Sophia Amoruso spent her teens hitchhiking, committing petty theft, and scrounging in dumpsters for leftover bagels. By age twenty-two she had dropped out of school, and was broke, directionless, and checking IDs in the lobby of an art school— a job she’d taken for the health insurance. It was in that lobby that Sophia decided to start selling vintage clothes on eBay. Flash forward ten years to today, and she’s the founder and executive chairman of Nasty Gal, a $250-million-plus fashion retailer with more than four hundred employees. Sophia was never a typical CEO, or a typical anything, and she’s written #GIRLBOSS for other girls like her: outsiders (and insiders) seeking a unique path to success, even when that path is windy as all hell and lined with naysayers. #GIRLBOSS proves that being successful isn’t about where you went to college or how popular you were in high school. It’s about trusting your instincts and following your gut; knowing which rules to follow and which to break; when to button up and when to let your freak flag fly.' to 'In the New York Times bestseller that the Washington Post called "Lean In for misfits," Sophia Amoruso shares how she went from dumpster diving to founding one of the fastest-growing retailers in the world Sophia Amoruso spent her teens hitchhiking, committing petty theft, and scrounging in dumpsters for leftover bagels. By age twenty-two she had dropped out of school, and was broke, directionless, and checking IDs in the lobby of an art school—a job she’d taken for the health insurance. It was in that lobby that Sophia decided to start selling vintage clothes on eBay. Flash forward ten years to today, and she’s the founder and executive chairman of Nasty Gal, a $250-million-plus fashion retailer with more than four hundred employees. Sophia was never a typical CEO, or a typical anything, and she’s written #GIRLBOSS for other girls like her: outsiders (and insiders) seeking a unique path to success, even when that path is windy as all hell and lined with naysayers. #GIRLBOSS proves that being successful isn’t about where you went to college or how popular you were in high school. It’s about trusting your instincts and following your gut; knowing which rules to follow and which to break; when to button up and when to let your freak flag fly.'

    It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research and now revised to reflect the growing danger of the avian flu, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the epidemics looming on our own horizon.

    Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.Then, Dr. Alexander’s own brain was attacked by a rare illness. The part of the brain that controls thought and emotion—and in essence makes us human—shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexander’s eyes popped open. He had come back.Alexander’s recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine source of the universe itself.Alexander’s story is not a fantasy. Before he underwent his journey, he could not reconcile his knowledge of neuroscience with any belief in heaven, God, or the soul. Today Alexander is a doctor who believes that true health can be achieved only when we realize that God and the soul are real and that death is not the end of personal existence but only a transition.This story would be remarkable no matter who it happened to. That it happened to Dr. Alexander makes it revolutionary. No scientist or person of faith will be able to ignore it. Reading it will change your life.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    Enduring half a dozen surgeries, the drugs he received were both miraculous and essential to his recovery. But his most profound suffering came several months later when he went into acute opioid withdrawal while following his physician’s orders. Over the course of four excruciating weeks, Rieder learned what it means to be “dope sick”—the physical and mental agony caused by opioid dependence. Clueless how to manage his opioid taper, Travis’s doctors suggested he go back on the drugs and try again later. Yet returning to pills out of fear of withdrawal is one route to full-blown addiction. Instead, Rieder continued the painful process of weaning himself.Rieder’s experience exposes a dark secret of American pain management: a healthcare system so conflicted about opioids, and so inept at managing them, that the crisis currently facing us is both unsurprising and inevitable. As he recounts his story, Rieder provides a fascinating look at the history of these drugs first invented in the 1800s, changing attitudes about pain management over the following decades, and the implementation of the pain scale at the beginning of the twenty-first century. He explores both the science of addiction and the systemic and cultural barriers we must overcome if we are to address the problem effectively in the contemporary American healthcare system.In Pain in America is not only a gripping personal account of dependence, but a groundbreaking exploration of the intractable causes of America’s opioid problem and their implications for resolving the crisis. Rieder makes clear that the opioid crisis exists against a backdrop of real, debilitating pain—and that anyone can fall victim to this epidemic.

    The child of two lawyers, they are staunchly anti-death penalty. But the moment convicted murderer Ricky Langley’s face flashes on the screen as they review old tapes—the moment they hear him speak of his crimes -- they are overcome with the feeling of wanting him to die. Shocked by their reaction, they dig deeper and deeper into the case. Despite their vastly different circumstances, something in his story is unsettlingly, uncannily familiar.Crime, even the darkest and most unsayable acts, can happen to any one of us. As Alex pores over the facts of the murder, they find themself thrust into the complicated narrative of Ricky’s childhood. And by examining the details of Ricky’s case, they are forced to face their own story, to unearth long-buried family secrets, and reckon with a past that colors their view of Ricky's crime.But another surprise awaits: They weren’t the only one who saw their life in Ricky’s.An intellectual and emotional thriller that is also a different kind of murder mystery, THE FACT OF A BODY is a book not only about how the story of one crime was constructed -- but about how we grapple with our own personal histories. Along the way it tackles questions about the nature of forgiveness, and if a single narrative can ever really contain something as definitive as the truth. This groundbreaking, heart-stopping work, ten years in the making, shows how the law is more personal than we would like to believe -- and the truth more complicated, and powerful, than we could ever imagine.

    He lifts the lid on government targets that led to poor patient care. He reveals the level of alcohol-related injuries that often bring the service to a near standstill. He shows just how bloody hard it is to look after the people who turn up at the hospital door.But he also shares the funny side - the unusual ‘accidents’ that result in with weird objects inserted in places they really should have ended up - and also the moving, tragic and heartbreaking.It really is an unforgettable read.

    With a slow chill that intensifies with each heart-pounding page, Rule describes her dawning awareness that Ted Bundy, her sensitive coworker on a crisis hotline, was one of the most prolific serial killers in America. He would confess to killing at least thirty-six young women from coast to coast, and was eventually executed for three of those cases. Drawing from their correspondence that endured until shortly before Bundy's death, and striking a seamless balance between her deeply personal perspective and her role as a crime reporter on the hunt for a savage serial killer -- the brilliant and charismatic Bundy, the man she thought she knew -- Rule changed the course of true-crime literature with this unforgettable chronicle.

    America faced a troubling question: What happened? How was this epidemic allowed to spread so far before it was taken seriously? In answering these questions, Shilts weaves the disparate threads into a coherent story, pinning down every evasion and contradiction at the highest levels of the medical, political, and media establishments. Shilts shows that the epidemic spread wildly because the federal government put budget ahead of the nation's welfare; health authorities placed political expediency before the public health; and scientists were often more concerned with international prestige than saving lives. Against this backdrop, Shilts tells the heroic stories of individuals in science and politics, public health and the gay community, who struggled to alert the nation to the enormity of the danger it faced. And the Band Played On is both a tribute to these heroic people and a stinging indictment of the institutions that failed the nation so badly.

    Lieberman illuminates how these ongoing changes have brought many benefits, but also have created novel conditions to which our bodies are not entirely adapted, resulting in a growing incidence of obesity and new but avoidable diseases, including type-2 diabetes. He proposes that many of these chronic illnesses persist and in some cases are intensifying because of "dysevolution," a pernicious dynamic whereby only the symptoms rather than the causes of these maladies are treated. And finally—provocatively—he advocates the use of evolutionary information to help nudge, push, and sometimes oblige us to create a more salubrious environment.(With charts and line drawings throughout.)From the Hardcover edition.

    She lost thirty pounds, chugged antacid, and visited doctors for three months before she was finally diagnosed with Stage IV colon cancer.As she navigates the aftermath of her diagnosis, Kate pulls the reader deeply into her life, which is populated with a colorful, often hilarious collection of friends, pastors, parents, and doctors, and shares her laser-sharp reflections on faith, friendship, love, and death. She wonders why suffering makes her feel like a loser and explores the burden of positivity. Trying to relish the time she still has with her son and husband, she realizes she must change her habit of skipping to the end and planning the next move. A historian of the "American prosperity gospel"--the creed of the mega-churches that promises believers a cure for tragedy, if they just want it badly enough--Bowler finds that, in the wake of her diagnosis, she craves these same "outrageous certainties." She wants to know why it's so hard to surrender control over that which you have no control. She contends with the terrifying fact that, even for her husband and child, she is not the lynchpin of existence, and that even without her, life will go on.On the page, Kate Bowler is warm, witty, and ruthless, and, like Paul Kalanithi, one of the talented, courageous few who can articulate the grief she feels as she contemplates her own mortality.

    We know, for example, that there are a few core truths to science of happiness. We know that being kind and altruistic makes us happy, that turning off devices, talking to people, forging relationships, living with meaning and delving into the concerns of others offer our best chance at achieving happiness. But how do we retain happiness? It often slips out of our hands as quickly as we find it. So, when we are exposed to, or learn, good things, how do we continue to burn with them?And more than that, when our world goes dark, when we're overwhelmed by illness or heartbreak, loss or pain, how do we survive, stay alive or even bloom? In the muck and grit of a daily existence full of disappointments and a disturbing lack of control over many of the things that matter most - finite relationships, fragile health, fraying economies, a planet in peril - how do we find, nurture and carry our own inner, living light - a light to ward off the darkness?Absorbing, achingly beautiful, inspiring and deeply moving, Julia Baird has written exactly the book we need for these times.

    Forever. But here’s the thing about crazy: It. Wants. Out.” In Scrappy Little Nobody, she invites readers inside her brain, sharing extraordinary and charmingly ordinary stories with candor and winningly wry observations.With her razor-sharp wit, Anna recounts the absurdities she’s experienced on her way to and from the heart of pop culture as only she can—from her unusual path to the performing arts (Vanilla Ice and baggy neon pants may have played a role) to her double life as a middle-school student who also starred on Broadway to her initial “dating experiments” (including only liking boys who didn’t like her back) to reviewing a binder full of butt doubles to her struggle to live like an adult woman instead of a perpetual “man-child.”Enter Anna’s world and follow her rise from “scrappy little nobody” to somebody who dazzles on the stage, the screen, and now the page—with an electric, singular voice, at once familiar and surprising, sharp and sweet, funny and serious (well, not that serious).

    The Sackler name adorns the walls of many storied institutions: Harvard, the Metropolitan Museum of Art, Oxford, the Louvre. They are one of the richest families in the world, known for their lavish donations to the arts and sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing OxyContin, a blockbuster painkiller that was a catalyst for the opioid crisis.Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

    A sensational disappearance that made headlines around the world. A quest for truth that leads to death, madness or disappearance for those who seek to solve it. The Lost City of Z is a blockbuster adventure narrative about what lies beneath the impenetrable jungle canopy of the Amazon.After stumbling upon a hidden trove of diaries, New Yorker writer David Grann set out to solve "the greatest exploration mystery of the 20th century": What happened to the British explorer Percy Fawcett & his quest for the Lost City of Z?In 1925, Fawcett ventured into the Amazon to find an ancient civilization, hoping to make one of the most important discoveries in history. For centuries Europeans believed the world's largest jungle concealed the glittering kingdom of El Dorado. Thousands had died looking for it, leaving many scientists convinced that the Amazon was truly inimical to humans. But Fawcett, whose daring expeditions inspired Conan Doyle's The Lost World, had spent years building his scientific case. Captivating the imagination of millions round the globe, Fawcett embarked with his 21-year-old son, determined to prove that this ancient civilisation--which he dubbed Z--existed. Then his expedition vanished. Fawcett's fate, & the tantalizing clues he left behind about Z, became an obsession for hundreds who followed him into the uncharted wilderness. For decades scientists & adventurers have searched for evidence of Fawcett's party & the lost City of Z. Countless have perished, been captured by tribes or gone mad. As Grann delved ever deeper into the mystery surrounding Fawcett's quest, & the greater mystery of what lies within the Amazon, he found himself, like the generations who preceded him, being irresistibly drawn into the jungle's green hell. His quest for the truth & discoveries about Fawcett's fate & Z form the heart of this complexly enthralling narrative.