Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    Just twelve, she’s tall, skinny, and weak. It’s four o’clock, and she hasn’t been allowed to eat anything all day. Her mother, on the other hand, seems curiously excited. She's about to suggest open-heart surgery on her child to "get to the bottom of this." She checks her teeth for lipstick and, as the doctor enters, shoots the girl a warning glance. This child will not ruin her plans.SickenedFrom early childhood, Julie Gregory was continually X-rayed, medicated, and operated on—in the vain pursuit of an illness that was created in her mother’s mind. Munchausen by proxy (MBP) is the world’s most hidden and dangerous form of child abuse, in which the caretaker—almost always the mother—invents or induces symptoms in her child because she craves the attention of medical professionals. Many MBP children die, but Julie Gregory not only survived, she escaped the powerful orbit of her mother's madness and rebuilt her identity as a vibrant, healthy young woman.Sickened is a remarkable memoir that speaks in an original and distinctive Midwestern voice, rising to indelible scenes in prose of scathing beauty and fierce humor. Punctuated with Julie's actual medical records, it re-creates the bizarre cocoon of her family's isolated double-wide trailer, their wild shopping sprees and gun-waving confrontations, the astonishing naïveté of medical professionals and social workers. It also exposes the twisted bonds of terror and love that roped Julie's family together—including the love that made a child willing to sacrifice herself to win her mother's happiness. The realization that the sickness lay in her mother, not in herself, would not come to Julie until adulthood. But when it did, it would strike like lightning. Through her painful metamorphosis, she discovered the courage to save her own life—and, ultimately, the life of the girl her mother had found to replace her. Sickened takes us to new places in the human heart and spirit. It is an unforgettable story, unforgettably told.

    Spelling and grammar errors go unseen after numerous reading. But then, as Bones might say, Jim, I'm a doctor, not an editor.

    It is 4 a.m. I have run arrest calls, treated life-threatening bleeding, held the hand of a young woman dying of cancer, scuttled down miles of dim corridors wanting to sob with sheer exhaustion, forgotten to eat, forgotten to drink, drawn on every fibre of strength that I possess to keep my patients safe from harm.'How does it feel to be spat out of medical school into a world of pain, loss and trauma that you feel wholly ill-equipped to handle? To be a medical novice who makes decisions which - if you get them wrong - might forever alter, or end, a person's life?In 'Your Life in My Hands', television journalist turned junior doctor Rachel Clarke captures the extraordinary realities of life on the NHS frontline. During last year's historic junior doctor strikes, Rachel was at the forefront of the campaign against the government's imposed contract upon young doctors. Her heartfelt, deeply personal account of life as a junior doctor in today's NHS is both a powerful polemic on the degradation of Britain's most vital public institution and a love letter of optimism and hope to that same health service.

    A gifted writer, Vertosick shows us that intelligence - the ability to react to the outside world, to change behaviour, to survive - can be found wherever life exists. He demonstrates the keen intelligence of our immune system, how lowly bacteria mutate and outwit antibiotics, and how canny cancer cells elude our natural defences.

    We take for granted that we can remember, feel emotion, navigate, empathize, and understand the world around us, but how would our lives change if these abilities were dramatically enhanced--or disappeared overnight?Helen Thomson has spent years traveling the world, tracking down incredibly rare brain disorders. In Unthinkable she tells the stories of nine extraordinary people she encountered along the way. From the man who thinks he's a tiger to the doctor who feels the pain of others just by looking at them to a woman who hears music that’s not there, their experiences illustrate how the brain can shape our lives in unexpected and, in some cases, brilliant and alarming ways.Story by remarkable story, Unthinkable takes us on an unforgettable journey through the human brain. Discover how to forge memories that never disappear, how to grow an alien limb, and how to make better decisions. Learn how to hallucinate and how to make yourself happier in a split second. Find out how to avoid getting lost, how to see more of your reality, even how exactly you can confirm you are alive. Think the unthinkable.

    Recounts stories from her vast case files that are alternately terrifying, tragically comic, and profoundly moving, all while she deals with her best friend and fellow doctor's fight with cancer.

     Former practicing psychiatrist Mark Rubinstein opens the door and takes the reader deep into the world of mental illness. From the chaos of a psychiatric emergency room to the bowels of a maximum security prison, the stories range from bizarre to poignant and the people from noble to callously uncaring. Bedlam's Door depicts the challenges mental illness poses for patients, their families, health-care professionals, and society. More importantly, it demystifies the subject while offering real hope.

    Linda grew up in the iconic immigrant community of Brighton Beach, Brooklyn, with her parents and a gifted older brother. But she spent her days at home alone with a mother who suffered major bouts of depression. At such times, young Linda was told, "Your mother…she’s not herself today." Those words did little to help Linda understand what she was witnessing. Instead, she experienced the anxiety and hyper-vigilance that often take root when secrecy and shame surround a family member who is ill. She’s Not Herself is a journey to make sense of the effects of multi-generational traumas. Shapiro is ultimately able to forgive (without forgetting) those who left her to fend for herself—and to provide readers with the wisdom of a seasoned psychotherapist who has examined human vulnerability in its many disguises and has moved through it all with dignity and hope. The result is a memoir of love, loss, loyalty, and healing.What others are saying:"An honest and compelling story by a brave and gifted writer." Wally Lamb, author of She’s Come Undone and I Know This Much Is True; winner of the National Alliance for the Mentally Ill's Kenneth Johnson Award for the anti-stigmatization of mental illness "A Story that applies to us all—truthful, carefully crafted, and created with a clear-eyed affection.” David Watts, MD, poet, writer, musician, NPR commentator "A riveting tale wrapped in elegant prose. A very human story—one of hope and perseverance that resonates deeply within the soul." Peggy Sanders, retired journalist, award-winning author “Lyrical and powerful in its use of story telling to subvert secrets and create new selfhood, this is a beautifully written memoir in the tradition of Eat, Pray, Love, Swallow The Ocean, Three Little Words, or Lucky Her Last Death.” Rachel Fichter, editor-at-large"For Shapiro's amazing recall and deep penetration into her past, this memoir reminds me of Remembrance of Things Past, and for its ease of readability, A Tree Grows in Brooklyn.” P. Topping, linguist "Inspiring and eloquent…vividly captures the cultural context of an immigrant family living with the trauma of mental illness and its effect on all family relationships.” Joseph Giordano, LCSW, co-editor, Ethnicity and Family Therapy "A compelling tale of human tragedy and triumph told with empathy and love, without sentimentality…offering a sense of awe for the human spirit.” Pamposh Dhar, founder of the Terataii Reiki and Counseling Centre, Singapore, Reiki healer/teacher/counselor/blogger "One feels privileged to share each of the traumas that Shapiro, her mother, and her mother before her had to endure. As to the writing, such complete recall is preserved for all time. Look to your laurels, Marcel Proust." Frederick Rolf, actor, director, co-author, translator, Berlin-Shanghai, New York: My Family's Flight From Hitler "Not another 'woe is me' account of dysfunction, but rather a heroic account of mastery and grace, which the general reading public as well as students and professionals will benefit from reading.” Roberta Temes, PhD, author of several books, including Learning How to Write a Memoir in Thirty Days "With extraordinary insight and honesty, Shapiro shares with us her journey from infinite pain to knowledge, healing, and forgiveness without a trace of melodrama. A truly inspiring read!" R.G.Sterling, musician, educator

    On one side are parents, bombarded with stories about the dangers of vaccines, now wary of immunizing their sons and daughters. On the other side are doctors, scared to send kids out of their offices vulnerable to illnesses like whooping cough and measles--the diseases of their grandparents.How did anyone come to view vaccines with horror? The answer is rooted in one of the most powerful citizen activist movements in our nation's history. In Deadly Choices, infectious disease expert Paul Offit relates the shocking story of anti-vaccine America--its origins, leaders, influences, and impact. Offering strategies to keep us from returning to an era when children routinely died from infections, Deadly Choices is a vigorous and definitive rebuttal of the powerful anti-vaccine movement.

    This book presents the best of them: pipe-smoking robots, clairvoyant pennies, zoo jailbreaks, literary cannibals, corned beef in space, revolving squirrels, disappearing Scottish lighthouse keepers, reincarnated pussycats, dueling Churchills, horse spectacles, onrushing molasses, and hundreds more. Plus the obscure words, odd inventions, puzzles and paradoxes that have made the website a quirky favorite with millions of readers -- hundreds of examples of the marvelous, the diverting, and the strange, now in a portable format to occupy your idle hours.

    Twirty-Something: A Young Woman's Guide to Giant Underwear is a hilarious new Kindle Single from Award-Winning and Amazon Best-Selling author and humorist Ingrid Reinke.On the cold January day when Ingrid Reinke turned 30, she looked back upon the last decade of her life in deep thought before finally shaking her head and mumbling to herself the following insight: "Wow, what a shit show."So, she sat down, braless and alone, and penned a collection of laugh-out-loud essays about the ridiculous, shocking and occasionally horrifying things that happen to us as we ungracefully age from 20 to 30, try, semi-successfully, to leave our clueless years behind and become mature, responsible grown-up women.From weird hairs to boob sweat, OCD to weddings, Twirty-Something swings between a no-holds-barred conversation and a cautionary tale about aging and all the crap that comes along with it.Sometime instruction manual, sometime commiseration partner, get ready for Reinke's honest and occasionally potty-mouthed accounts of this tumultuous decade.So hike up your yoga pants, plop another ice cube in your Pinot Grigio and get ready to laugh at the author, young women in general, and most of all at yourself.

     Early studies of the functions of the human brain used a simple method: wait for misfortune to strike-strokes, seizures, infectious diseases, lobotomies, horrendous accidents-and see how the victim coped. In many cases survival was miraculous, and observers could only marvel at the transformations that took place afterward, altering victims' personalities. An injury to one section can leave a person unable to recognize loved ones; some brain trauma can even make you a pathological gambler, pedophile, or liar. But a few scientists realized that these injuries were an opportunity for studying brain function at its extremes. With lucid explanations and incisive wit, Sam Kean explains the brain's secret passageways while recounting forgotten stories of common people whose struggles, resiliency, and deep humanity made modern neuroscience possible.

    By allowing women to control their fertility, the birth control pill has revolutionized women's lives. Women are going to college, graduating, and entering the workforce in greater numbers than ever before, and there's good reason to believe that the birth control pill has a lot to do with this. But there's a lot more to the pill than meets the eye.Although women go on the pill for a small handful of targeted effects (pregnancy prevention and clearer skin, yay!), sex hormones can't work that way. Sex hormones impact the activities of billions of cells in the body at once, many of which are in the brain. There, they play a role in influencing attraction, sexual motivation, stress, hunger, eating patterns, emotion regulation, friendships, aggression, mood, learning, and more. This means that being on the birth control pill makes women a different version of themselves than when they are off of it. And this is a big deal. For instance, women on the pill have a dampened cortisol spike in response to stress. While this might sound great (no stress!), it can have negative implications for learning, memory, and mood. Additionally, because the pill influences who women are attracted to, being on the pill may inadvertently influence who women choose as partners, which can have important implications for their relationships once they go off it. Sometimes these changes are for the better . . . but other times, they're for the worse. By changing what women's brains do, the pill also has the ability to have cascading effects on everything and everyone that a woman encounters. This means that the reach of the pill extends far beyond women's own bodies, having a major impact on society and the world.This paradigm-shattering book provides an even-handed, science-based understanding of who women are, both on and off the pill. It will change the way that women think about their hormones and how they view themselves. It also serves as a rallying cry for women to demand more information from science about how their bodies and brains work and to advocate for better research. This book will help women make more informed decisions about their health, whether they're on the pill or off of it.

    It is the most innovative, up-to-date and intelligent method which will lead you to become smokefree forever. The program is based on a natural and powerful approach which sets the record straight with our smoking while revealing every weak spot that keeps us dependent on cigarettes. Through this amazing method you will acquire the knowledge of how to use the same mechanisms that keep the addiction going, in order to set yourself absolutely free from smoking.