She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    Water pours from the faucet in crystalline patterns, numbers call to mind distinct geometric shapes, and intricate fractal patterns emerge from the movement of tree branches, revealing the intrinsic mathematical designs hidden in the objects around us.Yet Padgett wasn’t born this way. Twelve years ago, he had never made it past pre-algebra. But a violent mugging forever altered the way his brain works, giving him unique gifts. His ability to understand math and physics skyrocketed, and he developed the astonishing ability to draw the complex geometric shapes he saw everywhere. His stunning, mathematically precise artwork illustrates his intuitive understanding of complex mathematics.The first documented case of acquired savant syndrome with mathematical synesthesia, Padgett is a medical marvel. Struck by Genius recounts how he overcame huge setbacks and embraced his new mind. Along the way he fell in love, found joy in numbers, and spent plenty of time having his head examined. Like Born on a Blue Day and My Stroke of Insight, his singular story reveals the wondrous potential of the human brain.www.struckbygenius.com

    They always keep a bag packed. They seldom have more than twenty-four hours' notice before they are dispatched. The phone calls that tell them to head to the airport, sometimes in the middle of the night, may give them no more information than the country they are traveling to and the epidemic they will tackle when they get there.The universal human instinct is to run from an outbreak of disease. These doctors run toward it.They are the disease detective corps of the U.S. Centers for Disease Control and Prevention (CDC), the federal agency that tracks and tries to prevent disease outbreaks and bioterrorist attacks around the world. They are formally called the Epidemic Intelligence Service (EIS) -- a group founded more than fifty years ago out of fear that the Korean War might bring the use of biological weapons -- and, like intelligence operatives in the traditional sense, they perform their work largely in anonymity. They are not household names, but over the years they were first to confront the outbreaks that became known as hantavirus, Ebola virus, and AIDS. Now they hunt down the deadly threats that dominate our headlines: West Nile virus, anthrax, and SARS.In this riveting narrative, Maryn McKenna -- the only journalist ever given full access to the EIS in its fifty-three-year history -- follows the first class of disease detectives to come to the CDC after September 11, the first to confront not just naturally occurring outbreaks but the man-made threat of bioterrorism. They are talented researchers -- many with young families -- who trade two years of low pay and extremely long hours for the chance to be part of the group that has helped eradicate smallpox, push back polio, and solve the first major outbreaks of Legionnaires' disease, toxic shock syndrome, and "E. coli" O157.Urgent, exhilarating, and compelling, "Beating Back the Devil" goes with the EIS as they try to stop epidemics -- before the epidemics stop us.

    Homesick—why? She was standing right in her own kitchen. She felt homesick, she realized, with love for home itself. “Of all the elements of a happy life,” she thought, “my home is the most important.” In a flash, she decided to undertake a new happiness project, and this time, to focus on home.And what did she want from her home? A place that calmed her, and energized her. A place that, by making her feel safe, would free her to take risks. Also, while Rubin wanted to be happier at home, she wanted to appreciate how much happiness was there already. So, starting in September (the new January), Rubin dedicated a school year—September through May—to making her home a place of greater simplicity, comfort, and love.  In The Happiness Project, she worked out general theories of happiness. Here she goes deeper on factors that matter for home, such as possessions, marriage, time, and parenthood. How can she control the cubicle in her pocket? How might she spotlight her family’s treasured possessions? And it really was time to replace that dud toaster. Each month, Rubin tackles a different theme as she experiments with concrete, manageable resolutions—and this time, she coaxes her family to try some resolutions, as well.  With her signature blend of memoir, science, philosophy, and experimentation, Rubin’s passion for her subject jumps off the page, and reading just a few chapters of this book will inspire readers to find more happiness in their own lives.

    It left him sleepless, crippled, wracked with pain--a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which according to CDC definitions does not actually exist: the chronic form of Lyme disease, a hotly contested condition that devastates the lives of tens of thousands of people but has no official recognition--and no medically approved cure.From a rural dream house that now felt like a prison, Douthat's search for help takes him off the map of official medicine, into territory where cranks and conspiracies abound and patients are forced to take control of their own treatment and experiment on themselves. Slowly, against his instincts and assumptions, he realizes that many of the cranks and weirdos are right, that many supposed hypochondriacs are victims of an indifferent medical establishment, and that all kinds of unexpected experiences and revelations lurk beneath the surface of normal existence, in the places underneath.The Deep Places is a story about what happens when you are terribly sick and realize that even the doctors who are willing to treat you can only do so much. Along the way, Douthat describes his struggle back toward health with wit and candor, portraying sickness as the most terrible of gifts. It teaches you to appreciate the grace of ordinary life by taking that life away from you. It reveals the deep strangeness of the world, the possibility that the reasonable people might be wrong, and the necessity of figuring out things for yourself. And it proves, day by dreadful day, that you are stronger than you ever imagined, and that even in the depths there is always hope.

    In the aftermath of that critical moment, his once-carefree life would be consumed by confrontations with medical incompetence, discrimination that almost cost him his education and employment, physical abuse, and dark moments when he contemplated suicide.This is the story of one man's battle to pursue his dreams despite an often incapacitating brain disorder. From his early experiences of fear and denial to his exasperating search for treatment, Eichenwald provides a deeply candid account of his years facing this misunderstood and often stigmatized condition. He details his encounters with the doctors whose negligence could have killed him, but for the heroic actions of a brilliant neurologist and the family and friends who fought for him.Many of Eichenwald's recollections are drawn from his diaries, vivid and painstakingly kept records that helped sharpen his skills as a journalist. He raises important questions about the nature of memory, the revelations of brain science, and the profound mysteries of human perception.Ultimately, A Mind Unraveled is an inspirational story, one that chronicles how Eichenwald, faced often with his own mortality, transformed trauma into a guide for reaching the future he desired. Defying relentless threats to his emotional and physical well-being, he affirmed his decision to never give up, and in the process learned how to rise from the depths of despair to the heights of unimagined success.

    By 1988 she was living at home but was brain dead after a tragic cycle of misunderstanding, over-medication, and culture clash: "What the doctors viewed as clinical efficiency the Hmong viewed as frosty arrogance." The Spirit Catches You and You Fall Down is a tragedy of Shakespearean dimensions, written with the deepest of human feeling. Sherwin Nuland said of the account, "There are no villains in Fadiman's tale, just as there are no heroes. People are presented as she saw them, in their humility and their frailty—and their nobility.

    Just twelve, she’s tall, skinny, and weak. It’s four o’clock, and she hasn’t been allowed to eat anything all day. Her mother, on the other hand, seems curiously excited. She's about to suggest open-heart surgery on her child to "get to the bottom of this." She checks her teeth for lipstick and, as the doctor enters, shoots the girl a warning glance. This child will not ruin her plans.SickenedFrom early childhood, Julie Gregory was continually X-rayed, medicated, and operated on—in the vain pursuit of an illness that was created in her mother’s mind. Munchausen by proxy (MBP) is the world’s most hidden and dangerous form of child abuse, in which the caretaker—almost always the mother—invents or induces symptoms in her child because she craves the attention of medical professionals. Many MBP children die, but Julie Gregory not only survived, she escaped the powerful orbit of her mother's madness and rebuilt her identity as a vibrant, healthy young woman.Sickened is a remarkable memoir that speaks in an original and distinctive Midwestern voice, rising to indelible scenes in prose of scathing beauty and fierce humor. Punctuated with Julie's actual medical records, it re-creates the bizarre cocoon of her family's isolated double-wide trailer, their wild shopping sprees and gun-waving confrontations, the astonishing naïveté of medical professionals and social workers. It also exposes the twisted bonds of terror and love that roped Julie's family together—including the love that made a child willing to sacrifice herself to win her mother's happiness. The realization that the sickness lay in her mother, not in herself, would not come to Julie until adulthood. But when it did, it would strike like lightning. Through her painful metamorphosis, she discovered the courage to save her own life—and, ultimately, the life of the girl her mother had found to replace her. Sickened takes us to new places in the human heart and spirit. It is an unforgettable story, unforgettably told.

    The heart of her work on her national public radio program and podcast, On Being, has been to shine a light on people whose insights kindle in us a sense of wonder and courage. Scientists in a variety of fields; theologians from an array of faiths; poets, activists, and many others have all opened themselves up to Tippett's compassionate yet searching conversation.   In Becoming Wise, Tippett distills the insights she has gleaned from this luminous conversation in its many dimensions into a coherent narrative journey, over time and from mind to mind. The book is a master class in living, curated by Tippett and accompanied by a delightfully ecumenical dream team of teaching faculty.   The open questions and challenges of our time are intimate and civilizational all at once, Tippett says – definitions of when life begins and when death happens, of the meaning of community and family and identity, of our relationships to technology and through technology. The wisdom we seek emerges through the raw materials of the everyday. And the enduring question of what it means to be human has now become inextricable from the question of who we are to each other.   This book offers a grounded and fiercely hopeful vision of humanity for this century – of personal growth but also renewed public life and human spiritual evolution. It insists on the possibility of a common life for this century marked by resilience and redemption, with beauty as a core moral value and civility and love as muscular practice. Krista Tippett's great gift, in her work and in Becoming Wise, is to avoid reductive simplifications but still find the golden threads that weave people and ideas together into a shimmering braid.   One powerful common denominator of the lessons imparted to Tippett is the gift of presence, of the exhilaration of engagement with life for its own sake, not as a means to an end. But presence does not mean passivity or acceptance of the status quo. Indeed Tippett and her teachers are people whose work meets, and often drives, powerful forces of change alive in the world today. In the end, perhaps the greatest blessing conveyed by the lessons of spiritual genius Tippett harvests in Becoming Wise is the strength to meet the world where it really is, and then to make it better.

    A failed salesman turned local reporter, he wanted to test himself, see how he might respond to pressure and danger. He signed up for emergency medical training and became, at age twenty-six, a newly minted EMT running calls in the worst sections of Atlanta. His life entered a different realm—one of blood, violence, and amazing grace.Thoroughly intimidated at first and frequently terrified, he experienced on a nightly basis the adrenaline rush of walking into chaos. But in his downtime, Kevin reflected on how people’s facades drop away when catastrophe strikes. As his hours on the job piled up, he realized he was beginning to see into the truth of things. There is no pretense five beats into a chest compression, or in an alley next to a crack den, or on a dimly lit highway where cars have collided. Eventually, what had at first seemed impossible happened: Kevin acquired mastery. And in the process he was able to discern the professional differences between his freewheeling peers, what marked each—as he termed them—as “a tourist,” “true believer,” or “killer.”Combining indelible scenes that remind us of life’s fragile beauty with laugh-out-loud moments that keep us smiling through the worst, A Thousand Naked Strangers is an absorbing read about one man’s journey of self-discovery—a trip that also teaches us about ourselves.

    With swashbuckling wit and fierce honesty, she dishes on herself and her colleagues as they try to prod reluctant governments to fund HIV prevention for the people who need it most—drug injectors, gay men, sex workers, and johns.Pisani chats with flamboyant Indonesian transsexuals about their boob jobs and watches Chinese streetwalkers turn away clients because their SUVs aren't nice enough. With verve and clarity, she shows the general reader how her profession really works; how easy it is to draw wrong conclusions from "objective" data; and, shockingly, how much money is spent so very badly. "Exhibit A": the 45 billion taxpayer dollars the Bush administration is committing to international AIDS programs.

    You will learn how in this timely, urgent, and compassionate work by a world-renowned critical care doctor.Over the next ten years, 40 to 60 million people in this country will be admitted to the ICU. Most of these hospitalizations will be sudden, unexpected, and harrowing experiences that can alter patients and their families physically and emotionally, with effects that endure for years. In this rich blend of science, medical history, profoundly humane patient stories, and personal reflection, Dr. Wes Ely describes his mission to prevent patients from being inadvertently harmed by the technology that is keeping them alive. You will experience the world of critical care through the eyes of a physician who drastically changed his clinical practice to offer person-centered health care, and through cutting-edge research convinced others to do the same. For decades, ICU survivors left the hospital with disabling symptoms including newly acquired dementia, depression, PTSD, and nerve damage, all now recognized as Post Intensive Care Syndrome, or PICS. Dr. Ely’s groundbreaking investigations advanced the understanding of PICS and introduced crucial changes that reshaped intensive care: minimizing sedation, maximizing mobility, listening to the family, and providing supportive aftercare. Dr. Ely shows that there are ways to bring humanity into the ICU and that “technology plus touch” is the future of health care and is a proven path toward returning ICU patients to the lives they had before their hospital stay. An essential resource for anyone who will be affected by illness—which is all of us—Ely’s “personal, passionate return to the ethical heart of the Hippocratic oath…[offers] meaningful, thought-provoking insight into the world of critical care” (Kirkus Reviews).

    But as you will see in Playing God, earning an M.D. is just the first step to becoming a real physician.In this page-turning, thrilling, and moving memoir, Dr. Anthony Youn reveals that the true metamorphosis from student to doctor occurs not in medical school but in the formative years of residency training and early practice. It is only through actually saving and losing patients, taking on the medical establishment, wrestling with financial and emotional survival, and fighting for patients’ lives that a young doctor becomes a mature and competent physician.Dr. Youn takes you from the operating rooms of a university surgery residency program to the gleaming offices of top Beverly Hills plastic surgeons to opening the doors of his empty clinic as a new doctor with no money, no patients, and mountains of debt. Playing God leaves you with an unexpected answer to that profound question: “What does it mean to be a doctor?” In Playing God, you will take a journey through the world of surgery, hospitals, and the practice of medicine unlike any that you have traveled before.