Andrew had been considered the king of twentieth-century smut, with a writing career that began as a strategy to pay for his son's orthodontic needs and soon took on a life of its own, peaking during the 1970s when the commercial popularity of the erotic novel reached its height. With his dutiful wife serving as typist, Andrew wrote from their home in the Kentucky hills, locked away in an office no one dared intrude upon. In this fashion he wrote more than four hundred novels, including pirate porn, ghost porn, zombie porn, and secret agent porn. The more he wrote, the more intense his ambition became and the more difficult it was for his children to be part of his world. Over the long summer of 2013, Chris returned to his hometown to help his widowed mother move out of his childhood home. As he began to examine his father's manuscripts and memorabilia, journals, and letters, he realized he finally had an opportunity to gain insight into the difficult, mercurial, sometimes cruel man he'd loved and feared in equal measure. Only in his father's absence could he truly make sense of the man and his legacy. In My Father, the Pornographer, Offutt takes us on the journey with him, reading his father s prodigious literary output as both a critic and as a son seeking answers. This is a book about the life of a working writer who supports his family solely by the output of his typewriter; it's about the awful psychic burdens one generation unthinkingly passes along to the next; and it's about growing up in the Appalachian hills with a pack of fearless boys riding bicycles through the woods, happy and free."

    In this “remarkable act of reclamation” (Neil Gaiman), Ruth Franklin envisions Jackson as “belonging to the great tradition of Hawthorne, Poe and James” (New York Times Book Review) and demonstrates how her unique contribution to the canon “so uncannily channeled women’s nightmares and contradictions that it is ‘nothing less than the secret history of American women of her era’ ” (Washington Post). Franklin investigates the “interplay between the life, the work, and the times with real skill and insight, making this fine book a real contribution not only to biography, but to mid-20th-century women’s history” (Chicago Tribune). “Wisely rescu[ing] Shirley Jackson from any semblance of obscurity” (Lena Dunham), Franklin’s invigorating portrait stands as the definitive biography of a generational avatar and an American literary genius.

    The Barbary Plague transports us to the Gold Rush boomtown in 1900, at the end of the city’s Gilded Age. With a deep understanding of the effects on public health of politics, race, and geography, Chase shows how one city triumphed over perhaps the most frightening and deadly of all scourges.

    She spent ten years training and working as an Anatomical Pathology Technologist: where the mortuary slab was her desk, and that day's corpses her task list.Past Mortems tells Carla's stories of those years, as well as investigating the body alongside our attitudes towards death - shedding light on what the living can learn from dead and the toll the work can take on the living souls who carry it out. Fascinating and insightful, Past Mortems reveals the truth about what happens when the mortuary doors swing shut or the lid of the coffin closes . . .

    Mockingbird is good reading."—Star-Tribune (Minneapolis)To Kill a Mockingbird—the twentieth century's most widely read American novel—has sold thirty million copies and still sells a million yearly. Yet despite her book's perennial popularity, its creator, Harper Lee, has become a somewhat mysterious figure. Now, after years of research, Charles J. Shields brings to life the warmhearted, high-spirited, and occasionally hardheaded woman who gave us two of American literature's most unforgettable characters—Atticus Finch and his daughter, Scout.At the center of Shields's evocative, lively book is the story of Lee's struggle to create her famous novel, but her colorful life contains many highlights—her girlhood as a tomboy in overalls in tiny Monroeville, Alabama; the murder trial that made her beloved father's reputation and inspired her great work; her journey to Kansas as Truman Capote's ally and research assistant to help report the story of In Cold Blood. Mockingbird—unique, highly entertaining, filled with humor and heart—is a wide-ranging, idiosyncratic portrait of a writer, her dream, and the place and people whom she made immortal.

    Her fierce, sometimes comic novels and stories reflected the darkly funny, vibrant, and theologically sophisticated woman who wrote them. Brad Gooch brings to life O'Connor's significant friendships -- with Robert Lowell, Elizabeth Hardwick, Walker Percy, and James Dickey among others -- and her deeply felt convictions, as expressed in her communications with Thomas Merton, Elizabeth Bishop, and Betty Hester. Hester was famously known as "A" in O'Connor's collected letters, The Habit of Being, and a large cache of correspondence to her from O'Connor was made available to scholars, including Brad Gooch, in 2006. O'Connor's capacity to live fully -- despite the chronic disease that eventually confined her to her mother's farm in Georgia -- is illuminated in this engaging and authoritative biography. Praise for Flannery: "Flannery O'Connor, one of the best American writers of short fiction, has found her ideal biographer in Brad Gooch. With elegance and fairness, Gooch deals with the sensitive areas of race and religion in O'Connor's life. He also takes us back to those heady days after the war when O'Connor studied creative writing at Iowa. There is much that is new in this book, but, more important, everything is presented in a strong, clear light."-Edmund White "This splendid biography gives us no saint or martyr but the story of a gifted and complicated woman, bent on making the best of the difficult hand fate has dealt her, whether it is with grit and humor or with an abiding desire to make palpable to readers the terrible mystery of God's grace."-Frances Kiernan, author of Seeing Mary Plain: A Life of Mary McCarthy "A good biographer is hard to find. Brad Gooch is not merely good-he is extraordinary. Blessed with the eye and ear of a novelist, he has composed the life that admirers of the fierce and hilarious Georgia genius have long been hoping for."-Joel Conarroe, President Emeritus, John Simon Guggenheim Foundation

    Leslie Jamison deftly excavates the stories we tell about addiction--both her own and others'--and examines what we want these stories to do, and what happens when they fail us.All the while, she offers a fascinating look at the larger history of the recovery movement, and at the literary and artistic geniuses whose lives and works were shaped by alcoholism and substance dependence, including John Berryman, Jean Rhys, Raymond Carver, Billie Holiday, David Foster Wallace, and Denis Johnson, as well as brilliant figures lost to obscurity but newly illuminated here.For the power of her striking language and the sharpness of her piercing observations, Jamison has been compared to such iconic writers as Joan Didion and Susan Sontag. Yet her utterly singular voice also offers something new. With enormous empathy and wisdom, Jamison has given us nothing less than the story of addiction and recovery in America writ large, a definitive and revelatory account that will resonate for years to come.

    Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human.In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome.These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

    Nor do many know that she wrote it during a devastating and anxious period in her life. Thwarted in her passionate, secret, and forbidden love for a married man, she found herself living in a home suddenly imperiled by the fact that her father, a minister, the sole support of the family, was on the brink of blindness. After his hasty operation, as she nursed him in an isolated apartment kept dark to help him heal his eyes, Brontë began writing Jane Eyre, an invigorating romance that, despite her own fears and sorrows, gives voice to a powerfully rebellious and ultimately optimistic woman’s spirit.The Secret History of Jane Eyre expands our understanding of both Jane Eyre and the inner life of its notoriously private author. Pfordresher connects the people Brontë knew and the events she lived to the characters and story in the novel, and he explores how her fecund imagination used her inner life to shape one of the world’s most popular novels.By aligning his insights into Brontë’s life with the timeless characters, harrowing plot, and forbidden romance of Jane Eyre, Pfordresher reveals the remarkable parallels between one of literature’s most beloved heroines and her passionate creator, and arrives at a new understanding of Brontë’s brilliant, immersive genius.

    Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic; the visionary scientist Gregory Pincus, who was dismissed by Harvard in the 1930s as a result of his experimentation with in vitro fertilization but who, after he was approached by Sanger and McCormick, grew obsessed with the idea of inventing a drug that could stop ovulation; and the telegenic John Rock, a Catholic doctor from Boston who battled his own church to become an enormously effective advocate in the effort to win public approval for the drug that would be marketed by Searle as Enovid.Spanning the years from Sanger’s heady Greenwich Village days in the early twentieth century to trial tests in Puerto Rico in the 1950s to the cusp of the sexual revolution in the 1960s, this is a grand story of radical feminist politics, scientific ingenuity, establishment opposition, and, ultimately, a sea change in social attitudes. Brilliantly researched and briskly written, The Birth of the Pill is gripping social, cultural, and scientific history.

    But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.Cullen's murderous career in the world's most trusted profession spanned sixteen years and nine hospitals across New Jersey and Pennsylvania. When, in March of 2006, Charles Cullen was marched from his final sentencing in an Allentown, Pennsylvania, courthouse into a waiting police van, it seemed certain that the chilling secrets of his life, career, and capture would disappear with him. Now, in a riveting piece of investigative journalism nearly ten years in the making, journalist Charles Graeber presents the whole story for the first time. Based on hundreds of pages of previously unseen police records, interviews, wire-tap recordings and videotapes, as well as exclusive jailhouse conversations with Cullen himself and the confidential informant who helped bring him down, THE GOOD NURSE weaves an urgent, terrifying tale of murder, friendship, and betrayal.Graeber's portrait of Cullen depicts a surprisingly intelligent and complicated young man whose promising career was overwhelmed by his compulsion to kill, and whose shy demeanor masked a twisted interior life hidden even to his family and friends. Were it not for the hardboiled, unrelenting work of two former Newark homicide detectives racing to put together the pieces of Cullen's professional past, and a fellow nurse willing to put everything at risk, including her job and the safety of her children, there's no telling how many more lives could have been lost.In the tradition of In Cold Blood, THE GOOD NURSE does more than chronicle Cullen's deadly career and the breathless efforts to stop him; it paints an incredibly vivid portrait of madness and offers a penetrating look inside America's medical system. Harrowing and irresistibly paced, this book will make you look at medicine, hospitals, and the people who work in them, in an entirely different way.

    But AIDS is just one of the many emerging viruses for which we have, as yet, no cure. Even the old plagues – TB, cholera, bubonic plague – are making a comeback, resistant now to our drugs.Frank Ryan, a leading authority on disease, describes the groundbreaking research of the world’s leading experts in the field to show both where these viruses come from and why they prove to be so lethal, and advances a radical new biological theory for the origins and behaviour of plague viruses. Full of vivid despatches from the front line of research and medicine, 'Virus X' is terrifying and essential reading for anyone interested in the effects of plague viruses on human evolution.“Extremely well written…Frank Ryan has the page-turning and spine-chilling ability of a good novelist”MATT RIDLEY, 'Sunday Telegraph'“Compelling and frightening…the plot could not be bettered”MICHAEL SMITH, 'Scotsman'“Ryan is very good at making technical matters comprehensible to the lay reader but more impressive still is the way he conveys the intellectual excitement and elation of scientific discovery”ANTHONY DANIELS, 'Literary Review'“Ryan takes us through the drama of discovery and challenges the notion that certain questions are too appalling to contemplate”DAVID BRADLEY, 'New Scientist'“Dr Ryan writes well in a difficult technical field, weaving the technicalities of scientific history, medicine, molecular biology and evolution into the human narratives…very readable and disturbing”JOHN R.G. TURNER, 'New York Times'

    As an untried medical student studying the intersection of global health and communicable disease, Donaldson soon found himself in dangerous Sierra Leone, on the border of war-struck Liberia, where he struggled to control the spread of Lassa Fever. The words, “you know Lassa can kill you, don’t you?” haunted him each day. With the country in complete upheaval and working conditions suffering, he is forced to make life-and-death decisions alone as a never-ending onslaught of contagious patients flood the hospital. Soon however, he is not only fighting for others but himself when he becomes afflicted with a life threatening disease. The Lassa Ward is more than just an adventure story about the making of a physician; it is a portrait of the Sierra Leone people and the human struggle of those risking their daily comforts and lives to aid them.

    But it took a team of Oxford scientists headed by Howard Florey and Ernst Chain four more years to develop it as the first antibiotic, and the most important family of drugs in the twentieth century. At once the world was transformed—major bacterial scourges such as blood poisoning and pneumonia, scarlet fever and diphtheria, gonorrhea and syphilis were defeated as penicillin helped to foster not only a medical revolution but a sexual one as well. In his wonderfully engaging book, acclaimed author Eric Lax tells the real story behind the discovery and why it took so long to develop the drug. He reveals the reasons why credit for penicillin was misplaced, and why this astonishing achievement garnered a Nobel Prize but no financial rewards for Alexander Fleming, Florey, and his team. The Mold in Dr. Florey’s Coat is the compelling story of the passage of medicine from one era to the next and of the eccentric individuals whose participation in this extraordinary accomplishment has, until now, remained largely unknown.

    This fascinating collection of historical curiosities explores some of the strangest cases that have perplexed doctors across the world.From seventeenth-century Holland to Tsarist Russia, from rural Canada to a whaler in the Pacific, many are monuments to human stupidity – such as the sailor who swallowed dozens of penknives to amuse his shipmates, or the chemistry student who in 1850 arrived at a hospital in New York with his penis trapped inside a bottle, having unwisely decided to relieve himself into a vessel containing highly reactive potassium. Others demonstrate exceptional surgical ingenuity long before the advent of anaesthesia – such as a daring nineteenth-century operation to remove a metal fragment from beneath a conscious patient’s heart. We also hear of the weird, often hilarious remedies employed by physicians of yore – from crow’s vomit to port-wine enemas – the hazards of such everyday objects as cucumbers and false teeth, and miraculous recovery from apparently terminal injuries.