The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    They have destroyed cities and ended civilizations. John Dvorak, the acclaimed author of Earthquake Storms, looks into the early years of volcanology and its "father," Thomas Jaggar. Jaggar was the youngest of five scientists to investigate the explosion of Mount Pelee in Martinique, which leveled the entire city of St. Pierre and killed its entire population in two minutes. This explosion changed science forever, and Jaggar became obsessed with understanding the force of nature that could do this.A colorful cast of scientists wind their way through The Last Volcano, including an escaped slave who became the leading volcanic guide in Hawaii. But the focus is on Jaggar, who was so fixated on volcanology that he moved to a small house overlooking the lava lake of Kilauea, much to the derision of the scientific community.Falling in love a widowed schoolteacher who shared his passion, Jaggar devoted his life to studying volcanic activity and the mysteries beneath the earth's surface. From their precarious perch, this dynamic husband and wife duo would discover a way to predict volcanic eruptions and tsunamis, promote geothermal energy, and theorize new ways to study the ocean bottom.

    Her mother, a distant relative of William Faulkner, told neighbors and family that her daughter had died. The two never saw each other again. Nearly twenty-five years later, after building her own family and happy home life, a lawyer called to say her mother was dead. In this story about the fragility of memory and the complexity of family, Beam decides to look back at her own dark history, and for the secret to her mother’s madness.

    

    Intended for developers who are already familiar with the Apex language, and experienced Java and C# developers who are moving to Apex, this book starts where the Force.com documentation leaves off. Instead of trying to cover all of the features of the platform, Advanced Apex programming focuses entirely on the Apex language and core design patterns. You’ll learn how to truly think in Apex – to embrace limits and bulk patterns. You’ll see how to develop architectures for efficient and reliable trigger handling, and for asynchronous operations. You’ll discover that best practices differ radically depending on whether you are building software for a specific organization or for a managed package. And you’ll find approaches for incorporating testing and diagnostic code that can dramatically improve the reliability and deployment of Apex software, and reduce your lifecycle and support costs. Based on his experience both as a consultant and as architect of a major AppExchange package, Dan Appleman focuses on the real-world problems and issues that are faced by Apex developers every day, along with the obscure problems and surprises that can sneak up on you if you are unprepared.

    You would find yourself closely connected to these stories. They will encourage you to explore your own potential to inspire you, and to achieve your real worth. This book will also help you to understand the traits that keep you from achieving your dreams. The book lays down a process to help you emerge from the clutches of negativity and develop a positive approach towards life.By investing time in yourself, acknowledging your potential, setting a worthy goal, avoiding common traps, surviving bad days and harvesting the power of thoughts, you can be successful.Read this interesting book to Know Your Worth.-------------------------------------------------N.K. Sondhi:N.K. Sondhi’s first book was 'Management of Banking', which draws upon his experiences as a manager in the Punjab National Bank. He then turned to fiction writing, bringing forth the seen and unseen aftermaths of the partition of India in 1947 in his novel 'Cart full of Husk'. He followed it up with a short non-fiction, 'Forgotten City of Delhi (How Delhi became Delhi)'. He wrote his next book, 'A Match Made in Heaven: A 2000-year-old love story', based on the life of an Indian princess, who became first queen of Korea in 48 AD.Working with young people as he pursued social activities after his retirement, he sensed the restlessness among youngsters, who are facing a large number of problems due to stiff neck to neck competition in every field of life. Growing use of advanced technology has further alienated them from the main stream of the society. This has led him to initiate this book 'Know Your Worth' with the young and enterprising writer Ms. Vibha Malhotra.-------------------------------------------------Vibha Malhotra:Vibha Malhotra is the founder of 'Literature Studio' and editor-in-chief of the literary e-journal 'Literature Studio Review'. In the past, she has worked as an editor with Dorling Kindersley (Penguin Random House) where she has edited beautiful coffee table books on subjects such as history, nature, fitness, lifestyle, and travel.She is also a poet and a translator. Her work has been published in literary journals across the world such as Wasafiri, Muse India, Tipton Poetry Journal, The Luxembourg Review, Red Fez, and in dailies such as The Times of India and Ceylon Today. 'Know Your Worth' is her first work as an author.Vibha holds a Master of Arts in Creative Writing from Newcastle University, UK. She teaches creative writing to all age groups. By Profession, Vibha is a Lead Software Engineer at Adobe Systems.-------------------------------------------------CONTENTS1. Acknowledge Your Superpowers2. Invest in Yourself3. Take Charge4. Set a Worthy Goal5. Identify Your Worst Enemy6. Turn Your Fear into an Opportunity7. Avoid the Common Traps8. Harvest the Power of Thoughts9. Watch Your Attitude10. Keep Your Communication Clear11. Be Mindful12. Surviving Bad Days13. Nurture Your Ecosystem14. Stay SuccessfulINVEST IN YOURSELF Now that you know that you have superpowers that are there within you and can be harvested whenever you need them, it is important to take time to really explore all your strengths and weaknesses. Only then can you be fully prepared to achieve your goals. But we are mostly clueless that understanding ourselves doesn’t have to be a slow, tedious process, it can always be sped up.All of us are born with inherent likes and dislikes. Even a fetus in the womb has its own taste preferences, resulting in the seemingly irrational food cravings that expecting mothers experience. These preferences, likes, and dislikes are clues to the things you will be good at. If a child enjoys painting more than singing, chances are that the child will be better at painting than he/she is at singing. You can think of these as clues that nature chose to expose to us so that we can carve a satisfying path for ourselves.Most of us, even as adults, have whims, and mostly we choose to ignore them. Even as children, we are rarely able to indulge in every whim. There are always limitations – in terms of time, finances, facilities etc. – to keep us from fully exploring what we are capable of. But these are not the only factors that stop us. The biggest factor, in fact, is our own inhibitions, especially once we are grown-ups. We are afraid of new experiences, afraid of disappointment, afraid of failure, afraid of making fools of ourselves. And this fear keeps us from taking advantage of opportunities to gather new experiences. Let us try to understand this with the example of a young girl called Shikha. Shikha and the Ideation CompetitionShikha was an editor at a publishing house. She was very good at her job and apart from being an excellent editor, she also often proposed new book ideas to the publishing house.The publishing house announced a competition in which teams would work together and come up with new book ideas that they would then present to a jury comprising of senior publishers from all over the world. The selected idea would then be converted into a book that would be sold all over the world.Shikha had never ever participated in a competition, let alone won it. She wasn’t at all confident of her abilities to work in a team. And the fact that the competition was about new book ideas was making her restless. By proposing new book ideas in the past, she had earned a reputation in that area. Her colleagues and even her boss thought of her as a creative thinker. Shikha was worried that if she participated in this competition and lost it, her reputation as a creative thinker would be tarnished too. Can you guess why she was so full of doubts? It was because she had always attributed her past achievements to good luck, and had never given herself any credit for the book ideas she had come up with. Thus, she was afraid of being exposed as someone who really did not possess any great talent.She was still in this state of dilemma when she discovered that her manager had already nominated Shikha’s name for the competition. Now she had no choice, so she decided to go with the flow. With each passing day, her desperation to win the contest increased, and by the time the date of the competition arrived, she found herself unable to sleep. She knew that she would do anything to win this competition. For the first time in her life she was this passionate about something. She wanted to give it her all.On the day of the competition, she was put in a team and the team started with discussing the various ideas that all members had. Shikha had a great idea, but when she saw more merit in the idea proposed by another team member, she voted for it to be taken up for further preparation and the final presentation. She was almost feverish with excitement. And when her team members were of the opinion that they should give their best and not really care if they win or lose, Shikha was single-minded about her goal of winning the competition. Her focus proved to be contagious and soon all her team-members too were bubbling with enthusiasm. Guided by their single goal, the group of strangers really became a team and the initial idea evolved to become something they all believed in. Though the team leader was someone else, everyone could see that Shikha was the driving force for the team. When it was time to present their idea, the team leader proposed that Shikha should do it. And the presentation left the judges mesmerized. When their team emerged the winner, no one was surprised. Their idea and their presentation of it were deemed to be the best.Once she was out of the competition frenzy, Shikha herself was surprised. She couldn’t understand what had come over her during the competition. But she was glad to discover this other Shikha. She had gone into the competition based on her creative thinking, but her team had emerged a winner because of her team spirit and leadership skills. Shikha was surprised to discover these two new skills in herself. She had never thought herself capable of what she had achieved. Most of us are like Shikha – capable, but afraid of failure and public ridicule. And this is why we do not take chances in life. We like to play safe. But one can never really truly understand oneself by remaining in a shell. Unless you experience new things, you can never experience a new you. Unless you take risks, you can never transcend your normal, day-to-day existence.But, what gives us the capacity to take risks? Our confidence on our strengths and abilities. And from where do we get this confidence? Unfortunately, it isn’t a commodity and you cannot buy it from a shop. Money can’t buy you confidence. You need to work hard to develop it. You need to test yourself, which is again done by putting yourself in situations that you feel are beyond your reach. So, this is once again a chicken-and-egg situation. But after you have been through some such cycles and are confident of the situations you can handle, you are in a better position to fix your goals.However, it is easier said than done. Unfortunately, life is not a fairy tale and this means that we will not succeed every time we take up a challenge. There will also be times when we fail. This is inevitable. We will invariably have to face problems, and this may shake our confidence. Dealing with failures is not easy. It is like a double-edged sword. If you take failures too seriously, they may end up crushing you. On the other hand, if you take them too lightly, you will not learn any lessons from them, which means that the risk that you took would go to waste. So, you need to recognize failures for what they are – failures. Nothing more, nothing less. If you fail in a challenge, it does not mean that you yourself are a failure. This is the most common mistake we commit. Failing a challenge means that you failed that challenge. You need to analyze the situation, see what you could have done better, and move on to the next challenge where you can test your learnings.This act of never giving up, will give you confidence and this confidence helps us realize our capabilities. And this, in turn, shows in our personality. We hold our head high. We walk with determination. We talk with conviction, and we are normally in a good mood. Confidence also gives us perseverance – the ability to keep going after a failure. If you haven’t invested in yourself, you are more likely to give up after a failure or two.Confidence helps us stay on our path and not go astray. Many hurdles and problems may block our way and discourage us, but if we have confidence, we will not let these hurdles stop us. Instead we will search for an alternate path to our goal. The Little Bird and the BranchOnce a little bird landed on a branch high up a tall tree. The jungle below was full of dangerous predators but at this height, they posed no danger to the little bird. Feeling safe and protected, the little bird rested, enjoying the beautiful view around, and feeling completely at peace. Just as the bird became used to the branch, a strong wind started blowing, shaking the entire tree. The tree swayed with such intensity that it appeared the branch would break and fall down.To other animals, this could be a matter of great worry, but the little bird was not worried. Do you know why? Because the little bird knew its own powers and strengths. Even if the branch was to fall down, the bird knew that it had wings and the ability to fly. And the bird was also aware that if this branch was to fall, there are many other branches that could be used instead. Therefore, the bird, though tiny in size, sat on the branch, braving the high wind. The animals below, all of them much stronger than the bird, were filled with much admiration for this courageous little creature who was braving difficult circumstances. The story of this small bird tells us a lot about our own self-confidence and courage. If one road is blocked there are others we can follow. And if there are no new roads, there’s always the earth on which we can make a new road.

    In Understanding ECMAScript 6, expert developer Nicholas C. Zakas provides a complete guide to the object types, syntax, and other exciting changes that ECMAScript 6 brings to JavaScript. Every chapter is packed with example code that works in any JavaScript environment so you'll be able to see new features in action. You'll learn:How ECMAScript 6 class syntax relates to more familiar JavaScript conceptsWhat makes iterators and generators usefulHow arrow functions differ from regular functionsWays to store data with sets, maps, and moreThe power of inheritanceHow to improve asynchronous programming with promisesHow modules change the way you organize codeWhether you're a web developer or a Node.js developer, you'll find Understanding ECMAScript 6 indispensable on your journey from ECMAScript 5 to ECMAScript 6.

    The aim of The Node Beginner Book is to get you started with developing applications for Node.js, teaching you everything you need to know about advanced JavaScript along the way on 59 pages.

    Gates says, "we can work on a local, national, and global level to build the technologies, businesses, and industries to avoid the worst impacts of climate change." His interest in climate change is a natural outgrowth of the efforts by his foundation to reduce poverty and disease. Climate change, according to Gates, will have the biggest impact on the people who have done the least to cause it. As a technologist, he has seen first-hand how innovation can change the world. By investing in research, inventing new technologies, and by deploying them quickly at large scale, Gates believes climate change can be addressed in meaningful ways. According to Gates, "to prevent the worst effects of climate change, we have to get to net-zero emissions of greenhouse gases. This problem is urgent, and the debate is complex, but I believe we can come together to invent new carbon-zero technologies, deploy the ones we have, and ultimately avoid a climate catastrophe."

    From wild baboons to gooey slime molds, most every living organism instinctually knows how to balance their diets, except modern-day humans. When and why did we lose this ability, and how can we get it back? David Raubenheimer and Stephen Simpson reveal the answers to these questions in a gripping tale of evolutionary biology and nutritional science, based upon years of groundbreaking research. Their colorful scientific journey takes readers across the globe, from the foothills of Cape Town, to the deserts of Arizona, to a state-of-the-art research center in Sydney. Readers will encounter locusts, mice and even gorillas along the way as the scientists test their hypotheses on various members of the animal kingdom. This epic scientific adventure culminates in a unifying theory of nutrition that has profound implications for our current epidemic of metabolic diseases and obesity. Raubenheimer and Simpson ultimately offer useful advice to understand the unwanted side effects of fad diets, gain control over one’s food environment, and see that delicious and healthy are integral parts of proper eating.

    High-profile projects such as the Linux Kernel, Mozilla, Gnome, and Ruby on Rails are now using Distributed Version Control Systems (DVCS) instead of the old stand-bys of CVS or Subversion.Git is a modern, fast, DVCS. But understanding how it fits into your development can be a daunting task without an introduction to the new concepts. Whether you're just starting out as a professional programmer or are an old hand, this book will get you started using Git in this new distributed world. Whether you're making the switch from a traditional centralized version control system or are a new programmer just getting started, this book prepares you to start using Git in your everyday programming.Pragmatic Version Control Using Git starts with an overview of version control systems, and shows how being distributed enables you to work more efficiently in our increasingly mobile society. It then progresses through the basics necessary to get started using Git.You'll get a thorough overview of how to take advantage of Git. By the time you finish this book you'll have a firm grounding in how to use Git, both by yourself and as part of a team.Learn how to use how to use Git to protect all the pieces of your project Work collaboratively in a distributed environment Learn how to use Git's cheap branches to streamline your development Install and administer a Git server to share your repository

    The trial itself was sensational enough to attract the attention of the world’s largest association of professional forensic investigators. At the start, everyone expected a ‘guilty’ verdict. His fingerprints were at the scene, the murder weapon was in his car and a blood stain in the bathroom was matched to one of his shoes. And yet, he was acquitted and is now suing the Minister of Police, saying that the evidence was fabricated. Altbeker witnessed the trial, and looks closely at how the justice system failed both van der Vyver and Lotz.

    This involves taking detailed and technical product information and distilling it into key marketing and sales messages as well as working among several teams in an organization to plan and execute product releases and launches. This book is a must-have for anyone who works as, or with, a Product Marketing Manager. It not only explains the role but focuses on practical applications of the information presented and ties everything together with entertaining life lessons and anecdotes collected through years of experience by the author as well as interviews with his colleagues and other industry experts. If you are considering a career as a Product Marketing Manager, are new to the profession and looking for guidance and clarification, already have many years of experience in the role and are looking for new inspiration and ideas, or are interested in learning what a Product Marketing Manager colleague of yours is responsible for within your organization, this book is for you.

    If you want to leverage OpenGL 2.1's major improvements, you really need the Fourth Edition. It's a comprehensive tutorial, systematic API reference, and massive code library, all in one. You'll start with the fundamental techniques every graphics programmer needs: transformations, lighting, texture mapping, and so forth. Then, building on those basics, you'll move towards newer capabilities, from advanced buffers to vertex shaders. Of course, OpenGL's cross-platform availability remains one of its most compelling features. This book's extensive multiplatform coverage has been thoroughly rewritten, and now addresses everything from Windows Vista to OpenGL ES for handhelds. This is stuff you absolutely want the latest edition for. A small but telling point: This book's recently been invited into Addison-Wesley's OpenGL Series, making it an "official" OpenGL book -- and making a powerful statement about its credibility. Bill Camarda, from the August 2007 href="http://www.barnesandnoble.com/newslet... Only

    Her only worries are schoolwork, keeping up with her best friend and whether she should sleep with her boyfriend. Then her adoptive father disappears one winter's day. As she tries to find out why he left her, her past unravels in front of her.