On the morning of October 1, 1910, the walls of the Los Angeles Times Building buckled as a thunderous detonation sent men, machinery, and mortar rocketing into the night air. When at last the wreckage had been sifted and the hospital triage units consulted, twenty-one people were declared dead and dozens more injured. But as it turned out, this was just a prelude to the devastation that was to come.In American Lightning, acclaimed author Howard Blum masterfully evokes the incredible circumstances that led to the original “crime of the century”—and an aftermath more dramatic than even the crime itself. With smoke still wafting up from the charred ruins, the city’s mayor reacts with undisguised excitement when he learns of the arrival, only that morning, of America’s greatest detective, William J. Burns, a former Secret Service man who has been likened to Sherlock Holmes. Surely Burns, already world famous for cracking unsolvable crimes and for his elaborate disguises, can run the perpetrators to ground. Through the work of many months, snowbound stakeouts, and brilliant forensic sleuthing, the great investigator finally identifies the men he believes are responsible for so much destruction. Stunningly, Burns accuses the men—labor activists with an apparent grudge against the Los Angeles Times’s fiercely anti-union owner—of not just one heinous deed but of being part of a terror wave involving hundreds of bombings. While preparation is laid for America’s highest profile trial ever—and the forces of labor and capital wage hand-to-hand combat in the streets—two other notable figures are swept into the drama: industry-shaping filmmaker D.W. Griffith, who perceives in these events the possibility of great art and who will go on to alchemize his observations into the landmark film The Birth of a Nation; and crusading lawyer Clarence Darrow, committed to lend his eloquence to the defendants, though he will be driven to thoughts of suicide before events have fully played out.Simultaneously offering the absorbing reading experience of a can’t-put-it-down thriller and the perception-altering resonance of a story whose reverberations continue even today, American Lightning is a masterpiece of narrative nonfiction.

    He was bound for a New Jersey dueling ground to settle his bitter dispute with Aaron Burr. Hamilton took just two men with him: his “second” for the duel, and Dr. David Hosack.As historian Victoria Johnson reveals in her groundbreaking biography, Hosack was one of the few points the duelists did agree on. Summoned that morning because of his role as the beloved Hamilton family doctor, he was also a close friend of Burr. A brilliant surgeon and a world-class botanist, Hosack—who until now has been lost in the fog of history—was a pioneering thinker who shaped a young nation.Born in New York City, he was educated in Europe and returned to America inspired by his newfound knowledge. He assembled a plant collection so spectacular and diverse that it amazes botanists today, conducted some of the first pharmaceutical research in the United States, and introduced new surgeries to American. His tireless work championing public health and science earned him national fame and praise from the likes of Thomas Jefferson, James Madison, Alexander von Humboldt, and the Marquis de Lafayette.One goal drove Hosack above all others: to build the Republic’s first botanical garden. Despite innumerable obstacles and near-constant resistance, Hosack triumphed when, by 1810, his Elgin Botanic Garden at last crowned twenty acres of Manhattan farmland. “Where others saw real estate and power, Hosack saw the landscape as a pharmacopoeia able to bring medicine into the modern age” (Eric W. Sanderson, author of Mannahatta). Today what remains of America’s first botanical garden lies in the heart of midtown, buried beneath Rockefeller Center.Whether collecting specimens along the banks of the Hudson River, lecturing before a class of rapt medical students, or breaking the fever of a young Philip Hamilton, David Hosack was an American visionary who has been too long forgotten. Alongside other towering figures of the post-Revolutionary generation, he took the reins of a nation. In unearthing the dramatic story of his life, Johnson offers a lush depiction of the man who gave a new voice to the powers and perils of nature.

    As a result, antibiotic resistance now ranks among the gravest medical problems of modern times. Good Germs, Bad Germs addresses not only this issue but also what has become known as the "hygiene hypothesis"-- an argument that links the over-sanitation of modern life to now-epidemic increases in immune and other disorders. In telling the story of what went terribly wrong in our war on germs, Jessica Snyder Sachs explores our emerging understanding of the symbiotic relationship between the human body and its resident microbes--which outnumber its human cells by a factor of nine to one! The book also offers a hopeful look into a future in which antibiotics will be designed and used more wisely, and beyond that, to a day when we may replace antibacterial drugs and cleansers with bacterial ones--each custom-designed for maximum health benefits.

    What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

    Jonathan Eig's masterful narrative revolves around four principal characters: the fiery feminist Margaret Sanger, who was a champion of birth control in her campaign for the rights of women but neglected her own children in pursuit of free love; the beautiful Katharine McCormick, who owed her fortune to her wealthy husband, the son of the founder of International Harvester and a schizophrenic; the visionary scientist Gregory Pincus, who was dismissed by Harvard in the 1930s as a result of his experimentation with in vitro fertilization but who, after he was approached by Sanger and McCormick, grew obsessed with the idea of inventing a drug that could stop ovulation; and the telegenic John Rock, a Catholic doctor from Boston who battled his own church to become an enormously effective advocate in the effort to win public approval for the drug that would be marketed by Searle as Enovid.Spanning the years from Sanger’s heady Greenwich Village days in the early twentieth century to trial tests in Puerto Rico in the 1950s to the cusp of the sexual revolution in the 1960s, this is a grand story of radical feminist politics, scientific ingenuity, establishment opposition, and, ultimately, a sea change in social attitudes. Brilliantly researched and briskly written, The Birth of the Pill is gripping social, cultural, and scientific history.

    Lucy Worsley takes us through the bedroom, bathroom, living room and kitchen, covering the architectural history of each room, but concentrating on what people actually did in bed, in the bath, at the table, and at the stove.

    Poisons permeate our world. They are in the environment, the workplace, the home. They are in food, our favorite whiskey, medicine, well water. They have been used to cure disease as well as to incapacitate and kill. They smooth wrinkles, block pain, stimulate, and enhance athletic ability. In this entertaining and fact-filled book, science writer Peter Macinnis considers poisons in all their aspects. He recounts stories of the celebrated poisoners in history and literature, from Nero to Thomas Wainewright, and from the death of Socrates to Hamlet and Peter Pan. He discusses the sources of various poisons-from cyanide to strychnine, from Botox to ricin and Sarin gas-as well as their detection. Then he analyzes the science of their action in the body and their uses in medicine, cosmetics, war, and terrorism. With wit and precision, he weighs such questions as: Was Lincoln's volatility caused by mercury poisoning? Was Jack the Ripper an arsenic eater? Can wallpaper kill? For anyone who has ever wondered and been afraid to ask, here is a rich miscellany for your secret questions about toxins.

    Regularly, repeatedly, and with impunity, queens like Hatshepsut, Nefertiti, and Cleopatra controlled the totalitarian state as power-brokers and rulers. But throughout human history, women in positions of power were more often used as political pawns in a male-dominated society. What was so special about ancient Egypt that provided women this kind of access to the highest political office? What was it about these women that allowed them to transcend patriarchal obstacles? What did Egypt gain from its liberal reliance on female leadership, and could today's world learn from its example?Celebrated Egyptologist Kara Cooney delivers a fascinating tale of female power, exploring the reasons why it has seldom been allowed through the ages, and why we should care.

    Even Isaac Cline, resident meteorologist for the U.S. Weather Bureau failed to grasp the true meaning of the strange deep-sea swells and peculiar winds that greeted the city that morning. Mere hours later, Galveston found itself submerged in a monster hurricane that completely destroyed the town and killed over six thousand people in what remains the greatest natural disaster in American history--and Isaac Cline found himself the victim of a devastating personal tragedy.Using Cline's own telegrams, letters, and reports, the testimony of scores of survivors, and our latest understanding of the science of hurricanes, Erik Larson builds a chronicle of one man's heroic struggle and fatal miscalculation in the face of a storm of unimaginable magnitude. Riveting, powerful, and unbearably suspenseful, Isaac's Storm is the story of what can happen when human arrogance meets the great uncontrollable force of nature.

    An Edible History of Humanity is a pithy, entertaining account of how a series of changes—caused, enabled, or influenced by food—has helped to shape and transform societies around the world. The first civilizations were built on barley and wheat in the Near East, millet and rice in Asia, and corn and potatoes in the Americas. Why farming created a strictly ordered social hierarchy in contrast to the loose egalitarianism of hunter-gatherers is, as Tom Standage reveals, as interesting as the details of the complex cultures that emerged, eventually interconnected by commerce. Trade in exotic spices in particular spawned the age of exploration and the colonization of the New World. Food's influence over the course of history has been just as prevalent in modern times. In the late eighteenth century, Britain's solution to food shortages was to industrialize and import food rather than grow it. Food helped to determine the outcome of wars: Napoleon's rise and fall was intimately connected with his ability to feed his vast armies. In the twentieth century, Communist leaders employed food as an ideological weapon, resulting in the death by starvation of millions in the Soviet Union and China. And today the foods we choose in the supermarket connect us to global debates about trade, development, the environment, and the adoption of new technologies. Encompassing many fields, from genetics and archaeology to anthropology and economics—and invoking food as a special form of technology—An Edible History of Humanity is a fully satisfying discourse on the sweep of human history.

    She was repeatedly hospitalized in excruciating pain, but the doctors insisted it was a urinary tract infection and sent her home with antibiotics. Unable to get out of bed, much less attend class, Norman dropped out of college and embarked on what would become a years-long journey to discover what was wrong with her. It wasn't until she took matters into her own hands--securing a job in a hospital and educating herself over lunchtime reading in the medical library--that she found an accurate diagnosis of endometriosis.In Ask Me About My Uterus, Norman describes what it was like to have her pain dismissed, to be told it was all in her head, only to be taken seriously when she was accompanied by a boyfriend who confirmed that her sexual performance was, indeed, compromised. Putting her own trials into a broader historical, sociocultural, and political context, Norman shows that women's bodies have long been the battleground of a never-ending war for power, control, medical knowledge, and truth. It's time to refute the belief that being a woman is a preexisting condition.

    In Four Lost Cities, acclaimed science journalist Annalee Newitz takes readers on an entertaining and mind-bending adventure into the deep history of urban life. Investigating across the centuries and around the world, Newitz explores the rise and fall of four ancient cities, each the center of a sophisticated civilization: the Neolithic site of Çatalhöyük in Central Turkey, the Roman vacation town of Pompeii on Italy’s southern coast, the medieval megacity of Angkor in Cambodia, and the indigenous metropolis Cahokia, which stood beside the Mississippi River where East St. Louis is today.Newitz travels to all four sites and investigates the cutting-edge research in archaeology, revealing the mix of environmental changes and political turmoil that doomed these ancient settlements. Tracing the early development of urban planning, Newitz also introduces us to the often anonymous workers—slaves, women, immigrants, and manual laborers—who built these cities and created monuments that lasted millennia.Four Lost Cities is a journey into the forgotten past, but, foreseeing a future in which the majority of people on Earth will be living in cities, it may also reveal something of our own fate.

    When Theodore Roosevelt became president in 1901, his beautiful and flamboyant daughter was transformed into "Princess Alice," arguably the century's first global celebrity. Thirty-two years later, her first cousin Eleanor moved into the White House as First Lady. Born eight months and twenty blocks apart from each other in New York City, Eleanor and Alice spent a large part of their childhoods together and were far more alike than most historians acknowledge. But their politics and temperaments couldn't have been more distinct. Do-gooder Eleanor was committed to social justice but hated the limelight; acid-tongued Alice, who became the wife of philandering Republican congressman Nicholas Longworth, was an opponent of big government who gained notoriety for her cutting remarks (she famously quipped that dour President Coolidge “looked like he was weaned on a pickle”). While Eleanor revolutionized the role of First Lady with her outspoken passion for human rights, Alice made the most of her insider connections to influence politics, including doing as much to defeat the League of Nations as anyone in elective office.The cousins themselves liked to play up their oil-and-water relationship. “When I think of Frank and Eleanor in the White House I could grind my teeth to powder and blow them out my nose,” Alice once said. In the 1930s they even wrote opposing syndicated newspaper columns and embarked on competing nationwide speaking tours. Blood may be thicker than water, but when the family business is politics, winning trumps everything.Vivid, intimate, and stylishly written, Hissing Cousins finally sets this relationship center stage, revealing the contentious bond between two political trailblazers who short-circuited the rules of gender and power, each in her own way.

    In this narrative, readers experience The Great Hurricane of 1938, the most financially destructive storm on record.

    Moving up the Mississippi River in the late summer, in the span of just a few months the fever killed more than eighteen thousand people. The city of Memphis, Tennessee, was particularly hard hit: Of the approximately twenty thousand who didn’t flee the city, seventeen thousand contracted the fever, and more than five thousand died—the equivalent of a million New Yorkers dying in an epidemic today.Fever Season chronicles the drama in Memphis from the outbreak in August until the disease ran its course in late October. The story that Jeanette Keith uncovered is a profound–and never more relevant–account of how a catastrophe inspired reactions both heroic and cowardly. Some ministers, politicians, and police fled their constituents, while prostitutes and the poor risked their lives to nurse the sick. Using the vivid, anguished accounts and diaries of those who chose to stay and those who were left behind, Fever Season depicts the events of that summer and fall. In its pages we meet people of great courage and compassion, many of whom died for having those virtues. We also learn how a disaster can shape the future of a city.