When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    Her painful early life, however, was quite different. Regina and her four siblings survived an abusive and painful childhood only to find themselves faced with the challenges of the foster-care system and intermittent homelessness in the shadows of Manhattan and the Hamptons.

    Gifted Hands will transplace you into the operating room to witness surgeries that made headlines around the world, and into the private mind of a compassionate, God-fearing physician who lives to help others. In 1987, Dr. Carson gained worldwide recognition for his part in the first successful separation of Siamese twins joined at the back of the head -- an extremely complex and delicate operation that was five months of planning and twenty-two hours of actual surgery, involving a surgical plan that Carson helped initiate. Gifted Hands reveals a man with humility, decency, compassion, courage, and sensitivity who serves as a role model for young people (and everyone else) in need of encouragement to attempt the seemingly impossible and to excel in whatever they attempt. Dr. Carson also describes the key role that his highly intelligent though relatively uneducated mother played in his metamorphosis from an unmotivated ghetto youngster into one of the most respected neurosurgeons in the world.

    Before Nic became addicted to crystal meth, he was a charming boy, joyous and funny, a varsity athlete and honor student adored by his two younger siblings. After meth, he was a trembling wraith who lied, stole, and lived on the streets. David Sheff traces the first warning signs: the denial, the three a.m. phone calls—is it Nic? the police? the hospital? His preoccupation with Nic became an addiction in itself. But as a journalist, he instinctively researched every treatment that might save his son. And he refused to give up on Nic.

    At nine he started working on an original theory in astrophysics that experts believe may someday put him in line for a Nobel Prize, and at age twelve he became a paid researcher in quantum physics. But the story of Kristine’s journey with Jake is all the more remarkable because his extraordinary mind was almost lost to autism. At age two, when Jake was diagnosed, Kristine was told he might never be able to tie his own shoes. The Spark is a remarkable memoir of mother and son. Surrounded by “experts” at home and in special ed who tried to focus on Jake’s most basic skills and curtail his distracting interests—moving shadows on the wall, stars, plaid patterns on sofa fabric—Jake made no progress, withdrew more and more into his own world, and eventually stopped talking completely. Kristine knew in her heart that she had to make a change. Against the advice of her husband, Michael, and the developmental specialists, Kristine followed her instincts, pulled Jake out of special ed, and began preparing him for mainstream kindergarten on her own. Relying on the insights she developed at the daycare center she runs out of the garage in her home, Kristine resolved to follow Jacob’s “spark”—his passionate interests. Why concentrate on what he couldn’t do? Why not focus on what he could? This basic philosophy, along with her belief in the power of ordinary childhood experiences (softball, picnics, s’mores around the campfire) and the importance of play, helped Kristine overcome huge odds. The Barnetts were not wealthy people, and in addition to financial hardship, Kristine herself faced serious health issues. But through hard work and determination on behalf of Jake and his two younger brothers, as well as an undying faith in their community, friends, and family, Kristine and Michael prevailed. The results were beyond anything anyone could have imagined. Dramatic, inspiring, and transformative, The Spark is about the power of love and courage in the face of overwhelming obstacles, and the dazzling possibilities that can occur when we learn how to tap the true potential that lies within every child, and in all of us.

    But there comes a point in her preteen years - maybe it's the night she first tries to run away and is exposed to drugs, alcohol, and sex all at once - when Cupcake's story shifts from a tear-jerking tragedy to a dark, deeply disturbing journey through hell.Cupcake learned to survive by turning tricks, downing hard liquor and ingesting every drug she could find while hitchhiking up and down the California coast. At just 16 she stumbled into the terrifying world of the gangsta, dealing drugs, hustling and only just surviving a drive-by shooting. Ironically, it was Cupcake's rapid descent into the nightmare of crack cocaine addiction that finally saved her. After one four-day crack binge she woke up behind a dumpster. Half-dressed and half-dead, she finally realized she had to change her life or die on the streets - another trash-can addict, another sad statistic.Astonishingly, Cupcake turned her life around and this is her brutally frank, startlingly funny story. Unlike any memoir you will ever read, A Piece of Cake is a redemptive, gripping tale of a resilient spirit who took on the worst of contemporary urban life and survived it. It is also the most genuinely affecting rollercoaster ride through hell and back that you will ever take.

    Trapped in desperate poverty and confronted with unthinkable tragedies, all Andrew ever wanted was to be with his mom. But as her mental health steadily declined, and with no one else left to care for him, authorities arrived and tore Andrew from his screaming mother's arms. In that moment, the life he knew came crashing down around him. He was only seven years old. Hope was institutionalized, and Andrew was placed in what would be his devastating reality for the next eleven years--foster care. After surviving one of our country's most notorious children's facilities, Andrew was thrust into a savagely loveless foster family that refused to accept him as one of their own. Deprived of the nurturing he needed, Andrew clung to academics and the kindness of teachers. All the while, he refused to surrender the love he held for his mother in his heart. Ultimately, Andrew earned a scholarship to Wesleyan, went on to Harvard Law School, and became a Fulbright Scholar. Andrew has dedicated his life's work to helping children living in poverty and in the foster care system. He defied the staggering odds set against him, and here in this heartwrenching, brutally honest, and inspirational memoir, he reveals who Hope's boy really is.

    Nestled in the Smoky Mountains of eastern Tennessee, the town of Johnson City had always seemed exempt from the anxieties of modern American life. But when the local hospital treated its first AIDS patient, a crisis that had once seemed an urban problem had arrived in the town to stay. Working in Johnson City was Abraham Verghese, a young Indian doctor specializing in infectious diseases. Dr. Verghese became by necessity the local AIDS expert, soon besieged by a shocking number of male and female patients whose stories came to occupy his mind, and even take over his life. Verghese brought a singular perspective to Johnson City: as a doctor unique in his abilities; as an outsider who could talk to people suspicious of local practitioners; above all, as a writer of grace and compassion who saw that what was happening in this conservative community was both a medical and a spiritual emergency."

    For most of that time, she didn't know why. All of her trips to the ER and her daily anguish, pain, and lethargy only ever resulted in one question: How could any one person be this sick? Several drug addictions, three major hospitalizations, and over $100,000 later, she finally had a diagnosis: late-stage Lyme disease. Sick is Khakpour's arduous, emotional journey—as a woman, a writer, and a lifelong sufferer of undiagnosed health problems—through the chronic illness that perpetually left her a victim of anxiety, living a life stymied by an unknown condition.Divided by settings, Khakpour guides the reader through her illness by way of the locations that changed her course—New York, LA, New Mexico, and Germany—as she meditates on both the physical and psychological impacts of uncertainty, and the eventual challenge of accepting the diagnosis she had searched for over the course of her adult life. With candor and grace, she examines her subsequent struggles with mental illness, her addiction to the benzodiazepines prescribed by her psychiatrists, and her ever-deteriorating physical health. A story about survival, pain, and transformation, Sick is a candid, illuminating narrative of hope and uncertainty, boldly examining the deep impact of illness on one woman's life.

    After an emergency landing, she discovered that Dave—a healthy thirty-year-old athlete and surgical resident—had suffered a rare and life-threatening stroke. Next thing Allison knew, she was sitting alone in the ER in Fargo, North Dakota, waiting to hear if her husband would survive the night. When Dave woke up, he could not carry memories from hour to hour, much less from one day to the next. Allison lost the Dave she knew and loved when he lost consciousness on the plane. Within a few months, she found herself caring for both a newborn and a sick husband, struggling with the fear of what was to come. As a way to make sense of the pain and chaos of their new reality, Allison started to write daily letters to Dave. Not only would she work to make sense of the unfathomable experiences unfolding around her, but her letters would provide Dave with the memories he could not make on his own. She was writing to preserve their past, protect their present, and fight for their future. Those letters became the foundation for this beautiful, intimate memoir. And in the process, she fell in love with her husband all over again. This is a manifesto for living, an ultimately uplifting story about the transformative power of faith and resilience. It’s a tale of a husband’s turbulent road to recovery, the shifting nature of marriage, and the struggle of loving through pain and finding joy in the broken places.

    Parents and family members who never thought they could get inside the head of their autistic loved one, at last, have a way to break through to the curious, subtle, and complex life within.Using an alphabet grid to painstakingly construct words, sentences, and thoughts that he is unable to speak out loud, Naoki answers even the most delicate questions that people want to know. Questions such as: “Why do people with autism talk so loudly and weirdly?” “Why do you line up your toy cars and blocks?” “Why don’t you make eye contact when you’re talking?” and “What’s the reason you jump?” (Naoki’s answer: “When I’m jumping, it’s as if my feelings are going upward to the sky.”) With disarming honesty and a generous heart, Naoki shares his unique point of view on not only autism but life itself. His insights—into the mystery of words, the wonders of laughter, and the elusiveness of memory—are so startling, so strange, and so powerful that you will never look at the world the same way again.

    Merril Jessop already had three wives. But arranged plural marriages were an integral part of Carolyn’s heritage: She was born into and raised in the Fundamentalist Church of Jesus Christ of Latter-Day Saints (FLDS), the radical offshoot of the Mormon Church that had settled in small communities along the Arizona-Utah border. Over the next fifteen years, Carolyn had eight children and withstood her husband’s psychological abuse and the watchful eyes of his other wives who were locked in a constant battle for supremacy.Carolyn’s every move was dictated by her husband’s whims. He decided where she lived and how her children would be treated. He controlled the money she earned as a school teacher. He chose when they had sex; Carolyn could only refuse—at her peril. For in the FLDS, a wife’s compliance with her husband determined how much status both she and her children held in the family. Carolyn was miserable for years and wanted out, but she knew that if she tried to leave and got caught, her children would be taken away from her. No woman in the country had ever escaped from the FLDS and managed to get her children out, too. But in 2003, Carolyn chose freedom over fear and fled her home with her eight children. She had $20 to her name.Escape exposes a world tantamount to a prison camp, created by religious fanatics who, in the name of God, deprive their followers the right to make choices, force women to be totally subservient to men, and brainwash children in church-run schools. Against this background, Carolyn Jessop’s flight takes on an extraordinary, inspiring power. Not only did she manage a daring escape from a brutal environment, she became the first woman ever granted full custody of her children in a contested suit involving the FLDS. And in 2006, her reports to the Utah attorney general on church abuses formed a crucial part of the case that led to the arrest of their notorious leader, Warren Jeffs.

    After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony—and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family?What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations.With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

    She has managed to achieve this in spite of being diagnosed as schizophrenic and given a "grave" prognosis—and suffering the effects of her illness throughout her life.Saks was only eight, and living an otherwise idyllic childhood in sunny 1960s Miami, when her first symptoms appeared in the form of obsessions and night terrors. But it was not until she reached Oxford University as a Marshall Scholar that her first full-blown episode, complete with voices in her head and terrifying suicidal fantasies, forced her into a psychiatric hospital.Saks would later attend Yale Law School where one night, during her first term, she had a breakdown that left her singing on the roof of the law school library at midnight. She was taken to the emergency room, force-fed antipsychotic medication, and tied hand-and-foot to the cold metal of a hospital bed. She spent the next five months in a psychiatric ward.So began Saks's long war with her own internal demons and the equally powerful forces of stigma. Today she is a chaired professor of law who researches and writes about the rights of the mentally ill. She is married to a wonderful man.In The Center Cannot Hold, Elyn Saks discusses frankly and movingly the paranoia, the inability to tell imaginary fears from real ones, and the voices in her head insisting she do terrible things, as well as the many obstacles she overcame to become the woman she is today. It is destined to become a classic in the genre.

    Instead, he finds that he has joined a new world where race is front and center. The recipient of a scholarship designed to increase black student enrollment, Tweedy soon meets a professor who bluntly questions whether he belongs in medical school, a moment that crystallizes the challenges he will face throughout his career. Making matters worse, in lecture after lecture the common refrain for numerous diseases resounds, "More common in blacks than in whites."Black Man in a White Coat examines the complex ways in which both black doctors and patients must navigate the difficult and often contradictory terrain of race and medicine. As Tweedy transforms from student to practicing physician, he discovers how often race influences his encounters with patients. Through their stories, he illustrates the complex social, cultural, and economic factors at the root of many health problems in the black community. These issues take on greater meaning when Tweedy is himself diagnosed with a chronic disease far more common among black people. In this powerful, moving, and deeply empathic book, Tweedy explores the challenges confronting black doctors, and the disproportionate health burdens faced by black patients, ultimately seeking a way forward to better treatment and more compassionate care.