The result is this stunning memoir. Featuring 78 poems, 78 essays and intimate family photographs, Alexie shares raw, angry, funny, profane, tender memories of a childhood few can imagine--growing up dirt-poor on an Indian reservation, one of four children raised by alcoholic parents. Throughout, a portrait emerges of his mother as a beautiful, mercurial, abusive, intelligent, complicated woman. You Don't Have To Say You Love Me is a powerful account of a complicated relationship, an unflinching and unforgettable remembrance.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Now, in Love Life, he expands his scope, using stories and observations from his life in a poignant and humorous series of true tales about men and women, art and commerce, fathers and sons, addiction and recovery, and sex and love.In Love Life, you will find stories about:• Kissing Unexpectedly• The secrets they don't teach you in acting school• His great, great, great, great, great-grandfather's role in the American revolution• Parks and Recreation, Behind the Candelabra, and Californication• Trying to coach a kids' basketball team dominated by helicopter parents• The hot tub at the Playboy mansion• Starring in and producing a flop tv series• Camping at Sea World• Playing saxophone for president Bill Clinton• The first journey to college with his son• Warren Beatty• The benefits of marriageThroughout this entertaining book, you will find yourself in the presence of a master raconteur, a multi-talented performer whose love for life is as intriguing as his love life.

    When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    The daughter of immigrants, she was raised in an Oakland, California community that cared deeply about social justice; her parents--an esteemed economist from Jamaica and an admired cancer researcher from India--met as activists in the civil rights movement when they were graduate students at Berkeley. Growing up, Harris herself never hid her passion for justice, and when she became a prosecutor out of law school, a deputy district attorney, she quickly established herself as one of the most innovative change agents in American law enforcement. She progressed rapidly to become the elected District Attorney for San Francisco, and then the chief law enforcement officer of the state of California as a whole. Known for bringing a voice to the voiceless, she took on the big banks during the foreclosure crisis, winning a historic settlement for California's working families. Her hallmarks were applying a holistic, data-driven approach to many of California's thorniest issues, always eschewing stale "tough on crime" rhetoric as presenting a series of false choices. Neither "tough" nor "soft" but smart on crime became her mantra. Being smart means learning the truths that can make us better as a community, and supporting those truths with all our might. That has been the pole star that guided Harris to a transformational career as the top law enforcement official in California, and it is guiding her now as a transformational United States Senator, grappling with an array of complex issues that affect her state, our country, and the world, from health care and the new economy to immigration, national security, the opioid crisis, and accelerating inequality.By reckoning with the big challenges we face together, drawing on the hard-won wisdom and insight from her own career and the work of those who have most inspired her, Kamala Harris offers in The Truths We Hold a master class in problem-solving, in crisis management, and leadership in challenging times. Through the arc of her own life, on into the great work of our day, she communicates a vision of shared struggle, shared purpose, and shared values. In a book rich in many home truths, not least is that a relatively small number of people work very hard to convince a great many of us that we have less in common than we actually do, but it falls to us to look past them and get on with the good work of living our common truth. When we do, our shared effort will continue to sustain us and this great nation, now and in the years to come.

    Now as a chart-topping industry anomaly, he has learned to ignore the haters and make peace with his craft. The rap artist holds nothing back as he divulges the most sensitive details of his life, answers his critics, shares intimate handwritten journal entries, and powerfully models how to be a Christian in a secular age.This is the story of one man's journey to faith and freedom.

    “The days are long, but the years are short,” she realized. “Time is passing, and I’m not focusing enough on the things that really matter.” In that moment, she decided to dedicate a year to her happiness project.In this lively and compelling account, Rubin chronicles her adventures during the twelve months she spent test-driving the wisdom of the ages, current scientific research, and lessons from popular culture about how to be happier. Among other things, she found that novelty and challenge are powerful sources of happiness; that money can help buy happiness, when spent wisely; that outer order contributes to inner calm; and that the very smallest of changes can make the biggest difference.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible.Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers.With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

     “If you’re kicking yourself for not having accomplished all you should have by now, don’t worry about it. Even without any ‘big’ accomplishments yet to your name, you are enough.”   In this expansion of the 2017 commencement speech she gave at her hometown Langley High, Lauren Graham, the beloved star of Gilmore Girls and Parenthood, reflects on growing up, pursuing your dreams, and living in the here and now. “Whatever path you choose, whatever career you decide to go after, the important thing is that you keep finding joy in what you’re doing, especially when the joy isn’t finding you.” In her hilarious, relatable voice, Graham reminds us to be curious and compassionate, no matter where life takes us or what we’ve yet to achieve. Grounded and inspiring—and illustrated throughout with drawings by Graham herself—here is a comforting road map to a happy life.   “I’ve had ups and downs. I’ve had successes and senior slumps. I’ve been the girl who has the lead, and the one who wished she had the bigger part. The truth? They don’t feel that different from each other.”

    But the diversity of our philosophies, beliefs, concepts, and views about the soul often leads to confusion. To reconcile the noise that clouds spirituality, Michael Singer combines accounts of his own life journey to enlightenment—from his years as a hippie-loner to his success as a computer program engineer to his work in spiritual and humanitarian efforts—with lessons on how to put aside conflicting beliefs, let go of worries, and transform misdirected desires. Singer provides a road map to a new way of living not in the moment, but to exist in a state of perpetual happiness.

    Maybe I’ll have another five years. Maybe, with the advances in oncology, they’ll find new treatments for my cancer that will extend my life. Maybe I’ll be gone before you read this. My predicament is, well, rather unpredictable. But I’m prepared for either contingency, or at least I’m getting prepared. I have some things I’d like to take care of first, some work that needs finishing, and some people I need to see. And I want to talk to my fellow Americans a little more if I may.So writes John McCain in this inspiring, moving, frank, and deeply personal memoir. Written while confronting a mortal illness, McCain looks back with appreciation on his years in the Senate, his historic 2008 campaign for the presidency against Barack Obama, and his crusades on behalf of democracy and human rights in Eastern Europe and the Middle East.Always the fighter, McCain attacks the “spurious nationalism” and political polarization afflicting American policy. He makes an impassioned case for democratic internationalism and bi-partisanship. He tells stories of his most satisfying moments of public service, including his work with another giant of the Senate, Edward M. Kennedy. Senator McCain recalls his disagreements with several presidents, and minces no words in his objections to some of President Trump’s statements and policies. At the same time, he offers a positive vision of America that looks beyond the Trump presidency.The Restless Wave is John McCain at his best.

    The bedrock, the topsoil, and everything in between that generates the health of your local watershed. In his new book, Nick takes a humorous, inspiring, and elucidating trip to America's trails, farms, and frontier to celebrate the people, landscape, and stories, both historical and fresh, that have made it great.The seeds of this book were planted in 2019, when Nick took two memorable journeys with friends--a hiking trip to Glacier National Park with his friends Jeff Tweedy and George Saunders, as well as an extended visit to his friend James Rebanks, the author of A Shepherd's Life and English Pastoral. He followed that up with an excursion that could only have come about in 2020--Nick and his wife, Megan Mullally, bought an Airstream trailer to drive across the US in late 2020. All three journeys inspired some "deep-ish thinking from Nick, about the history and philosophy of our relationship with nature in our national parks, in our farming, and in our wildlife; what we mean when we talk about conservation; the importance of outdoor recreation; and the healthy building of both local and national communities across party lines, all subjects very close to Nick's heart.With witty, heartwarming stories, and a keen insight into the problems we all confront, this is both a ramble through and celebration of the land we all love.

    Morale had deteriorated, competition was more intense, and technology was changing faster than at any time in the company's history. "I knew there was nothing to be gained from arguing over the past," Iger writes. "The only thing that mattered was the future, and I believed I had a clear idea of the direction Disney needed to go." It came down to three clear ideas: 1) Create the highest quality content Disney could produce. 2) Embrace and adopt technology instead of fighting it. And 3) Think bigger--think global--and turn Disney into a stronger brand in international markets.Twelve years later, Disney is the largest, most respected media company in the world counting Pixar, Marvel, Lucasfilm and 21st Century Fox among its properties. Its value is nearly five times what it was when Iger took over, and Iger is recognized as one of the most innovative and successful CEOs of our time.Now, he's sharing the lessons he's learned while running Disney and leading its 200,000 employees--taking big risks in the face of historic disruption; learning to inspire the people who work for you; leading with fairness and communicating principles clearly. This book is about the relentless curiosity that has driven Iger for forty-five years, since the day he started as a studio supervisor at ABC. It's also about thoughtfulness and respect, and a decency-over-dollars approach that has become the bedrock of every project and partnership Iger pursues, from a deep friendship with Steve Jobs in his final years to an abiding love of the evolving Star Wars myth."Over the past fourteen years, I think I've learned so much about what real leadership is," Iger writes. "But I couldn't have articulated all of this until I lived it. You can't fake it--and that's one of the key lessons in this book."Librarian Note: This is an Advance Reader Copy issued with ISBN 9780399592096. That ISBN has been moved to the final published copy, found here

    Here she interweaves a personal story with the work that she loves, illuminating how, for better and worse, religious traditions have shaped how we understand ourselves; how we relate to one another; and, most importantly, how to get through the most difficult challenges we face.Drawing upon the perspectives of neurologists, anthropologists, and historians, as well as her own research, Pagels opens unexpected ways of understanding persistent religious aspects of our culture.A provocative and deeply moving account from one of the most compelling religious thinkers at work today, Why Religion? explores the spiritual dimension of human experience.