The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Experience how to use movies and mythology to uncover the path that is truly yours.This is your Call to Adventure: Unroll the Map of Self-Discovery and embrace a whole new world of joy and wisdom. Gain access to the hidden location that holds the answers to the meaning of life and the secrets to happines. Explore the pathways and side roads of the Inner Journey with strength and confidence. Unlock the secrets of the Ancient Greeks who mastered the success principles of Know Thyself. Demystify the process of understanding and actualizing your purpose and passion. Meet your mentor and learn how to earn the essential and indispensable gift. Summon the courage to be the hero in the action-adventure story that is your life! In an age where people look outward for direction and upward for inspiration, Living the Hero's Journey provides a time-honored template for looking inward and going deep for the answers we seek.Begin your journey today!

    Warring nations came together to honour tradition and celebrate their shared humanity, proclaiming an unofficial ceasefire as they swapped food, sung carols, and even played football matches against one another. It is one of those very rare moments during the bloody twentieth century which provide a glimmer of light. It is in some ways the great overlooked moment of the past century – moving, hopeful and filled with possibility. But how was it viewed at the time? And why did it never successfully happen again? What risks did the men in the trenches run, how did it come about, and did it change their view of the enemy? The Christmas Truce has become a symbol of hope for human beings working together in desperate situations. But historians have argued ever since about its significance, ranging from those who believe it was an irrelevance to those for whom it was a moment of enormous significance – and part of that argument is the question of when - and why - the truce officially ended. This book is designed to tell the story of the truce to a wider audience, as a compelling narrative, stitching together first-hand accounts of the soldiers who lived through it. A hundred years on, it is still a moment that resonates with audiences around the world.

    Sipser's candid, crystal-clear style allows students at every level to understand and enjoy this field. His innovative "proof idea" sections explain profound concepts in plain English. The new edition incorporates many improvements students and professors have suggested over the years, and offers updated, classroom-tested problem sets at the end of each chapter.

    Rethinking the usage guide for the twenty-first century, Pinker doesn’t carp about the decline of language or recycle pet peeves from the rulebooks of a century ago. Instead, he applies insights from the sciences of language and mind to the challenge of crafting clear, coherent, and stylish prose. In this short, cheerful, and eminently practical book, Pinker shows how writing depends on imagination, empathy, coherence, grammatical knowhow, and an ability to savor and reverse engineer the good prose of others. He replaces dogma about usage with reason and evidence, allowing writers and editors to apply the guidelines judiciously, rather than robotically, being mindful of what they are designed to accomplish. Filled with examples of great and gruesome prose, Pinker shows us how the art of writing can be a form of pleasurable mastery and a fascinating intellectual topic in its own right.

    Hand argues that extraordinarily rare events are anything but. In fact, they’re commonplace. Not only that, we should all expect to experience a miracle roughly once every month.     But Hand is no believer in superstitions, prophecies, or the paranormal. His definition of “miracle” is thoroughly rational. No mystical or supernatural explanation is necessary to understand why someone is lucky enough to win the lottery twice, or is destined to be hit by lightning three times and still survive. All we need, Hand argues, is a firm grounding in a powerful set of laws: the laws of inevitability, of truly large numbers, of selection, of the probability lever, and of near enough.     Together, these constitute Hand’s groundbreaking Improbability Principle. And together, they explain why we should not be so surprised to bump into a friend in a foreign country, or to come across the same unfamiliar word four times in one day. Hand wrestles with seemingly less explicable questions as well: what the Bible and Shakespeare have in common, why financial crashes are par for the course, and why lightning does strike the same place (and the same person) twice. Along the way, he teaches us how to use the Improbability Principle in our own lives—including how to cash in at a casino and how to recognize when a medicine is truly effective.     An irresistible adventure into the laws behind “chance” moments and a trusty guide for understanding the world and universe we live in, The Improbability Principle will transform how you think about serendipity and luck, whether it’s in the world of business and finance or you’re merely sitting in your backyard, tossing a ball into the air and wondering where it will land.

    Metaphor, the authors explain, is a fundamental mechanism of mind, one that allows us to use what we know about our physical and social experience to provide understanding of countless other subjects. Because such metaphors structure our most basic understandings of our experience, they are "metaphors we live by", metaphors that can shape our perceptions and actions without our ever noticing them.In this updated edition of Lakoff and Johnson's influential book, the authors supply an afterword surveying how their theory of metaphor has developed within the cognitive sciences to become central to the contemporary understanding of how we think and how we express our thoughts in language.

    “In an account chock full of real-world examples reinforced by experimental research, Hood’s marvelous book is an important contribution to the psychological literature that is revealing the actuality of our very irrational human nature.” — ScienceIn the vein of Malcolm Gladwell’s Blink, Mary Roach’s Spook, and Dan Ariely’s Predictably Irrational, The Science of Superstition uses hard science to explain pervasive irrational beliefs and behaviors: from the superstitious rituals of sports stars, to the depreciated value of houses where murders were committed, to the adoration of Elvis.

    One of the chapters in each trivia book was “Disturbing Facts about Our World”. I decided to fill an entire volume with facts about upsetting crimes and mayhem, combined with unbelievable yet real instances of misfortune and misery. This is a book where grim examples of bigotry and hypocrisy are intertwined with amusing stories of bad luck. In the spirit of the times we live in, I dedicated a whole chapter to COVID-19 trivia and weird medical conditions. I am well aware that many potential readers might be overwhelmed by the condensed negativity, but hey… a fact is a fact! Continue to read if you are curious to learn:- Why were the trousers of New Zealand’s farmers exploding?- What is the depressing origin of the phrase “Hip Hip, Hooray”?- Why did the Spanish Habsburgs royal family sleep with human mummies?- Why was it legal in Iceland until 2015 to kill Basque people?- Who was the “Deep Throat” informer from the Watergate scandal?- How many people were killed trying to cross the notorious Berlin Wall?- Why do snakes make a better pet than cats or dogs?- How can millipedes cause a train crash?- What is the etymology of “thug”?- What are the chances of getting killed by rubbish falling from space?- How did polygamist men in Kuwait manage to visit all their wives during the coronavirus lockdown?However incredible these pieces of trivia might sound, all entries have been verified and fact-checked.

    We're all conspiracy theorists--some of us just hide it better than others.Conspiracy theorists aren't just a handful of people who wear tin-foil hats and have bizarre ideas about shape-shifting reptilian aliens. Conspiracy theories are as likely to appeal to women as to men, college students as to retired professors, middle-class bloggers as to blue-collar workers.Psychological research sheds light on why some people are more drawn to conspiracy thinking, especially when they feel discontented, distrustful, and desire privileged knowledge. But ultimately we are all natural-born conspiracy theorists. Our brains are wired to see patterns and to weave unrelated data points into complex stories. We instinctively see events in the world in terms of human motives and intentions, leading us to discount the role of chance and unintended consequences, and we look for some hidden hand behind catastrophic events. These psychological quirks can lead us to suspect a conspiracy where none exists.Conspiracy theories have existed throughout history, from ancient Athens and Rome to present day theories about 9/11 and who shot JFK. Suspicious Minds explores the phenomenon and reveals the important consequences conspiracy theories can have--from discouraging parents from vaccinating their children against deadly diseases to hampering political policies to combat climate change.

    A large stone Venus. Nothing unusual about it_except that it was found on an island in the Pacific Northwest. Archaeologist Hannah Green and her shovelbum nephew find themselves in a tangled web of competing interests avaricious land owners, hungry media, and a cult of goddess worshippers while investigating one of the finds of the century. In untangling the mystery of the Washington Venus, Hannah and Sean have to confront questions of archaeological evidence, of ethics, of conflicting interpretation of data, and of the very nature of archaeological truths. Helping them are a cadre of disdainful graduate students who propose various theories processualist, marxist, feminist, postmodernist to explain the bizarre events. Teach your students archaeological theory in a fashion they'll enjoy, while they solve the mystery in Adrian Praetzellis's delightful textbook-as-novel.

    Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: A Short History of Nearly Everything, the Life and Times of the Thunderbolt Kid, a Walk in the Woods, Notes From a Small Island, Neither Here nor There: Travels in Europe, Shakespeare: the World as Stage, the Lost Continent: Travels in Small-Town America, the Mother Tongue, Notes From a Big Country, Bryson's Dictionary of Troublesome Words, Down Under, Made in America, Bill Bryson's African Diary. Source: Wikipedia. Free updates online. Not illustrated. Excerpt: A Short History of Nearly Everything (ISBN 0-7679-0817-1) is a general science book by Bill Bryson, which explains some areas of science, using a style of language more accessible to the general public than many other books dedicated to the subject. It was the bestselling popular science book of 2005 in the UK, selling over 300,000 copies. A Short History deviates from Bryson's popular travel book genre, instead describing general sciences such as chemistry, paleontology, astronomy, and particle physics. In it, he explores time from the Big Bang to the discovery of quantum mechanics, via evolution and geology. Bryson tells the story of science through the stories of the people who made the discoveries, such as Edwin Hubble, Isaac Newton, and Albert Einstein. Bill Bryson wrote this book because he was dissatisfied with his scientific knowledge that was, not much at all. He writes that science was a distant, unexplained subject at school. Textbooks and teachers alike did not ignite the passion for knowledge in him, mainly because they never delved in the whys, hows, and whens. "It was as if wanted to keep the good stuff secret by making all of it soberly unfathomable." Bryson, on the state of science books used within his school. It was in his later years that he realized with stunning shame ...More: http: //booksllc.net/?id=101240

    Indeed, logic goes to the very core of what we mean by human intelligence. In this concise, crisply readable book, distinguished professor D. Q. McInerny offers an indispensable guide to using logic to advantage in everyday life. Written explicitly for the layperson, McInerny’s Being Logical promises to take its place beside Strunk and White’s The Elements of Style as a classic of lucid, invaluable advice. As McInerny notes, logic is a deep, wide, and wonderfully varied field, with a bearing on every aspect of our intellectual life. A mastery of logic begins with an understanding of right reasoning–and encompasses a grasp of the close kinship between logical thought and logical expression, a knowledge of the basic terms of argument, and a familiarity with the pitfalls of illogical thinking. Accordingly, McInerny structures his book in a series of brief, penetrating chapters that build on one another to form a unified and coherent introduction to clear and effective reasoning.At the heart of the book is a brilliant consideration of argument–how an argument is founded and elaborated, how it differs from other forms of intellectual discourse, and how it critically embodies the elements of logic. McInerny teases out the subtleties and complexities of premises and conclusions, differentiates statements of fact from statements of value, and discusses the principles and uses of every major type of argument, from the syllogistic to the conditional. In addition, he provides an incisive look at illogical thinking and explains how to recognize and avoid the most common errors of logic.Elegant, pithy, and precise, Being Logical breaks logic down to its essentials through clear analysis, accessible examples, and focused insights. Whether you are a student or a teacher, a professional sharpening your career skills or an amateur devoted to the fine points of thought and expression, you are sure to find this brief guide to effecting reasoning both fascinating and illuminating.From the Hardcover edition.

    Opening with an introductory chapter on how to read philosophy, the book then moves into the basics of writing summaries and analyzing arguments. It provides step-by-step instructions for each phase of the writing process, from formulating a thesis, to creating an outline, to writing a final draft, supplementing this tutorial approach with model essays, outlines, introductions, and conclusions. Skills essential to evaluating arguments, citing sources, avoiding plagiarism, detecting fallacies, and formatting final drafts are dealt with in detail. The final two chapters serve as a reference guide to common mistakes and basic skills in sentence construction, writing style, and word choice. Employing a rulebook format similar to that of the classic Elements of Style (by Strunk, White, and Angell), Lewis Vaughn distills helpful writing advice into simple rules that students can easily remember and apply--and that instructors can refer to when reviewing student papers. These rules cover essay organization, sentence structure, documentation styles, plagiarism, grammar, usage, and more. Written in a clear and engaging style and incorporating samples of student writing, Writing Philosophy is an indispensable resource for virtually any philosophy course.

    Or perhaps you're trying to find a nice way of dissuading someone from wasting money on a homeopathy cure. Or you met someone at a party who insisted the Holocaust never happened or that no one ever walked on the moon. How do you find a gently persuasive way of steering people away from unfounded beliefs, bogus cures, conspiracy theories, and the like? This down-to-earth, entertaining exploration of commonly held extraordinary claims will help you set the record straight. The author, a veteran journalist, has not only surveyed a vast body of literature, but has also interviewed leading scientists, explored "the most haunted house in America," frolicked in the inviting waters of the Bermuda Triangle, and even talked to a "contrite Roswell alien." He is not out simply to debunk unfounded beliefs. Wherever possible, he presents alternative scientific explanations, which in most cases are even more fascinating than the wildest speculation. For example, stories about UFOs and alien abductions lack good evidence, but science gives us plenty of reasons to keep exploring outer space for evidence that life exists elsewhere in the vast universe. The proof for Bigfoot or the Loch Ness Monster may be nonexistent, but scientists are regularly discovering new species, some of which are truly stranger than fiction.Stressing the excitement of scientific discovery and the legitimate mysteries and wonder inherent in reality, this book invites readers to share the joys of rational thinking and the skeptical approach to evaluating our extraordinary world.