These individuals all lost some part of what we think of as our self, but they then offer remarkable, sometimes heart-wrenching insights into what remains. One man cut off his own leg. Another became one with the universe.We are learning about the self at a level of detail that Descartes (“I think therefore I am”) could never have imagined. Recent research into Alzheimer’s illuminates how memory creates your narrative self by using the same part of your brain for your past as for your future. But wait, those afflicted with Cotard’s syndrome think they are already dead; in a way, they believe that “I think therefore I am not.” Who—or what—can say that? Neuroscience has identified specific regions of the brain that, when they misfire, can cause the self to move back and forth between the body and a doppelgänger, or to leave the body entirely. So where in the brain, or mind, or body, is the self actually located? As Ananthaswamy elegantly reports, neuroscientists themselves now see that the elusive sense of self is both everywhere and nowhere in the human brain.

    In this sensational and macabre story, we meet the surgeon who counted not only luminaries Benjamin Franklin, Lord Byron, Adam Smith, and Thomas Gainsborough among his patients but also “resurrection men” among his close acquaintances. A captivating portrait of his ruthless devotion to uncovering the secrets of the human body, and the extraordinary lengths to which he went to do so—including body snatching, performing pioneering medical experiments, and infecting himself with venereal disease—this rich historical narrative at last acknowledges this fascinating man and the debt we owe him today.

    From a fortress-like former bank building, American Pain's doctors distributed massive quantities of oxycodone to hundreds of customers a day, mostly traffickers and addicts who came by the vanload. Inked muscle-heads ran the clinic's security. Former strippers operated the pharmacy, counting out pills and stashing cash in garbage bags. Under their lab coats, the doctors carried guns and it was all legal sort of. American Pain was the brainchild of Chris George, a 27-year-old convicted drug felon. The son of a South Florida home builder, Chris George grew up in ultra-rich Wellington, where Bill Gates, Springsteen, and Madonna kept houses. Thick-necked from weightlifting, he and his twin brother hung out with mobsters, invested in strip clubs, brawled with cops, and grinned for their mug shots. After the housing market stalled, a local doctor clued in the brothers to the burgeoning underground market for lightly regulated prescription painkillers. In Florida, pain clinics could dispense the meds, and no one tracked the patients. Seizing the opportunity, Chris George teamed up with the doctor, and word got out. Just two years later Chris had raked in $40 million, and 90 percent of the pills his doctors prescribed flowed north to feed the rest of the country's insatiable narcotics addiction. Meanwhile, hundreds more pain clinics in the mold of American Pain had popped up in the Sunshine State, creating a gigantic new drug industry. American Pain chronicles the rise and fall of this game-changing pill mill, and how it helped tip the nation into its current opioid crisis, the deadliest drug epidemic in American history. The narrative swings back and forth between Florida and Kentucky, and is populated by a gaudy and diverse cast of characters. This includes the incongruous band of wealthy bad boys, thugs and esteemed physicians who built American Pain, as well as penniless Kentucky clans who transformed themselves into painkiller trafficking rings. It includes addicts whose lives were devastated by American Pain's drugs, and the federal agents and grieving mothers who labored for years to bring the clinic's crew to justice."

    Whether it is with the kind of tweets that led Rolling Stone to name her one of the Funniest People on Twitter, or with pictures of her hilariously adorable family (human and animal), or with something much more serious, like creating the hashtag #NotOkay, where millions of women came together to share their stories of sexual assault, Kelly has a unique, razor-sharp perspective on modern life. As a screen writer, professional sh*t disturber, wife and mother of three, Kelly is about everything but the status quo.Perfect for anyone who ever wished David Sedaris and Mindy Kaling would just finally write a book together already, When You Find Out the World Is Against You is filled with the biting, wise, and laugh-out-loud insights that have won Kelly legions of fans. Whether she’s detailing her obsession with going to camp as an eleven-year-old so she can become a “kissing bandit,” exploring the bittersweet boredom that so often accompanies parenthood, calling out the insanity of a posse of Internet poodle vigilantes, writing bracingly about the anxiety that has plagued her for as long as she can remember or taking us to ride shotgun as she stalks her husband on an accidental date with another man, When You Find Out the World Is Against You is Kelly at her most honest and disarmingly funny best. Her comedic skill, down-to-earth voice and bull’s-eye observations on the absurdity of modern life mean there is nothing quite like seeing the world through Kelly’s eyes.

    Animal combines autobiography and evolutionary history to create a funny, fascinating insight into the forces that mould and affect modern women.Animal is entertaining and informative, personal and universal – silly about lots of things and serious about some. It's a laugh-out-loud investigation to help us understand and forgive our animal urges and insecurities.

    He’s been bitten by twenty-six venomous snakes, been stung by three stingrays, and survived a near-fatal scorpion sting while deep in the Amazon jungle. He’s received more than four hundred stitches and broken twenty-three bones, including breaking his back in three places, and had to learn how to walk again. But when you research only the venom you yourself have collected, the adventures—and danger—never stop.Imagine a three-week-long first date in Siberia catching venomous water shrews with the daughter of a Russian war hero; a wedding attended by Eastern European prime ministers and their machine-gun-wielding bodyguards and snakes; or leading a team to Antarctica that results in the discovery of four new species of venomous octopi. Bryan’s discoveries have radically reshaped views on venom evolution and contributed to the creation of venom-based life-saving medications. In pursuit of venom, he has traveled the world collecting samples from Indonesia to Mexico, Germany, and Brazil. He’s encountered venomous creatures of all kinds, including the Malaysian king cobra, the Komodo dragon, and the brush-footed trapdoor spider. Bryan recounts his lifelong passion for studying the world’s most venomous creatures in this outlandish, captivating memoir, where he and danger are never far apart.

    She conjures up early operating theaters--no place for the squeamish--and surgeons, working before anesthesia, who were lauded for their speed and brute strength. These medical pioneers knew that the aftermath of surgery was often more dangerous than their patients' afflictions, and they were baffled by the persistent infections that kept mortality rates stubbornly high. At a time when surgery couldn't have been more hazardous, an unlikely figure stepped forward: a young, melancholy Quaker surgeon named Joseph Lister, who would solve the deadly riddle and change the course of history.Fitzharris dramatically recounts Lister's discoveries in gripping detail, culminating in his audacious claim that germs were the source of all infection--and could be countered by antiseptics. Focusing on the tumultuous period from 1850 to 1875, she introduces us to Lister and his contemporaries--some of them brilliant, some outright criminal--and takes us through the grimy medical schools and dreary hospitals where they learned their art, the deadhouses where they studied anatomy, and the graveyards they occasionally ransacked for cadavers.Eerie and illuminating, The Butchering Art celebrates the triumph of a visionary surgeon whose quest to unite science and medicine delivered us into the modern world.

    Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. Those in cows and termites digest the plants they eat. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squids with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. I Contain Multitudes is the story of these extraordinary partnerships, between the creatures we are familiar with and those we are not. It reveals how we humans are disrupting these partnerships and how we might manipulate them for our own good. It will change both our view of nature and our sense of where we belong in it.

    While it's true our ER doesn't see the stabbing and gunshot action ERs see in inner cities, we have no shortage of the sad, the scary, the painful, and the just plain dumb. With more than 20 stories, things ER workers want to say to patients, and Emergency Room BINGO, 'A Double Dose of Dilaudid' will take you on a joyride to the funnier side of the ER. See what a bored husband did to get out of a date night with his wife, learn what happens when you try to make your own meth, and read about items men and women have inserted in their bodies.

    Before the trip’s end, she develops psychosis. In desperation, her husband admits her to a nearby psychiatric hospital, where she begins the hard work of rebuilding her identity.In this memoir Catherine reconstructs her sense of self, starting with her childhood as the daughter of Korean immigrants, moving through a traumatic past relationship, and on to the early years of her courtship with and marriage to her husband, James. She interweaves these parts of her past with an immediate recounting of the days she spent in the ward.

    Then social services placed her in a residential unit known to be 'a target for prostitution', and suddenly Zoe's life was worse than it had ever been before.Abused and ostracized by her mother, humiliated by her father’s sexual innuendos, physically assaulted and bullied by her eldest brother, even as a young child Zoe thought she deserved the desperately unhappy life she was living.‘I’ve sharpened a knife for you,’ her mother told her the first time she noticed angry red wounds on her daughter’s arms. And when Zoe didn’t kill herself, her mother gave her whisky, which she drank in the hope that it would dull the miserable, aching loneliness of her life.One day at school Zoe showed her teacher the livid bruises that were the result of her mother’s latest physical assault and within days she was taken into care.Zoe had been at Denver House for just three weeks when an older girl asked if she’d like to go to a party, then took her to a house where there were just three men. Zoe was a virgin until that night, when two of the men raped her. Having returned to the residential unit in the early hours of the morning, when she told a member of staff what had happened to her, her social worker made a joke about it, then took her to get the morning-after pill.For Zoe, the indifference of the staff at the residential unit seemed like further confirmation of what her mother had always told her – she was worthless. Before long, she realised that the only way to survive in the unit was to go to the ‘parties’ the older girls were paid to take her to, drink the drinks, smoke the cannabis and try to blank out what was done to her when she was abused, controlled and trafficked around the country.No action was taken by the unit's staff or social workers when Zoe asked for their help, and without anyone to support or protect her, the horrific abuse continued for the next few years, even after she left the unit. But in her heart Zoe was always a fighter. This is the harrowing, yet uplifting story, of how she finally broke free of the abuse and neglect that destroyed her childhood and obtained justice for her years of suffering.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    From Mary Lamb, sister of Charles, who in the throes of a nervous breakdown turned on her mother with a kitchen knife, to Freud, Jung, and Lacan, who developed the new women-centered therapies, Lisa Appignanesi’s research traces how more and more of the inner lives and emotions of women have become a matter for medics and therapists. Here too is the story of how over the years symptoms and diagnoses have developed together to create fashions in illness and how treatments have succeeded or sometimes failed. Mad, Bad, and Sad takes us on a fascinating journey through the fragile, extraordinary human mind.

    Bill Rawls understands Lyme disease sufferers seeking clarity and relief because, like myself, he has experienced the pain and frustration firsthand. Through this ground-breaking book, he shares everything he has discovered on his journey to reclaiming his health... it may just be the answer you've been waiting for." – Neil Spector, MD, Author of Gone in a Heartbeat Lyme disease is one of the most puzzling illnesses on the planet. Anyone who has suffered from its debilitating symptoms knows the frustrations of trying to find a cure. Many sufferers drag themselves from one doctor or alternative practitioner to the next, getting lost in a maze of lab tests, prescription drugs, and treatments. Thousands of dollars and months (or years) later, they realize they are no better off than where they started. Unlocking Lyme puts an end to this desperate quest. Written by Dr. Bill Rawls, a physician who overcame Lyme disease himself, this book is a comprehensive, practical resource full of solutions that work. What took Dr. Rawls 10 years to learn through intense research and personal experience, you can now learn and implement in a matter of months. DR. RAWLS’ STORY Dr. Rawls was in the middle of a successful OB/GYN career when Lyme disease interrupted his life. In his struggle to overcome it, he explored every treatment option – from conventional medicine to the full range of alternative therapies. Ultimately, he embraced modern herbal therapy as his preferred solution, but he recognizes that the path may be different for each person. INSIDE THE BOOK Unlocking Lyme is the sum of Dr. Rawls’ experience, research, and practical solutions to date. The book is divided into four parts, each part addressing a critical aspect of recovery: PART 1 - Provides an overview of common misconceptions about what Lyme disease is (hint: it’s more than just a tick bite and Borrelia infection) PART 2 - Provides information on how to obtain a diagnosis, despite current limitations in diagnostic testing for Lyme PART 3 - Discusses limitations of long-term antibiotic use, and offers an overview of holistic and non-toxic therapies for healing and symptom control (including pain, depression, insomnia) PART 4 - Explains how to embrace a healthier lifestyle so you can stay well; learn how to strengthen your immune system, microbiome, and balance in your body In the years since his recovery, Dr. Rawls has helped thousands of patients find their path to healing from Lyme disease. Unlocking Lyme brings together Dr. Rawls’ accumulated knowledge and is the key you need to get your life back. TESTIMONIALS “Dr. Rawls understands the misery of chronic Lyme disease firsthand. Unlocking Lyme shares the approaches that he used to successfully recover his own health, and helps the reader understand that there is so much that can be done to regain a state of wellness and optimal health.” – Scott Forsgren Editor & Founder, BetterHealthGuy.com “Dr. Rawls has spoken on his approach to Lyme disease for the past several years; his comprehensive approach and lifestyle guidance has helped many of our members. We heartily endorse his approach to helping deal with the symptoms of Lyme and other tick-borne illnesses.” – John Dorney, President NC Lyme Disease Foundation "Unlocking Lyme delves into the science behind Lyme disease, explaining what it is, but more importantly how it can be overcome. Dr. Rawls carefully explains the various treatments for Lyme, leaving the reader feeling informed and empowered.

    She just knew she felt her best when she was empty, "like a straw", as she says "something you could blow through."For almost thirty years, Susan Burton has hidden her obsession with food and the secret life of compulsive eating and starving that dominated her adolescence. This is the relentlessly honest, fiercely intelligent story of living with both anorexia and binge-eating disorder, moving past her shame, and learning to tell her secret.When Burton was thirteen, her stable life in suburban Michigan was turned upside down by her parents' abrupt divorce, and she moved to Colorado with her mother and sister. She seized on this move west as an adventure and an opportunity to reinvent herself from middle-school nerd to popular teenage girl. But she hadn't escaped unscathed, and in the fallout from her parents' breakup, an inherited fixation on thinness went from "peculiarity to pathology." She entered into a painful cycle of anorexia and binge eating that formed a subterranean layer to her sunny life. She went from success to success--she went to Yale, scored a dream job at a magazine right out of college, and married her college boyfriend. But in college the compulsive eating got worse--she'd binge, swear it would be the last time, and then, hours later, do it again--and after she graduated she descended into anorexia, her attempt to "quit food."Binge eating is more prevalent than anorexia or bulimia, but there is less research and little storytelling to help us understand it. In tart, soulful prose Susan Burton strikes a blow for the importance of this kind of story; brings to life an indelible cast of characters; and tells an exhilarating story of longing, compulsion and hard-earned self-revelation.