It is the moment when the universe suffers a crisis of conscience. Should it expand or make a great big bang? It decides to wind the clock back a decade to 1991, making everyone in the world endure ten years of deja-vu and a total loss of free will - not to mention the torture of reliving every nanosecond of one of the tawdiest and most hollow decades. With his trademark wicked wit, Vonnegut addresses memory, suicide, the Great Depression, the loss of American eloquence, and the obsolescent thrill of reading books.

    Complications lays bare a science not in its idealized form but as it actually is--uncertain, perplexing, and profoundly human.Complications is a 2002 National Book Award Finalist for Nonfiction.

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    It is also the tale of a long weekend road trip that has gone down in the annals of American pop culture as one of the strangest journeys ever undertaken.

    It recounts the life histories of those who had been victims of the 1920s encephalitis lethargica epidemic. Sacks chronicles his efforts in the late 1960s to help these patients at the Beth Abraham Hospital in the Bronx, New York.

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    The plot centers on a 30-year-old actress named Suzanne Vale, and follows her challenges as she overcomes her drug addiction, gets back into the swing of things, and falls in love, sort of.

    It has been translated into sixteen languages, made into a prize-winning motion picture, and staged as a play at high schools all over the United States; its very title has become part of the American idiom.Never before has a novel so compellingly laid bare the inner workings of a metropolitan high school. Up the Down Staircase is the funny and touching story of a committed, idealistic teacher whose clash with school bureaucracy is a timeless lesson for students, teachers, parents--anyone concerned about public education. Bel Kaufman lets her characters speak for themselves through memos, letters, directives from the principal, comments by students, notes between teachers, and papers from desk drawers and wastebaskets, evoking a vivid picture of teachers fighting the good fight against all that stands in the way of good teaching.

    Stephen Fry's breathtakingly outrageous debut novel, by turns eccentric, shocking, brilliantly comic and achingly romantic.Adrian Healey is magnificently unprepared for the long littleness of life; unprepared too for the afternoon in Salzburg when he will witness the savage murder of a Hungarian violinist; unprepared to learn about the Mendax device; unprepared for more murders and wholly unprepared for the truth.The Liar is a thrilling, sophisticated and laugh out loud hilarious novel from a brilliantly talented writer.

    After decades of slacking off at low-paying dead-end jobs, blowing his cash on booze and women, and scrimping by in flea-bitten apartments, Chinaski sees his poetic star rising at last. Now, at fifty, he is reveling in his sudden rock-star life, running three hundred hangovers a year, and maintaining a sex life that would cripple Casanova.With all of Bukowski's trademark humor and gritty, dark honesty, this 1978 follow-up to Post Office and Factotum is an uncompromising account of life on the edge.

    The newest Palahniuk novel concerns Madison, a thirteen year old girl who finds herself in Hell, unsure of why she will be there for all eternity, but tries to make the best of it.The author described the novel as "if The Shawshank Redemption had a baby by The Lovely Bones and it was raised by Judy Blume." And "it's kind of like The Breakfast Club set in Hell."

    "Filled with warmth and humor, sadness and tenderness, songs and poems, Lake Wobegon Days is an unforgettable portrait of small-town American life, of why 'we are what we are' and why 'smart doesn't count for much."

    Set in an addicts' halfway house and a tennis academy, and featuring the most endearingly screwed-up family to come along in recent fiction, Infinite Jest explores essential questions about what entertainment is and why it has come to so dominate our lives; about how our desire for entertainment affects our need to connect with other people; and about what the pleasures we choose say about who we are. Equal parts philosophical quest and screwball comedy, Infinite Jest bends every rule of fiction without sacrificing for a moment its own entertainment value. It is an exuberant, uniquely American exploration of the passions that make us human—and one of those rare books that renew the idea of what a novel can do.

    Hilarious, horrifying and heartbreaking, this diary is everything you wanted to know – and more than a few things you didn't – about life on and off the hospital ward. As seen on ITV's Zoe Ball Book Club This edition includes extra diary entries and a new afterword by the author.

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.