With rivalries, reversals, and a race against time, the struggle to eradicate polio is one of the great tales of modern history. It begins with the birth of Jonas Salk, shortly before one of the worst polio epidemics in United States history. At the time, the disease was a terrifying enigma: striking from out of nowhere, it afflicted tens of thousands of children in this country each year and left them-literally overnight-paralyzed, and sometimes at death's door. Salk was in medical school just as a president crippled by the disease, Franklin D. Roosevelt, was taking office-and providing the impetus to the drive for studies on polio. By the early 1950s, Salk had already helped create an influenza vaccine, and was hot on the trail of the polio virus. He was nearly thwarted, though, by the politics of medicine and by a rival researcher eager to discredit his proposed solution. Meanwhile, in 1952, polio was spreading in record numbers, with 57,000 cases in the United States that summer alone. In early 1954, Salk was weighing the possibility of trials of a not-yet-perfected vaccine against-as the summer approached-the prospect of thousands more children being struck down by the disease. The results of the history-making trials were announced at a press conference on April 12, 1955: "The vaccine works." The room-and an entire nation-erupted in cheers for this singular medical achievement. Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program-and as humanity is tantalizingly close to eradicating polio worldwide-comes this unforgettable chronicle. Salk's work was an unparalleled achievement-and it makes for a magnificent read.

    His full accounting does honor to the medical professionals around the country who've risked their lives to fight the virus, revealing America in all its vulnerability, courage, and potential.

    Operations on the brain carry grave risks. Every day, leading neurosurgeon Henry Marsh must make agonizing decisions, often in the face of great urgency and uncertainty.If you believe that brain surgery is a precise and exquisite craft, practiced by calm and detached doctors, this gripping, brutally honest account will make you think again. With astonishing compassion and candor, Marsh reveals the fierce joy of operating, the profoundly moving triumphs, the harrowing disasters, the haunting regrets, and the moments of black humor that characterize a brain surgeon's life.Do No Harm provides unforgettable insight into the countless human dramas that take place in a busy modern hospital. Above all, it is a lesson in the need for hope when faced with life's most difficult decisions.

    As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power.The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village.Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable.Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito's reign through human history and her indelible impact on our modern world order.

     A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments. Around the globe, 16 million people are alive today thanks to their efforts. Not since the publication of Randy Shilts's classic And the Band Played On has a book measured the AIDS plague in such brutally human, intimate, and soaring terms. In dramatic fashion, we witness the founding of ACT UP and TAG (Treatment Action Group), and the rise of an underground drug market in opposition to the prohibitively expensive (and sometimes toxic) AZT. We watch as these activists learn to become their own researchers, lobbyists, drug smugglers, and clinicians, establishing their own newspapers, research journals, and laboratories, and as they go on to force reform in the nation s disease-fighting agencies. With his unparalleled access to this community David France illuminates the lives of extraordinary characters, including the closeted Wall Street trader-turned-activist, the high school dropout who found purpose battling pharmaceutical giants in New York, the South African physician who helped establish the first officially recognized buyers club at the height of the epidemic, and the public relations executive fighting to save his own life for the sake of his young daughter. Expansive yet richly detailed, this is an insider's account of a pivotal moment in the history of American civil rights. Powerful, heart-wrenching, and finally exhilarating, How to Survive a Plague is destined to become an essential part of the literature of AIDS.

    Days later, the madman was dead and Denis was framed for murder. A riveting exposé of the fierce debates, deadly politics, and cutthroat rivalries behind the first transfusion experiments, Blood Work takes us from dissection rooms in palaces to the streets of Paris, providing an unforgettable portrait of an era that wrestled with the same questions about morality and experimentation that haunt medical science today.

    Arthur Allen reveals a history of vaccination that is both illuminated with hope and shrouded by controversy - covering Jenner's discovery to Pasteur's vaccines for rabies and cholera, to those that safeguarded the children of the 20th century.

    Conventional wisdom may be wrong. In this controversial book, the eminent biologist Paul W. Ewald offers some startling arguments:-Germs appear to be at the root of heart disease, Alzheimer’s, schizophrenia, many forms of cancer, and other chronic diseases.-The greatest threats to our health come not from sensational killers such as Ebola, West Nile virus, and super-virulent strains of influenza, but from agents that are already here causing long-term infections, which eventually lead to debilitation and death. -The medical establishment has largely ignored the evidence that implicates these germs, to the detriment of our public health.-New evolutionary theories are available, which explain how germs function and offer opportunities for controlling these modern plagues — if we are willing to listen to them.Plague Time is an eye-opening exploration of the revolutionary new understanding of disease that may set the course of medical research for the twenty-first century.

    An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    By the summer of 1918, the second wave struck as a highly contagious and lethal epidemic and within weeks exploded into a pandemic, an illness that travels rapidly from one continent to another. It would impact the course of the war, and kill many millions more soldiers than warfare itself.Of all diseases, the 1918 flu was by far the worst that has ever afflicted humankind; not even the Black Death of the Middle Ages comes close in terms of the number of lives it took. No war, no natural disaster, no famine has claimed so many. In the space of eighteen months in 1918-1919, about 500 million people--one-third of the global population at the time--came down with influenza. The exact total of lives lost will never be known, but the best estimate is between 50 and 100 million. In this powerful book, filled with black and white photographs, nonfiction master Albert Marrin examines the history, science, and impact of this great scourge--and the possibility for another worldwide pandemic today.

    But the president insisted there was nothing to worry about.Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios. Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19.The characters you will meet in these pages are as fascinating as they are unexpected. A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

    That is until 1904, when the disease broke out in a household in Oyster Bay, Long Island. Authorities suspected the family cook, Mary Mallon, of being a carrier. But before she could be tested, the woman, soon to be known as Typhoid Mary, had disappeared. Over the course of the next three years, Mary worked at several residences, spreading her pestilence as she went. In 1907, she was traced to a home on Park Avenue, and taken into custody. Institutionalized at Riverside Hospital for three years, she was released only when she promised never to work as a cook again. She promptly disappeared.For the next five years Mary worked in homes and institutions in and around New York, often under assumed names. In February 1915, a devastating outbreak of typhoid at the Sloane Hospital for Women was traced to her. She was finally apprehended and reinstitutionalized at Riverside Hospital, where she would remain for the rest of her life.Typhoid Mary is the story of her infamous life. Anthony Bourdain reveals the seedier side of the early 1900s, and writes with his renowned panache about life in the kitchen, uncovering the horrifying conditions that allowed the deadly spread of typhoid over a decade. Typhoid Mary is a true feast for history lovers and Bourdain lovers alike.

    Scourges that have plagued human beings since the ancients still threaten to unleash themselves; new maladies are brewing that have yet to make their appearance in the headlines; lethal germs employed as weapons of warfare and terrorism have reemerged as a worldwide menace. Regardless of their mode of attack, microbes exist to multiply, thrive, and find new hosts; they cross national boundaries and social classes, attacking without prejudice. Now medical historian and pediatrician Howard Markel, author of Quarantine! (“Engrossing . . . Meticulously documented” —Sherwin Nuland, The New Republic), tells the story of six epidemics that broke out during the two great waves of immigration to the United States—from 1880 through 1924, and from 1965 to the present—and shows how federal legislation closed the gates to newcomers for almost forty-one years out of fear that these new people would alter the social, political, economic, and even genetic face of the nation. Markel writes about tuberculosis today, the most serious public health threat facing the contemporary world. He writes about bubonic plague and how it came to this country in the early twentieth century; about trachoma in the years before World War I; about Ellis Island and how an East European rabbi was diagnosed and treated for the dreaded eye infection; about typhus fever and an epidemic on the Texas-Mexico border in the aftermath of Pancho Villa’s revolution; and about AIDS, the Haitian exodus, and the early years of the AIDS epidemic.Markel explains how immigration in the twenty-first century is characterized by porous borders, rapid travel, and scattered destinations. While more than 75 percent of all immigrants during the first great wave of immigration came through New York Harbor, transportation today allows travel to all parts of the United States from the farthest reaches of the globe, giving public health physicians little opportunity to definitively diagnose infectious diseases that can incubate silently in a traveler, making the spread of epidemics far more than a theoretical concern.Markel looks at our nation’s response to the pathogens present in our midst and examines our foolhardy attempts at isolation and our vacillation between demanding a public health system so punitive that it worsens matters rather than protects and settling for one that is too lax; how we are fascinated with all things infectious and then hardly give microbes a second thought; how the United States, a country that since its inception has prided itself on being a nation of immigrants, continues its tradition of blaming newcomers for its physical and social ills; and how globalization, social upheaval, and international travel render us all potential inhabitants of the so-called Hot Zone. Finally, Markel puts forth a plan for a globally funded public health program that could stop the spread of epidemics, help eradicate certain diseases, and protect us all.

    When a highly lethal strain of avian flu broke out in Asia in recent years and raced westward, the Washington Post’s Alan Sipress chased the emerging threat as it infiltrated remote jungle villages, mountain redoubts, and teeming cities. He tracked the virus across nine countries, watching its secrets repeatedly elude the world’s brightest scientists and most intrepid disease hunters. Savage and mercurial, this novel influenza strain—H5N1—has been called the kissing cousin of the Spanish flu and, with just a few genetic tweaks, could kill millions of people. None of us is immune.The Fatal Strain is a fast-moving account that weaves cultural, political, and scientific strands into a tale of inevitable epidemic. In his vivid portrayal of the struggle between man and microbe, Sipress chronicles the accelerating number of near misses and explores the cruel dynamic that has often made Asia the fountainhead of killer flu strains. Even more than modern medicine, it is chicken smugglers, fighting cock breeders, and witch doctors who could determine the evolution of this viral menace by allowing it to breed and speeding it on its way.The ease of international travel and the delicate balance of today’s global economy have left the world vulnerable to pandemic in a way the victims of 1918 could never imagine. But it is human failings that may pose the greatest peril. Political bosses in country after country have covered up outbreaks. Ancient customs, like trading in live poultry and the ritual release of birds to earn religious merit, have failed to adapt to the microbial threat. The world’s wealthy countries have left poorer, frontline countries without affordable vaccines or other weapons for confronting the disease, fostering a sense of grievance that endangers us all.The chilling truth is that we don’t have command over the H5N1 virus. It continues to spread, thwarting efforts to uproot it. And as it does, the viral dice continue to roll, threatening to produce a pandemic strain that is both deadly and can spread as easily as the common cold. Swine flu has reminded us that flu epidemics happen. Sipress reminds us something far worse could be brewing.