Cacioppo’s groundbreaking research topples one of the pillars of modern medicine and psychology: the focus on the individual as the unit of inquiry. By employing brain scans, monitoring blood pressure, and analyzing immune function, he demonstrates the overpowering influence of social context—a factor so strong that it can alter DNA replication. He defines an unrecognized syndrome—chronic loneliness—brings it out of the shadow of its cousin depression, and shows how this subjective sense of social isolation uniquely disrupts our perceptions, behavior, and physiology, becoming a trap that not only reinforces isolation but can also lead to early death. He gives the lie to the Hobbesian view of human nature as a “war of all against all,” and he shows how social cooperation is, in fact, humanity’s defining characteristic. Most important, he shows how we can break the trap of isolation for our benefit both as individuals and as a society.

    This edition provides increased coverage of taste and smell, circadian rhythms, brain development, and developmental disorders and includes new information on molecular mechanisms and functional brain imaging. Path of Discovery boxes, written by leading researchers, highlight major current discoveries. In addition, readers will be able to assess their knowledge of neuroanatomy with the Illustrated Guide to Human Neuroanatomy, which includes a perforated self-testing workbook.This edition's robust ancillary package includes a bound-in student CD-ROM, an Instructor's Resource CD-ROM, and resources online.

    Today, it is the most common form of officially classified mental illness. Scott Stossel gracefully guides us across the terrain of an affliction that is pervasive yet too often misunderstood. Drawing on his own long-standing battle with anxiety, Stossel presents an astonishing history, at once intimate and authoritative, of the efforts to understand the condition from medical, cultural, philosophical, and experiential perspectives. He ranges from the earliest medical reports of Galen and Hippocrates, through later observations by Robert Burton and Søren Kierkegaard, to the investigations by great nineteenth-century scientists, such as Charles Darwin, William James, and Sigmund Freud, as they began to explore its sources and causes, to the latest research by neuroscientists and geneticists. Stossel reports on famous individuals who struggled with anxiety, as well as on the afflicted generations of his own family. His portrait of anxiety reveals not only the emotion’s myriad manifestations and the anguish anxiety produces but also the countless psychotherapies, medications, and other (often outlandish) treatments that have been developed to counteract it. Stossel vividly depicts anxiety’s human toll—its crippling impact, its devastating power to paralyze—while at the same time exploring how those who suffer from it find ways to manage and control it. My Age of Anxiety is learned and empathetic, humorous and inspirational, offering the reader great insight into the biological, cultural, and environmental factors that contribute to the affliction.

    Veterans and their families deal with the painful aftermath of combat; one in five Americans has been molested; one in four grew up with alcoholics; one in three couples have engaged in physical violence. Such experiences inevitably leave traces on minds, emotions, and even on biology. Sadly, trauma sufferers frequently pass on their stress to their partners and children. Renowned trauma expert Bessel van der Kolk has spent over three decades working with survivors. In The Body Keeps the Score, he transforms our understanding of traumatic stress, revealing how it literally rearranges the brain’s wiring—specifically areas dedicated to pleasure, engagement, control, and trust. He shows how these areas can be reactivated through innovative treatments including neurofeedback, mindfulness techniques, play, yoga, and other therapies. Based on Dr. van der Kolk’s own research and that of other leading specialists, The Body Keeps the Score offers proven alternatives to drugs and talk therapy—and a way to reclaim lives.

    From Edward Lorenz’s discovery of the Butterfly Effect, to Mitchell Feigenbaum’s calculation of a universal constant, to Benoit Mandelbrot’s concept of fractals, which created a new geometry of nature, Gleick’s engaging narrative focuses on the key figures whose genius converged to chart an innovative direction for science. In Chaos, Gleick makes the story of chaos theory not only fascinating but also accessible to beginners, and opens our eyes to a surprising new view of the universe.

    This engaging book--part scientific overview, part memoir, part futurist speculation--describes Koch's search for an empirical explanation for consciousness. Koch recounts not only the birth of the modern science of consciousness but also the subterranean motivation for his quest--his instinctual (if "romantic") belief that life is meaningful.Koch describes his own groundbreaking work with Francis Crick in the 1990s and 2000s and the gradual emergence of consciousness (once considered a "fringy" subject) as a legitimate topic for scientific investigation. Present at this paradigm shift were Koch and a handful of colleagues, including Ned Block, David Chalmers, Stanislas Dehaene, Giulio Tononi, Wolf Singer, and others. Aiding and abetting it were new techniques to listen in on the activity of individual nerve cells, clinical studies, and brain-imaging technologies that allowed safe and noninvasive study of the human brain in action.Koch gives us stories from the front lines of modern research into the neurobiology of consciousness as well as his own reflections on a variety of topics, including the distinction between attention and awareness, the unconscious, how neurons respond to Homer Simpson, the physics and biology of free will, dogs, Der Ring des Nibelungen, sentient machines, the loss of his belief in a personal God, and sadness. All of them are signposts in the pursuit of his life's work--to uncover the roots of consciousness.

    The information is stuck on the tip of your tongue. It's an experience so frustrating that it seems like it must be a brain malfunction. In fact, it's actually a hallmark of our greatest power: self-awareness. As cognitive neuroscientist Stephen M. Fleming shows in Know Thyself,self-awareness shapes our intelligence, memory, and conscious experience. It's integral to how we teach and learn. We use it every time we weigh difficult questions, such as assessing how we'd respond in a crisis. Drawing on psychology and neuroscience, Fleming provides deep insight into how self-awareness works, and how we can enhance our ability to know our strengths and weaknesses. In the end, this book isn'tjust about psychology: it's about the science of human excellence.

    However, with advances in neurobiology and neuroscience, researchers are demonstrating that this position is wrong as they move closer to a lasting understanding of the biology and psychology of emotion. In Affective Neuroscience, Jaak Panksepp provides the most up-to-date information about the brain-operating systems that organize the fundamental emotional tendencies of all mammals. Presenting complex material in a readable manner, the book offers a comprehensive summary of the fundamental neural sources of human and animal feelings, as well as a conceptual framework for studying emotional systems of the brain. Panksepp approaches emotions from the perspective of basic emotion theory but does not fail to address the complex issues raised by constructionist approaches. These issues include relations to human consciousness and the psychiatric implications of this knowledge. The book includes chapters on sleep and arousal, pleasure and fear systems, the sources of rage and anger, and the neural control of sexuality, as well as the more subtle emotions related to maternal care, social loss, and playfulness. Representing a synthetic integration of vast amounts of neurobehavioral knowledge, including relevant neuroanatomy, neurophysiology, and neurochemistry, this book will be one of the most important contributions to understanding the biology of emotions since Darwins The Expression of the Emotions in Man and Animals.

    The lectures lead a startling voyage into the human mind, explaining not only how the various aspects of your memory operate, but the impact memory has on your daily experience of life.The various memory systems provide the continuity of consciousness that allows the concept of "you" to make sense, creating the ongoing narrative that makes your life truly yours. Without those systems and the overall experience of memory they make possible, you would have no context for the most crucial decisions of your life. You would have to make—without the benefit of experience and knowledge—the decisions that determine not only your quality of life, but your very survival. And your ability to learn, or even to form the personality that makes you unique, would similarly be set adrift.Course Lecture Titles24 Lectures, 30 minutes per lecture 1.Memory Is a PartyUsing the metaphor of a party whose “guests” include the different components of the complex interactions that make up memory, Professor Joordens introduces you to several kinds of memory—including episodic, semantic, and procedural—to arrive at an initial understanding of the variety of processes at work in human “memory.”2. The Ancient “Art of Memory”Techniques to embed and retrieve memories more easily—so-called mnemonic strategies—date back at least to classical Greece. See how one such technique—the Method of Loci—can help improve the episodic memory you depend on to recall a group of items such as grocery or to-do lists.3. Rote Memorization and a Science of ForgettingIs a mnemonic strategy always the most useful? Examine rote memorization and how it differs from mnemonics. Also, get an introduction to the work of Hermann Ebbinghaus, whose 19th-century experiments in remembering and forgetting marked the first scientific examination of memory.4. Sensory Memory—Brief Traces of the PastBegin a deeper discussion of the different kinds of memory, beginning with sensory memory and how its brief retentive power lets you switch from one stimulus to another—and even gives you your sense of “the present moment.” Here, the focus is on iconic (or visual) memory and its auditory counterpart, echoic memory.5. The Conveyor Belt of Working MemoryPlunge into the mental processes that allow you to work with information, often with the goal of solving a problem. You learn that these processes can also be used to keep information briefly “in mind,” though they require effort and are prone to interference.6. Encoding—Our Gateway into Long-Term MemoryHow does information make its way from your temporary working memory into long-term memory so you can access it again when you need it? This introduction to encoding explains the process and offers useful tips for improving your own recall.7. Episodic and Semantic Long-Term MemoryStrengthen your grasp of how these two key memory systems function. You explore the relationship between them with analogies that range from the job requirements of London taxi drivers to the famed “holo-deck” of the Star Trek television series.8. The Secret Passage—Implicit MemoryEncounter still another category of memory—a way in which your experiences can enter long-term memory without the kind of “effortful encoding” discussed earlier. You learn why this sort of memory creation is vitally important, yet also unreliable as a substitute for conscious effort.9. From Procedural Memory to HabitIn this lecture, you see that your memory for procedures is useful not only in the “muscle memory” of physical skills, but also in cognitive processes. Also, learn about constructivist learning, in which the explicit structure of a procedure—which is usually taught verbally—instead is learned implicitly during exploratory practice.10. When Memory Systems Battle—Habits vs. GoalsWhat happens when implicit or procedural memories become so powerful they seize control? In this examination of the tenacity of habits, learn how and why habits are formed and what steps might be useful in changing them, or at least regaining control.11. Sleep and the Consolidation of MemoriesDoes sleep play a role in strengthening memories of your experiences during the day? Gain a sense of the latest research about a subject that is difficult to study as you explore the relationship between sleep and memory, including the possible link between specific sleep stages and specific kinds of memory.12. Infant and Early Childhood MemoryHow does the maturation of memory fit into a child’s overall brain development? Gain invaluable and surprising insights into the month-by-month and year-by-year development of a child’s capacity for memory, beginning in the womb and continuing on with its dramatic development after entry into the world.13. Animal Cognition and MemoryDoes an elephant really never forget? Expand your study of memory to investigate the extent to which the mysterious abilities of humans may also exist in animals and, if so, how they might differ from our own.14. Mapping Memory in the BrainAlmost two decades since its revolutionary appearance, fMRI—functional magnetic resonance imaging—is allowing researchers to watch the living human brain at work, with no harm or discomfort to the subject. Explore what happens in several areas of the brain as memories are created or retrieved.15. Neural Network ModelsCan computer models mimic the operations of the human brain? Examine the use of neural network modeling, in which biologically inspired models posited by researchers in cognitive neuroscience are advancing our understanding of just how those operations take place.16. Learning from Brain Damage and AmnesiasLeave the world of computers for that of neuropsychology as you focus on the life situations of several patients who have suffered some form of brain injury. You learn how damage to different areas of the brain can have dramatically different impacts on memory and how these patients experience the world.17. The Many Challenges of Alzheimer’s DiseaseIn a lecture that explores one of our most frightening diseases from both the caregiver’s and sufferer’s perspectives, learn how Alzheimer’s progresses, how that progression may be forestalled, and ways in which technology may be able to help through the emerging field of “cognitive prosthetics.”18. That Powerful Glow of Warm FamiliarityWhy does something familiar to us actually feel that way? Discover the sources of familiarity as you are introduced to the concepts of perceptual fluency and prototypes, and explore some surprising ways that those feelings of familiarity can trump other considerations.19. Déjà Vu and the Illusion of MemoryIs déjà vu simply an illusion of memory? If so, can we learn more about memory by trying to understand how this common phenomenon comes about? Examine some of the theories that have 20. Recovered Memories or False Memories?Is episodic memory subject to the same pitfalls as misattributed feelings of familiarity? Can we “remember” things that never took place with the same intensity and certainty as those that did? Gain new insights into what is at stake when long-forgotten “memories” resurface.21. Mind the Gaps! Memory as ReconstructionMetaphors for memory usually reference information storehouses of some kind, such as library stacks or computer hard drives, from which episodic memories are “retrieved.” Learn about the extent to which we actually construct our memories anew each time we summon them and how this explains common memory errors.22. How We Choose What's Important to RememberDoes our brain always make decisions for us about which aspects of our experience to encode for later recall, or can we influence that process ourselves? Learn potentially powerful techniques for influencing the shape of future memories.23. Aging, Memory, and Cognitive TransitionApply a reality check to the popularly held belief that memory naturally declines as we age. Learn what happened when a researcher corrected for the age-related variables long-ignored by traditional testers—and what conclusions we can draw about what lies ahead for us as we grow older.24. The Monster at the End of the BookContemplate the significance of what you’ve learned, with special attention to the common question of whether you can improve your episodic memory—remembering what you want to recall, forgetting what you’d rather not, and making choices about how to achieve a balance.

    But over the past decade, a wave of dramatic findings in the cutting-edge science of endurance has completely overturned our understanding of human limitation. Endure widely disseminates these findings for the first time: It’s the brain that dictates how far we can go—which means we can always push ourselves further.Hutchinson presents an overview of science’s search for understanding human fatigue, from crude experiments with electricity and frogs’ legs to sophisticated brain imaging technology. Going beyond the traditional mechanical view of human limits (like a car with a brick on its gas pedal, we go until the tank runs out of gas), he instead argues that a key element in endurance is how the brain responds to distress signals—whether heat, or cold, or muscles screaming with lactic acid—and reveals that we can train to improve brain response.An elite distance runner himself, Hutchinson takes us to the forefront of the new sports psychology—brain electrode jolts, computer-based training, subliminal messaging—and presents startling new discoveries enhancing the performance of athletes today and shows how anyone can utilize these tactics to bolster their own performance—and get the most out of their bodies.

    In The Ego Tunnel, philosopher Thomas Metzinger claims otherwise: No such thing as a self exists. The conscious self is the content of a model created by our brain—an internal image, but one we cannot experience as an image. Everything we experience is “a virtual self in a virtual reality.”But if the self is not “real,” why and how did it evolve? How does the brain construct it? Do we still have souls, free will, personal autonomy, or moral accountability? In a time when the science of cognition is becoming as controversial as evolution, The Ego Tunnel provides a stunningly original take on the mystery of the mind.

    Drawing on his breakthrough research in comparative neuroscience, Terrence Deacon offers a wealth of insights into the significance of symbolic thinking: from the co-evolutionary exchange between language and brains over two million years of hominid evolution to the ethical repercussions that followed man's newfound access to other people's thoughts and emotions.Informing these insights is a new understanding of how Darwinian processes underlie the brain's development and function as well as its evolution. In contrast to much contemporary neuroscience that treats the brain as no more or less than a computer, Deacon provides a new clarity of vision into the mechanism of mind. It injects a renewed sense of adventure into the experience of being human.

     Her pioneering research on how the chemicals inside our bodies form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. By establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way, Pert empowers us to understand ourselves, our feelings, and the connection between our minds and our bodies -- body-minds -- in ways we could never possibly have imagined before. Molecules of Emotion is a landmark work, full of insight and wisdom and possessing that rare power to change the way we see the world and ourselves.

    One of the greatest partnerships in the history of science, Kahneman and Tversky’s extraordinary friendship incited a revolution in Big Data studies, advanced evidence-based medicine, led to a new approach to government regulation, and made much of Michael Lewis’s own work possible. In The Undoing Project, Lewis shows how their Nobel Prize–winning theory of the mind altered our perception of reality.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.