Whether it's something as minor as a brush with the common cold or as serious as Ebola, we all have grappled with infections and will continue to encounter them as we age.On a worldwide scale, infectious diseases account for 26 percent of all deaths, second only to cardiovascular diseases. And unlike chronic diseases, infectious diseases are unique in their potential for explosive global impacts.Now, in the 24 engaging lectures of Introduction to Infectious Diseases, you can get a comprehensive overview of diseases from the mundane to the fatal from renowned physician and award-winning professor Dr. Barry Fox.Begin with an overview of the microscopic particles responsible for disease: bacteria, fungi, hybrid germs, and viruses. You will see how they invade the body; look through the microscope at pathogens to identify their inner components; follow germs through to different body systems and see what effects they have; and learn why we may be losing the battle against some germs.

    But the Black Death was arguably the most significant event in Western history, profoundly affecting every aspect of human life, from the economic and social to the political, religious, and cultural. In its wake the plague left a world that was utterly changed, forever altering the traditional structure of European societies and forcing a rethinking of every single system of Western civilization: food production and trade, the church, political institutions, law, art, and more. In large measure, by the profundity of the changes it brought, the Black Death produced the modern world we live in today.While the story of the Black Death is one of destruction and loss, its breathtaking scope and effects make it one of the most compelling and deeply intriguing episodes in human history. Understanding the remarkable unfolding of the plague and its aftermath provides a highly revealing window not only on the medieval world but also on the forces that brought about the Renaissance, the Protestant Reformation, and modernity itself.Speaking to the full magnitude of this world-changing historical moment, The Black Death: The World's Most Devastating Plague, taught by celebrated medievalist Dorsey Armstrong of Purdue University, takes you on an unforgettable excursion into the time period of the plague, its full human repercussions, and its transformative effects on European civilization. In 24 richly absorbing lectures, you'll follow the path of the epidemic in its complete trajectory across medieval Europe. Majestic in scope and remarkable in detail, this course goes to the heart of one of Western history's most catalytic and galvanizing moments, the effects of which gave us the modern world.

    While it’seasy to see that stress affects health and well-being, or that your blood pressure rises when you’re angry, cutting-edge research shows that the mind-body connection goes much further.Numerous studies on the brain’s interaction with the body demonstrate that health is directly affected by our social environments, socioeconomic status, culture, behaviors, relationships, psychological states, and habits of mind, among many factors. Current mind-body science reveals facts such as these: As few as eight weeks of mindfulness meditation can meaningfully boost your immune system. Extreme stress and low social support increase the risk of breast cancer by a factor of 9. Contact with nature is correlated with numerous positive health outcomes, including improved attention for children, reduced stress, and enhanced work performance. Chronic hostility portends calcification of the coronary arteries, even in young people. Expressive writing by patients is correlated with improved outcomes for both asthma and rheumatoid arthritis.Mind-body medicine—working in tandem with traditional medical practice—makes use of a large spectrum of psychological, physical, and behavioral treatments, drawn from many disciplines, in an approach to health care that aims to treat the whole person. It provides highly effective resources for preventing and treating a wide range of medical conditions, such as cardiovascular disease, stress, cancer, and depression—as well as for fostering the ultimate goals of health care: truly optimal and lasting physical health, and emotional and psychological well-being.A knowledge of this exciting field offers you critical understanding of the state of the art of health care and a significant new direction in medicine. But beyond valuable knowledge, a grounding in mind-body medicine gives you numerous practical, empowering tools for your own health care, as well as that of your family—tools that can make a profound difference for healthful, vibrant living.In Mind-Body Medicine: The New Science of Optimal Health, you’ll study this subject in compelling depth, with the expert guidance of Professor Jason M. Satterfield of the University of California, San Francisco. These 36 eye-opening lectures offer you a comprehensive overview of the field, providing rigorous answers to the questions of what makes us sick, what makes us well, and what we can do about it.You’ll look closely at the anatomical and biological systems through which what is “outside” in the environment gets “inside” to affect our minds and bodies. You’ll also examine recent research on subjects ranging from the impact our emotions and psychology have on health to the crucial roles that social, cultural, and behavioral factors play. And you’ll learn about effective mind-body treatments for numerous common medical conditions and diseases.Finally, you’ll finish the course with a toolbox of ideas and interventions for your personal wellness goals, empowering you to partner more effectively with your medical providers and maximize your own health.A Remarkable New Context for Health Care Professor Satterfield, a highly respected professor of clinical medicine and a specialist on the intersection of psychological factors and physical health, brings to the table his deep knowledge of mind-body science and extensive clinical experience in its application.In the course’s opening, he introduces you to the model of “biopsychosocial medicine,” which looks at the relationship between biological, psychological, and social factors in health.In studying how the biopsychosocial model is applied in modern medicine, you delve into these core subject areas:Biological pathways:You first investigate the anatomy and physiology of four biological systems through which the “outside” gets “in.” By reviewing a detailed study of the autonomic nervous system and the neuroendocrine system, discover how the brain activates the body’s two stress-response systems, and how these systems crucially affect health and well-being. Learn also about the physiology of immune function and the effects of stress on immune response and healing. Study the mechanisms of genetics as well as fascinating research indicating that your behavior can alter your genetic material, for better or worse—changes that can be passed on to future generations.Psychological factors in health: In the course of nine lectures, you look in depth at the critical ways in which psychology affects the body. Learn how negative emotional states such as anger and hostility can influence both the onset and progression of disease, and how positive emotions aid substantially in healing and wellness. Study how cognition—the ways in which we think and process our experiences—affects emotional states and behavior. Drawing from cognitive and other behavioral therapies, learn effective techniques for reshaping thinking, emotions, and behavior. Review evidence that certain personality types may be predisposed to conditions such as cardiovascular disease and depression, and learn how we can compensate for risk-carrying personality traits by working with cognitions and emotions. Investigate the neuroscience of behavior and the important effects of our behaviors on both disease and disease prevention. Look at stress as an integration of biological, cognitive, and social factors, and see how we can approach stress response and coping as a developmental skill. Social and ecological factors: You also study the important effects on health of factors such as culture, identity, socioeconomic status, social support, communities, and public health policy. Examine the studied correlations of income to health, education level to longevity, and ethnicity to susceptibility to disease, and consider how we can use this knowledge to benefit both individual and public health. Review research linking social support to health in many medical conditions, such as heart disease, cancer, and pregnancy; and do a detailed assessment to evaluate and strengthen your own social support network. Investigate how spiritual affiliations and practices have distinct physical benefits, such as reducing blood pressure, cortisol, and inflammation; improving lipid profiles and cardiovascular health; and extending life expectancy. Assess how physical environments affect health, how national and local culture impacts health-related behaviors, and how public initiatives can create healthier behaviors, environments, and communities.Tools and Strategies for Optimal WellnessBuilding on the biopsychosocial model, you study mind-body treatments for common conditions such as cardiovascular disease, stress, cancer, obesity, chronic pain, depression, anxiety, and post-traumatic stress disorder.Here, you learn about specific practices and interventions that you can use in your own health care program, such as these. Stress management: For both personal and occupational stress, learn about a spectrum of stress management approaches, from cognitive restructuring and perspective shifting to meditation, breathing techniques, relaxation training, and the learnable skill of resilience. Strategies for successful behavior change: With reference to concerns such as lifestyle change, weight management, and disease prevention, study the leading models of effective behavior change, as well as specific approaches such as the strategies of motivational interviewing, the four key elements of change, and the internal skills of self-regulation. Heart disease—prevention and treatment: Survey psychosocial interventions for heart disease, including a range of behavior change approaches, stress and emotion management, somatic quieting, social connection, and dramatic evidence that cardiac disease can be reversed through lifestyle change. Treatment of pain: Study mind-body factors in pain experience, and learn about treatments including cognitive and behavior change, acupuncture, mindfulness-based stress reduction, and biofeedback. Fatigue, headaches, insomnia: Investigate the variety of medical conditions that show no clear organic cause, such as chronic fatigue, tension headaches, and sleep disorders; and review effective psychological, physical, and behavioral approaches to treatment.Professor Satterfield’s teaching combines an extraordinary breadth of knowledge, clear and accessible explanations of the science involved, and a highly compassionate approach to patient care. He enriches the lectures with stories and case studies of patients in treatment for stress, heart conditions, insomnia, trauma, and other health challenges, showing you what mind-body medicine looks like in clinical practice and how you can integrate its lessons into your health program and daily life.With the knowledge and tools you’ll learn in Mind-Body Medicine: The New Science of Optimal Health, you can begin your own biopsychosocial assessment, identify your strengths and challenges in partnership with your medical providers, and take authentic steps toward your fullest physical and mental wellness.

    But getting here has not been a simple story of selfless men working tirelessly in the pursuit of medical advancement. Instead it's a bloodstained tale of blunders, arrogance, mishap and murder. In trying to keep us alive, surgeons have all too often killed us off, and life-saving solutions have often come from the most surprising places. Accompanying a major BBC series, "Blood and Guts" is an incredible story of stolen corpses, medical fraud, lobotomized patients - and every now and then courageous advances that have saved the lives of millions around the world. You may think twice before going under the knife.

    From its origins in 1738 as an almshouse and pesthouse, Bellevue today is a revered public hospital bringing first-class care to anyone in need. With its diverse, ailing, and unprotesting patient population, the hospital was a natural laboratory for the nation's first clinical research. It treated tens of thousands of Civil War soldiers, launched the first civilian ambulance corps and the first nursing school for women, pioneered medical photography and psychiatric treatment, and spurred New York City to establish the country's first official Board of Health. As medical technology advanced, "voluntary" hospitals began to seek out patients willing to pay for their care. For charity cases, it was left to Bellevue to fill the void. The latter decades of the twentieth century brought rampant crime, drug addiction, and homelessness to the nation's struggling cities problems that called a public hospital's very survival into question. It took the AIDS crisis to cement Bellevue's enduring place as New York's ultimate safety net, the iconic hospital of last resort.

    Each part contains six audio tapes and a booklet.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    We ignore this reality most of the time, but when a new threat (Ebola, SARS, Zika) seems imminent, we send our best and bravest doctors to contain it--people like Dr. Ali S. Khan.In his long career as a public health first responder—protected by a thin mask from infected patients, napping under nets to keep out scorpions, making life-and-death decisions on limited, suspect information—Khan has found that rogue microbes will always be a problem, but outbreaks are often caused by people. We make mistakes, politicize emergencies, and, too often, fail to imagine the consequences of our actions.The Next Pandemic is a firsthand account of disasters like anthrax, bird flu, and others and how we could do more to prevent their return. It's both a gripping story of our brushes with fate and an urgent lesson on how we can keep ourselves safe from the inevitable next pandemic.

    His revolutionary new book shows, for the first time, how the amazing process of neuroplastic healing really works. It describes natural, non-invasive avenues into the brain provided by the forms of energy around us—light, sound, vibration, movement—which pass through our senses and our bodies to awaken the brain’s own healing capacities without producing unpleasant side effects. Doidge explores cases where patients alleviated years of chronic pain or recovered from debilitating strokes or accidents; children on the autistic spectrum or with learning disorders normalizing; symptoms of multiple sclerosis, Parkinson’s disease, and cerebral palsy radically improved, and other near-miracle recoveries. And we learn how to vastly reduce the risk of dementia with simple approaches anyone can use. For centuries it was believed that the brain’s complexity prevented recovery from damage or disease. The Brain’s Way of Healing shows that this very sophistication is the source of a unique kind of healing. As he did so lucidly in The Brain That Changes Itself, Doidge uses stories to present cutting-edge science with practical real-world applications, and principles that everyone can apply to improve their brain’s performance and health.

    That one bite changed her life forever, pulling her into the abyss of a devastating illness that took ten doctors to diagnose and years to recover: Newby had become one of the 300,000 Americans who are afflicted with Lyme disease each year.As a science writer, she was driven to understand why this disease is so misunderstood, and its patients so mistreated. This quest led her to Willy Burgdorfer, the Lyme microbe's discoverer, who revealed that he had developed bug-borne bioweapons during the Cold War, and believed that the Lyme epidemic was started by a military experiment gone wrong.In a superb, meticulous work of narrative journalism, Bitten takes readers on a journey to investigate these claims, from biological weapons facilities to interviews with biosecurity experts and microbiologists doing cutting-edge research, all the while uncovering darker truths about Willy. It also leads her to uncomfortable questions about why Lyme can be so difficult to both diagnose and treat, and why the government is so reluctant to classify chronic Lyme as a disease.A gripping, infectious page-turner, Bitten will shed a terrifying new light on an epidemic that is exacting an incalculable toll on us, upending much of what we believe we know about it.

    As a result, whether we realize it or not, the drive to obtain food has been a major catalyst across all of history, from prehistoric times to the present. Epicure Jean-Anthelme Brillat-Savarin said it best: "Gastronomy governs the whole life of man." In fact, civilization itself began in the quest for food. Humanity's transition to agriculture was not only the greatest social revolution in history, but it directly produced the structures and institutions we call "civilization." In 36 fascinating lectures, award-winning Professor Albala puts this extraordinary subject on the table, taking you on an enthralling journey into the human relationship to food. With this innovative course, you'll travel the world discovering fascinating food lore and culture of all regions and eras - as an eye-opening lesson in history as well as a unique window on what we eat today.

    Yet all too often, we're exposed to information and techniques that promise quick and easy results but can be harmful to your overall health: crash diets, experimental medications, ever-changing studies on what you should eat more or less of, and more. It can be confusing to dig through the mass of hype, myth, and misconceptions about good nutrition habits. So in the face of potentially misleading information and aids, where can you find the key to nutritional success?The answer: in understanding the concepts, practices, and science behind good nutrition. Once you master the intricate—and undeniably captivating—interaction between what you eat and its effect on your body and mind, you unlock a powerful and scientifically proven tool to use in the quest for maintaining or improving your personal health.Nutrition Made Clear is your opportunity to finally sort through nutrition misconceptions and replace them with hard science you can understand. In 36 in-depth lectures taught by dietitian and award-winning Professor Roberta H. Anding, you explore the fundamentals of good nutrition and get a practical and personal guide to applying these fundamentals to your unique lifestyle. Designed to appeal to anyone at any age, this course is an invaluable source of medically backed, statistically proven information about the guidelines for healthy eating and living.

    But here’s a secret: There’s a lot that’s quirky and intriguing about how human language works—and much of it is downright fun to learn about.Every day, linguists ponder and try to solve some of the most intriguing scientific, historical, and sociological puzzles behind the inner workings of language—how it emerged, how it evolved, how it’s used, and where it’s going in the future.What’s the deal with slang like “baby mama” and “LOL”— where does it come from and can it actually be OK to use?Why don’t English speakers use words like “thou” and “thee” anymore?What makes “mama” and “papa” the first words spoken by children in many languages?These and other curious questions (and their surprising answers) are all part of what makes linguistics a field of study that’s anything but dry and dull. But with so many languages and so many potential avenues of exploration, it can often seem daunting to try to understand it. Where does one even start?Look no further than Language A to Z, in which acclaimed linguist and celebrated Great Courses professor John McWhorter of Columbia University creates a delightful way to get accessible, bite-sized introductions to language. These twenty-four 15-minute lectures by one of the best-known popularizers of language use the English alphabet as a unique, offbeat way to let you hopscotch through some of the field’s major topics, hot-button issues, curious factoids, and more. Filled with humor, whimsy, and no shortage of insights, this course is a fast-paced tour of the same territory linguists tread each and every day.

    Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.Through a fresh and engaging examination of our evolutionary history, Dr. Moalem reveals how many of the conditions that are diseases today actually gave our ancestors a leg up in the survival sweepstakes. When the option is a long life with a disease or a short one without it, evolution opts for disease almost every time.Everything from the climate our ancestors lived in to the crops they planted and ate to their beverage of choice can be seen in our genetic inheritance. But Survival of the Sickest doesn't stop there. It goes on to demonstrate just how little modern medicine really understands about human health, and offers a new way of thinking that can help all of us live longer, healthier lives..