After 3.8 billion years humankind is about to start evolving by new rules...From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives -- sex, war, love, and death.At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

    The author argues for the preservation of the time and space in which to walk in an ever more car-dependent and accelerated world.

    A staunch atheist and rationalist, she is profoundly shaken by the implications of her life-long search. Part memoir, part philosophical and spiritual inquiry, Living with a Wild God brings an older woman's wry and erudite perspective to a young girl's uninhibited musings on the questions that, at one point or another, torment us all. Ehrenreich's most personal book ever will spark a lively and heated conversation about religion and spirituality, science and morality, and the "meaning of life." Certain to be a classic, Living with a Wild God combines intellectual rigor with a frank account of the inexplicable, in Ehrenreich's singular voice, to produce a true literary achievement.

    What is it like to try to heal the body when the mind is under attack? In this book, Dr. Allan Ropper and Brian Burrell take the reader behind the scenes at Harvard Medical School's neurology unit to show how a seasoned diagnostician faces down bizarre, life-altering afflictions. Like Alice in Wonderland, Dr. Ropper inhabits a world where absurdities abound:• A figure skater whose body has become a ticking time-bomb • A salesman who drives around and around a traffic rotary, unable to get off • A college quarterback who can't stop calling the same play • A child molester who, after falling on the ice, is left with a brain that is very much dead inside a body that is very much alive • A mother of two young girls, diagnosed with ALS, who has to decide whether a life locked inside her own head is worth livingHow does one begin to treat such cases, to counsel people whose lives may be changed forever? How does one train the next generation of clinicians to deal with the moral and medical aspects of brain disease? Dr. Ropper and his colleague answer these questions by taking the reader into a rarified world where lives and minds hang in the balance.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.

    They are promises. They are the only way to walk from one night to the other."Nina Riggs was just thirty-seven years old when initially diagnosed with breast cancer--one small spot. Within a year, the mother of two sons, ages seven and nine, and married sixteen years to her best friend, received the devastating news that her cancer was terminal.How does one live each day, "unattached to outcome"? How does one approach the moments, big and small, with both love and honesty?Exploring motherhood, marriage, friendship, and memory, even as she wrestles with the legacy of her great-great-great grandfather, Ralph Waldo Emerson, Nina Riggs's breathtaking memoir continues the urgent conversation that Paul Kalanithi began in his gorgeous When Breath Becomes Air. She asks, what makes a meaningful life when one has limited time?Brilliantly written, disarmingly funny, and deeply moving, The Bright Hour is about how to love all the days, even the bad ones, and it's about the way literature, especially Emerson, and Nina's other muse, Montaigne, can be a balm and a form of prayer. It's a book about looking death squarely in the face and saying "this is what will be."Especially poignant in these uncertain times, The Bright Hour urges us to live well and not lose sight of what makes us human: love, art, music, words.

    But it wasn’t long before they noticed a marked difference between Jonas and his brother, Wyatt. Jonas preferred sports and trucks and many of the things little boys were “supposed” to like; but Wyatt liked princess dolls and dress-up and playing Little Mermaid. By the time the twins were toddlers, confusion over Wyatt’s insistence that he was female began to tear the family apart. In the years that followed, the Maineses came to question their long-held views on gender and identity, to accept and embrace Wyatt’s transition to Nicole, and to undergo an emotionally wrenching transformation of their own that would change all their lives forever.Becoming Nicole chronicles a journey that could have destroyed a family but instead brought it closer together. It’s the story of a mother whose instincts told her that her child needed love and acceptance, not ostracism and disapproval; of a Republican, Air Force veteran father who overcame his deepest fears to become a vocal advocate for trans rights; of a loving brother who bravely stuck up for his twin sister; and of a town forced to confront its prejudices, a school compelled to rewrite its rules, and a courageous community of transgender activists determined to make their voices heard. Ultimately, Becoming Nicole is the story of an extraordinary girl who fought for the right to be herself.Granted wide-ranging access to personal diaries, home videos, clinical journals, legal documents, medical records, and the Maineses themselves, Amy Ellis Nutt spent almost four years reporting this immersive account of an American family confronting an issue that is at the center of today’s cultural debate. Becoming Nicole will resonate with anyone who’s ever raised a child, felt at odds with society’s conventions and norms, or had to embrace life when it plays out unexpectedly. It’s a story of standing up for your beliefs and yourself—and it will inspire all of us to do the same.

    Then he disappeared, eluding capture by multiple police forces and some of the best detectives in the area.Three decades later, Michelle McNamara, a true crime journalist who created the popular website TrueCrimeDiary.com, was determined to find the violent psychopath she called "the Golden State Killer." Michelle pored over police reports, interviewed victims, and embedded herself in the online communities that were as obsessed with the case as she was.At the time of the crimes, the Golden State Killer was between the ages of eighteen and thirty, Caucasian, and athletic—capable of vaulting tall fences. He always wore a mask. After choosing a victim—he favored suburban couples—he often entered their home when no one was there, studying family pictures, mastering the layout. He attacked while they slept, using a flashlight to awaken and blind them. Though they could not recognize him, his victims recalled his voice: a guttural whisper through clenched teeth, abrupt and threatening.I’ll Be Gone in the Dark—the masterpiece McNamara was writing at the time of her sudden death—offers an atmospheric snapshot of a moment in American history and a chilling account of a criminal mastermind and the wreckage he left behind. It is also a portrait of a woman’s obsession and her unflagging pursuit of the truth. Framed by an introduction by Gillian Flynn and an afterword by her husband, Patton Oswalt, the book was completed by Michelle’s lead researcher and a close colleague. Utterly original and compelling, it is destined to become a true crime classic—and may at last unmask the Golden State Killer.

    In this remarkable symphony of essays adapted and expanded from his ground-breaking, critically acclaimed podcast, John Green reviews different facets of the human-centered planet - from the QWERTY keyboard and Halley's Comet to Penguins of Madagascar - on a five-star scale.Complex and rich with detail, the Anthropocene's reviews have been praised as 'observations that double as exercises in memoiristic empathy', with over 10 million lifetime downloads. John Green's gift for storytelling shines throughout this artfully curated collection about the shared human experience; it includes beloved essays along with six all-new pieces exclusive to the book.

    From distressed small communities in Central Appalachia to wealthy suburbs; from disparate cities to once-idyllic farm towns; it's a heartbreaking trajectory that illustrates how this national crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy endeavors to answer a grieving mother's question-why her only son died-and comes away with a harrowing story of greed and need. From the introduction of OxyContin in 1996, Macy parses how America embraced a medical culture where overtreatment with painkillers became the norm. In some of the same distressed communities featured in her bestselling book Factory Man, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.Through unsparing, yet deeply human portraits of the families and first responders struggling to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows, astonishingly, that the only thing that unites Americans across geographic and class lines is opioid drug abuse. But in a country unable to provide basic healthcare for all, Macy still finds reason to hope-and signs of the spirit and tenacity necessary in those facing addiction to build a better future for themselves and their families.

    She could barely find the strength to get off the sofa, let alone piece her life back together. Until one day she did something she had never done of her own free will – she pulled on a pair of trainers and went for a run.That first attempt didn’t last very long. But to her surprise, she was back out there the next day. And the day after that. She began to set herself achievable goals – to run 5k in under 30 minutes, to walk to work every day for a week, to attempt 10 push-ups in a row. Before she knew it, her mood was lifting for the first time in years.In Jog On, Bella explains with hilarious and unfiltered honesty how she used running to battle crippling anxiety and depression, without having to sacrifice her main loves: booze, cigarettes and ice cream. With the help of a supporting cast of doctors, psychologists, sportspeople and friends, she shares a wealth of inspirational stories, research and tips that show how exercise often can be the best medicine. This funny, moving and motivational book will encourage you to say ‘jog on’ to your problems and get your life back on track – no matter how small those first steps may be.

    But when he stole a young kestrel from its nest, he was about to embark on a friendship that would teach him what it meant to love, and that would change him forever. In his rich, lyrical and emotionally exposing memoir, Chris brings to life his childhood in the 70s, from his bedroom bursting with fox skulls, birds' eggs and sweaty jam jars, to his feral adventures. But pervading his story is the search for freedom, meaning and acceptance in a world that didn’t understand him.Beautifully wrought, this coming-of-age memoir will be unlike any you’ve ever read.

    None of this felt right; and as she got older, she longed for more stories that allowed disability to be complex and ordinary, uncomfortable and fine, painful and fulfilling.Writing about the rhythms and textures of what it means to live in a body that doesn’t fit, Rebekah reflects on everything from the complications of kindness and charity, living both independently and dependently, experiencing intimacy, and how the pervasiveness of ableism in our everyday media directly translates to everyday life.Disability affects all of us, directly or indirectly, at one point or another. By exploring this truth in poignant and lyrical essays, Taussig illustrates the need for more stories and more voices to understand the diversity of humanity. Sitting Pretty challenges us as a society to be patient and vigilant, practical and imaginative, kind and relentless, as we set to work to write an entirely different story.

    Meredith May recalls the first time a honeybee crawled on her arm. She was five years old, her parents had recently split and suddenly she found herself in the care of her grandfather, an eccentric beekeeper who made honey in a rusty old military bus in the yard. That first close encounter was at once terrifying and exhilarating for May, and in that moment she discovered that everything she needed to know about life and family was right before her eyes, in the secret world of bees.May turned to her grandfather and the art of beekeeping as an escape from her troubled reality. Her mother had receded into a volatile cycle of neurosis and despair and spent most days locked away in the bedroom. It was during this pivotal time in May's childhood that she learned to take care of herself, forged an unbreakable bond with her grandfather and opened her eyes to the magic and wisdom of nature.The bees became a guiding force in May's life, teaching her about family and community, loyalty and survival and the unequivocal relationship between a mother and her child. Part memoir, part beekeeping odyssey, The Honey Bus is an unforgettable story about finding home in the most unusual of places, and how a tiny, little-understood insect could save a life.

    The new nanny gives a mother an uneasy feeling. A stranger in a deserted parking lot offers unsolicited help. The threat of violence surrounds us every day. But we can protect ourselves, by learning to trust—and act on—our gut instincts.In this empowering book, Gavin de Becker, the man Oprah Winfrey calls the nation's leading expert on violent behavior, shows you how to spot even subtle signs of danger—before it's too late. Shattering the myth that most violent acts are unpredictable, de Becker, whose clients include top Hollywood stars and government agencies, offers specific ways to protect yourself and those you love, including how to act when approached by a stranger, when you should fear someone close to you, what to do if you are being stalked, how to uncover the source of anonymous threats or phone calls, the biggest mistake you can make with a threatening person, and more. Learn to spot the danger signals others miss. It might just save your life.