A fresh, honest, and practical guide to living with bipolar disorder.Paul Jones, a stand-up comedian and workshop leader who suffers from bipolar disorder, uses humor, honesty, and hard-won practical advice to dispel the stigma surrounding mental illnesses and shed light on the challenges of living with bipolar disorder.Offering an intimate view of life with bipolar disorder—including the most common mistakes bipolar individuals make and how to avoid them— and covering every aspect from diagnosis, social life, home life, and career, this is an accessible and engaging guide from someone who’s been there and can help readers cope and thrive.

    But AIDS is just one of the many emerging viruses for which we have, as yet, no cure. Even the old plagues – TB, cholera, bubonic plague – are making a comeback, resistant now to our drugs.Frank Ryan, a leading authority on disease, describes the groundbreaking research of the world’s leading experts in the field to show both where these viruses come from and why they prove to be so lethal, and advances a radical new biological theory for the origins and behaviour of plague viruses. Full of vivid despatches from the front line of research and medicine, 'Virus X' is terrifying and essential reading for anyone interested in the effects of plague viruses on human evolution.“Extremely well written…Frank Ryan has the page-turning and spine-chilling ability of a good novelist”MATT RIDLEY, 'Sunday Telegraph'“Compelling and frightening…the plot could not be bettered”MICHAEL SMITH, 'Scotsman'“Ryan is very good at making technical matters comprehensible to the lay reader but more impressive still is the way he conveys the intellectual excitement and elation of scientific discovery”ANTHONY DANIELS, 'Literary Review'“Ryan takes us through the drama of discovery and challenges the notion that certain questions are too appalling to contemplate”DAVID BRADLEY, 'New Scientist'“Dr Ryan writes well in a difficult technical field, weaving the technicalities of scientific history, medicine, molecular biology and evolution into the human narratives…very readable and disturbing”JOHN R.G. TURNER, 'New York Times'

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    For someone who hates exercise, Kristy Chambers is pretty good at running away, and coming back again when her credit cards are declined. She’s not so much an international jetsetter as a loose cannon with a passport. So, in the manner of Eat, Pray, Love, a privileged white girl takes her privileged white arse on the road in an attempt to find happiness. With a family history of mental illness that goes back generations and a complicated long-term relationship with depression, will eating all the pasta in Italy help her to find the silver lining she’s looking for? Of course it won’t. It’s pasta, not magic beans. Joined by the most unreliable travel companion of them all—her mental health—Kristy openly, honestly, and humorously recounts their adventures together.

    A slip of the hand and life ebbs away.The balance between life and death is so delicate, and the heart surgeon walks that rope between the two. In the operating room there is no time for doubt. It is flesh, blood, rib-retractors and pumping the vital organ with your bare hand to squeeze the life back into it. An off-day can have dire consequences – this job has a steep learning curve, and the cost is measured in human life. Cardiac surgery is not for the faint of heart.Professor Stephen Westaby took chances and pushed the boundaries of heart surgery. He saved hundreds of lives over the course of a thirty-five year career and now, in his astounding memoir, Westaby details some of his most remarkable and poignant cases – such as the baby who had suffered multiple heart attacks by six months old, a woman who lived the nightmare of locked-in syndrome, and a man whose life was powered by a battery for eight years.A powerful, important and incredibly moving book, Fragile Lives offers an exceptional insight into the exhilarating and sometimes tragic world of heart surgery, and how it feels to hold someone’s life in your hands.

    . . The book soars." --"The San Diego Union-Tribune" Jamie Weisman was a patient long before she was a doctor. She was born with a rare defect in her immune system that leaves her prey to a range of ailments and crises and that, because it is treatable but not curable, will keep her a patient for life. In this probing and inspiring book, she brings her sojourns on both sides of the doctor-patient divide to bear on the issues of the flesh that preoccupy us all. It is a worthy addition to the best that has been written about our physical selves, a meditation on our extraordinary powers of healing and the limitations that leave intact the miracle and tragedy of being.

    Two ends of the same spectrum. And sometimes the only person standing between is a tired, overworked resident with personal problems of her own.Welcome to the world of Catching Babies. In the halls of a busy metropolitan teaching hospital, a group of OB/GYN doctors complete their residencies and embark on ambitious careers, all while trying to hold their lives together at the seams. Jay is running from a life he’s tried to leave behind, while Katie sacrifices everything she has to serve an endless parade of needy patients. Anna is out trying to save the world, while Tracy is trying to save twins dying in utero. Based on true stories from delivery rooms and labor decks, Catching Babies spins the doctors’ stories into a gripping mosaic of the obsessions, the anxieties, and the heroism of doctors who have chosen to preside over life’s greatest medical drama—high-risk childbirth.

    A caring and thoughtful doctor, he also writes beautifully.” —Siddhartha Mukherjee, New York Times bestselling author on Modern Death In Heart of the Matter, Dr. Haider Warraich takes readers inside the ER, inside patients' rooms, and inside the history and technology of heart disease.More people die of heart disease than any other disease in the world, including even cancer. In fact, deaths from heart disease are on the rise around the world and in the United States. When any heart disease becomes advanced enough, it results in the development of heart failure. In the United States, heart failure is the most common reason for admission to the hospital. Heart failure strikes both the abject and the affluent. And yet, even the most basic facts about heart failure remain known by few who don’t work in medicine for a living. Many patients develop heart failure without having any problems with their coronary arteries. Heart failure can affect anyone at any time: a child recovering from a viral infection, a woman who has just given birth, a cancer patient who received chemotherapy or anyone with any number of common conditions such as high blood pressure, diabetes, or sleep apnea.Warraich's signature blend of lucid writing and compelling narrative explores the complex discussion about heart failure with accessibility and compassion.

    His passing on March 6, 1900, would have been unremarkable if a city health officer hadn’t noticed a swollen black lymph node on his groin—a sign of bubonic plague. Empowered by racist pseudoscience, officials rushed to quarantine Chinatown while doctors examined Wong’s tissue for telltale bacteria. If the devastating disease was not contained, San Francisco would become the American epicenter of an outbreak that had already claimed ten million lives worldwide.To local press, railroad barons, and elected officials, such a possibility was inconceivable—or inconvenient. As they mounted a cover-up to obscure the threat, ending the career of one of the most brilliant scientists in the nation in the process, it fell to federal health officer Rupert Blue to save a city that refused to be rescued. Spearheading a relentless crusade for sanitation, Blue and his men patrolled the squalid streets of fast-growing San Francisco, examined gory black buboes, and dissected diseased rats that put the fate of the entire country at risk.In the tradition of Erik Larson and Steven Johnson, Randall spins a spellbinding account of Blue’s race to understand the disease and contain its spread—the only hope of saving San Francisco, and the nation, from a gruesome fate.

    In a life filled with risk-taking and injuries, this was the most serious accident yet. It spurred Dunn to question her inclination toward carelessness, and she learned that a pattern of accidents often indicates deeper issues bubbling below the surface. This last near-fatal episode was a wake-up call; she had been looking away, not only from her horse, who had shown clear signs of panic, but also from her complicated past and troubled marriage. "Not by Accident" follows the stages of Dunn's long and painful recovery, during which the emotional healing process proved even more challenging than the physical one.

    Barbara Ravage has fashioned an enlightening, invaluable book.” —Stewart O’Nan, author of The Circus Fire: A True Story of an American TragedyThough each of us is just a spark away from being a burn victim, the public knows little and understands less about the world that patients inhabit. Pulling the curtains back on this private and sterile environment, Burn Unit is a riveting account of the frontline efforts—both modern-day and historical—to save lives devastated by fire. With unflinching urgency, Barbara Ravage follows an extraordinary team of healers at Massachusetts General Hospital, the cradle of modern burn treatment and the site of one of the best burn units in the world. From Boston’s Cocoanut Grove fire of 1942 to the treatment of the victims of the Rhode Island nightclub fire in early 2003, we watch everyday heroes do their incredible but punishing work against the backdrop of history. Both a moving human drama and an engrossing scientific exploration of this little-known field of medicine, Burn Unit is an unforgettably powerful read.

    Such was the opening line to many patient encounters in the emergency departments and clinics where I spent my career as a physician. Shadow me back through the years in a series of vignettes that will give you a peek into a world of medicine that few on the outside ever see. Along the way you may laugh a little, tear up a bit or even learn something, but through it all you will experience the highs and lows of the day to day practice of emergency and urgent care medicine. Put on your scrubs and come join me now: your first shift working in the emergency department is about to begin.

    

    She had survived both a diagnosis of lupus and brain surgery, had a fulfilling career, and was married at last to the love of her life. Everything was good as she coasted along, meeting the eyes of a truck driver as he approached the stop sign beside her.He didn't stop. The truck hit Colleen, running over her lower body with front and back tires and dragging her across the pavement. As she bled out in the street, nearby strangers surrounded her and the driver attempted to get away. An EMT herself, Colleen knew she had to stay awake. "I've just been reconnected with my soulmate," she told the medic. "We want to have a baby. I can't die now. Please don't let me die."Five weeks in a coma and twenty-nine surgeries later, Colleen survived. Rather than let the trauma and PTSD control her life, she became determined to find a way to make something positive from her pain. She decided she'd run again and dedicate her race medals to the everyday heroes around us, including the medical staff and blood donors who saved her life. Since then Colleen has run fifty races and completed forty triathlons, including four half-Ironman events. Now a spokesperson for the Red Cross, Colleen shares her incredible inspirational story to encourage others to take that first step forward.

    In Bones, orthopedic surgeon Roy A. Meals explores and extols this amazing material that both supports and records vertebrate life.Inside the body, bone proves itself the world’s best building material. Meals examines the biological makeup of bones; demystifies how they grow, break, and heal; and compares the particulars of human bone to variations throughout the animal kingdom. In engaging and clear prose, he debunks familiar myths—humans don’t have exactly 206 bones—and illustrates common bone diseases, like osteoporosis and arthritis, and their treatments. Along the way, he highlights the medical innovations—from the first X-rays to advanced operative techniques—that enhance our lives and introduces the giants of orthopedic surgery who developed them.After it has supported vertebrate life, bone reveals itself in surprising ways—sometimes hundreds of millions of years later. With enthusiasm and humor, Meals investigates the diverse roles bone has played in human culture throughout history. He highlights allusions to bone in religion and literature, from Adam’s rib to Hamlet’s skull, and uncovers its enduring presence as fossils, technological tools, and musical instruments ranging from the Tibetan thighbone kangling horn to everyday drumsticks. From the dawn of civilization through to the present day, humankind has repurposed bone to serve and protect, and even to teach, amuse, and inspire.Approachable and entertaining, Bones richly illuminates our bodies’ essential framework.