As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Before Nic became addicted to crystal meth, he was a charming boy, joyous and funny, a varsity athlete and honor student adored by his two younger siblings. After meth, he was a trembling wraith who lied, stole, and lived on the streets. David Sheff traces the first warning signs: the denial, the three a.m. phone calls—is it Nic? the police? the hospital? His preoccupation with Nic became an addiction in itself. But as a journalist, he instinctively researched every treatment that might save his son. And he refused to give up on Nic.

    Do you know where your sugar is coming from?Most likely everywhere. Sure, it's in ice cream and cookies, but what scared Eve O. Schaub was the secret world of sugar--hidden in bacon, crackers, salad dressing, pasta sauce, chicken broth, and baby food.With her eyes open by the work of obesity expert Dr. Robert Lustig and others, Eve challenged her husband and two school-age daughters to join her on a quest to eat no added sugar for an entire year.Along the way, Eve uncovered the real costs of our sugar-heavy American diet--including diabetes, obesity, and increased incidences of health problems such as heart disease and cancer. The stories, tips, and recipes she shares throw fresh light on questionable nutritional advice we've been following for years and show that it is possible to eat at restaurants and go grocery shopping--with less and even no added sugar.Year of No Sugar is what the conversation about "kicking the sugar addiction" looks like for a real American family--a roller coaster of unexpected discoveries and challenges.

    In “Nowhere Near First,” Cory shares his deeply personal story about experiencing his father’s suicide at a young age, and how this led to a career in endurance running and a desire to live life to the fullest. “Nowhere Near First” is a humorous, captivating, and uplifting account of Cory’s memorable ultramarathon experiences. Not only does Cory’s entertaining and powerful writing allow readers a unique perspective into the challenges and rewards of running, but it also inspires each of us to turn tragedy into triumph. “Cory Reese writes with humor, humbleness and honesty. His story is both uplifting and real, and his tales of persistence and perseverance are sure to inspire, whether you’re at the front of the pack or nowhere near first. Regardless of the title, this book’s a winner!”
 ~ Dean Karnazes, author of Ultramarathon Man: Confessions of an All-Night Runner “Cory Reese’s book, Nowhere Near First, is an immensely entertaining and profoundly educational story about overcoming challenges to forge a meaningful life. Reese’s story is must-read for people looking to find meaning and purpose in modern-day society.” ~ Karl Hoagland, Publisher, UltraRunning Magazine “Cory has penned a very personal account of overcoming hardship in his personal and athletic life. Nowhere Near First tells his story of perseverance and survival in a vivid, down and dirty way that peaks with his extraordinarily positive way of looking at life.” ~ Marshall Ulrich, author of Running On Empty: An Ultramarathoner’s Story of Love, Loss, and a Record-Setting Run Across America

    She was a poor Southern tobacco farmer who worked the same land as her enslaved ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia — a land of wooden quarters for enslaved people, faith healings, and voodoo — to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family — past and present — is inextricably connected to the history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

    A failed salesman turned local reporter, he wanted to test himself, see how he might respond to pressure and danger. He signed up for emergency medical training and became, at age twenty-six, a newly minted EMT running calls in the worst sections of Atlanta. His life entered a different realm—one of blood, violence, and amazing grace.Thoroughly intimidated at first and frequently terrified, he experienced on a nightly basis the adrenaline rush of walking into chaos. But in his downtime, Kevin reflected on how people’s facades drop away when catastrophe strikes. As his hours on the job piled up, he realized he was beginning to see into the truth of things. There is no pretense five beats into a chest compression, or in an alley next to a crack den, or on a dimly lit highway where cars have collided. Eventually, what had at first seemed impossible happened: Kevin acquired mastery. And in the process he was able to discern the professional differences between his freewheeling peers, what marked each—as he termed them—as “a tourist,” “true believer,” or “killer.”Combining indelible scenes that remind us of life’s fragile beauty with laugh-out-loud moments that keep us smiling through the worst, A Thousand Naked Strangers is an absorbing read about one man’s journey of self-discovery—a trip that also teaches us about ourselves.

    Caldwell's odds-defying feat was the culmination of an entire lifetime of pushing himself to his limits as an athlete.This engrossing memoir chronicles the journey of a boy with a fanatical mountain-guide father who was determined to instill toughness in his son to a teen whose obsessive nature drove him to the top of the sport-climbing circuit. Caldwell's affinity for adventure then led him to the vertigo-inducing and little understood world of big wall free climbing. But his evolution as a climber was not without challenges; in his early twenties, he was held hostage by militants in a harrowing ordeal in the mountains of Kyrgyzstan. Soon after, he lost his left index finger in an accident. Later his wife, and main climbing partner, left him. Caldwell emerged from these hardships with a renewed sense of purpose and determination. He set his sights on free climbing El Capitan's biggest, steepest, blankest face--the Dawn Wall. This epic assault took more than seven years, during which time Caldwell redefined the sport, found love again, and became a father.The Push is an arresting story of focus, drive, motivation, endurance, and transformation, a book that will appeal to anyone seeking to overcome fear and doubt, cultivate perseverance, turn failure into growth, and find connection with family and with the natural world.

    In 1887, 23-year-old reporter Nellie Bly had herself committed to a New York City asylum for 10 days to expose the horrific conditions for 19th-century century mental patients.

    Joyce Maynard's memoir broke a silence concerning her relationship--at age eighteen--with the famously reclusive author J.D. Salinger, then age fifty-three, who had read a story she wrote for "The New York Times" in her freshman year of college and sent her a letter that changed her life.With what some have viewed as shocking honesty, Maynard explores her coming of age in an alcoholic family, her mother's dream to mold her into a writer, her self-imposed exile from the world of her peers when she left Yale to live with Salinger, and her struggle to reclaim her self of sense in the crushing aftermath of his dismissal of her not long after her nineteenth birthday. A quarter of a century later--having become a writer, survived the end of her marriage and the deaths of her parents, and with an eighteen-year-old daughter of her own--Maynard pays a visit to the man who broke her heart. The story she tells--of the girl she was and the woman she became--is at once devastating, inspiring, and triumphant.

    Covered head-to-toe in strict, modest clothing, she received a rigorous education at Alta Academy, the Fundamentalist Church of Jesus Christ of Latter Day Saints' school headed by Warren Jeffs. Always seeking to be an obedient Priesthood girl, in her teens she became the nineteenth wife of her people's prophet: 85-year-old Rulon Jeffs, Warren's father. Finally sickened by the abuse she suffered and saw around her, she pulled off a daring escape and sought to build a new life and family.The church, however, had a way of pulling her back in-and by 2007, Rebecca had no choice but to take the witness stand against the new prophet of the FLDS in order to protect her little sisters and other young girls from being forced to marry at shockingly young ages. The following year, Rebecca and the rest of the world watched as a team of Texas Rangers raided the Yearning for Zion Ranch, a stronghold of the FLDS. Rebecca's subsequent testimony would reveal the horrific secrets taking place behind closed doors of the temple, sending their leaders to prison for years, and Warren Jeffs for life.THE WITNESS WORE RED is a gripping account of one woman's struggle to escape the perverse embrace of religious fanaticism and sexual slavery, and a courageous story of hope and transformation.

    She witnesses nurses drawing straws to see who would tend to the patient inside, all of them reluctant to enter the room. Out of impulse, Ruth herself enters the quarantined space and immediately begins to care for the young man who cries for his mother in the last moments of his life. Before she can even process what she's done, word spreads in the community that Ruth is the only person willing to help these young men afflicted by AIDS, and is called upon to nurse them. As she forges deep friendships with the men she helps, she works tirelessly to find them housing and jobs, even searching for funeral homes willing to take their bodies - often in the middle of the night. She cooks meals for tens of people out of discarded food found in the dumpsters behind supermarkets, stores rare medications for her most urgent patients, teaches sex-ed to drag queens after hours at secret bars, and becomes a beacon of hope to an otherwise spurned group of ailing gay men on the fringes of a deeply conservative state.Throughout the years, Ruth defies local pastors and nurses to help the men she cares for: Paul and Billy, Angel, Chip, Todd and Luke. Emboldened by the weight of their collective pain, she fervently advocates for their safety and visibility, ultimately advising Governor Bill Clinton on the national HIV-AIDS crisis.This deeply moving and elegiac memoir honors the extraordinary life of Ruth Coker Burks and the beloved men who fought valiantly for their lives with AIDS during a most hostile and misinformed time in America.

    The result is an explosive book that takes us, for the first time, deep inside a shadowy, fascinating, and surreal world of unscrupulous doctors, anything-goes team directors, and athletes so relentlessly driven to succeed that they would do anything—and take any risk, physical, mental, or moral—to gain the edge they need to win.Tyler Hamilton was once one of the world’s best-liked and top-ranked cyclists—a fierce competitor renowned among his peers for his uncanny endurance and epic tolerance for pain. In the 2003 Tour de France, he finished fourth despite breaking his collarbone in the early stages—and grinding eleven of his teeth down to the nerves along the way. He started his career with the U.S. Postal Service team in the 1990s and quickly rose to become Lance Armstrong’s most trusted lieutenant, and a member of his inner circle. For the first three of Armstrong’s record seven Tour de France victories, Hamilton was by Armstrong’s side, clearing his way. But just weeks after Hamilton reached his own personal pinnacle—winning the gold medal at the 2004 Olympics—his career came to a sudden, ignominious end: He was found guilty of doping and exiled from the sport.From the exhilaration of his early, naïve days in the peloton, Hamilton chronicles his ascent to the uppermost reaches of this unforgiving sport. In the mid-1990s, the advent of a powerful new blood-boosting drug called EPO reshaped the world of cycling, and a relentless, win-at-any-cost ethos took root. Its psychological toll would drive many of the sport’s top performers to substance abuse, depression, even suicide. For the first time ever, Hamilton recounts his own battle with clinical depression, speaks frankly about the agonizing choices that go along with the decision to compete at a world-class level, and tells the story of his complicated relationship with Lance Armstrong.A journey into the heart of a never-before-seen world, The Secret Race is a riveting, courageous act of witness from a man who is as determined to reveal the hard truth about his sport as he once was to win the Tour de France.

    Sidibe tells the engrossing, inspiring story of her first job as a phone sex “talker.” And she shares her unconventional (of course!) rise to fame as a movie star, alongside “a superstar cast of rich people who lived in mansions and had their own private islands and amazing careers while I lived in my mom's apartment.” Sidibe’s memoir hits hard with self-knowing dispatches on friendship, depression, celebrity, haters, fashion, race, and weight (“If I could just get the world to see me the way I see myself,” she writes, “would my body still be a thing you walked away thinking about?”). Irreverent, hilarious, and nontraditional, This Is Just My Face takes its place and fills a void on the shelf of writers from Mindy Kaling to David Sedaris to Lena Dunham.

    First diagnosed when he was only ten years old, she was the model of resilience throughout his childhood, fighting her disease with tenacity and a mouth foul enough to make a sailor blush. But just as she faces a relapse, her husband —a successful businessman and devoted father—is diagnosed with ALS. He is told that in a few months' time, he be unable to walk, eat, or breathe on his own. Dan, a recent college graduate living the good life in Los Angeles, has no choice but to return home to help. Reinstalled in his parents' basement (in one of the only non-Mormon homes in a Salt Lake City subdivision) Dan is reunited with his siblings. His older sister Tiffany is resentful, having stayed closer to home to bear the brunt of their mother's illness. Younger brother Greg comes to lend a hand, giving up a journalism career and evenings cruising Chicago gay bars. Younger sister Michelle is a sullen teenager experimenting with drinking and flirting with her 35-year-old soccer coach. And baby sister Chelsea—the oddest duck in a family of misfits—can only think about dance. Together they form Team Terminal, going to battle against their parents' illnesses and cracking plenty of jokes along the way. As Dan steps into his role as caregiver, wheelchair wrangler, and sibling referee, he watches pieces of his previous life slip away, and comes to realize that you don't get to choose when it's time to grow up.

    . . .There was a time in my life when I walked through the world known to myself and others as an athlete. It was part of my own definition of who I was and certainly the part I most respected. When I was a young man, I was well-built and agile and ready for the rough and tumble of games, and athletics provided the single outlet for a repressed and preternaturally shy boy to express himself in public....I lost myself in the beauty of sport and made my family proud while passing through the silent eye of the storm that was my childhood.” So begins Pat Conroy’s journey back to 1967 and his startling realization “that this season had been seminal and easily the most consequential of my life.” The place is the Citadel in Charleston, South Carolina, that now famous military college, and in memory Conroy gathers around him his team to relive their few triumphs and humiliating defeats. In a narrative that moves seamlessly between the action of the season and flashbacks into his childhood, we see the author’s love of basketball and how crucial the role of athlete is to all these young men who are struggling to find their own identity and their place in the world.In fast-paced exhilarating games, readers will laugh in delight and cry in disappointment. But as the story continues, we gradually see the self-professed “mediocre” athlete merge into the point guard whose spirit drives the team. He rallies them to play their best while closing off the shouts of “Don’t shoot, Conroy” that come from the coach on the sidelines. For Coach Mel Thompson is to Conroy the undermining presence that his father had been throughout his childhood. And in these pages finally, heartbreakingly, we learn the truth about the Great Santini.In My Losing Season Pat Conroy has written an American classic about young men and the bonds they form, about losing and the lessons it imparts, about finding one’s voice and one’s self in the midst of defeat. And in his trademark language, we see the young Conroy walk from his life as an athlete to the writer the world knows him to be.