Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    They were young and in love, with a perfect little house and not a care in the world. Then they brought home Marley, a wiggly yellow furball of a puppy. Life would never be the same.Marley quickly grew into a barreling, ninety-seven-pound streamroller of a Labrador retriever, a dog like no other. He crashed through screen doors, gouged through drywall, flung drool on guests, stole women's undergarments, and ate nearly everything he could get his mouth around, including couches and fine jewelry. Obedience school did no good—Marley was expelled. Neither did the tranquilizers the veterinarian prescribed for him with the admonishment, "Don't hesitate to use these."And yet Marley's heart was pure. Just as he joyfully refused any limits on his behavior, his love and loyalty were boundless, too. Marley shared the couple's joy at their first pregnancy, and their heartbreak over the miscarriage. He was there when babies finally arrived and when the screams of a seventeen-year-old stabbing victim pierced the night. Marley shut down a public beach and managed to land a role in a feature-length movie, always winning hearts as he made a mess of things. Through it all, he remained steadfast, a model of devotion, even when his family was at its wit's end. Unconditional love, they would learn, comes in many forms.

    But as the twins approached adolescence, Pamela began to succumb to schizophrenia, hearing disembodied voices and eventually suffering many breakdowns and hospitalizations.Divided Minds is a dual memoir of identical twins, one of whom faces a life sentence of schizophrenia, and the other who becomes a psychiatrist, after entering the spotlight that had for so long been focused on her sister. Told in the alternating voices of the sisters, Divided Minds is a heartbreaking account of the far reaches of madness, as well as the depths of ambivalence and love between twins. It is a true and unusually frank story of identical twins with very different identities and wildly different experiences of the world around them.

    In Naked, Sedaris turns the mania for memoir on its proverbial ear, mining the exceedingly rich terrain of his life, his family, and his unique worldview—a sensibility at once take-no-prisoners sharp and deeply charitable. A tart-tongued mother does dead-on imitations of her young son's nervous tics, to the great amusement of his teachers; a stint of Kerouackian wandering is undertaken (of course!) with a quadriplegic companion; a family gathers for a wedding in the face of imminent death. Through it all is Sedaris's unmistakable voice, without doubt one of the freshest in American writing.

    Anthony Fauci had already devoted three decades to public service. Those looking to live a more compassionate and purposeful life will find inspiration in his unique perspective on leadership, expecting the unexpected, and finding joy in difficult times.With more than three decades spent combating some of the most dangerous diseases to strike humankind-- AIDS, Ebola, COVID-19--Dr. Fauci has worked in daunting professional conditions and shouldered great responsibility. The earnest reflections in these pages offer a universal message on how to lead in times of crisis and find resilience in the face of disappointments and obstacles.Filled with inspiring words of wisdom, this profound book will offer readers a concrete path to a bright and hopeful future.

    From Comic Strip to Comic Relief, from Bolly-swilling Edina in Ab Fab to her takes on Madonna or Mamma Mia, her characters are household names.But it's Jennifer herself who has a place in all our hearts. This is her funny, moving and frankly bonkers memoir, filled with laughter, friends and occasional heartache - but never misery.BONKERS is full of riotous adventures: accidentally enrolling on a teacher training course with a young Dawn French, bluffing her way to each BBC series, shooting Lulu, trading wild faxes with Joanna Lumley, touring India with Ruby Wax and Goldie Hawn.There's cancer, too, when she becomes 'Brave Jen'. But her biggest battle is with the bane of her life: the Laws of Procrastination. As she admits, 'There has never been a Plan. Everything has been fairly random, happened by accident or just fallen into place. I'm off now, to do some sweeping...'Prepare to chuckle, whoop, and go BONKERS.

    Pistone carried out the most audacious sting operation ever, working undercover for six years to infiltrate the flamboyant community of mafia soldiers, "connected guys," captains, and godfathers. Now his unforgettable eyewitness account brings to pulsating life the entire world of wiseguys—their code of honor and their treachery, their wives, girlfriends and whores, their lavish spending and dirty dealings.With the drama and suspense of a high-tension thriller, Joseph Pistone reveals every incredible aspect of the jealously guarded world he penetrated...and draws a chilling picture of what the mafia is, does, and means in America today.

    Tammet's ability to think abstractly, deviate from routine, and empathize, interact and communicate with others is impaired, yet he's capable of incredible feats of memorization and mental calculation. Besides being able to effortlessly multiply and divide huge sums in his head with the speed and accuracy of a computer, Tammet, the subject of the 2005 documentary Brainman, learned Icelandic in a single week and recited the number pi up to the 22,514th digit, breaking the European record. He also experiences synesthesia, an unusual neurological syndrome that enables him to experience numbers and words as "shapes, colors, textures and motions." Tammet traces his life from a frustrating, withdrawn childhood and adolescence to his adult achievements, which include teaching in Lithuania, achieving financial independence with an educational Web site and sustaining a long-term romantic relationship. As one of only about 50 people living today with synesthesia and autism, Tammet's condition is intriguing to researchers; his ability to express himself clearly and with a surprisingly engaging tone (given his symptoms) makes for an account that will intrigue others as well.

    Well, maybe there are harder things in life…but being an adult is difficult! So Grace Helbig has written a guide that’s perfect for anyone who is faced with the daunting task of becoming an adult.Infused with her trademark saucy, sweet, and funny voice, Grace’s Guide is a tongue-in-cheek handbook for millennials, encompassing everything a young or new (or regular or old) adult needs to know, from surviving a breakup to recovering from a hangover. Beautifully illustrated and full-color, Grace’s Guide features interactive elements and exclusive stories from Grace’s own misadventures—like losing her virginity solely because her date took her to a Macaroni Grill—and many other hilarious lessons she learned the hard way.Amusing and unexpectedly educational, this refreshing and colorful guide proves that becoming an adult doesn’t necessarily mean you have to grow up.

    It’s about how people, organizations and societies can and must hit refresh—transform—in their persistent quest for new energy, new ideas, relevance and renewal. At the core, it’s about us humans and our unique qualities, like empathy, which will become ever more valuable in a world where the torrent of technology will disrupt like never before. As much a humanist as a technologist, Nadella defines his mission and that of the company he leads as empowering every person and every organization on the planet to achieve more.

    Despite what David Miliband might think

    Or that’s how Damon saw it, anyway. Damon wanted a book that talked a lot about love. Damon Courtenay died on the morning of April Fool’s Day. In this tribute to his son, Bryce Courtenay lays bare the suffering behind this young man’s life. Damon’s story is one of life-long struggle, his love for Celeste, the compassion of family, and a fight to the end for integrity. A testimony to the power of love, April Fool’s Day is also about understanding: how when we confront our worst, we can become our best.

    He has fronted his own satirical show on TV in Karachi, worked as a journalist and been a highly regarded newspaper columnist - all dangerous occupations to be involved in - when the combination of seeing the aftermaths of a devastating bomb attack and being the target of death threats convinced him to leave Pakistan. Under the terms of their Australian migration visa, Sami and his wife and young daughter were obliged to settle in a rural area, and so they moved to Northam in WA.Now Sami is battling a crippling addiction to meat pies, but at least is no longer constantly mistaken for an escaped asylum seeker from the nearby detention centre. He has also been the star of Australian Story, the subject of an article in The New York Times, and has performed countless comedy shows to ever-growing and appreciative audiences.I, Migrant tells the hilarious and moving story of what it's like to leave the home you love to start a new life in another country so your child can be safe and grow up with a limitless future. Australia is lucky to have Sami Shah. Read I, Migrant, and laugh till you cry.

    When he emerged he had under his arm a manuscript, a genre-smashing book about comedy, tragedy, love, loss, war, and redemption. When asked if this was the celebrity memoir, Norm replied, "Call it anything you damn like."

    The most up-to-date and beautifully illustrated text on the market, it has a strong molecular and cellular approach, firmly relating the molecular and cellular biological underpinnings of physiology to the study of human physiology and disease. Contributions from leading physiologists ensure authoritative, cutting-edge information, and thorough and consistent editing have produced a readable and student-friendly text.The smart way to study!Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.