivotal Iowa caucus victory that demonstrated the power of grassroots activism to the watershed night of November 4, 2008, when he was elected 44th president of the United States, becoming the first African American to hold the nation’s highest office.Reflecting on the presidency, he offers a unique and thoughtful exploration of both the awesome reach and the limits of presidential power, as well as singular insights into the dynamics of U.S. partisan politics and international diplomacy. Obama brings readers inside the Oval Office and the White House Situation Room, and to Moscow, Cairo, Beijing, and points beyond. We are privy to his thoughts as he assembles his cabinet, wrestles with a global financial crisis, takes the measure of Vladimir Putin, overcomes seemingly insurmountable odds to secure passage of the Affordable Care Act, clashes with generals about U.S. strategy in Afghanistan, tackles Wall Street reform, responds to the devastating Deepwater Horizon blowout, and authorizes Operation Neptune’s Spear, which leads to the death of Osama bin Laden.A Promised Land is extraordinarily intimate and introspective—the story of one man’s bet with history, the faith of a community organizer tested on the world stage. Obama is candid about the balancing act of running for office as a Black American, bearing the expectations of a generation buoyed by messages of “hope and change,” and meeting the moral challenges of high-stakes decision-making. He is frank about the forces that opposed him at home and abroad, open about how living in the White House affected his wife and daughters, and unafraid to reveal self-doubt and disappointment. Yet he never wavers from his belief that inside the great, ongoing American experiment, progress is always possible.This beautifully written and powerful book captures Barack Obama’s conviction that democracy is not a gift from on high but something founded on empathy and common understanding and built together, day by day.

    Scandalous affairs rage behind closed doors, broken hearts are tossed aside, fires rip through the wings of the house and paparazzi lie in wait outside the front door for the latest tragedy in this never-ending saga. This is the home of the great architect of the twentieth century, a man of extremes in both his work and his private life: at once a force of nature and an avalanche of need and emotion that sweeps aside everything in its path. Sharp, savage and subtle in equal measure, "The Women" plumbs the chaos, horrors and uncontainable passions of a formidable American icon.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    Then, slowly, a mist settled deep inside the mind she once knew so well, blurring the world around her. She didn't know it then, but dementia was starting to take hold. In 2014, at age fifty-eight, she was diagnosed with young-onset Alzheimer's.Mitchell shares the heartrending story of her cognitive decline and how she has fought to stave it off. What lay ahead of her after the diagnosis was scary and unknowable, but Mitchell was determined and resourceful, and she vowed to outwit the disease for as long as she could.As Mitchell learned to embrace her new life, she began to see her condition as a gift, a chance to experience the world with fresh eyes and to find her own way to make a difference. Even now, her sunny outlook persists: She devotes her time to educating doctors, caregivers, and other people living with dementia, helping to reduce the stigma surrounding this insidious disease.Still living independently, Mitchell now uses Post-it notes and technology to remind her of her routines and has created a "memory room" where she displays photos--with labels--of her daughters, friends, and special places. It is a room where she feels calm and happy, especially on days when the mist descends.

    Soon it was gone, only to be succeeded by another. And another. Strange, Karinthy thought, it had been years since Budapest had streetcars. Only then did he realize he was suffering from an auditory hallucination of extraordinary intensity. What in fact Karinthy was suffering from was a brain tumor, not cancerous but hardly benign, though it was only much later—after spells of giddiness, fainting fits, friends remarking that his handwriting had altered, and books going blank before his eyes—that he consulted a doctor and embarked on a series of examinations that would lead to brain surgery. Karinthy’s description of his descent into illness and his observations of his symptoms, thoughts, and feelings, as well as of his friends’ and doctors’ varied responses to his predicament, are exact and engrossing and entirely free of self-pity. A Journey Round My Skull is not only an extraordinary piece of medical testimony, but a powerful work of literature—one that dances brilliantly on the edge of extinction.

    Hours later she found herself in a dark cellar, wrapped in a blanket. When she emerged eight years later, her childhood had gone. In "3,096 Days" Natascha tells her incredible story for the first time: her difficult childhood, what exactly happened on the day of her abduction, her imprisonment in a five-square-metre dungeon, and the mental and physical abuse she suffered from her abductor, Wolfgang Priklopil. "3,096 Days" is ultimately a story about the triumph of the human spirit. It describes how, in a situation of almost unbearable hopelessness, she slowly learned how to manipulate her captor. And how, against inconceivable odds, she managed to escape unbroken.

    It was the first time Rushdie heard the word fatwa. His crime? To have written a novel called The Satanic Verses, which was accused of being “against Islam, the Prophet, and the Quran.” So begins the extraordinary story of how a writer was forced underground, moving from house to house, with the constant presence of an armed police protection team. Rushdie was asked to choose an alias that the police could call him by. He thought of writers he loved and various combinations of their names. Then it came to him: Conrad and Chekhov—Joseph Anton. How do a writer and his family live with the threat of murder for more than nine years? How does he go on working? How does he fall in and out of love? How does despair shape his thoughts and actions, and how does he learn to fight back? In this remarkable memoir, Rushdie tells that story for the first time; the story of the crucial battle for freedom of speech. He shares the sometimes grim, sometimes comic realities of living with armed policemen, and the close bonds he formed with his protectors; of his struggle for support and understanding from governments, intelligence chiefs, publishers, journalists, and fellow writers; and of how he regained his freedom. Compelling, provocative, and moving, Joseph Anton is a book of exceptional frankness, honesty, and vital importance. Because what happened to Salman Rushdie was the first act of a drama that is still unfolding somewhere in the world every day.

    Ruby Wax - comedian, writer and mental health campaigner - shows us how our minds can jeopardize our sanity. With her own periods of depression and now a Masters from Oxford in Mindfulness-based Cognitive Therapy to draw from, she explains how our busy, chattering, self-critical thoughts drive us to anxiety and stress. If we are to break the cycle, we need to understand how our brains work, rewire our thinking and find calm in a frenetic world. Helping you become the master, not the slave, of your mind, here is the manual to saner living