Complications lays bare a science not in its idealized form but as it actually is--uncertain, perplexing, and profoundly human.Complications is a 2002 National Book Award Finalist for Nonfiction.

    Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

    Everything in Its Place is a celebration of Sacks's myriad interests, all told with his characteristic compassion, erudition, and luminous prose. From the celebrated case history of Spalding Gray that appeared in The New Yorker four months before his death to reflections on mental asylums; from piercing accounts of Schizophrenia to a reminiscence of Robin Williams; from the riveting tale of a medical colleague falling victim to Alzheimer's to the cinematography of Michael Powell, this volume celebrates and reflects the wondrous curiosity of Oliver Sacks.

    J. O'Rourke takes on his scariest subjects yet--business, investment, finance, and the political chicanery behind them. Want to get rich overnight for free in 3 easy steps with no risk? Then don't buy this book. (Actually, if you believe there's a book that can do that, you shouldn't buy any books because you probably can't read.) P.J.'s approach to business, investment, and finance is different. He takes the risks for you in his chapter "How I Learned Economics by Watching People Try to Kill Each Other." He proposes "A Way to Raise Taxes That We'll All Love"--a 200% tax on celebrities. He offers a brief history of economic transitions before exploring the world of high tech innovation with a chapter on "Unnovations," which asks, "The Internet--whose idea was it to put all the idiots on earth in touch with each other?" He misunderstands bitcoin, which seems "like a weird scam invented by strange geeks with weaponized slide rules in the high school Evil Math Club." He closes with a fanciful short story about the morning that P.J. wakes up and finds that all the world's goods and services are free! This is P.J. at his finest, a book not to be missed.

    They fear those things – the knife, the shipwreck, the illness, the bomb – which precede, by microseconds if you’re lucky, and many years if you’re not, the moment of death.’When Terry Pratchett was diagnosed with Alzheimer’s in his fifties he was angry - not with death but with the disease that would take him there, and with the suffering disease can cause when we are not allowed to put an end to it. In this essay, broadcast to millions as the BBC Richard Dimblebly Lecture 2010 and previously only available as part of A Slip of the Keyboard, he argues for our right to choose - our right to a good life, and a good death too.

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.

    Yet for all our advanced scientific knowledge, only one human disease – smallpox – has ever been eradicated globally.In recent years, outbreaks of Ebola and Zika have provided vivid examples of how difficult it is to contain an infection once it strikes, and the panic that a rapidly spreading epidemic can ignite. But while we chase the diseases we are already aware of, new ones are constantly emerging, initiating a new race to identify them. At the same time, antimicrobial resistance is harnessing infections that we once knew how to control, enabling them to thrive once more. Meera Senthilingam presents a timely look at humanity’s ongoing battle against infection, examining the successes and failures of the past, along with how we are confronting the challenges of today, and our chances of eradicating disease in the future.

    But it's not, perhaps, the story you expect.Gavin Francis is a GP who works in both urban and rural communities, splitting his time between Edinburgh and the islands of Orkney. When the pandemic ripped through our society he saw how it affected every walk of life: the anxious teenager, the isolated care home resident, the struggling furloughed worker and homeless ex-prisoner, all united by their vulnerability in the face of a global disaster. And he saw how the true cost of the virus was measured not just in infections, or deaths, or ITU beds, but in the consequences of the measures taken against it.In this deeply personal account of nine months spent caring for a society in crisis, Francis will take you from rural village streets to local clinics and communal city stairways. And in telling this story, he reveals others: of loneliness and hope, illness and recovery, and of what we can achieve when we care for each other.

    Psychiatrist and psychoanalyst, Norman Doidge, M.D., traveled the country to meet both the brilliant scientists championing neuroplasticity and the people whose lives they’ve transformed - people whose mental limitations or brain damage were seen as unalterable. We see a woman born with half a brain that rewired itself to work as a whole, blind people who learn to see, learning disorders cured, IQs raised, aging brains rejuvenated, stroke patients learning to speak, children with cerebral palsy learning to move with more grace, depression and anxiety disorders successfully treated, and lifelong character traits changed. Using these marvelous stories to probe mysteries of the body, emotion, love, sex, culture, and education, Dr. Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.

    The stunning rise, fall, and rescue of Wall Street in the bubble-and-bailout era was the coming-out party for the network of looters who sit at the nexus of American political and economic power. The grifter class—made up of the largest players in the financial industry and the politicians who do their bidding—has been growing in power for a generation, transferring wealth upward through increasingly complex financial mechanisms and political maneuvers. The crisis was only one terrifying manifestation of how they’ve hijacked America’s political and economic life.Rolling Stone’s Matt Taibbi here unravels the whole fiendish story, digging beyond the headlines to get into the deeper roots and wider implications of the rise of the grifters. He traces the movement’s origins to the cult of Ayn Rand and her most influential—and possibly weirdest—acolyte, Alan Greenspan, and offers fresh reporting on the backroom deals that decided the winners and losers in the government bailouts. He uncovers the hidden commodities bubble that transferred billions of dollars to Wall Street while creating food shortages around the world, and he shows how finance dominates politics, from the story of investment bankers auctioning off America’s infrastructure to an inside account of the high-stakes battle for health-care reform—a battle the true reformers lost. Finally, he tells the story of Goldman Sachs, the “vampire squid wrapped around the face of humanity.” Taibbi has combined deep sources, trailblazing reportage, and provocative analysis to create the most lucid, emotionally galvanizing, and scathingly funny account yet written of the ongoing political and financial crisis in America. This is essential reading for anyone who wants to understand the labyrinthine inner workings of politics and finance in this country, and the profound consequences for us all.

    In only a few decades, the medical system has been overrun by organizations seeking to exploit for profit the trust that vulnerable and sick Americans place in their healthcare. Our politicians have proven themselves either unwilling or incapable of reining in the increasingly outrageous costs faced by patients, and market-based solutions only seem to funnel larger and larger sums of our money into the hands of corporations. Impossibly high insurance premiums and inexplicably large bills have become facts of life; fatalism has set in. Very quickly Americans have been made to accept paying more for less. How did things get so bad so fast?Breaking down this monolithic business into the individual industries--the hospitals, doctors, insurance companies, and drug manufacturers--that together constitute our healthcare system, Rosenthal exposes the recent evolution of American medicine as never before. How did healthcare, the caring endeavor, become healthcare, the highly profitable industry? Hospital systems, which are managed by business executives, behave like predatory lenders, hounding patients and seizing their homes. Research charities are in bed with big pharmaceutical companies, which surreptitiously profit from the donations made by working people. Patients receive bills in code, from entrepreneurial doctors they never even saw.The system is in tatters, but we can fight back. Dr. Elisabeth Rosenthal doesn't just explain the symptoms, she diagnoses and treats the disease itself. In clear and practical terms, she spells out exactly how to decode medical doublespeak, avoid the pitfalls of the pharmaceuticals racket, and get the care you and your family deserve. She takes you inside the doctor-patient relationship and to hospital C-suites, explaining step-by-step the workings of a system badly lacking transparency. This is about what we can do, as individual patients, both to navigate the maze that is American healthcare and also to demand far-reaching reform. An American Sickness is the frontline defense against a healthcare system that no longer has our well-being at heart.

     Filled with stories about injuries sustained while patients were not thinking so clearly, sad tales that reveal the not-so-funny side of the emergency room, things I've learned after years of being in this position, and signs you work in the ER, this condensed book has just enough to tickle your funny bone and then make you cry.

    She documents how the low-fat nutrition advice of the past sixty years has amounted to a vast uncontrolled experiment on the entire population, with disastrous consequences for our health.For decades, we have been told that the best possible diet involves cutting back on fat, especially saturated fat, and that if we are not getting healthier or thinner it must be because we are not trying hard enough. But what if the low-fat diet is itself the problem? What if the very foods we’ve been denying ourselves—the creamy cheeses, the sizzling steaks—are themselves the key to reversing the epidemics of obesity, diabetes, and heart disease?In this captivating, vibrant, and convincing narrative, based on a nine-year-long investigation, Teicholz shows how the misinformation about saturated fats took hold in the scientific community and the public imagination, and how recent findings have overturned these beliefs. She explains why the Mediterranean Diet is not the healthiest, and how we might be replacing trans fats with something even worse. This startling history demonstrates how nutrition science has gotten it so wrong: how overzealous researchers, through a combination of ego, bias, and premature institutional consensus, have allowed dangerous misrepresentations to become dietary dogma.With eye-opening scientific rigor, The Big Fat Surprise upends the conventional wisdom about all fats with the groundbreaking claim that more, not less, dietary fat—including saturated fat—is what leads to better health and wellness. Science shows that we have been needlessly avoiding meat, cheese, whole milk, and eggs for decades and that we can now, guilt-free, welcome these delicious foods back into our lives.

    Brian Goldman is both an emergency room physician at Mount Sinai and a prominent medical journalist. Never one to shy away from controversy, Goldman specializes in kicking open the doors to the medical establishment, revealing what really goes on behind the scenes -- and in the minds of doctors and nurses.In The Night Shift, Goldman shares his experiences in the witching hours at Mount Sinai Hospital in downtown Toronto. We meet the kinds of patients who walk into an ER after midnight: late-night revellers injured on their way home after last call, teens assaulted in the streets by other teens and a woman who punches another woman out of jealousy over a man. But Goldman also reveals the emotional, heartbreaking side of everyday ER visits: adult children forced to make life and death decisions about critically ill parents, victims of sexual assault, and mentally ill and homeless patients looking for understanding and a quick fix in the twenty-four hour waiting room. Written with Goldman's trademark honesty and with surprising humour, The Night Shift is also a frank look at many issues facing the medical profession today, and offers a highly compelling inside view into an often shrouded world.

    In Ten Arguments For Deleting Your Social Media Accounts Right Now Jaron Lanier draws on his insider's expertise to explain precisely how social media works and why its cruel and dangerous effects are at the heart of its current business model and design. As well as offering ten simple arguments for liberating yourself from its addictive hold, his witty and urgent manifesto outlines a vision for an alternative that provides all the benefits of social media without the harm. nicer person in the process.