An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    Authors Peter Tompkins and Christopher Bird suggest that the most far-reaching revolution of the 20th century — one that could save or destroy the planet — may come from the bottom of your garden."Almost incredible ... bristles with plenty of hard facts and astounding scientific and practical lore." —S. K. Oberbeck, Newsweek“This fascinating book roams ... over that marvelous no man's land of mystical glimmerings into the nature of science and life itself." —Henry Mitchell, Washington Post Book World“If I can't ‘get inside a plant’ or ‘feel emanations’ from a plant and don't know anyone else who can. that doesn't detract one whit from the possibility that some people can and do. . . .According to The Secret Life of Plants, plants and men do inter-relate, with plants exhibiting empathetic and spiritual relationships and showing reactions interpreted as demonstrating physical-force connections with men. As my students say, ‘hey, wow!’"—Richard M. Klein, Professor of Botany, University of Vermont (in Smithsonian)

    Now she builds on those insights to show us how to give our animals the best and happiest life—on their terms, not ours.It’s usually easy to pinpoint the cause of physical pain in animals, but to know what is causing them emotional distress is much harder. rawing on the latest research and her own work,Grandin identifies the core emotional needs of animals. Then she explains how to fulfill them for dogs and cats, horses, farm animals, and zoo animals.Whether it’s how to make the healthiest environment for the dog you must leave alone most of the day, how to keep pigs from being bored, or how to know if the lion pacing in the zoo is miserable or just exercising, Grandin teaches us to challenge our assumptions about animal contentment and honor our bond with our fellow creatures.Animals Make Us Human is the culmination of almost thirty years of research, experimentation, and experience.This is essential reading for anyone who’s ever owned, cared for, or simply cared about an animal.

    . . a book that enriches our understanding of how the struggle to think new thoughts is shared across time and space and people.”—The Sunday Telegraph (London)Christmas, 1859. Just one month after the publication of On the Origin of Species, Charles Darwin received an unsettling letter. He had expected criticism; in fact, letters were arriving daily, most expressing outrage and accusations of heresy. But this letter was different. It accused him of failing to acknowledge his predecessors, of taking credit for a theory that had already been discovered by others. Darwin realized that he had made an error in omitting from Origin of Species any mention of his intellectual forebears. Yet when he tried to trace all of the natural philosophers who had laid the groundwork for his theory, he found that history had already forgotten many of them.Darwin’s Ghosts tells the story of the collective discovery of evolution, from Aristotle, walking the shores of Lesbos with his pupils, to Al-Jahiz, an Arab writer in the first century, from Leonardo da Vinci, searching for fossils in the mine shafts of the Tuscan hills, to Denis Diderot in Paris, exploring the origins of species while under the surveillance of the secret police, and the brilliant naturalists of the Jardin de Plantes, finding evidence for evolutionary change in the natural history collections stolen during the Napoleonic wars. Evolution was not discovered single-handedly, Rebecca Stott argues, contrary to what has become standard lore, but is an idea that emerged over many centuries, advanced by daring individuals across the globe who had the imagination to speculate on nature’s extraordinary ways, and who had the courage to articulate such speculations at a time when to do so was often considered heresy.With each chapter focusing on an early evolutionary thinker, Darwin’s Ghosts is a fascinating account of a diverse group of individuals who, despite the very real dangers of challenging a system in which everything was presumed to have been created perfectly by God, felt compelled to understand where we came from. Ultimately, Stott demonstrates, ideas—including evolution itself—evolve just as animals and plants do, by intermingling, toppling weaker notions, and developing over stretches of time. Darwin’s Ghosts presents a groundbreaking new theory of an idea that has changed our very understanding of who we are.

    Thus began one of the boldest scientific projects in history, the Search for Extraterrestrial Intelligence (SETI). But after a half century of scanning the skies, astronomers have little to report but an eerie silence—eerie because many scientists are convinced that the universe is teeming with life. The problem, argues the leading physicist-astrobiologist Paul Davies, is that we’ve been looking in the wrong place, at the wrong time & in the wrong way. Davies should know. For more than three decades, he's been closely involved with SETI & now chairs its Post-Detection Taskgroup, charged with deciding what to do if we’re confronted with evidence of alien intelligence. In this extraordinary book, he shows how SETI has lost its edge & offers a new exciting road map for the future. Davies believes our search so far has been overly anthropocentric: we tend to assume an alien species will look, think & behave like us. He argues that we need to be far more expansive in our efforts, & in this book he completely redefines the search, challenging existing ideas of what form an alien intelligence might take, how it might try to communicate with us & how we should respond if it does. A provocative & mind-expanding journey, The Eerie Silence will thrill fans of science & science fiction alike.

    Breaking down the symbols themselves, they pose a series of questions: What is energy? What is mass? What has the speed of light got to do with energy and mass? In answering these questions, they take us to the site of one of the largest scientific experiments ever conducted. Lying beneath the city of Geneva, straddling the Franco-Swiss boarder, is a 27 km particle accelerator, known as the Large Hadron Collider. Using this gigantic machine—which can recreate conditions in the early Universe fractions of a second after the Big Bang—Cox and Forshaw will describe the current theory behind the origin of mass.Alongside questions of energy and mass, they will consider the third, and perhaps, most intriguing element of the equation: 'c' - or the speed of light. Why is it that the speed of light is the exchange rate? Answering this question is at the heart of the investigation as the authors demonstrate how, in order to truly understand why E=mc2, we first must understand why we must move forward in time and not backwards and how objects in our 3-dimensional world actually move in 4-dimensional space-time. In other words, how the very fabric of our world is constructed. A collaboration between two of the youngest professors in the UK, Why Does E=mc2? promises to be one of the most exciting and accessible explanations of the theory of relativity in recent years.

    At the time, Watson was only 24, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions & bitter rivalries. With humility unspoiled by false modesty, Watson relates his & Crick's desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

    The "star" of the show is the star-nosed mole, with its nose containing some 25,000 touch-sensitive nerve organs and the ability to gobble small invertebrate prey in world record-breaking time. The mole was author's first real biological assignment; his "strange path of discovery" is brilliantly documented, from figuring how to find and capture his elusive subject to eventually mapping its brain. He also studies tentacled snakes that deploy some devilish hunting strategies, worms that leave the ground in response to "grunts," eels that paralyze their prey with Taser-like jolts, bloodthirsty water shrews, and zombie-making wasps. The author's witty style and amazing findings are complemented by stunning photography and movie shorts that readers with smart phones can scan and play. The astonishing animals are only half the story. Just as compelling is the enquiring-human side--i.e., seeing a scientist at work (and at play), applying a Sherlockian credo

    In this book, he expands the points he has made, and claims that this debate is not so much about religion versus science, as about the nature of science itself. With infectious enthusiasm, he reveals the mechanics of evolutionary theory, explains how it is rooted in the testable and verifiable scientific method, and why it is therefore a sound explanation of our beginning. He argues passionately that to continue to assert otherwise, to continue to insist that creationism has a place in the science classroom is harmful not only to our children, but to the future of the greater world as well.

    During the summer before the United States entered World War I, when ocean swimming was just becoming popular and luxurious Jersey Shore resorts were thriving as a chic playland for an opulent yet still innocent era's new leisure class, Americans were abruptly introduced to the terror of sharks. In July 1916 a lone Great White left its usual deep-ocean habitat and headed in the direction of the New Jersey shoreline. There, near the towns of Beach Haven and Spring Lake-and, incredibly, a farming community eleven miles inland-the most ferocious and unpredictable of predators began a deadly rampage: the first shark attacks on swimmers in U.S. history. For Americans celebrating an astoundingly prosperous epoch much like our own, fueled by the wizardry of revolutionary inventions, the arrival of this violent predator symbolized the limits of mankind's power against nature.Interweaving a vivid portrait of the era and meticulously drawn characters with chilling accounts of the shark's five attacks and the frenzied hunt that ensued, Michael Capuzzo has created a nonfiction historical thriller with the texture of Ragtime and the tension of Jaws. From the unnerving inevitability of the first attack on the esteemed son of a prosperous Philadelphia physician to the spine-tingling moment when a farm boy swimming in Matawan Creek feels the sandpaper-like skin of the passing shark, Close to Shore is an undeniably gripping saga.Heightening the drama are stories of the resulting panic in the citizenry, press and politicians, and of colorful personalities such as Herman Oelrichs, a flamboyant millionaire who made a bet that a shark was no match for a man (and set out to prove it); Museum of Natural History ichthyologist John Treadwell Nichols, faced with the challenge of stopping a mythic sea creature about which little was known; and, most memorable, the rogue Great White itself moving through a world that couldn't conceive of either its destructive power or its moral right to destroy.Scrupulously researched and superbly written, Close to Shore brings to life a breathtaking, pivotal moment in American history. Masterfully written and suffused with fascinating period detail and insights into the science and behavior of sharks, Close to Shore recounts a breathtaking, pivotal moment in American history with startling immediacy.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    While they're at it, they helpfully demystify many complicated things we do know about, from quarks and neutrinos to gravitational waves and exploding black holes. With equal doses of humor and delight, they invite us to see the universe as a vast expanse of mostly uncharted territory that's still ours to explore.This entertaining illustrated science primer is the perfect book for anyone who's curious about all the big questions physicists are still trying to answer.

    Someday, we know, we will all die. And, we know, so too will the universe itself.Until the End of Time is Brian Greene's breathtaking new exploration of the cosmos and our quest to understand it. Greene takes us on a journey across time, from our most refined understanding of the universe's beginning, to the closest science can take us to the very end. He explores how life and mind emerged from the initial chaos, and how our minds, in coming to understand their own impermanence, seek in different ways to give meaning to experience: in story, myth, religion, creative expression, science, the quest for truth, and our longing for the timeless, or eternal. Through a series of nested stories that explain distinct but interwoven layers of reality-from the quantum mechanics to consciousness to black holes-Greene provides us with a clearer sense of how we came to be, a finer picture of where we are now, and a firmer understanding of where we are headed.Yet all this understanding, which arose with the emergence of life, will dissolve with its conclusion. Which leaves us with one realization: during our brief moment in the sun, we are tasked with the charge of finding our own meaning.Let us embark.

    Will temperatures rise by 2�C or 8�C over the next hundred years? Will sea levels rise by 2 or 30 feet? The only way that we can accurately answer questions like these is by looking into the distant past, for a comparison with the world long before the rise of mankind.We may currently believe that atmospheric shifts, like global warming, result from our impact on the planet, but the earth's atmosphere has been dramatically shifting since its creation. This book reveals the crucial role that plants have played in determining atmospheric change - and hence the conditions on the planet we know today. Along the way a number of fascinating puzzles arise: Why did plants evolve leaves? When and how did forests once grow on Antarctica? How did prehistoric insects manage to grow so large? The answers show the extraordinary amount plants can tell us about the history of the planet -- something that has often been overlooked amongst the preoccuputations with dinosaur bones and animal fossils.David Beerling's surprising conclusions are teased out from various lines of scientific enquiry, with evidence being brought to bear from fossil plants and animals, computer models of the atmosphere, and experimental studies. Intimately bound up with the narrative describing the dynamic evolution of climate and life through Earth's history, we find Victorian fossil hunters, intrepid polar explorers and pioneering chemists, alongside wallowing hippos, belching volcanoes, and restless landmasses.

    Traveling through the dizzying expanse of geologic time—from prehistoric art in Norwegian sea caves, to the blue depths of the Greenland ice cap, to a deep-sunk "hiding place" where nuclear waste will be stored for 100,000 years to come—Underland takes us on an extraordinary journey into our relationship with darkness, burial, and what lies beneath the surface of both place and mind.Global in its geography and written with great lyricism, Underland speaks powerfully to our present moment. At once ancient and urgent, this is a book that will change the way you see the world.